Dipeptidyl-peptidase 8-like serine peptidase,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine peptidase, Clan SC, Family S9B

Species:

Leishmania mexicana

UniProt:

E9AT19_LEIMU

TriTrypDb:

LmxM.36.2420

Length:

852

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AT19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT19

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008233	peptidase activity	3	12
GO:0008236	serine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0017171	serine hydrolase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0008238	exopeptidase activity	4	1
GO:0008239	dipeptidyl-peptidase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.343
CLV_C14_Caspase3-7	366	370	PF00656	0.276
CLV_NRD_NRD_1	310	312	PF00675	0.530
CLV_NRD_NRD_1	583	585	PF00675	0.409
CLV_PCSK_FUR_1	473	477	PF00082	0.559
CLV_PCSK_KEX2_1	310	312	PF00082	0.512
CLV_PCSK_KEX2_1	475	477	PF00082	0.559
CLV_PCSK_KEX2_1	538	540	PF00082	0.482
CLV_PCSK_KEX2_1	582	584	PF00082	0.426
CLV_PCSK_KEX2_1	698	700	PF00082	0.454
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.559
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.554
CLV_PCSK_PC1ET2_1	698	700	PF00082	0.454
CLV_PCSK_PC7_1	694	700	PF00082	0.454
CLV_PCSK_SKI1_1	443	447	PF00082	0.472
CLV_PCSK_SKI1_1	475	479	PF00082	0.351
CLV_PCSK_SKI1_1	575	579	PF00082	0.314
CLV_PCSK_SKI1_1	74	78	PF00082	0.609
CLV_Separin_Metazoa	81	85	PF03568	0.456
DEG_SCF_FBW7_2	498	503	PF00400	0.315
DEG_SCF_FBW7_2	679	686	PF00400	0.376
DOC_CKS1_1	571	576	PF01111	0.535
DOC_CYCLIN_RxL_1	296	306	PF00134	0.151
DOC_MAPK_DCC_7	299	309	PF00069	0.304
DOC_MAPK_DCC_7	599	607	PF00069	0.448
DOC_MAPK_gen_1	123	131	PF00069	0.465
DOC_MAPK_gen_1	299	309	PF00069	0.304
DOC_MAPK_gen_1	473	483	PF00069	0.359
DOC_MAPK_gen_1	538	544	PF00069	0.433
DOC_MAPK_gen_1	582	591	PF00069	0.226
DOC_MAPK_gen_1	626	635	PF00069	0.491
DOC_MAPK_HePTP_8	579	591	PF00069	0.227
DOC_MAPK_JIP1_4	26	32	PF00069	0.394
DOC_MAPK_MEF2A_6	302	309	PF00069	0.358
DOC_MAPK_MEF2A_6	325	334	PF00069	0.340
DOC_MAPK_MEF2A_6	476	485	PF00069	0.359
DOC_MAPK_MEF2A_6	582	591	PF00069	0.226
DOC_MAPK_MEF2A_6	599	608	PF00069	0.192
DOC_MAPK_MEF2A_6	626	635	PF00069	0.400
DOC_MAPK_RevD_3	569	583	PF00069	0.519
DOC_PP1_RVXF_1	232	239	PF00149	0.315
DOC_PP1_RVXF_1	461	467	PF00149	0.265
DOC_PP1_RVXF_1	722	728	PF00149	0.322
DOC_PP4_FxxP_1	592	595	PF00568	0.400
DOC_USP7_MATH_1	145	149	PF00917	0.567
DOC_USP7_MATH_1	156	160	PF00917	0.512
DOC_USP7_UBL2_3	126	130	PF12436	0.489
