Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT22_LEIMU

TriTrypDb:

LmxM.36.2450

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AT22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.776
CLV_C14_Caspase3-7	326	330	PF00656	0.664
CLV_C14_Caspase3-7	62	66	PF00656	0.657
CLV_MEL_PAP_1	26	32	PF00089	0.543
CLV_NRD_NRD_1	345	347	PF00675	0.406
CLV_NRD_NRD_1	35	37	PF00675	0.486
CLV_NRD_NRD_1	394	396	PF00675	0.643
CLV_PCSK_FUR_1	33	37	PF00082	0.356
CLV_PCSK_KEX2_1	33	35	PF00082	0.466
CLV_PCSK_KEX2_1	345	347	PF00082	0.407
CLV_PCSK_KEX2_1	394	396	PF00082	0.643
CLV_PCSK_KEX2_1	40	42	PF00082	0.506
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.531
CLV_PCSK_PC7_1	29	35	PF00082	0.468
CLV_PCSK_PC7_1	36	42	PF00082	0.519
CLV_PCSK_SKI1_1	174	178	PF00082	0.407
CLV_PCSK_SKI1_1	188	192	PF00082	0.509
CLV_PCSK_SKI1_1	444	448	PF00082	0.656
DEG_APCC_DBOX_1	187	195	PF00400	0.534
DEG_Nend_UBRbox_3	1	3	PF02207	0.419
DEG_SCF_FBW7_1	244	251	PF00400	0.629
DEG_SPOP_SBC_1	243	247	PF00917	0.651
DEG_SPOP_SBC_1	249	253	PF00917	0.789
DOC_ANK_TNKS_1	179	186	PF00023	0.541
DOC_CKS1_1	19	24	PF01111	0.424
DOC_CYCLIN_RxL_1	169	179	PF00134	0.631
DOC_CYCLIN_yCln2_LP_2	19	25	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	272	275	PF00134	0.605
DOC_MAPK_gen_1	342	351	PF00069	0.696
DOC_MAPK_MEF2A_6	345	353	PF00069	0.607
DOC_PP1_RVXF_1	338	344	PF00149	0.701
DOC_PP2B_LxvP_1	272	275	PF13499	0.789
DOC_PP4_FxxP_1	205	208	PF00568	0.608
DOC_PP4_FxxP_1	418	421	PF00568	0.463
DOC_USP7_MATH_1	248	252	PF00917	0.843
DOC_USP7_MATH_1	321	325	PF00917	0.715
DOC_USP7_MATH_1	50	54	PF00917	0.701
DOC_USP7_UBL2_3	101	105	PF12436	0.631
DOC_USP7_UBL2_3	440	444	PF12436	0.496
DOC_WW_Pin1_4	18	23	PF00397	0.424
DOC_WW_Pin1_4	220	225	PF00397	0.816
DOC_WW_Pin1_4	244	249	PF00397	0.708
DOC_WW_Pin1_4	289	294	PF00397	0.640
DOC_WW_Pin1_4	304	309	PF00397	0.663
LIG_14-3-3_CanoR_1	167	177	PF00244	0.589
LIG_14-3-3_CanoR_1	188	197	PF00244	0.690
LIG_14-3-3_CanoR_1	34	44	PF00244	0.699
LIG_14-3-3_CanoR_1	345	350	PF00244	0.577
LIG_14-3-3_CanoR_1	405	414	PF00244	0.493
LIG_14-3-3_CanoR_1	428	434	PF00244	0.450
LIG_14-3-3_CanoR_1	76	86	PF00244	0.443
LIG_APCC_ABBAyCdc20_2	430	436	PF00400	0.545
LIG_Clathr_ClatBox_1	149	153	PF01394	0.621
LIG_deltaCOP1_diTrp_1	92	98	PF00928	0.589
LIG_EVH1_2	274	278	PF00568	0.746
LIG_FHA_1	146	152	PF00498	0.515
LIG_FHA_1	19	25	PF00498	0.424
