Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT26_LEIMU

TriTrypDb:

LmxM.36.2490

Length:

488

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AT26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT26

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	478	482	PF00656	0.657
CLV_NRD_NRD_1	386	388	PF00675	0.602
CLV_PCSK_KEX2_1	138	140	PF00082	0.776
CLV_PCSK_KEX2_1	386	388	PF00082	0.602
CLV_PCSK_KEX2_1	400	402	PF00082	0.419
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.776
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.650
CLV_PCSK_SKI1_1	256	260	PF00082	0.573
CLV_PCSK_SKI1_1	83	87	PF00082	0.570
DEG_SCF_FBW7_1	54	60	PF00400	0.796
DEG_SPOP_SBC_1	147	151	PF00917	0.808
DEG_SPOP_SBC_1	310	314	PF00917	0.724
DEG_SPOP_SBC_1	78	82	PF00917	0.635
DOC_CKS1_1	23	28	PF01111	0.811
DOC_CKS1_1	434	439	PF01111	0.531
DOC_CKS1_1	54	59	PF01111	0.841
DOC_CYCLIN_RxL_1	253	261	PF00134	0.527
DOC_CYCLIN_yClb5_NLxxxL_5	259	268	PF00134	0.595
DOC_MAPK_MEF2A_6	428	435	PF00069	0.591
DOC_MAPK_NFAT4_5	428	436	PF00069	0.596
DOC_PP1_RVXF_1	46	53	PF00149	0.750
DOC_PP2B_LxvP_1	200	203	PF13499	0.702
DOC_PP2B_LxvP_1	480	483	PF13499	0.758
DOC_SPAK_OSR1_1	381	385	PF12202	0.615
DOC_USP7_MATH_1	117	121	PF00917	0.515
DOC_USP7_MATH_1	146	150	PF00917	0.695
DOC_USP7_MATH_1	303	307	PF00917	0.715
DOC_USP7_MATH_1	462	466	PF00917	0.721
DOC_USP7_MATH_1	476	480	PF00917	0.596
DOC_USP7_MATH_1	483	487	PF00917	0.728
DOC_USP7_MATH_1	73	77	PF00917	0.758
DOC_USP7_MATH_1	98	102	PF00917	0.564
DOC_WW_Pin1_4	169	174	PF00397	0.675
DOC_WW_Pin1_4	19	24	PF00397	0.664
DOC_WW_Pin1_4	433	438	PF00397	0.454
DOC_WW_Pin1_4	441	446	PF00397	0.607
DOC_WW_Pin1_4	50	55	PF00397	0.831
DOC_WW_Pin1_4	57	62	PF00397	0.727
LIG_14-3-3_CanoR_1	139	148	PF00244	0.653
LIG_14-3-3_CanoR_1	240	248	PF00244	0.608
LIG_14-3-3_CanoR_1	381	385	PF00244	0.615
LIG_14-3-3_CanoR_1	386	392	PF00244	0.502
LIG_14-3-3_CanoR_1	68	72	PF00244	0.722
LIG_BIR_III_2	116	120	PF00653	0.548
LIG_BIR_III_2	145	149	PF00653	0.537
LIG_BIR_III_4	155	159	PF00653	0.822
LIG_BRCT_BRCA1_1	204	208	PF00533	0.701
LIG_BRCT_BRCA1_1	378	382	PF00533	0.599
LIG_CaM_IQ_9	373	389	PF13499	0.603
LIG_FHA_1	170	176	PF00498	0.856
LIG_FHA_1	217	223	PF00498	0.575
LIG_FHA_1	286	292	PF00498	0.579
LIG_FHA_1	404	410	PF00498	0.597
LIG_FHA_1	434	440	PF00498	0.547
LIG_FHA_1	57	63	PF00498	0.745
