LeishMANIAdb
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Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Guanine nucleotide-binding protein subunit beta-like protein
Gene product:
chromatin assembly factor 1 subunit b-like protein
Species:
Leishmania mexicana
UniProt:
E9AT27_LEIMU
TriTrypDb:
LmxM.36.2500
Length:
674

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 10
GO:0005840 ribosome 5 7
GO:0032991 protein-containing complex 1 7
GO:0043226 organelle 2 11
GO:0043227 membrane-bounded organelle 3 10
GO:0043228 non-membrane-bounded organelle 3 7
GO:0043229 intracellular organelle 3 11
GO:0043231 intracellular membrane-bounded organelle 4 10
GO:0043232 intracellular non-membrane-bounded organelle 4 7
GO:0110165 cellular anatomical entity 1 11
GO:1990904 ribonucleoprotein complex 2 7
GO:0000417 HIR complex 2 1
GO:0005654 nucleoplasm 2 1

Expansion

Sequence features

E9AT27
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT27

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006325 chromatin organization 4 11
GO:0006351 DNA-templated transcription 7 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009058 biosynthetic process 2 11
GO:0009059 macromolecule biosynthetic process 4 11
GO:0009987 cellular process 1 11
GO:0016043 cellular component organization 3 11
GO:0016070 RNA metabolic process 5 11
GO:0018130 heterocycle biosynthetic process 4 11
GO:0019438 aromatic compound biosynthetic process 4 11
GO:0032774 RNA biosynthetic process 5 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0034654 nucleobase-containing compound biosynthetic process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044249 cellular biosynthetic process 3 11
GO:0044271 cellular nitrogen compound biosynthetic process 4 11
GO:0046483 heterocycle metabolic process 3 11
GO:0071704 organic substance metabolic process 2 11
GO:0071840 cellular component organization or biogenesis 2 11
GO:0090304 nucleic acid metabolic process 4 11
GO:0097659 nucleic acid-templated transcription 6 11
GO:1901360 organic cyclic compound metabolic process 3 11
GO:1901362 organic cyclic compound biosynthetic process 4 11
GO:1901576 organic substance biosynthetic process 3 11
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 174 178 PF00656 0.625
CLV_C14_Caspase3-7 647 651 PF00656 0.541
CLV_C14_Caspase3-7 80 84 PF00656 0.523
CLV_NRD_NRD_1 12 14 PF00675 0.473
CLV_NRD_NRD_1 277 279 PF00675 0.510
CLV_NRD_NRD_1 284 286 PF00675 0.435
CLV_NRD_NRD_1 301 303 PF00675 0.345
