Putative acid phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acid phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9AT24_LEIMU

TriTrypDb:

LmxM.36.2470

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 7, no: 4
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AT24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT24

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0003993	acid phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.329
CLV_NRD_NRD_1	16	18	PF00675	0.596
CLV_NRD_NRD_1	192	194	PF00675	0.382
CLV_NRD_NRD_1	51	53	PF00675	0.452
CLV_PCSK_KEX2_1	16	18	PF00082	0.596
CLV_PCSK_KEX2_1	192	194	PF00082	0.367
CLV_PCSK_KEX2_1	92	94	PF00082	0.293
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.417
CLV_PCSK_SKI1_1	217	221	PF00082	0.426
CLV_PCSK_SKI1_1	297	301	PF00082	0.471
CLV_PCSK_SKI1_1	332	336	PF00082	0.355
CLV_PCSK_SKI1_1	53	57	PF00082	0.541
CLV_PCSK_SKI1_1	59	63	PF00082	0.479
DEG_APCC_DBOX_1	296	304	PF00400	0.433
DEG_Nend_UBRbox_3	1	3	PF02207	0.736
DOC_CKS1_1	387	392	PF01111	0.334
DOC_MAPK_MEF2A_6	270	278	PF00069	0.368
DOC_USP7_MATH_1	24	28	PF00917	0.572
DOC_USP7_MATH_1	357	361	PF00917	0.325
DOC_USP7_UBL2_3	49	53	PF12436	0.596
DOC_WW_Pin1_4	259	264	PF00397	0.355
DOC_WW_Pin1_4	308	313	PF00397	0.568
DOC_WW_Pin1_4	386	391	PF00397	0.324
DOC_WW_Pin1_4	431	436	PF00397	0.420
LIG_14-3-3_CanoR_1	117	121	PF00244	0.309
LIG_14-3-3_CanoR_1	142	150	PF00244	0.333
LIG_14-3-3_CanoR_1	270	275	PF00244	0.313
LIG_14-3-3_CanoR_1	384	388	PF00244	0.398
LIG_14-3-3_CanoR_1	420	424	PF00244	0.245
LIG_14-3-3_CanoR_1	5	12	PF00244	0.756
LIG_Actin_WH2_2	239	257	PF00022	0.521
LIG_APCC_ABBA_1	172	177	PF00400	0.274
LIG_APCC_ABBA_1	367	372	PF00400	0.435
LIG_CSL_BTD_1	387	390	PF09270	0.369
LIG_DLG_GKlike_1	270	277	PF00625	0.320
LIG_FHA_1	213	219	PF00498	0.422
LIG_FHA_1	24	30	PF00498	0.511
LIG_FHA_1	376	382	PF00498	0.372
LIG_FHA_1	394	400	PF00498	0.503
LIG_FHA_1	439	445	PF00498	0.667
LIG_FHA_1	61	67	PF00498	0.372
LIG_FHA_2	20	26	PF00498	0.699
LIG_FHA_2	239	245	PF00498	0.337
LIG_FHA_2	319	325	PF00498	0.393
LIG_FHA_2	432	438	PF00498	0.407
LIG_FHA_2	46	52	PF00498	0.568
LIG_LIR_Gen_1	119	128	PF02991	0.387
LIG_LIR_Gen_1	203	213	PF02991	0.507
LIG_LIR_Gen_1	234	243	PF02991	0.364
LIG_LIR_Gen_1	289	296	PF02991	0.314
LIG_LIR_Gen_1	379	390	PF02991	0.429
LIG_LIR_Gen_1	424	435	PF02991	0.386
LIG_LIR_LC3C_4	63	67	PF02991	0.456
LIG_LIR_Nem_3	109	115	PF02991	0.362
LIG_LIR_Nem_3	119	123	PF02991	0.317
LIG_LIR_Nem_3	203	209	PF02991	0.546
LIG_LIR_Nem_3	234	239	PF02991	0.410
LIG_LIR_Nem_3	289	293	PF02991	0.325
LIG_LIR_Nem_3	424	430	PF02991	0.346
LIG_PCNA_PIPBox_1	275	284	PF02747	0.367
LIG_PCNA_yPIPBox_3	270	282	PF02747	0.373
LIG_Pex14_2	155	159	PF04695	0.308
LIG_Pex14_2	171	175	PF04695	0.274
LIG_Pex14_2	338	342	PF04695	0.337
LIG_Rb_pABgroove_1	276	284	PF01858	0.299
LIG_SH2_CRK	236	240	PF00017	0.387
LIG_SH2_CRK	395	399	PF00017	0.306
LIG_SH2_NCK_1	346	350	PF00017	0.396
LIG_SH2_SRC	164	167	PF00017	0.350
LIG_SH2_SRC	236	239	PF00017	0.459
LIG_SH2_SRC	28	31	PF00017	0.626
LIG_SH2_STAP1	94	98	PF00017	0.310
LIG_SH2_STAT3	433	436	PF00017	0.577
LIG_SH2_STAT5	115	118	PF00017	0.269
