FYVE-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT21_LEIMU

TriTrypDb:

LmxM.36.2440

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0020018	ciliary pocket membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0060170	ciliary membrane	5	1
GO:0097014	ciliary plasm	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AT21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT21

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	47	51	PF00656	0.341
CLV_NRD_NRD_1	102	104	PF00675	0.594
CLV_NRD_NRD_1	12	14	PF00675	0.282
CLV_NRD_NRD_1	186	188	PF00675	0.497
CLV_PCSK_FUR_1	100	104	PF00082	0.536
CLV_PCSK_KEX2_1	102	104	PF00082	0.538
CLV_PCSK_KEX2_1	12	14	PF00082	0.356
CLV_PCSK_KEX2_1	186	188	PF00082	0.475
CLV_PCSK_SKI1_1	55	59	PF00082	0.246
DEG_SPOP_SBC_1	143	147	PF00917	0.668
DOC_CYCLIN_yCln2_LP_2	138	144	PF00134	0.572
DOC_MAPK_gen_1	210	219	PF00069	0.272
DOC_MAPK_gen_1	52	60	PF00069	0.361
DOC_MAPK_MEF2A_6	212	221	PF00069	0.263
DOC_PP2B_LxvP_1	138	141	PF13499	0.536
DOC_USP7_MATH_1	143	147	PF00917	0.762
DOC_USP7_MATH_1	153	157	PF00917	0.714
DOC_USP7_MATH_1	197	201	PF00917	0.676
DOC_USP7_MATH_1	4	8	PF00917	0.418
DOC_WW_Pin1_4	144	149	PF00397	0.723
DOC_WW_Pin1_4	155	160	PF00397	0.642
DOC_WW_Pin1_4	198	203	PF00397	0.652
DOC_WW_Pin1_4	204	209	PF00397	0.556
DOC_WW_Pin1_4	6	11	PF00397	0.394
LIG_14-3-3_CanoR_1	154	161	PF00244	0.739
LIG_14-3-3_CanoR_1	196	202	PF00244	0.608
LIG_14-3-3_CterR_2	252	255	PF00244	0.346
LIG_Actin_WH2_2	218	235	PF00022	0.609
LIG_BIR_III_4	50	54	PF00653	0.306
LIG_FHA_1	209	215	PF00498	0.351
LIG_FHA_1	44	50	PF00498	0.478
LIG_FHA_2	34	40	PF00498	0.293
LIG_LIR_Nem_3	24	29	PF02991	0.338
LIG_SH2_STAT5	243	246	PF00017	0.408
LIG_SH3_1	137	143	PF00018	0.544
LIG_SH3_3	137	143	PF00018	0.672
LIG_SH3_3	157	163	PF00018	0.695
LIG_SUMO_SIM_anti_2	216	221	PF11976	0.260
LIG_WW_3	151	155	PF00397	0.615
MOD_CDC14_SPxK_1	207	210	PF00782	0.542
MOD_CDC14_SPxK_1	9	12	PF00782	0.173
MOD_CDK_SPxK_1	204	210	PF00069	0.581
MOD_CDK_SPxK_1	6	12	PF00069	0.173
MOD_CDK_SPxxK_3	6	13	PF00069	0.173
MOD_CK1_1	146	152	PF00069	0.710
MOD_CK1_1	167	173	PF00069	0.674
MOD_CK2_1	93	99	PF00069	0.584
MOD_GlcNHglycan	149	152	PF01048	0.791
MOD_GlcNHglycan	155	158	PF01048	0.753
MOD_GlcNHglycan	166	169	PF01048	0.669
MOD_GlcNHglycan	6	9	PF01048	0.481
MOD_GlcNHglycan	72	75	PF01048	0.684
MOD_GlcNHglycan	78	81	PF01048	0.733
MOD_GSK3_1	142	149	PF00069	0.726
MOD_GSK3_1	17	24	PF00069	0.266
MOD_GSK3_1	2	9	PF00069	0.465
MOD_GSK3_1	204	211	PF00069	0.451
MOD_GSK3_1	76	83	PF00069	0.580
MOD_N-GLC_1	110	115	PF02516	0.451
MOD_N-GLC_1	204	209	PF02516	0.487
MOD_NEK2_1	21	26	PF00069	0.468
MOD_PIKK_1	110	116	PF00454	0.542
MOD_PIKK_1	169	175	PF00454	0.732
MOD_PKA_2	153	159	PF00069	0.745
MOD_PKA_2	43	49	PF00069	0.381
MOD_Plk_1	17	23	PF00069	0.378
MOD_Plk_1	208	214	PF00069	0.391
MOD_Plk_2-3	93	99	PF00069	0.635
MOD_ProDKin_1	144	150	PF00069	0.724
MOD_ProDKin_1	155	161	PF00069	0.643
MOD_ProDKin_1	198	204	PF00069	0.648
MOD_ProDKin_1	6	12	PF00069	0.186
MOD_SUMO_for_1	51	54	PF00179	0.355
MOD_SUMO_rev_2	236	240	PF00179	0.409
TRG_DiLeu_BaEn_1	209	214	PF01217	0.377
TRG_DiLeu_BaEn_1	216	221	PF01217	0.365
TRG_DiLeu_LyEn_5	209	214	PF01217	0.456
TRG_ENDOCYTIC_2	243	246	PF00928	0.551
TRG_ER_diArg_1	102	105	PF00400	0.623
TRG_ER_diArg_1	117	120	PF00400	0.505
TRG_ER_diArg_1	185	187	PF00400	0.490
TRG_NLS_MonoExtC_3	247	252	PF00514	0.267
TRG_NLS_MonoExtN_4	248	253	PF00514	0.277
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.655
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.173

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I764	Leptomonas seymouri	51%	93%
A0A0S4JVE6	Bodo saltans	29%	100%
A0A1X0P7S3	Trypanosomatidae	32%	100%
A0A3Q8IR10	Leishmania donovani	88%	100%
A0A422NCC4	Trypanosoma rangeli	36%	100%
A4HPB0	Leishmania braziliensis	67%	100%
A4ICF0	Leishmania infantum	87%	100%
Q4Q1H7	Leishmania major	85%	100%
V5D8K6	Trypanosoma cruzi	36%	100%