CLV_NRD_NRD_1 363 365 PF00675 0.496
CLV_NRD_NRD_1 492 494 PF00675 0.618
CLV_NRD_NRD_1 614 616 PF00675 0.755
CLV_NRD_NRD_1 638 640 PF00675 0.657
CLV_NRD_NRD_1 641 643 PF00675 0.640
CLV_PCSK_FUR_1 490 494 PF00082 0.668
CLV_PCSK_FUR_1 639 643 PF00082 0.675
CLV_PCSK_KEX2_1 12 14 PF00082 0.473
CLV_PCSK_KEX2_1 277 279 PF00082 0.505
CLV_PCSK_KEX2_1 301 303 PF00082 0.369
CLV_PCSK_KEX2_1 363 365 PF00082 0.531
CLV_PCSK_KEX2_1 492 494 PF00082 0.601
CLV_PCSK_KEX2_1 641 643 PF00082 0.660
CLV_PCSK_PC1ET2_1 641 643 PF00082 0.660
CLV_PCSK_SKI1_1 189 193 PF00082 0.334
CLV_PCSK_SKI1_1 208 212 PF00082 0.144
CLV_PCSK_SKI1_1 419 423 PF00082 0.365
CLV_PCSK_SKI1_1 502 506 PF00082 0.307
CLV_PCSK_SKI1_1 533 537 PF00082 0.471
CLV_PCSK_SKI1_1 76 80 PF00082 0.261
CLV_Separin_Fungi 596 602 PF03568 0.587
DOC_CKS1_1 376 381 PF01111 0.468
DOC_MAPK_gen_1 116 124 PF00069 0.487
DOC_MAPK_gen_1 48 57 PF00069 0.472
DOC_MAPK_MEF2A_6 589 597 PF00069 0.608
DOC_PP1_RVXF_1 241 248 PF00149 0.350
DOC_PP1_RVXF_1 299 306 PF00149 0.441
DOC_PP1_RVXF_1 417 424 PF00149 0.344
DOC_PP2B_LxvP_1 312 315 PF13499 0.436
DOC_PP2B_LxvP_1 422 425 PF13499 0.383
DOC_PP4_FxxP_1 427 430 PF00568 0.453
DOC_USP7_MATH_1 11 15 PF00917 0.626
DOC_USP7_MATH_1 159 163 PF00917 0.679
DOC_USP7_MATH_1 478 482 PF00917 0.590
DOC_USP7_MATH_1 579 583 PF00917 0.595
DOC_USP7_MATH_1 599 603 PF00917 0.358
DOC_USP7_MATH_1 652 656 PF00917 0.762
DOC_WW_Pin1_4 126 131 PF00397 0.404
DOC_WW_Pin1_4 303 308 PF00397 0.359
DOC_WW_Pin1_4 356 361 PF00397 0.717
DOC_WW_Pin1_4 375 380 PF00397 0.572
DOC_WW_Pin1_4 574 579 PF00397 0.650
DOC_WW_Pin1_4 650 655 PF00397 0.463
LIG_14-3-3_CanoR_1 116 122 PF00244 0.475
LIG_14-3-3_CanoR_1 252 258 PF00244 0.396
LIG_14-3-3_CanoR_1 413 422 PF00244 0.385
LIG_14-3-3_CanoR_1 523 530 PF00244 0.426
LIG_14-3-3_CanoR_1 533 540 PF00244 0.381
LIG_AP2alpha_2 248 250 PF02296 0.384
LIG_CaM_NSCaTE_8 167 174 PF13499 0.416
LIG_deltaCOP1_diTrp_1 248 257 PF00928 0.368
LIG_deltaCOP1_diTrp_1 40 45 PF00928 0.540
LIG_FHA_1 190 196 PF00498 0.541
LIG_FHA_1 226 232 PF00498 0.385
LIG_FHA_1 249 255 PF00498 0.491
LIG_FHA_1 328 334 PF00498 0.615
LIG_FHA_1 36 42 PF00498 0.443
LIG_FHA_1 458 464 PF00498 0.727
LIG_FHA_1 547 553 PF00498 0.352
LIG_FHA_1 60 66 PF00498 0.577
LIG_FHA_1 651 657 PF00498 0.489
LIG_FHA_2 172 178 PF00498 0.555
LIG_FHA_2 4 10 PF00498 0.689
LIG_FHA_2 453 459 PF00498 0.743
LIG_FHA_2 64 70 PF00498 0.520
LIG_FHA_2 645 651 PF00498 0.655
LIG_FHA_2 78 84 PF00498 0.475
LIG_Integrin_RGD_1 612 614 PF01839 0.524