LIG_SH2_STAT5	134	137	PF00017	0.423
LIG_SH2_STAT5	164	167	PF00017	0.417
LIG_SH2_STAT5	183	186	PF00017	0.274
LIG_SH2_STAT5	229	232	PF00017	0.532
LIG_SH2_STAT5	238	241	PF00017	0.259
LIG_SH2_STAT5	28	31	PF00017	0.368
LIG_SH2_STAT5	328	331	PF00017	0.336
LIG_SH2_STAT5	382	385	PF00017	0.322
LIG_SH2_STAT5	395	398	PF00017	0.482
LIG_SH2_STAT5	433	436	PF00017	0.415
LIG_SH3_3	135	141	PF00018	0.274
LIG_SH3_3	163	169	PF00018	0.274
LIG_SH3_3	290	296	PF00018	0.329
LIG_SH3_3	73	79	PF00018	0.341
LIG_SUMO_SIM_anti_2	63	69	PF11976	0.372
LIG_TRAF2_1	321	324	PF00917	0.382
LIG_TRAF2_1	434	437	PF00917	0.538
LIG_TRAF2_2	312	317	PF00917	0.653
LIG_WRC_WIRS_1	206	211	PF05994	0.356
MOD_CK1_1	375	381	PF00069	0.294
MOD_CK1_1	42	48	PF00069	0.584
MOD_CK2_1	19	25	PF00069	0.730
MOD_CK2_1	318	324	PF00069	0.421
MOD_CK2_1	431	437	PF00069	0.387
MOD_CK2_1	45	51	PF00069	0.552
MOD_GlcNHglycan	145	148	PF01048	0.274
MOD_GlcNHglycan	352	355	PF01048	0.229
MOD_GlcNHglycan	7	10	PF01048	0.720
MOD_GSK3_1	173	180	PF00069	0.307
MOD_GSK3_1	19	26	PF00069	0.671
MOD_GSK3_1	299	306	PF00069	0.474
MOD_GSK3_1	318	325	PF00069	0.362
MOD_GSK3_1	372	379	PF00069	0.616
MOD_GSK3_1	393	400	PF00069	0.420
MOD_GSK3_1	41	48	PF00069	0.546
MOD_GSK3_1	419	426	PF00069	0.318
MOD_N-GLC_1	128	133	PF02516	0.205
MOD_N-GLC_1	270	275	PF02516	0.321
MOD_N-GLC_1	303	308	PF02516	0.477
MOD_N-GLC_1	36	41	PF02516	0.572
MOD_N-GLC_1	376	381	PF02516	0.592
MOD_N-GLC_1	431	436	PF02516	0.348
MOD_N-GLC_1	45	50	PF02516	0.524
MOD_NEK2_1	128	133	PF00069	0.183
MOD_NEK2_1	265	270	PF00069	0.502
MOD_NEK2_1	303	308	PF00069	0.448
MOD_NEK2_1	318	323	PF00069	0.370
MOD_NEK2_1	60	65	PF00069	0.329
MOD_NEK2_2	398	403	PF00069	0.378
MOD_PIKK_1	36	42	PF00454	0.543
MOD_PKA_2	116	122	PF00069	0.388
MOD_PKA_2	383	389	PF00069	0.396
MOD_PKA_2	419	425	PF00069	0.319
MOD_Plk_1	108	114	PF00069	0.169
MOD_Plk_1	128	134	PF00069	0.205
MOD_Plk_1	24	30	PF00069	0.691
MOD_Plk_1	270	276	PF00069	0.320
MOD_Plk_1	303	309	PF00069	0.529
MOD_Plk_1	323	329	PF00069	0.354
MOD_Plk_2-3	205	211	PF00069	0.257
MOD_Plk_4	205	211	PF00069	0.276
MOD_Plk_4	24	30	PF00069	0.652
MOD_Plk_4	286	292	PF00069	0.452
MOD_Plk_4	323	329	PF00069	0.388
MOD_Plk_4	358	364	PF00069	0.345
MOD_Plk_4	383	389	PF00069	0.306
MOD_ProDKin_1	259	265	PF00069	0.349
MOD_ProDKin_1	308	314	PF00069	0.572
MOD_ProDKin_1	386	392	PF00069	0.331
MOD_ProDKin_1	431	437	PF00069	0.433
MOD_SUMO_rev_2	406	413	PF00179	0.401
MOD_SUMO_rev_2	45	55	PF00179	0.567
TRG_ENDOCYTIC_2	120	123	PF00928	0.289
TRG_ENDOCYTIC_2	206	209	PF00928	0.498
TRG_ENDOCYTIC_2	236	239	PF00928	0.335
TRG_ENDOCYTIC_2	290	293	PF00928	0.313
TRG_ENDOCYTIC_2	382	385	PF00928	0.337
TRG_ER_diArg_1	191	193	PF00400	0.393
TRG_NES_CRM1_1	264	275	PF08389	0.365
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKN6	Leptomonas seymouri	76%	97%
A0A0S4JT27	Bodo saltans	50%	100%
A0A1X0P7L7	Trypanosomatidae	59%	92%
A0A3S7XAY1	Leishmania donovani	91%	100%
A0A422NCB6	Trypanosoma rangeli	58%	97%
A4HPB3	Leishmania braziliensis	79%	100%
A4ICF3	Leishmania infantum	92%	100%
D0A3C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
Q4Q1H4	Leishmania major	91%	100%
V5BCK5	Trypanosoma cruzi	59%	98%