Nuclear pore protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP96

Species:

Leishmania mexicana

UniProt:

E9AT28_LEIMU

TriTrypDb:

LmxM.36.2510

Length:

900

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	12
GO:0016020	membrane	2	12
GO:0032991	protein-containing complex	1	12
GO:0110165	cellular anatomical entity	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0044612	nuclear pore linkers	3	1

Expansion

Sequence features

E9AT28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT28

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0015931	nucleobase-containing compound transport	5	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0050657	nucleic acid transport	6	12
GO:0050658	RNA transport	4	12
GO:0051028	mRNA transport	5	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051236	establishment of RNA localization	3	12
GO:0051641	cellular localization	2	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0006405	RNA export from nucleus	5	1
GO:0006406	mRNA export from nucleus	6	1
GO:0006606	protein import into nucleus	5	1
GO:0006886	intracellular protein transport	4	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0016973	poly(A)+ mRNA export from nucleus	7	1
GO:0033365	protein localization to organelle	5	1
GO:0034504	protein localization to nucleus	6	1
GO:0046907	intracellular transport	3	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051170	import into nucleus	6	1
GO:0051649	establishment of localization in cell	3	1
GO:0072594	establishment of protein localization to organelle	4	1

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	12
GO:0017056	structural constituent of nuclear pore	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.547
CLV_C14_Caspase3-7	407	411	PF00656	0.473
CLV_C14_Caspase3-7	55	59	PF00656	0.585
CLV_C14_Caspase3-7	555	559	PF00656	0.348
CLV_C14_Caspase3-7	789	793	PF00656	0.488
CLV_MEL_PAP_1	386	392	PF00089	0.475
CLV_NRD_NRD_1	11	13	PF00675	0.771
CLV_NRD_NRD_1	126	128	PF00675	0.515
CLV_NRD_NRD_1	176	178	PF00675	0.584
CLV_NRD_NRD_1	318	320	PF00675	0.449
CLV_NRD_NRD_1	333	335	PF00675	0.341
CLV_NRD_NRD_1	337	339	PF00675	0.315
CLV_NRD_NRD_1	603	605	PF00675	0.395
CLV_NRD_NRD_1	712	714	PF00675	0.451
CLV_NRD_NRD_1	73	75	PF00675	0.545
CLV_PCSK_KEX2_1	11	13	PF00082	0.785
CLV_PCSK_KEX2_1	126	128	PF00082	0.638
CLV_PCSK_KEX2_1	176	178	PF00082	0.575
CLV_PCSK_KEX2_1	318	320	PF00082	0.449
CLV_PCSK_KEX2_1	333	335	PF00082	0.413
CLV_PCSK_KEX2_1	603	605	PF00082	0.349
CLV_PCSK_KEX2_1	712	714	PF00082	0.475
CLV_PCSK_KEX2_1	861	863	PF00082	0.402
CLV_PCSK_PC1ET2_1	861	863	PF00082	0.455
CLV_PCSK_SKI1_1	285	289	PF00082	0.517
CLV_PCSK_SKI1_1	468	472	PF00082	0.437
CLV_PCSK_SKI1_1	512	516	PF00082	0.362
CLV_PCSK_SKI1_1	547	551	PF00082	0.388
CLV_PCSK_SKI1_1	830	834	PF00082	0.372
DEG_APCC_DBOX_1	337	345	PF00400	0.328
DEG_APCC_DBOX_1	39	47	PF00400	0.664
DEG_APCC_DBOX_1	511	519	PF00400	0.363
DEG_Nend_Nbox_1	1	3	PF02207	0.695