DOC_USP7_UBL2_3	140	144	PF12436	0.515
DOC_USP7_UBL2_3	74	78	PF12436	0.630
DOC_WW_Pin1_4	124	129	PF00397	0.525
DOC_WW_Pin1_4	254	259	PF00397	0.332
DOC_WW_Pin1_4	496	501	PF00397	0.248
DOC_WW_Pin1_4	548	553	PF00397	0.637
DOC_WW_Pin1_4	570	575	PF00397	0.531
DOC_WW_Pin1_4	591	596	PF00397	0.394
DOC_WW_Pin1_4	679	684	PF00397	0.344
LIG_14-3-3_CanoR_1	100	108	PF00244	0.371
LIG_14-3-3_CanoR_1	288	292	PF00244	0.332
LIG_14-3-3_CanoR_1	362	372	PF00244	0.359
LIG_14-3-3_CanoR_1	476	482	PF00244	0.341
LIG_14-3-3_CanoR_1	527	536	PF00244	0.514
LIG_14-3-3_CanoR_1	584	590	PF00244	0.385
LIG_14-3-3_CanoR_1	86	94	PF00244	0.496
LIG_Actin_WH2_2	305	323	PF00022	0.326
LIG_Actin_WH2_2	460	477	PF00022	0.340
LIG_BIR_III_4	600	604	PF00653	0.538
LIG_BRCT_BRCA1_1	691	695	PF00533	0.162
LIG_deltaCOP1_diTrp_1	388	395	PF00928	0.279
LIG_EH1_1	805	813	PF00400	0.427
LIG_eIF4E_1	789	795	PF01652	0.364
LIG_FHA_1	107	113	PF00498	0.202
LIG_FHA_1	165	171	PF00498	0.602
LIG_FHA_1	287	293	PF00498	0.279
LIG_FHA_1	296	302	PF00498	0.279
LIG_FHA_1	327	333	PF00498	0.269
LIG_FHA_1	454	460	PF00498	0.304
LIG_FHA_1	571	577	PF00498	0.495
LIG_FHA_1	674	680	PF00498	0.427
LIG_FHA_1	769	775	PF00498	0.427
LIG_FHA_1	89	95	PF00498	0.554
LIG_FHA_2	181	187	PF00498	0.265
LIG_FHA_2	270	276	PF00498	0.335
LIG_FHA_2	364	370	PF00498	0.275
LIG_FHA_2	497	503	PF00498	0.351
LIG_FHA_2	556	562	PF00498	0.611
LIG_FHA_2	747	753	PF00498	0.294
LIG_FHA_2	75	81	PF00498	0.573
LIG_FHA_2	845	851	PF00498	0.415
LIG_GBD_Chelix_1	844	852	PF00786	0.434
LIG_HCF-1_HBM_1	503	506	PF13415	0.279
LIG_HCF-1_HBM_1	513	516	PF13415	0.279
LIG_LIR_Gen_1	14	24	PF02991	0.343
LIG_LIR_Gen_1	232	241	PF02991	0.279
LIG_LIR_Gen_1	276	287	PF02991	0.263
LIG_LIR_Gen_1	328	338	PF02991	0.300
LIG_LIR_Gen_1	340	350	PF02991	0.203
LIG_LIR_Gen_1	394	402	PF02991	0.305
LIG_LIR_Gen_1	669	679	PF02991	0.323
LIG_LIR_LC3C_4	289	293	PF02991	0.258
LIG_LIR_Nem_3	113	118	PF02991	0.441
LIG_LIR_Nem_3	14	19	PF02991	0.318
LIG_LIR_Nem_3	221	226	PF02991	0.254
LIG_LIR_Nem_3	232	238	PF02991	0.265
LIG_LIR_Nem_3	276	282	PF02991	0.266
LIG_LIR_Nem_3	328	334	PF02991	0.259
LIG_LIR_Nem_3	394	398	PF02991	0.305
LIG_LIR_Nem_3	424	430	PF02991	0.273
LIG_LIR_Nem_3	440	445	PF02991	0.205
LIG_LIR_Nem_3	58	63	PF02991	0.265
LIG_LIR_Nem_3	669	675	PF02991	0.323
LIG_LIR_Nem_3	706	710	PF02991	0.296
LIG_LIR_Nem_3	734	738	PF02991	0.307
LIG_PCNA_yPIPBox_3	211	225	PF02747	0.340
LIG_PDZ_Class_3	847	852	PF00595	0.399
LIG_Pex14_2	723	727	PF04695	0.322
LIG_PTAP_UEV_1	594	599	PF05743	0.559
LIG_SH2_CRK	279	283	PF00017	0.263