LIG_FHA_2	101	107	PF00498	0.548
LIG_FHA_2	210	216	PF00498	0.660
LIG_FHA_2	448	454	PF00498	0.674
LIG_IRF3_LxIS_1	343	348	PF10401	0.573
LIG_LIR_Gen_1	227	236	PF02991	0.612
LIG_LIR_Gen_1	25	36	PF02991	0.734
LIG_LIR_Gen_1	276	286	PF02991	0.510
LIG_LIR_Gen_1	419	426	PF02991	0.554
LIG_LIR_LC3C_4	453	457	PF02991	0.623
LIG_LIR_Nem_3	227	232	PF02991	0.614
LIG_LIR_Nem_3	25	31	PF02991	0.740
LIG_LIR_Nem_3	252	258	PF02991	0.603
LIG_LIR_Nem_3	274	280	PF02991	0.608
LIG_LIR_Nem_3	394	399	PF02991	0.584
LIG_LIR_Nem_3	419	424	PF02991	0.552
LIG_PTAP_UEV_1	130	135	PF05743	0.568
LIG_PTB_Apo_2	319	326	PF02174	0.719
LIG_PTB_Phospho_1	319	325	PF10480	0.721
LIG_REV1ctd_RIR_1	278	287	PF16727	0.391
LIG_SH2_STAP1	278	282	PF00017	0.547
LIG_SH2_STAP1	295	299	PF00017	0.355
LIG_SH2_STAT3	295	298	PF00017	0.599
LIG_SH2_STAT5	229	232	PF00017	0.619
LIG_SH2_STAT5	295	298	PF00017	0.599
LIG_SH3_2	131	136	PF14604	0.748
LIG_SH3_3	101	107	PF00018	0.742
LIG_SH3_3	128	134	PF00018	0.751
LIG_SH3_3	193	199	PF00018	0.653
LIG_SH3_3	20	26	PF00018	0.804
LIG_SH3_3	204	210	PF00018	0.751
LIG_SH3_3	251	257	PF00018	0.606
LIG_SH3_3	409	415	PF00018	0.617
LIG_SH3_3	431	437	PF00018	0.588
LIG_SH3_3	454	460	PF00018	0.451
LIG_SH3_3	51	57	PF00018	0.832
LIG_SUMO_SIM_anti_2	221	228	PF11976	0.551
LIG_SUMO_SIM_anti_2	231	237	PF11976	0.407
LIG_SUMO_SIM_anti_2	453	458	PF11976	0.615
LIG_SUMO_SIM_par_1	221	228	PF11976	0.551
LIG_SUMO_SIM_par_1	256	261	PF11976	0.612
LIG_SUMO_SIM_par_1	405	411	PF11976	0.600
LIG_SUMO_SIM_par_1	453	458	PF11976	0.615
LIG_SUMO_SIM_par_1	465	471	PF11976	0.584
LIG_SUMO_SIM_par_1	58	66	PF11976	0.663
LIG_TRAF2_1	103	106	PF00917	0.553
MOD_CK1_1	171	177	PF00069	0.827
MOD_CK1_1	178	184	PF00069	0.702
MOD_CK1_1	22	28	PF00069	0.810
MOD_CK1_1	221	227	PF00069	0.628
MOD_CK1_1	306	312	PF00069	0.718
MOD_CK1_1	348	354	PF00069	0.678
MOD_CK1_1	444	450	PF00069	0.586
MOD_CK1_1	465	471	PF00069	0.637
MOD_CK1_1	53	59	PF00069	0.772
MOD_CK1_1	60	66	PF00069	0.675
MOD_CK2_1	100	106	PF00069	0.556
MOD_CK2_1	266	272	PF00069	0.390
MOD_CK2_1	324	330	PF00069	0.781
MOD_CK2_1	60	66	PF00069	0.770
MOD_CK2_1	73	79	PF00069	0.658
MOD_GlcNHglycan	100	103	PF01048	0.745
MOD_GlcNHglycan	119	122	PF01048	0.525
MOD_GlcNHglycan	131	134	PF01048	0.548
MOD_GlcNHglycan	180	183	PF01048	0.655
MOD_GlcNHglycan	204	207	PF01048	0.754
MOD_GlcNHglycan	243	246	PF01048	0.556
MOD_GlcNHglycan	268	271	PF01048	0.311
MOD_GlcNHglycan	303	306	PF01048	0.720
MOD_GlcNHglycan	313	316	PF01048	0.658
MOD_GlcNHglycan	317	320	PF01048	0.622
MOD_GlcNHglycan	347	350	PF01048	0.598
MOD_GlcNHglycan	393	396	PF01048	0.533
MOD_GSK3_1	167	174	PF00069	0.818
MOD_GSK3_1	221	228	PF00069	0.628
MOD_GSK3_1	306	313	PF00069	0.746
MOD_GSK3_1	348	355	PF00069	0.685
MOD_GSK3_1	35	42	PF00069	0.736
MOD_GSK3_1	376	383	PF00069	0.596
MOD_GSK3_1	387	394	PF00069	0.334
MOD_GSK3_1	468	475	PF00069	0.714
MOD_GSK3_1	53	60	PF00069	0.669
MOD_GSK3_1	73	80	PF00069	0.562
MOD_GSK3_1	96	103	PF00069	0.693
MOD_LATS_1	385	391	PF00433	0.593
MOD_N-GLC_1	241	246	PF02516	0.558
MOD_N-GLC_1	369	374	PF02516	0.467
MOD_N-GLC_1	476	481	PF02516	0.831
MOD_NEK2_1	160	165	PF00069	0.772
MOD_NEK2_1	175	180	PF00069	0.672
MOD_NEK2_1	225	230	PF00069	0.628
MOD_NEK2_1	258	263	PF00069	0.599
MOD_NEK2_1	345	350	PF00069	0.437
MOD_NEK2_1	352	357	PF00069	0.549
MOD_NEK2_1	364	369	PF00069	0.518
MOD_NEK2_1	376	381	PF00069	0.401
MOD_NEK2_1	391	396	PF00069	0.292
MOD_NEK2_1	455	460	PF00069	0.597
MOD_NEK2_1	67	72	PF00069	0.763
MOD_NEK2_2	148	153	PF00069	0.529
MOD_NEK2_2	380	385	PF00069	0.607
MOD_NEK2_2	395	400	PF00069	0.425
MOD_PIKK_1	123	129	PF00454	0.585
MOD_PIKK_1	444	450	PF00454	0.671
MOD_PIKK_1	8	14	PF00454	0.811
MOD_PKA_2	306	312	PF00069	0.796
MOD_PKA_2	380	386	PF00069	0.610
MOD_PKA_2	67	73	PF00069	0.761
MOD_Plk_1	329	335	PF00069	0.761
MOD_Plk_1	369	375	PF00069	0.628
MOD_Plk_1	476	482	PF00069	0.751
MOD_Plk_2-3	329	335	PF00069	0.761
MOD_Plk_4	218	224	PF00069	0.638
MOD_Plk_4	231	237	PF00069	0.397
MOD_Plk_4	462	468	PF00069	0.666
MOD_Plk_4	67	73	PF00069	0.547
MOD_ProDKin_1	169	175	PF00069	0.678
MOD_ProDKin_1	19	25	PF00069	0.665
MOD_ProDKin_1	433	439	PF00069	0.468
MOD_ProDKin_1	441	447	PF00069	0.595
MOD_ProDKin_1	50	56	PF00069	0.831
MOD_ProDKin_1	57	63	PF00069	0.726
MOD_SUMO_rev_2	17	23	PF00179	0.799
TRG_DiLeu_BaEn_1	451	456	PF01217	0.657
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.589
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.443
TRG_ENDOCYTIC_2	229	232	PF00928	0.619
TRG_ENDOCYTIC_2	277	280	PF00928	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAX1	Leishmania donovani	90%	99%
A4HPB5	Leishmania braziliensis	73%	100%
A4ICF5	Leishmania infantum	90%	99%
Q4Q1H2	Leishmania major	88%	100%