LIG_FHA_1	245	251	PF00498	0.629
LIG_FHA_1	290	296	PF00498	0.607
LIG_FHA_1	298	304	PF00498	0.713
LIG_FHA_1	331	337	PF00498	0.679
LIG_FHA_1	407	413	PF00498	0.487
LIG_FHA_1	79	85	PF00498	0.646
LIG_FHA_2	198	204	PF00498	0.785
LIG_FHA_2	324	330	PF00498	0.662
LIG_GBD_Chelix_1	150	158	PF00786	0.427
LIG_Integrin_RGD_1	72	74	PF01839	0.447
LIG_LIR_Apic_2	203	208	PF02991	0.607
LIG_LIR_Apic_2	415	421	PF02991	0.493
LIG_LIR_Gen_1	315	321	PF02991	0.638
LIG_LIR_Gen_1	359	368	PF02991	0.424
LIG_LIR_Gen_1	65	75	PF02991	0.596
LIG_LIR_Gen_1	92	103	PF02991	0.606
LIG_LIR_LC3C_4	148	151	PF02991	0.566
LIG_LIR_LC3C_4	348	351	PF02991	0.551
LIG_LIR_Nem_3	118	123	PF02991	0.473
LIG_LIR_Nem_3	141	145	PF02991	0.517
LIG_LIR_Nem_3	315	319	PF02991	0.625
LIG_LIR_Nem_3	359	364	PF02991	0.424
LIG_LIR_Nem_3	397	403	PF02991	0.462
LIG_LIR_Nem_3	408	414	PF02991	0.377
LIG_LIR_Nem_3	65	70	PF02991	0.651
LIG_LIR_Nem_3	92	98	PF02991	0.588
LIG_MYND_1	270	274	PF01753	0.764
LIG_NRBOX	153	159	PF00104	0.624
LIG_PCNA_yPIPBox_3	340	354	PF02747	0.485
LIG_PDZ_Class_1	446	451	PF00595	0.540
LIG_Pex14_2	414	418	PF04695	0.515
LIG_Pex14_2	67	71	PF04695	0.638
LIG_SH2_CRK	361	365	PF00017	0.410
LIG_SH2_GRB2like	142	145	PF00017	0.690
LIG_SH2_PTP2	316	319	PF00017	0.469
LIG_SH2_SRC	419	422	PF00017	0.487
LIG_SH2_SRC	49	52	PF00017	0.700
LIG_SH2_STAP1	282	286	PF00017	0.738
LIG_SH2_STAT5	115	118	PF00017	0.610
LIG_SH2_STAT5	142	145	PF00017	0.590
LIG_SH2_STAT5	25	28	PF00017	0.325
LIG_SH2_STAT5	316	319	PF00017	0.566
LIG_SH2_STAT5	401	404	PF00017	0.456
LIG_SH2_STAT5	419	422	PF00017	0.388
LIG_SH2_STAT5	434	437	PF00017	0.510
LIG_SH2_STAT5	85	88	PF00017	0.584
LIG_SH3_1	129	135	PF00018	0.654
LIG_SH3_3	128	134	PF00018	0.721
LIG_SH3_3	261	267	PF00018	0.794
LIG_SH3_3	268	274	PF00018	0.789
LIG_SH3_3	291	297	PF00018	0.679
LIG_SH3_4	101	108	PF00018	0.628
LIG_SUMO_SIM_anti_2	148	153	PF11976	0.661
LIG_SUMO_SIM_par_1	136	141	PF11976	0.611
LIG_SUMO_SIM_par_1	147	153	PF11976	0.642
LIG_SUMO_SIM_par_1	173	179	PF11976	0.588
LIG_SUMO_SIM_par_1	304	312	PF11976	0.677
LIG_WRC_WIRS_1	117	122	PF05994	0.494
LIG_WRC_WIRS_1	350	355	PF05994	0.210
MOD_CK1_1	276	282	PF00069	0.694
MOD_CK1_1	352	358	PF00069	0.231
MOD_CK1_1	375	381	PF00069	0.622
MOD_CK1_1	39	45	PF00069	0.763
MOD_CK1_1	438	444	PF00069	0.627
MOD_CK2_1	321	327	PF00069	0.673
MOD_GlcNHglycan	109	112	PF01048	0.516
MOD_GlcNHglycan	212	215	PF01048	0.500