LIG_SH2_CRK	408	412	PF00017	0.345
LIG_SH2_CRK	430	434	PF00017	0.368
LIG_SH2_CRK	479	483	PF00017	0.279
LIG_SH2_CRK	48	52	PF00017	0.442
LIG_SH2_CRK	610	614	PF00017	0.345
LIG_SH2_CRK	710	714	PF00017	0.307
LIG_SH2_CRK	818	822	PF00017	0.364
LIG_SH2_GRB2like	118	121	PF00017	0.524
LIG_SH2_NCK_1	279	283	PF00017	0.302
LIG_SH2_NCK_1	294	298	PF00017	0.359
LIG_SH2_NCK_1	430	434	PF00017	0.315
LIG_SH2_PTP2	672	675	PF00017	0.392
LIG_SH2_SRC	118	121	PF00017	0.532
LIG_SH2_SRC	240	243	PF00017	0.340
LIG_SH2_SRC	672	675	PF00017	0.427
LIG_SH2_STAP1	270	274	PF00017	0.326
LIG_SH2_STAP1	506	510	PF00017	0.279
LIG_SH2_STAP1	710	714	PF00017	0.307
LIG_SH2_STAP1	742	746	PF00017	0.307
LIG_SH2_STAP1	818	822	PF00017	0.427
LIG_SH2_STAT3	217	220	PF00017	0.254
LIG_SH2_STAT3	38	41	PF00017	0.379
LIG_SH2_STAT5	108	111	PF00017	0.406
LIG_SH2_STAT5	115	118	PF00017	0.382
LIG_SH2_STAT5	217	220	PF00017	0.254
LIG_SH2_STAT5	226	229	PF00017	0.254
LIG_SH2_STAT5	235	238	PF00017	0.265
LIG_SH2_STAT5	240	243	PF00017	0.265
LIG_SH2_STAT5	318	321	PF00017	0.264
LIG_SH2_STAT5	331	334	PF00017	0.210
LIG_SH2_STAT5	365	368	PF00017	0.196
LIG_SH2_STAT5	465	468	PF00017	0.326
LIG_SH2_STAT5	508	511	PF00017	0.296
LIG_SH2_STAT5	517	520	PF00017	0.221
LIG_SH2_STAT5	529	532	PF00017	0.360
LIG_SH2_STAT5	565	568	PF00017	0.548
LIG_SH2_STAT5	672	675	PF00017	0.307
LIG_SH2_STAT5	678	681	PF00017	0.307
LIG_SH2_STAT5	742	745	PF00017	0.307
LIG_SH2_STAT5	789	792	PF00017	0.392
LIG_SH3_3	252	258	PF00018	0.232
LIG_SH3_3	262	268	PF00018	0.279
LIG_SH3_3	279	285	PF00018	0.210
LIG_SH3_3	395	401	PF00018	0.286
LIG_SH3_3	530	536	PF00018	0.513
LIG_SH3_3	539	545	PF00018	0.534
LIG_SH3_3	568	574	PF00018	0.549
LIG_SH3_3	592	598	PF00018	0.435
LIG_SUMO_SIM_anti_2	248	254	PF11976	0.295
LIG_SUMO_SIM_anti_2	640	645	PF11976	0.396
LIG_SUMO_SIM_par_1	189	198	PF11976	0.333
LIG_SUMO_SIM_par_1	289	296	PF11976	0.279
LIG_SUMO_SIM_par_1	480	487	PF11976	0.340
LIG_SUMO_SIM_par_1	575	581	PF11976	0.502
LIG_TRAF2_1	356	359	PF00917	0.359
LIG_TRAF2_1	77	80	PF00917	0.436
LIG_TRAF2_1	847	850	PF00917	0.530
LIG_TYR_ITIM	406	411	PF00017	0.304
LIG_TYR_ITSM	327	334	PF00017	0.315
LIG_UBA3_1	131	140	PF00899	0.555
LIG_WRC_WIRS_1	157	162	PF05994	0.579
LIG_WRC_WIRS_1	170	175	PF05994	0.265
MOD_CDK_SPK_2	570	575	PF00069	0.504
MOD_CDK_SPxK_1	124	130	PF00069	0.383
MOD_CK1_1	163	169	PF00069	0.587
MOD_CK1_1	224	230	PF00069	0.290
MOD_CK1_1	254	260	PF00069	0.332
MOD_CK1_1	333	339	PF00069	0.279
MOD_CK1_1	363	369	PF00069	0.302
MOD_CK1_1	484	490	PF00069	0.304
MOD_CK1_1	531	537	PF00069	0.443
MOD_CK1_1	759	765	PF00069	0.374
MOD_CK1_1	772	778	PF00069	0.415
MOD_CK1_1	89	95	PF00069	0.458
MOD_CK2_1	107	113	PF00069	0.532
MOD_CK2_1	156	162	PF00069	0.583
MOD_CK2_1	180	186	PF00069	0.252
MOD_CK2_1	269	275	PF00069	0.319
MOD_CK2_1	74	80	PF00069	0.528
MOD_CK2_1	746	752	PF00069	0.354
MOD_CK2_1	844	850	PF00069	0.410
MOD_GlcNHglycan	109	112	PF01048	0.458
MOD_GlcNHglycan	21	24	PF01048	0.533
MOD_GlcNHglycan	48	51	PF01048	0.491
MOD_GlcNHglycan	486	489	PF01048	0.525
MOD_GlcNHglycan	533	536	PF01048	0.461
MOD_GlcNHglycan	595	598	PF01048	0.411
MOD_GlcNHglycan	758	761	PF01048	0.354
MOD_GSK3_1	1	8	PF00069	0.606
MOD_GSK3_1	156	163	PF00069	0.546
MOD_GSK3_1	236	243	PF00069	0.279
MOD_GSK3_1	250	257	PF00069	0.279
MOD_GSK3_1	326	333	PF00069	0.264
MOD_GSK3_1	477	484	PF00069	0.319
MOD_GSK3_1	543	550	PF00069	0.619
MOD_GSK3_1	765	772	PF00069	0.356
MOD_GSK3_1	84	91	PF00069	0.543
MOD_N-GLC_1	765	770	PF02516	0.162
MOD_N-GLC_2	451	453	PF02516	0.559
MOD_NEK2_1	107	112	PF00069	0.398
MOD_NEK2_1	160	165	PF00069	0.581
MOD_NEK2_1	251	256	PF00069	0.340
MOD_NEK2_1	330	335	PF00069	0.340
MOD_NEK2_1	46	51	PF00069	0.300
MOD_NEK2_1	528	533	PF00069	0.449
MOD_NEK2_1	547	552	PF00069	0.457
MOD_NEK2_1	737	742	PF00069	0.321
MOD_NEK2_1	770	775	PF00069	0.364
MOD_NEK2_1	801	806	PF00069	0.322
MOD_NEK2_2	746	751	PF00069	0.386
MOD_PIKK_1	37	43	PF00454	0.455
MOD_PIKK_1	453	459	PF00454	0.332
MOD_PIKK_1	673	679	PF00454	0.454
MOD_PIKK_1	86	92	PF00454	0.613
MOD_PK_1	655	661	PF00069	0.341
MOD_PKA_2	224	230	PF00069	0.254
MOD_PKA_2	287	293	PF00069	0.299
MOD_PKA_2	833	839	PF00069	0.380
MOD_PKA_2	99	105	PF00069	0.426
MOD_PKB_1	763	771	PF00069	0.162
MOD_PKB_1	84	92	PF00069	0.489
MOD_Plk_1	11	17	PF00069	0.524
MOD_Plk_1	221	227	PF00069	0.302
MOD_Plk_1	540	546	PF00069	0.543
MOD_Plk_1	655	661	PF00069	0.299
MOD_Plk_1	673	679	PF00069	0.307
MOD_Plk_1	765	771	PF00069	0.295
MOD_Plk_2-3	133	139	PF00069	0.534
MOD_Plk_4	166	172	PF00069	0.546
MOD_Plk_4	28	34	PF00069	0.444
MOD_Plk_4	287	293	PF00069	0.340
MOD_Plk_4	326	332	PF00069	0.254
MOD_Plk_4	543	549	PF00069	0.568
MOD_Plk_4	709	715	PF00069	0.269
MOD_Plk_4	746	752	PF00069	0.386
MOD_Plk_4	765	771	PF00069	0.162
MOD_Plk_4	816	822	PF00069	0.384
MOD_ProDKin_1	124	130	PF00069	0.525
MOD_ProDKin_1	254	260	PF00069	0.332
MOD_ProDKin_1	496	502	PF00069	0.248
MOD_ProDKin_1	548	554	PF00069	0.636
MOD_ProDKin_1	570	576	PF00069	0.530
MOD_ProDKin_1	591	597	PF00069	0.393
MOD_ProDKin_1	679	685	PF00069	0.344
MOD_SUMO_for_1	356	359	PF00179	0.304
MOD_SUMO_rev_2	66	76	PF00179	0.592
MOD_SUMO_rev_2	692	700	PF00179	0.240
TRG_DiLeu_BaEn_4	359	365	PF01217	0.151
TRG_DiLeu_BaEn_4	783	789	PF01217	0.415
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.329
TRG_ENDOCYTIC_2	16	19	PF00928	0.253
TRG_ENDOCYTIC_2	235	238	PF00928	0.267
TRG_ENDOCYTIC_2	279	282	PF00928	0.254
TRG_ENDOCYTIC_2	331	334	PF00928	0.254
TRG_ENDOCYTIC_2	342	345	PF00928	0.254
TRG_ENDOCYTIC_2	408	411	PF00928	0.321
TRG_ENDOCYTIC_2	412	415	PF00928	0.301
TRG_ENDOCYTIC_2	672	675	PF00928	0.322
TRG_ENDOCYTIC_2	710	713	PF00928	0.307
TRG_ENDOCYTIC_2	818	821	PF00928	0.364
TRG_ER_diArg_1	309	311	PF00400	0.151
TRG_ER_diArg_1	582	584	PF00400	0.270
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	362	367	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	846	850	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAL6	Leptomonas seymouri	71%	100%
A0A0S4JPE0	Bodo saltans	39%	100%
A0A1X0NDT3	Trypanosomatidae	46%	98%
A0A3R7RCW5	Trypanosoma rangeli	47%	100%
A0A3S7XAZ8	Leishmania donovani	91%	100%
A1CHP1	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	24%	100%
A2QEK7	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	22%	95%
A4HPA8	Leishmania braziliensis	82%	100%
A4IDL6	Leishmania infantum	91%	100%
A4QYQ5	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	22%	91%
A7EQZ1	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	24%	93%
B0XYK8	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	24%	93%
B2A951	Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)	23%	92%
B2WC36	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	22%	97%
B6HFS8	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	23%	94%
B8MTH6	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	24%	95%
B8N970	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	25%	100%
C5FYZ3	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)	23%	93%
D0A3B6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
D4AQT0	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	25%	94%
D4DCG0	Trichophyton verrucosum (strain HKI 0517)	25%	95%
D5GM60	Tuber melanosporum (strain Mel28)	23%	94%
E4UYL6	Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893)	24%	93%
Q2UH35	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	25%	100%
Q4Q1H9	Leishmania major	91%	100%
Q4WX13	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	93%
Q6V1X1	Homo sapiens	27%	95%
Q80YA7	Mus musculus	27%	96%
Q86TI2	Homo sapiens	27%	99%
Q8BVG4	Mus musculus	27%	99%
Q96VT7	Aspergillus niger	22%	95%
V5B849	Trypanosoma cruzi	46%	100%