Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chromatin assembly factor 1 subunit b-like protein

Species:

Leishmania mexicana

UniProt:

E9AT27_LEIMU

TriTrypDb:

LmxM.36.2500

Length:

674

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0000417	HIR complex	2	1
GO:0005634	nucleus	5	10
GO:0005654	nucleoplasm	2	1
GO:0005840	ribosome	5	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	10
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	10

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Expansion

Sequence features

E9AT27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT27

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006325	chromatin organization	4	11
GO:0006351	DNA-templated transcription	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.625
CLV_C14_Caspase3-7	647	651	PF00656	0.541
CLV_C14_Caspase3-7	80	84	PF00656	0.523
CLV_NRD_NRD_1	12	14	PF00675	0.473
CLV_NRD_NRD_1	277	279	PF00675	0.510
CLV_NRD_NRD_1	284	286	PF00675	0.435
CLV_NRD_NRD_1	301	303	PF00675	0.345
CLV_NRD_NRD_1	363	365	PF00675	0.496
CLV_NRD_NRD_1	492	494	PF00675	0.618
CLV_NRD_NRD_1	614	616	PF00675	0.755

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBV3	Leptomonas seymouri	64%	99%
A0A1X0P8Z1	Trypanosomatidae	45%	100%
A0A3S7XAX4	Leishmania donovani	88%	100%
A0A422NCI3	Trypanosoma rangeli	46%	100%
A4HPB6	Leishmania braziliensis	80%	99%
A4ICF6	Leishmania infantum	88%	100%
D0A3C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
O13985	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
Q4Q1H1	Leishmania major	92%	100%
V5BH36	Trypanosoma cruzi	46%	100%

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