LIG_LIR_Gen_1 248 257 PF02991 0.479
LIG_LIR_Gen_1 525 535 PF02991 0.423
LIG_LIR_Gen_1 553 561 PF02991 0.357
LIG_LIR_Nem_3 119 124 PF02991 0.417
LIG_LIR_Nem_3 183 188 PF02991 0.424
LIG_LIR_Nem_3 248 253 PF02991 0.387
LIG_LIR_Nem_3 299 303 PF02991 0.384
LIG_LIR_Nem_3 525 530 PF02991 0.425
LIG_LIR_Nem_3 553 558 PF02991 0.344
LIG_NRBOX 582 588 PF00104 0.543
LIG_NRBOX 666 672 PF00104 0.408
LIG_PDZ_Class_1 669 674 PF00595 0.676
LIG_Pex14_1 423 427 PF04695 0.376
LIG_Pex14_2 253 257 PF04695 0.454
LIG_SH2_CRK 300 304 PF00017 0.419
LIG_SH2_CRK 31 35 PF00017 0.427
LIG_SH2_CRK 316 320 PF00017 0.454
LIG_SH2_PTP2 555 558 PF00017 0.357
LIG_SH2_STAP1 199 203 PF00017 0.491
LIG_SH2_STAP1 548 552 PF00017 0.445
LIG_SH2_STAT5 209 212 PF00017 0.457
LIG_SH2_STAT5 291 294 PF00017 0.494
LIG_SH2_STAT5 396 399 PF00017 0.366
LIG_SH2_STAT5 516 519 PF00017 0.394
LIG_SH2_STAT5 548 551 PF00017 0.352
LIG_SH2_STAT5 555 558 PF00017 0.371
LIG_SH2_STAT5 573 576 PF00017 0.564
LIG_SH3_1 27 33 PF00018 0.385
LIG_SH3_2 30 35 PF14604 0.551
LIG_SH3_3 27 33 PF00018 0.599
LIG_SH3_3 373 379 PF00018 0.542
LIG_SUMO_SIM_anti_2 38 43 PF11976 0.426
LIG_SUMO_SIM_anti_2 633 639 PF11976 0.708
LIG_TYR_ITIM 29 34 PF00017 0.353
LIG_TYR_ITIM 298 303 PF00017 0.492
LIG_UBA3_1 310 318 PF00899 0.243
LIG_UBA3_1 333 342 PF00899 0.604
LIG_WRC_WIRS_1 254 259 PF05994 0.364
MOD_CDK_SPxxK_3 356 363 PF00069 0.587
MOD_CDK_SPxxK_3 574 581 PF00069 0.636
MOD_CK1_1 152 158 PF00069 0.600
MOD_CK1_1 166 172 PF00069 0.671
MOD_CK1_1 175 181 PF00069 0.362
MOD_CK1_1 204 210 PF00069 0.316
MOD_CK1_1 3 9 PF00069 0.692
MOD_CK1_1 358 364 PF00069 0.720
MOD_CK1_1 472 478 PF00069 0.661
MOD_CK1_1 522 528 PF00069 0.442
MOD_CK1_1 59 65 PF00069 0.591
MOD_CK1_1 602 608 PF00069 0.579
MOD_CK2_1 3 9 PF00069 0.692
MOD_CK2_1 452 458 PF00069 0.575
MOD_CK2_1 478 484 PF00069 0.451
MOD_CK2_1 57 63 PF00069 0.620
MOD_CMANNOS 247 250 PF00535 0.373
MOD_GlcNHglycan 13 16 PF01048 0.542
MOD_GlcNHglycan 136 139 PF01048 0.329
MOD_GlcNHglycan 150 154 PF01048 0.451
MOD_GlcNHglycan 168 171 PF01048 0.583
MOD_GlcNHglycan 174 177 PF01048 0.627
MOD_GlcNHglycan 203 206 PF01048 0.368
MOD_GlcNHglycan 211 214 PF01048 0.426
MOD_GlcNHglycan 464 467 PF01048 0.635
MOD_GlcNHglycan 469 472 PF01048 0.583
MOD_GlcNHglycan 574 577 PF01048 0.622
MOD_GlcNHglycan 606 609 PF01048 0.684
MOD_GlcNHglycan 620 624 PF01048 0.679
MOD_GSK3_1 122 129 PF00069 0.437
MOD_GSK3_1 159 166 PF00069 0.687
MOD_GSK3_1 171 178 PF00069 0.574
MOD_GSK3_1 189 196 PF00069 0.426
MOD_GSK3_1 232 239 PF00069 0.538
