EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT17_LEIMU

TriTrypDb:

LmxM.36.2400

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AT17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT17

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0005509	calcium ion binding	5	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	144	146	PF00675	0.564
CLV_NRD_NRD_1	293	295	PF00675	0.553
CLV_PCSK_KEX2_1	144	146	PF00082	0.564
CLV_PCSK_KEX2_1	32	34	PF00082	0.554
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.397
CLV_PCSK_SKI1_1	172	176	PF00082	0.396
CLV_PCSK_SKI1_1	179	183	PF00082	0.347
DEG_APCC_DBOX_1	239	247	PF00400	0.403
DEG_Nend_Nbox_1	1	3	PF02207	0.421
DOC_MAPK_FxFP_2	195	198	PF00069	0.316
DOC_PP2B_LxvP_1	324	327	PF13499	0.493
DOC_PP4_FxxP_1	195	198	PF00568	0.316
DOC_USP7_MATH_1	13	17	PF00917	0.369
DOC_USP7_MATH_1	327	331	PF00917	0.602
DOC_USP7_UBL2_3	319	323	PF12436	0.531
DOC_WW_Pin1_4	124	129	PF00397	0.454
LIG_14-3-3_CanoR_1	263	268	PF00244	0.461
LIG_BRCT_BRCA1_1	69	73	PF00533	0.380
LIG_Clathr_ClatBox_1	139	143	PF01394	0.421
LIG_CtBP_PxDLS_1	198	202	PF00389	0.396
LIG_FHA_1	20	26	PF00498	0.481
LIG_FHA_2	100	106	PF00498	0.286
LIG_FHA_2	181	187	PF00498	0.346
LIG_FHA_2	237	243	PF00498	0.377
LIG_FHA_2	70	76	PF00498	0.481
LIG_Integrin_RGD_1	184	186	PF01839	0.356
LIG_LIR_Apic_2	207	211	PF02991	0.480
LIG_LIR_Gen_1	70	79	PF02991	0.479
LIG_LIR_Nem_3	227	233	PF02991	0.356
LIG_LIR_Nem_3	70	76	PF02991	0.480
LIG_PTB_Apo_2	272	279	PF02174	0.470
LIG_PTB_Phospho_1	272	278	PF10480	0.467
LIG_REV1ctd_RIR_1	318	326	PF16727	0.383
LIG_SH2_CRK	313	317	PF00017	0.520
LIG_SH2_PTP2	208	211	PF00017	0.412
LIG_SH2_SRC	37	40	PF00017	0.254
LIG_SH2_SRC	88	91	PF00017	0.473
LIG_SH2_STAP1	132	136	PF00017	0.379
LIG_SH2_STAP1	219	223	PF00017	0.410
LIG_SH2_STAP1	88	92	PF00017	0.538
LIG_SH2_STAT3	309	312	PF00017	0.543
LIG_SH2_STAT5	194	197	PF00017	0.435
LIG_SH2_STAT5	208	211	PF00017	0.480
LIG_SH2_STAT5	230	233	PF00017	0.408
LIG_SH2_STAT5	34	37	PF00017	0.458
LIG_SH3_3	117	123	PF00018	0.431
LIG_SH3_3	144	150	PF00018	0.404
LIG_SH3_3	174	180	PF00018	0.298
LIG_SUMO_SIM_par_1	22	29	PF11976	0.463
LIG_UBA3_1	168	175	PF00899	0.453
LIG_UBA3_1	273	280	PF00899	0.443
LIG_WRC_WIRS_1	301	306	PF05994	0.542
MOD_CK1_1	157	163	PF00069	0.541
MOD_CK1_1	262	268	PF00069	0.532
MOD_CK2_1	69	75	PF00069	0.459
MOD_CK2_1	99	105	PF00069	0.421
MOD_GlcNHglycan	152	155	PF01048	0.714
MOD_GlcNHglycan	159	162	PF01048	0.636
MOD_GlcNHglycan	199	204	PF01048	0.373
MOD_GlcNHglycan	282	285	PF01048	0.533
MOD_GlcNHglycan	49	52	PF01048	0.429
MOD_GSK3_1	150	157	PF00069	0.658
MOD_GSK3_1	219	226	PF00069	0.325
MOD_GSK3_1	259	266	PF00069	0.414
MOD_GSK3_1	327	334	PF00069	0.515
MOD_GSK3_1	43	50	PF00069	0.549
MOD_LATS_1	298	304	PF00433	0.461
MOD_N-GLC_1	19	24	PF02516	0.423
MOD_PIKK_1	122	128	PF00454	0.387
MOD_PKA_1	279	285	PF00069	0.515
MOD_PKA_2	211	217	PF00069	0.453
MOD_PKA_2	262	268	PF00069	0.438
MOD_PKA_2	52	58	PF00069	0.480
MOD_Plk_1	219	225	PF00069	0.358
MOD_Plk_1	99	105	PF00069	0.423
MOD_Plk_4	132	138	PF00069	0.359
MOD_Plk_4	263	269	PF00069	0.494
MOD_Plk_4	99	105	PF00069	0.450
MOD_ProDKin_1	124	130	PF00069	0.455
TRG_ENDOCYTIC_2	230	233	PF00928	0.326
TRG_ENDOCYTIC_2	313	316	PF00928	0.521
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.323

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBZ0	Leptomonas seymouri	71%	98%
A0A1X0NFQ9	Trypanosomatidae	43%	100%
A0A3Q8IH99	Leishmania donovani	93%	100%
A0A3R7N4F8	Trypanosoma rangeli	43%	100%
A4HPA6	Leishmania braziliensis	81%	100%
A4IDL4	Leishmania infantum	94%	100%
D0A3B4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4Q1I1	Leishmania major	93%	100%