DEG_SCF_FBW7_2	415	422	PF00400	0.398
DOC_CKS1_1	500	505	PF01111	0.398
DOC_CYCLIN_yCln2_LP_2	580	586	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	795	801	PF00134	0.449
DOC_MAPK_gen_1	347	356	PF00069	0.425
DOC_MAPK_MEF2A_6	163	170	PF00069	0.632
DOC_MAPK_MEF2A_6	447	455	PF00069	0.344
DOC_MAPK_MEF2A_6	592	601	PF00069	0.449
DOC_MAPK_MEF2A_6	686	694	PF00069	0.363
DOC_MAPK_MEF2A_6	830	837	PF00069	0.184
DOC_MAPK_NFAT4_5	163	171	PF00069	0.635
DOC_PP2B_LxvP_1	580	583	PF13499	0.449
DOC_PP2B_LxvP_1	726	729	PF13499	0.449
DOC_PP2B_LxvP_1	795	798	PF13499	0.420
DOC_PP4_FxxP_1	701	704	PF00568	0.184
DOC_PP4_FxxP_1	799	802	PF00568	0.449
DOC_USP7_MATH_1	144	148	PF00917	0.631
DOC_USP7_MATH_1	232	236	PF00917	0.718
DOC_USP7_MATH_1	242	246	PF00917	0.438
DOC_USP7_MATH_1	503	507	PF00917	0.385
DOC_USP7_MATH_1	729	733	PF00917	0.475
DOC_USP7_MATH_1	848	852	PF00917	0.417
DOC_USP7_MATH_1	881	885	PF00917	0.490
DOC_WW_Pin1_4	415	420	PF00397	0.397
DOC_WW_Pin1_4	459	464	PF00397	0.398
DOC_WW_Pin1_4	499	504	PF00397	0.475
DOC_WW_Pin1_4	716	721	PF00397	0.425
LIG_14-3-3_CanoR_1	225	234	PF00244	0.685
LIG_14-3-3_CanoR_1	338	342	PF00244	0.443
LIG_14-3-3_CanoR_1	40	44	PF00244	0.580
LIG_14-3-3_CanoR_1	468	474	PF00244	0.428
LIG_14-3-3_CanoR_1	488	495	PF00244	0.296
LIG_14-3-3_CanoR_1	531	536	PF00244	0.328
LIG_14-3-3_CanoR_1	575	584	PF00244	0.447
LIG_14-3-3_CanoR_1	592	597	PF00244	0.296
LIG_14-3-3_CanoR_1	604	610	PF00244	0.383
LIG_14-3-3_CanoR_1	661	668	PF00244	0.475
LIG_14-3-3_CanoR_1	731	735	PF00244	0.437
LIG_14-3-3_CanoR_1	834	844	PF00244	0.480
LIG_14-3-3_CanoR_1	849	858	PF00244	0.320
LIG_14-3-3_CanoR_1	868	873	PF00244	0.407
LIG_14-3-3_CanoR_1	882	886	PF00244	0.276
LIG_Actin_WH2_2	474	490	PF00022	0.427
LIG_BIR_III_4	401	405	PF00653	0.475
LIG_Clathr_ClatBox_1	598	602	PF01394	0.369
LIG_CSL_BTD_1	193	196	PF09270	0.638
LIG_EH1_1	534	542	PF00400	0.449
LIG_eIF4E_1	446	452	PF01652	0.363
LIG_eIF4E_1	593	599	PF01652	0.344
LIG_FHA_1	105	111	PF00498	0.605
LIG_FHA_1	177	183	PF00498	0.607
LIG_FHA_1	221	227	PF00498	0.522
LIG_FHA_1	286	292	PF00498	0.424
LIG_FHA_1	3	9	PF00498	0.776
LIG_FHA_1	305	311	PF00498	0.229
LIG_FHA_1	34	40	PF00498	0.679
LIG_FHA_1	476	482	PF00498	0.367
LIG_FHA_1	658	664	PF00498	0.369
LIG_FHA_1	686	692	PF00498	0.475
LIG_FHA_1	806	812	PF00498	0.484
LIG_FHA_2	292	298	PF00498	0.612
LIG_FHA_2	439	445	PF00498	0.328
LIG_FHA_2	553	559	PF00498	0.348
LIG_FHA_2	869	875	PF00498	0.475
LIG_GBD_Chelix_1	532	540	PF00786	0.321
LIG_LIR_Apic_2	699	704	PF02991	0.184
LIG_LIR_Gen_1	203	212	PF02991	0.611
LIG_LIR_Gen_1	303	313	PF02991	0.499
LIG_LIR_Gen_1	483	492	PF02991	0.328
LIG_LIR_Gen_1	613	624	PF02991	0.441
LIG_LIR_Gen_1	765	772	PF02991	0.343
LIG_LIR_Gen_1	792	802	PF02991	0.425
LIG_LIR_Nem_3	147	152	PF02991	0.700
LIG_LIR_Nem_3	203	208	PF02991	0.570
LIG_LIR_Nem_3	303	309	PF02991	0.388
LIG_LIR_Nem_3	483	489	PF02991	0.328
LIG_LIR_Nem_3	613	619	PF02991	0.392
LIG_LIR_Nem_3	765	769	PF02991	0.343
LIG_LIR_Nem_3	792	797	PF02991	0.425
LIG_LIR_Nem_3	884	890	PF02991	0.575
LIG_LYPXL_yS_3	887	890	PF13949	0.559
LIG_NRBOX	340	346	PF00104	0.413
LIG_NRBOX	450	456	PF00104	0.328
LIG_NRBOX	545	551	PF00104	0.417
LIG_PDZ_Class_2	895	900	PF00595	0.466
LIG_Pex14_1	194	198	PF04695	0.652
LIG_Pex14_1	283	287	PF04695	0.374
LIG_Pex14_1	381	385	PF04695	0.344
LIG_Pex14_2	190	194	PF04695	0.648
LIG_RPA_C_Fungi	69	81	PF08784	0.696
LIG_SH2_CRK	593	597	PF00017	0.344
LIG_SH2_NCK_1	278	282	PF00017	0.551
LIG_SH2_NCK_1	393	397	PF00017	0.363
LIG_SH2_NCK_1	94	98	PF00017	0.709
LIG_SH2_PTP2	198	201	PF00017	0.674
LIG_SH2_SRC	278	281	PF00017	0.548
LIG_SH2_SRC	436	439	PF00017	0.449
LIG_SH2_SRC	814	817	PF00017	0.449
LIG_SH2_SRC	94	97	PF00017	0.720
LIG_SH2_STAP1	779	783	PF00017	0.427
LIG_SH2_STAT5	198	201	PF00017	0.648
LIG_SH2_STAT5	290	293	PF00017	0.540
LIG_SH2_STAT5	328	331	PF00017	0.349
LIG_SH2_STAT5	593	596	PF00017	0.363
LIG_SH2_STAT5	618	621	PF00017	0.321
LIG_SH2_STAT5	814	817	PF00017	0.449
LIG_SH2_STAT5	818	821	PF00017	0.449
LIG_SH3_3	795	801	PF00018	0.330
LIG_SH3_3	882	888	PF00018	0.449
LIG_Sin3_3	449	456	PF02671	0.184
LIG_SUMO_SIM_anti_2	247	256	PF11976	0.575
LIG_SUMO_SIM_anti_2	301	308	PF11976	0.428
LIG_SUMO_SIM_anti_2	595	600	PF11976	0.345
LIG_SUMO_SIM_par_1	520	525	PF11976	0.390
LIG_TRAF2_1	76	79	PF00917	0.660
LIG_TYR_ITIM	885	890	PF00017	0.568
LIG_WRC_WIRS_1	532	537	PF05994	0.449
LIG_WRC_WIRS_1	766	771	PF05994	0.475
MOD_CK1_1	147	153	PF00069	0.699
MOD_CK1_1	228	234	PF00069	0.629
MOD_CK1_1	244	250	PF00069	0.664
MOD_CK1_1	256	262	PF00069	0.522
MOD_CK1_1	3	9	PF00069	0.744
MOD_CK1_1	42	48	PF00069	0.615
MOD_CK1_1	506	512	PF00069	0.449
MOD_CK1_1	622	628	PF00069	0.439
MOD_CK1_1	679	685	PF00069	0.449
MOD_CK1_1	730	736	PF00069	0.348
MOD_CK2_1	575	581	PF00069	0.393
MOD_CK2_1	86	92	PF00069	0.722
MOD_CK2_1	868	874	PF00069	0.475
MOD_GlcNHglycan	14	17	PF01048	0.710
MOD_GlcNHglycan	142	145	PF01048	0.645
MOD_GlcNHglycan	146	149	PF01048	0.652
MOD_GlcNHglycan	21	26	PF01048	0.665
MOD_GlcNHglycan	234	237	PF01048	0.677
MOD_GlcNHglycan	244	247	PF01048	0.474
MOD_GlcNHglycan	255	258	PF01048	0.525
MOD_GlcNHglycan	362	365	PF01048	0.475
MOD_GlcNHglycan	496	500	PF01048	0.482
MOD_GlcNHglycan	566	569	PF01048	0.459
MOD_GlcNHglycan	577	580	PF01048	0.396
MOD_GlcNHglycan	621	624	PF01048	0.449
MOD_GlcNHglycan	676	681	PF01048	0.441
MOD_GlcNHglycan	837	840	PF01048	0.452
MOD_GlcNHglycan	852	855	PF01048	0.298
MOD_GSK3_1	140	147	PF00069	0.481
MOD_GSK3_1	220	227	PF00069	0.680
MOD_GSK3_1	228	235	PF00069	0.662
MOD_GSK3_1	240	247	PF00069	0.659
MOD_GSK3_1	285	292	PF00069	0.462
MOD_GSK3_1	29	36	PF00069	0.601
MOD_GSK3_1	300	307	PF00069	0.359
MOD_GSK3_1	324	331	PF00069	0.413
MOD_GSK3_1	371	378	PF00069	0.427
MOD_GSK3_1	495	502	PF00069	0.441
MOD_GSK3_1	657	664	PF00069	0.413
MOD_GSK3_1	729	736	PF00069	0.338
MOD_LATS_1	175	181	PF00433	0.655
MOD_N-GLC_1	360	365	PF02516	0.475
MOD_N-GLC_1	552	557	PF02516	0.367
MOD_N-GLC_1	785	790	PF02516	0.406
MOD_N-GLC_1	849	854	PF02516	0.359
MOD_N-GLC_2	528	530	PF02516	0.398
MOD_N-GLC_2	85	87	PF02516	0.709
MOD_NEK2_1	1	6	PF00069	0.716
MOD_NEK2_1	104	109	PF00069	0.537
MOD_NEK2_1	226	231	PF00069	0.597
MOD_NEK2_1	305	310	PF00069	0.409
MOD_NEK2_1	487	492	PF00069	0.385
MOD_NEK2_1	564	569	PF00069	0.364
MOD_NEK2_1	610	615	PF00069	0.372
MOD_NEK2_1	619	624	PF00069	0.293
MOD_NEK2_1	641	646	PF00069	0.406
MOD_NEK2_1	696	701	PF00069	0.403
MOD_NEK2_1	70	75	PF00069	0.650
MOD_NEK2_2	404	409	PF00069	0.475
MOD_NEK2_2	503	508	PF00069	0.475
MOD_PIKK_1	104	110	PF00454	0.554
MOD_PIKK_1	522	528	PF00454	0.449
MOD_PIKK_1	696	702	PF00454	0.411
MOD_PIKK_1	737	743	PF00454	0.433
MOD_PK_1	177	183	PF00069	0.684
MOD_PK_1	592	598	PF00069	0.449
MOD_PKA_1	176	182	PF00069	0.624
MOD_PKA_1	318	324	PF00069	0.475
MOD_PKA_2	176	182	PF00069	0.602
MOD_PKA_2	224	230	PF00069	0.666
MOD_PKA_2	318	324	PF00069	0.449
MOD_PKA_2	337	343	PF00069	0.443
MOD_PKA_2	39	45	PF00069	0.582
MOD_PKA_2	475	481	PF00069	0.413
MOD_PKA_2	487	493	PF00069	0.379
MOD_PKA_2	605	611	PF00069	0.479
MOD_PKA_2	730	736	PF00069	0.415
MOD_PKA_2	848	854	PF00069	0.417
MOD_PKA_2	881	887	PF00069	0.385
MOD_Plk_1	21	27	PF00069	0.800
MOD_Plk_1	292	298	PF00069	0.580
MOD_Plk_1	300	306	PF00069	0.444
MOD_Plk_1	360	366	PF00069	0.367
MOD_Plk_1	552	558	PF00069	0.344
MOD_Plk_4	177	183	PF00069	0.616
MOD_Plk_4	185	191	PF00069	0.558
MOD_Plk_4	246	252	PF00069	0.609
MOD_Plk_4	300	306	PF00069	0.513
MOD_Plk_4	324	330	PF00069	0.374
MOD_Plk_4	531	537	PF00069	0.328
MOD_Plk_4	592	598	PF00069	0.363
MOD_Plk_4	605	611	PF00069	0.317
MOD_Plk_4	730	736	PF00069	0.449
MOD_Plk_4	868	874	PF00069	0.393
MOD_ProDKin_1	415	421	PF00069	0.397
MOD_ProDKin_1	459	465	PF00069	0.398
MOD_ProDKin_1	499	505	PF00069	0.475
MOD_ProDKin_1	716	722	PF00069	0.425
MOD_SUMO_rev_2	331	341	PF00179	0.329
MOD_SUMO_rev_2	853	863	PF00179	0.452
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.639
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.449
TRG_DiLeu_BaLyEn_6	544	549	PF01217	0.328
TRG_DiLeu_BaLyEn_6	637	642	PF01217	0.449
TRG_DiLeu_BaLyEn_6	861	866	PF01217	0.449
TRG_ENDOCYTIC_2	198	201	PF00928	0.648
TRG_ENDOCYTIC_2	205	208	PF00928	0.670
TRG_ENDOCYTIC_2	593	596	PF00928	0.344
TRG_ENDOCYTIC_2	766	769	PF00928	0.449
TRG_ENDOCYTIC_2	887	890	PF00928	0.559
TRG_ER_diArg_1	10	12	PF00400	0.772
TRG_ER_diArg_1	333	335	PF00400	0.413
TRG_ER_diArg_1	603	606	PF00400	0.413
TRG_ER_diArg_1	711	713	PF00400	0.475
TRG_ER_diArg_1	862	865	PF00400	0.421
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	347	352	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	661	665	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6C7	Leptomonas seymouri	73%	100%
A0A0S4JS37	Bodo saltans	31%	100%
A0A1X0P8L0	Trypanosomatidae	35%	100%
A0A3Q8IW16	Leishmania donovani	94%	100%
A0A422NCE5	Trypanosoma rangeli	37%	100%
A4HPB7	Leishmania braziliensis	89%	100%
A4ICF7	Leishmania infantum	94%	100%
D0A3C7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q1H0	Leishmania major	94%	100%
V5BCK1	Trypanosoma cruzi	36%	100%