MOD_GSK3_1 292 299 PF00069 0.468
MOD_GSK3_1 343 350 PF00069 0.671
MOD_GSK3_1 438 445 PF00069 0.731
MOD_GSK3_1 457 464 PF00069 0.633
MOD_GSK3_1 514 521 PF00069 0.490
MOD_GSK3_1 538 545 PF00069 0.433
MOD_GSK3_1 59 66 PF00069 0.584
MOD_GSK3_1 600 607 PF00069 0.648
MOD_GSK3_1 652 659 PF00069 0.622
MOD_LATS_1 353 359 PF00433 0.490
MOD_LATS_1 531 537 PF00433 0.426
MOD_N-GLC_1 356 361 PF02516 0.486
MOD_NEK2_1 117 122 PF00069 0.514
MOD_NEK2_1 134 139 PF00069 0.232
MOD_NEK2_1 171 176 PF00069 0.554
MOD_NEK2_1 224 229 PF00069 0.442
MOD_NEK2_1 232 237 PF00069 0.470
MOD_NEK2_1 253 258 PF00069 0.378
MOD_NEK2_1 264 269 PF00069 0.335
MOD_NEK2_1 347 352 PF00069 0.492
MOD_NEK2_1 561 566 PF00069 0.489
MOD_NEK2_1 57 62 PF00069 0.551
MOD_NMyristoyl 1 7 PF02799 0.580
MOD_PIKK_1 438 444 PF00454 0.666
MOD_PIKK_1 478 484 PF00454 0.700
MOD_PKA_2 11 17 PF00069 0.464
MOD_PKA_2 117 123 PF00069 0.490
MOD_PKA_2 522 528 PF00069 0.428
MOD_PKA_2 600 606 PF00069 0.618
MOD_Plk_1 343 349 PF00069 0.648
MOD_Plk_1 536 542 PF00069 0.429
MOD_Plk_4 117 123 PF00069 0.476
MOD_Plk_4 215 221 PF00069 0.314
MOD_Plk_4 259 265 PF00069 0.448
MOD_ProDKin_1 126 132 PF00069 0.405
MOD_ProDKin_1 303 309 PF00069 0.359
MOD_ProDKin_1 356 362 PF00069 0.718
MOD_ProDKin_1 375 381 PF00069 0.569
MOD_ProDKin_1 574 580 PF00069 0.637
MOD_ProDKin_1 650 656 PF00069 0.463
MOD_SUMO_for_1 270 273 PF00179 0.618
MOD_SUMO_rev_2 137 144 PF00179 0.378
MOD_SUMO_rev_2 178 187 PF00179 0.568
MOD_SUMO_rev_2 611 617 PF00179 0.472
TRG_ENDOCYTIC_2 188 191 PF00928 0.314
TRG_ENDOCYTIC_2 300 303 PF00928 0.421
TRG_ENDOCYTIC_2 31 34 PF00928 0.436
TRG_ENDOCYTIC_2 316 319 PF00928 0.447
TRG_ENDOCYTIC_2 555 558 PF00928 0.357
TRG_ER_diArg_1 277 279 PF00400 0.548
TRG_ER_diArg_1 300 302 PF00400 0.374
TRG_ER_diArg_1 34 37 PF00400 0.456
TRG_ER_diArg_1 490 493 PF00400 0.684
TRG_NLS_MonoCore_2 638 643 PF00514 0.606
TRG_NLS_MonoExtC_3 638 643 PF00514 0.606
TRG_NLS_MonoExtN_4 639 644 PF00514 0.613
TRG_Pf-PMV_PEXEL_1 533 537 PF00026 0.377
TRG_PTS2 1 45 PF00400 0.646

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBV3 Leptomonas seymouri 64% 99%
A0A1X0P8Z1 Trypanosomatidae 45% 100%
A0A3S7XAX4 Leishmania donovani 88% 100%
A0A422NCI3 Trypanosoma rangeli 46% 100%
A4HPB6 Leishmania braziliensis 80% 99%
A4ICF6 Leishmania infantum 88% 100%
D0A3C6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
O13985 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 21% 100%
Q4Q1H1 Leishmania major 92% 100%
V5BH36 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS