Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT25_LEIMU

TriTrypDb:

LmxM.36.2480

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AT25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT25

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	69	73	PF00656	0.551
CLV_NRD_NRD_1	139	141	PF00675	0.557
CLV_NRD_NRD_1	255	257	PF00675	0.579
CLV_NRD_NRD_1	47	49	PF00675	0.435
CLV_NRD_NRD_1	92	94	PF00675	0.507
CLV_PCSK_FUR_1	92	96	PF00082	0.566
CLV_PCSK_KEX2_1	139	141	PF00082	0.575
CLV_PCSK_KEX2_1	18	20	PF00082	0.459
CLV_PCSK_KEX2_1	47	49	PF00082	0.435
CLV_PCSK_KEX2_1	5	7	PF00082	0.433
CLV_PCSK_KEX2_1	92	94	PF00082	0.505
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.592
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.459
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.433
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.593
CLV_PCSK_SKI1_1	58	62	PF00082	0.549
CLV_Separin_Metazoa	210	214	PF03568	0.602
CLV_Separin_Metazoa	23	27	PF03568	0.598
DEG_APCC_DBOX_1	5	13	PF00400	0.444
DEG_Nend_UBRbox_2	1	3	PF02207	0.523
DOC_USP7_MATH_1	150	154	PF00917	0.535
DOC_USP7_MATH_1	233	237	PF00917	0.772
DOC_USP7_MATH_1	32	36	PF00917	0.568
DOC_USP7_UBL2_3	253	257	PF12436	0.589
DOC_USP7_UBL2_3	269	273	PF12436	0.535
DOC_WW_Pin1_4	28	33	PF00397	0.553
LIG_Actin_WH2_2	56	73	PF00022	0.551
LIG_BIR_III_4	41	45	PF00653	0.452
LIG_deltaCOP1_diTrp_1	107	117	PF00928	0.513
LIG_FHA_2	15	21	PF00498	0.440
LIG_FHA_2	250	256	PF00498	0.614
LIG_LIR_Apic_2	73	79	PF02991	0.548
LIG_LIR_Gen_1	46	57	PF02991	0.569
LIG_LIR_Nem_3	46	52	PF02991	0.570
LIG_PROFILIN_1	243	249	PF00235	0.762
LIG_SH2_CRK	142	146	PF00017	0.513
LIG_SH2_NCK_1	142	146	PF00017	0.489
LIG_SH2_NCK_1	76	80	PF00017	0.553
LIG_SH2_SRC	166	169	PF00017	0.741
LIG_SH2_SRC	76	79	PF00017	0.556
LIG_SH2_SRC	88	91	PF00017	0.631
LIG_SH2_STAP1	142	146	PF00017	0.489
LIG_SH2_STAP1	84	88	PF00017	0.580
LIG_SH3_2	248	253	PF14604	0.622
LIG_SH3_3	238	244	PF00018	0.665
LIG_SH3_3	245	251	PF00018	0.601
LIG_SUMO_SIM_par_1	59	66	PF11976	0.533
LIG_TRAF2_1	252	255	PF00917	0.592
LIG_WW_3	210	214	PF00397	0.488
MOD_CK1_1	229	235	PF00069	0.776
MOD_CK2_1	14	20	PF00069	0.473
MOD_CK2_1	249	255	PF00069	0.619
MOD_GlcNHglycan	180	183	PF01048	0.703
MOD_GlcNHglycan	188	191	PF01048	0.645
MOD_GlcNHglycan	200	203	PF01048	0.456
MOD_GlcNHglycan	258	261	PF01048	0.559
MOD_GSK3_1	229	236	PF00069	0.766
MOD_GSK3_1	28	35	PF00069	0.534
MOD_GSK3_1	62	69	PF00069	0.534
MOD_N-GLC_1	26	31	PF02516	0.502
MOD_NEK2_1	118	123	PF00069	0.523
MOD_NEK2_1	135	140	PF00069	0.476
MOD_NEK2_1	70	75	PF00069	0.551
MOD_PIKK_1	233	239	PF00454	0.571
MOD_PKA_1	256	262	PF00069	0.570
MOD_PKA_2	212	218	PF00069	0.625
MOD_PKA_2	229	235	PF00069	0.771
MOD_PKA_2	70	76	PF00069	0.555
MOD_Plk_1	71	77	PF00069	0.519
MOD_Plk_4	71	77	PF00069	0.555
MOD_ProDKin_1	28	34	PF00069	0.558
MOD_SUMO_rev_2	254	259	PF00179	0.563
MOD_SUMO_rev_2	37	46	PF00179	0.533
TRG_DiLeu_BaEn_1	20	25	PF01217	0.542
TRG_DiLeu_BaEn_4	101	107	PF01217	0.561
TRG_ENDOCYTIC_2	142	145	PF00928	0.470
TRG_ENDOCYTIC_2	49	52	PF00928	0.392
TRG_ER_diArg_1	114	117	PF00400	0.584
TRG_ER_diArg_1	25	28	PF00400	0.462
TRG_ER_diArg_1	47	49	PF00400	0.455
TRG_ER_diArg_1	92	95	PF00400	0.509
TRG_ER_diLys_1	269	274	PF00400	0.627
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXA6	Leptomonas seymouri	63%	98%
A0A0S4JT72	Bodo saltans	41%	100%
A0A3Q8IJE0	Leishmania donovani	86%	100%
A0A422NCV8	Trypanosoma rangeli	44%	99%
A4HPB4	Leishmania braziliensis	82%	100%
A4ICF4	Leishmania infantum	86%	100%
D0A3C3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
Q4Q1H3	Leishmania major	86%	95%
V5D8K3	Trypanosoma cruzi	45%	100%