Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT23_LEIMU

TriTrypDb:

LmxM.36.2460

Length:

707

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AT23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.688
CLV_C14_Caspase3-7	354	358	PF00656	0.524
CLV_NRD_NRD_1	349	351	PF00675	0.718
CLV_NRD_NRD_1	385	387	PF00675	0.621
CLV_NRD_NRD_1	94	96	PF00675	0.623
CLV_PCSK_KEX2_1	385	387	PF00082	0.621
CLV_PCSK_KEX2_1	94	96	PF00082	0.623
CLV_PCSK_PC7_1	381	387	PF00082	0.598
CLV_PCSK_SKI1_1	111	115	PF00082	0.382
CLV_PCSK_SKI1_1	119	123	PF00082	0.364
CLV_PCSK_SKI1_1	361	365	PF00082	0.626
CLV_PCSK_SKI1_1	371	375	PF00082	0.522
CLV_PCSK_SKI1_1	386	390	PF00082	0.432
CLV_PCSK_SKI1_1	451	455	PF00082	0.495
CLV_PCSK_SKI1_1	526	530	PF00082	0.553
CLV_PCSK_SKI1_1	582	586	PF00082	0.418
CLV_PCSK_SKI1_1	84	88	PF00082	0.468
CLV_Separin_Metazoa	523	527	PF03568	0.445
DEG_APCC_DBOX_1	525	533	PF00400	0.481
DEG_APCC_DBOX_1	581	589	PF00400	0.415
DEG_Nend_Nbox_1	1	3	PF02207	0.460
DEG_SCF_FBW7_2	560	565	PF00400	0.520
DOC_CYCLIN_RxL_1	116	126	PF00134	0.276
DOC_CYCLIN_yCln2_LP_2	498	504	PF00134	0.500
DOC_MAPK_gen_1	134	143	PF00069	0.451
DOC_MAPK_MEF2A_6	137	145	PF00069	0.417
DOC_MAPK_MEF2A_6	477	486	PF00069	0.474
DOC_MAPK_MEF2A_6	534	543	PF00069	0.315
DOC_MAPK_MEF2A_6	582	590	PF00069	0.527
DOC_PP1_RVXF_1	384	391	PF00149	0.554
DOC_PP2B_LxvP_1	79	82	PF13499	0.593
DOC_PP4_FxxP_1	445	448	PF00568	0.526
DOC_USP7_MATH_1	102	106	PF00917	0.600
DOC_USP7_MATH_1	205	209	PF00917	0.567
DOC_USP7_MATH_1	315	319	PF00917	0.674
DOC_USP7_MATH_1	55	59	PF00917	0.530
DOC_USP7_MATH_1	563	567	PF00917	0.657
DOC_USP7_MATH_1	578	582	PF00917	0.360
DOC_USP7_MATH_1	635	639	PF00917	0.422
DOC_USP7_MATH_1	74	78	PF00917	0.484
DOC_WW_Pin1_4	208	213	PF00397	0.342
DOC_WW_Pin1_4	223	228	PF00397	0.568
DOC_WW_Pin1_4	265	270	PF00397	0.503
DOC_WW_Pin1_4	404	409	PF00397	0.602
DOC_WW_Pin1_4	412	417	PF00397	0.578
DOC_WW_Pin1_4	454	459	PF00397	0.697
DOC_WW_Pin1_4	558	563	PF00397	0.736
DOC_WW_Pin1_4	88	93	PF00397	0.676
LIG_14-3-3_CanoR_1	111	117	PF00244	0.477
LIG_14-3-3_CanoR_1	22	26	PF00244	0.571
LIG_14-3-3_CanoR_1	220	226	PF00244	0.579
LIG_14-3-3_CanoR_1	385	391	PF00244	0.458
LIG_14-3-3_CanoR_1	451	459	PF00244	0.497
LIG_14-3-3_CanoR_1	517	521	PF00244	0.527
LIG_14-3-3_CanoR_1	84	93	PF00244	0.490
LIG_14-3-3_CanoR_1	94	98	PF00244	0.539
LIG_BIR_III_2	305	309	PF00653	0.681
LIG_BIR_III_4	357	361	PF00653	0.520
LIG_CtBP_PxDLS_1	458	462	PF00389	0.575
LIG_FHA_1	341	347	PF00498	0.574
LIG_FHA_1	413	419	PF00498	0.542
LIG_FHA_1	454	460	PF00498	0.530
LIG_FHA_1	506	512	PF00498	0.444
LIG_FHA_1	549	555	PF00498	0.390
LIG_FHA_1	58	64	PF00498	0.536
LIG_FHA_1	641	647	PF00498	0.443
LIG_FHA_1	676	682	PF00498	0.639
LIG_FHA_2	321	327	PF00498	0.688
LIG_FHA_2	85	91	PF00498	0.475
LIG_LIR_Apic_2	645	651	PF02991	0.548
LIG_LIR_Gen_1	256	267	PF02991	0.482
LIG_LIR_Gen_1	463	468	PF02991	0.637
LIG_LIR_Nem_3	236	240	PF02991	0.387
LIG_LIR_Nem_3	24	28	PF02991	0.585
LIG_LIR_Nem_3	256	262	PF02991	0.413
LIG_LIR_Nem_3	367	373	PF02991	0.467
LIG_LIR_Nem_3	463	467	PF02991	0.660
LIG_LIR_Nem_3	620	624	PF02991	0.583
LIG_NRBOX	584	590	PF00104	0.521
LIG_SH2_CRK	259	263	PF00017	0.479
LIG_SH2_CRK	495	499	PF00017	0.322
LIG_SH2_NCK_1	259	263	PF00017	0.479
LIG_SH2_NCK_1	536	540	PF00017	0.438
LIG_SH2_SRC	536	539	PF00017	0.555
LIG_SH2_STAP1	254	258	PF00017	0.501
LIG_SH2_STAP1	479	483	PF00017	0.553
LIG_SH2_STAT5	131	134	PF00017	0.459
LIG_SH2_STAT5	170	173	PF00017	0.458
LIG_SH2_STAT5	237	240	PF00017	0.392
LIG_SH2_STAT5	352	355	PF00017	0.665
LIG_SH2_STAT5	68	71	PF00017	0.368
LIG_SH3_3	440	446	PF00018	0.559
LIG_SUMO_SIM_anti_2	512	517	PF11976	0.530
LIG_SUMO_SIM_par_1	454	463	PF11976	0.636
LIG_SUMO_SIM_par_1	481	487	PF11976	0.309
LIG_SUMO_SIM_par_1	58	66	PF11976	0.523
LIG_TRAF2_1	623	626	PF00917	0.566
LIG_TRAF2_1	87	90	PF00917	0.410
LIG_TRFH_1	259	263	PF08558	0.456
LIG_UBA3_1	28	36	PF00899	0.591
LIG_WRC_WIRS_1	461	466	PF05994	0.643
MOD_CDC14_SPxK_1	268	271	PF00782	0.567
MOD_CDC14_SPxK_1	91	94	PF00782	0.710
MOD_CDK_SPK_2	404	409	PF00069	0.602
MOD_CDK_SPxK_1	265	271	PF00069	0.530
MOD_CDK_SPxK_1	88	94	PF00069	0.685
MOD_CDK_SPxxK_3	88	95	PF00069	0.535
MOD_CK1_1	162	168	PF00069	0.553
MOD_CK1_1	208	214	PF00069	0.573
MOD_CK1_1	24	30	PF00069	0.431
MOD_CK1_1	430	436	PF00069	0.700
MOD_CK1_1	460	466	PF00069	0.640
MOD_CK1_1	642	648	PF00069	0.499
MOD_CK1_1	8	14	PF00069	0.560
MOD_CK2_1	102	108	PF00069	0.516
MOD_CK2_1	112	118	PF00069	0.348
MOD_CK2_1	374	380	PF00069	0.523
MOD_CK2_1	84	90	PF00069	0.436
MOD_GlcNHglycan	161	164	PF01048	0.528
MOD_GlcNHglycan	207	210	PF01048	0.432
MOD_GlcNHglycan	255	258	PF01048	0.430
MOD_GlcNHglycan	309	312	PF01048	0.684
MOD_GlcNHglycan	326	329	PF01048	0.574
MOD_GlcNHglycan	376	379	PF01048	0.535
MOD_GlcNHglycan	436	439	PF01048	0.571
MOD_GlcNHglycan	474	477	PF01048	0.597
MOD_GlcNHglycan	565	568	PF01048	0.567
MOD_GlcNHglycan	592	595	PF01048	0.317
MOD_GlcNHglycan	632	635	PF01048	0.530
MOD_GlcNHglycan	652	655	PF01048	0.423
MOD_GlcNHglycan	672	675	PF01048	0.504
MOD_GlcNHglycan	76	79	PF01048	0.467
MOD_GSK3_1	179	186	PF00069	0.401
MOD_GSK3_1	223	230	PF00069	0.578
MOD_GSK3_1	320	327	PF00069	0.661
MOD_GSK3_1	346	353	PF00069	0.579
MOD_GSK3_1	426	433	PF00069	0.634
MOD_GSK3_1	453	460	PF00069	0.630
MOD_GSK3_1	466	473	PF00069	0.530
MOD_GSK3_1	484	491	PF00069	0.279
MOD_GSK3_1	5	12	PF00069	0.549
MOD_GSK3_1	505	512	PF00069	0.592
MOD_GSK3_1	63	70	PF00069	0.464
MOD_GSK3_1	635	642	PF00069	0.509
MOD_GSK3_1	646	653	PF00069	0.384
MOD_GSK3_1	84	91	PF00069	0.507
MOD_N-GLC_1	563	568	PF02516	0.590
MOD_NEK2_1	136	141	PF00069	0.419
MOD_NEK2_1	21	26	PF00069	0.591
MOD_NEK2_1	453	458	PF00069	0.519
MOD_NEK2_1	639	644	PF00069	0.580
MOD_NEK2_1	676	681	PF00069	0.573
MOD_NEK2_1	701	706	PF00069	0.446
MOD_NEK2_1	93	98	PF00069	0.552
MOD_PIKK_1	484	490	PF00454	0.378
MOD_PKA_1	350	356	PF00069	0.639
MOD_PKA_2	136	142	PF00069	0.538
MOD_PKA_2	205	211	PF00069	0.443
MOD_PKA_2	21	27	PF00069	0.565
MOD_PKA_2	270	276	PF00069	0.636
MOD_PKA_2	488	494	PF00069	0.401
MOD_PKA_2	516	522	PF00069	0.525
MOD_PKA_2	93	99	PF00069	0.655
MOD_Plk_1	426	432	PF00069	0.647
MOD_Plk_1	509	515	PF00069	0.505
MOD_Plk_1	676	682	PF00069	0.499
MOD_Plk_2-3	187	193	PF00069	0.412
MOD_Plk_4	24	30	PF00069	0.636
MOD_Plk_4	364	370	PF00069	0.523
MOD_Plk_4	42	48	PF00069	0.296
MOD_Plk_4	427	433	PF00069	0.709
MOD_Plk_4	516	522	PF00069	0.458
MOD_Plk_4	617	623	PF00069	0.511
MOD_Plk_4	63	69	PF00069	0.478
MOD_Plk_4	676	682	PF00069	0.521
MOD_ProDKin_1	208	214	PF00069	0.334
MOD_ProDKin_1	223	229	PF00069	0.565
MOD_ProDKin_1	265	271	PF00069	0.516
MOD_ProDKin_1	404	410	PF00069	0.610
MOD_ProDKin_1	412	418	PF00069	0.583
MOD_ProDKin_1	454	460	PF00069	0.695
MOD_ProDKin_1	558	564	PF00069	0.742
MOD_ProDKin_1	88	94	PF00069	0.685
MOD_SUMO_rev_2	487	494	PF00179	0.319
MOD_SUMO_rev_2	565	574	PF00179	0.577
TRG_DiLeu_BaEn_1	243	248	PF01217	0.504
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.437
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.401
TRG_DiLeu_BaLyEn_6	448	453	PF01217	0.563
TRG_ENDOCYTIC_2	259	262	PF00928	0.498
TRG_ENDOCYTIC_2	479	482	PF00928	0.454
TRG_ENDOCYTIC_2	495	498	PF00928	0.447
TRG_ENDOCYTIC_2	536	539	PF00928	0.526
TRG_ER_diArg_1	93	95	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	451	455	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBJ6	Leptomonas seymouri	36%	100%
A0A3Q8INV1	Leishmania donovani	86%	100%
A4HPB2	Leishmania braziliensis	74%	99%
A4ICF2	Leishmania infantum	86%	100%
Q4Q1H5	Leishmania major	86%	100%