MOD_GlcNHglycan	323	326	PF01048	0.409
MOD_GlcNHglycan	354	357	PF01048	0.426
MOD_GlcNHglycan	358	361	PF01048	0.371
MOD_GlcNHglycan	377	380	PF01048	0.426
MOD_GSK3_1	244	251	PF00069	0.712
MOD_GSK3_1	273	280	PF00069	0.723
MOD_GSK3_1	297	304	PF00069	0.558
MOD_GSK3_1	345	352	PF00069	0.439
MOD_GSK3_1	35	42	PF00069	0.695
MOD_GSK3_1	366	373	PF00069	0.535
MOD_N-GLC_1	276	281	PF02516	0.688
MOD_N-GLC_1	321	326	PF02516	0.673
MOD_N-GLC_1	406	411	PF02516	0.612
MOD_N-GLC_1	42	47	PF02516	0.670
MOD_N-GLC_1	436	441	PF02516	0.643
MOD_NEK2_1	138	143	PF00069	0.500
MOD_NEK2_1	176	181	PF00069	0.514
MOD_NEK2_1	236	241	PF00069	0.724
MOD_NEK2_1	278	283	PF00069	0.530
MOD_NEK2_1	349	354	PF00069	0.231
MOD_NEK2_1	44	49	PF00069	0.481
MOD_NEK2_1	446	451	PF00069	0.644
MOD_NEK2_2	429	434	PF00069	0.593
MOD_PIKK_1	207	213	PF00454	0.749
MOD_PIKK_1	406	412	PF00454	0.613
MOD_PKA_1	345	351	PF00069	0.528
MOD_PKA_1	35	41	PF00069	0.606
MOD_PKA_2	168	174	PF00069	0.469
MOD_PKA_2	345	351	PF00069	0.473
MOD_PKA_2	35	41	PF00069	0.628
MOD_PKA_2	380	386	PF00069	0.447
MOD_PKA_2	429	435	PF00069	0.600
MOD_PKB_1	33	41	PF00069	0.650
MOD_Plk_1	370	376	PF00069	0.530
MOD_Plk_1	406	412	PF00069	0.613
MOD_Plk_2-3	366	372	PF00069	0.549
MOD_Plk_4	138	144	PF00069	0.480
MOD_Plk_4	145	151	PF00069	0.562
MOD_Plk_4	312	318	PF00069	0.492
MOD_Plk_4	345	351	PF00069	0.528
MOD_Plk_4	387	393	PF00069	0.552
MOD_Plk_4	429	435	PF00069	0.600
MOD_ProDKin_1	18	24	PF00069	0.424
MOD_ProDKin_1	220	226	PF00069	0.793
MOD_ProDKin_1	244	250	PF00069	0.645
MOD_ProDKin_1	289	295	PF00069	0.548
MOD_ProDKin_1	304	310	PF00069	0.571
TRG_DiLeu_BaEn_1	173	178	PF01217	0.473
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.524
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.529
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.424
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.515
TRG_ENDOCYTIC_2	316	319	PF00928	0.528
TRG_ENDOCYTIC_2	361	364	PF00928	0.410
TRG_ENDOCYTIC_2	400	403	PF00928	0.668
TRG_ENDOCYTIC_2	58	61	PF00928	0.500
TRG_ER_diArg_1	33	36	PF00400	0.588
TRG_ER_diArg_1	340	343	PF00400	0.561
TRG_ER_diArg_1	427	430	PF00400	0.551
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL22	Leptomonas seymouri	51%	98%
A0A3Q8IJ49	Leishmania donovani	87%	100%
A4HPB1	Leishmania braziliensis	67%	98%
A4ICF1	Leishmania infantum	87%	100%
Q4Q1H6	Leishmania major	85%	100%
V5B844	Trypanosoma cruzi	26%	100%