Nitrogen permease regulator 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

base J-associated glucosyltransferase

Species:

Leishmania mexicana

UniProt:

E9AT14_LEIMU

TriTrypDb:

LmxM.36.2370

Length:

956

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AT14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT14

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006304	DNA modification	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016757	glycosyltransferase activity	3	1
GO:0016758	hexosyltransferase activity	4	1
GO:0046527	glucosyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.763
CLV_C14_Caspase3-7	754	758	PF00656	0.688
CLV_C14_Caspase3-7	878	882	PF00656	0.451
CLV_C14_Caspase3-7	896	900	PF00656	0.598
CLV_NRD_NRD_1	260	262	PF00675	0.490
CLV_NRD_NRD_1	362	364	PF00675	0.556
CLV_NRD_NRD_1	609	611	PF00675	0.453
CLV_NRD_NRD_1	704	706	PF00675	0.535
CLV_NRD_NRD_1	772	774	PF00675	0.724
CLV_NRD_NRD_1	795	797	PF00675	0.615
CLV_PCSK_KEX2_1	260	262	PF00082	0.504
CLV_PCSK_KEX2_1	362	364	PF00082	0.556
CLV_PCSK_KEX2_1	609	611	PF00082	0.453
CLV_PCSK_KEX2_1	704	706	PF00082	0.459
CLV_PCSK_KEX2_1	774	776	PF00082	0.660
CLV_PCSK_KEX2_1	795	797	PF00082	0.615
CLV_PCSK_PC1ET2_1	774	776	PF00082	0.660
CLV_PCSK_SKI1_1	126	130	PF00082	0.442
CLV_PCSK_SKI1_1	275	279	PF00082	0.387
CLV_PCSK_SKI1_1	565	569	PF00082	0.524
CLV_PCSK_SKI1_1	684	688	PF00082	0.408
DEG_APCC_DBOX_1	125	133	PF00400	0.428
DEG_Nend_Nbox_1	1	3	PF02207	0.614
DEG_SCF_FBW7_1	194	200	PF00400	0.606
DEG_SCF_TRCP1_1	383	389	PF00400	0.500
DEG_SPOP_SBC_1	364	368	PF00917	0.593
DEG_SPOP_SBC_1	371	375	PF00917	0.590
DEG_SPOP_SBC_1	411	415	PF00917	0.775
DEG_SPOP_SBC_1	752	756	PF00917	0.689
DEG_SPOP_SBC_1	808	812	PF00917	0.672
DOC_ANK_TNKS_1	320	327	PF00023	0.546
DOC_ANK_TNKS_1	598	605	PF00023	0.505
DOC_CKS1_1	194	199	PF01111	0.615
DOC_CKS1_1	393	398	PF01111	0.486
DOC_CKS1_1	495	500	PF01111	0.649
DOC_CKS1_1	72	77	PF01111	0.614
DOC_CYCLIN_RxL_1	202	212	PF00134	0.546
DOC_CYCLIN_RxL_1	646	656	PF00134	0.247
DOC_CYCLIN_yCln2_LP_2	687	693	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	714	720	PF00134	0.399
DOC_MAPK_DCC_7	108	116	PF00069	0.371
DOC_MAPK_gen_1	704	710	PF00069	0.426
DOC_MAPK_MEF2A_6	100	107	PF00069	0.496
DOC_MAPK_MEF2A_6	108	116	PF00069	0.362
DOC_MAPK_MEF2A_6	294	302	PF00069	0.433
DOC_MAPK_MEF2A_6	918	925	PF00069	0.477
DOC_PP1_RVXF_1	649	656	PF00149	0.352
DOC_PP1_RVXF_1	707	713	PF00149	0.423
DOC_PP1_RVXF_1	905	911	PF00149	0.511
DOC_PP2B_LxvP_1	729	732	PF13499	0.415
DOC_PP4_FxxP_1	495	498	PF00568	0.656
DOC_PP4_FxxP_1	655	658	PF00568	0.373
DOC_PP4_FxxP_1	903	906	PF00568	0.418
DOC_PP4_FxxP_1	929	932	PF00568	0.488
DOC_SPAK_OSR1_1	627	631	PF12202	0.376
DOC_USP7_MATH_1	10	14	PF00917	0.613
DOC_USP7_MATH_1	223	227	PF00917	0.519
DOC_USP7_MATH_1	249	253	PF00917	0.627
DOC_USP7_MATH_1	411	415	PF00917	0.593
DOC_USP7_MATH_1	499	503	PF00917	0.654
DOC_USP7_MATH_1	63	67	PF00917	0.691
DOC_USP7_MATH_1	752	756	PF00917	0.577
DOC_USP7_MATH_1	786	790	PF00917	0.704
DOC_USP7_MATH_1	876	880	PF00917	0.549
DOC_USP7_MATH_1	939	943	PF00917	0.490
DOC_WW_Pin1_4	15	20	PF00397	0.648
DOC_WW_Pin1_4	166	171	PF00397	0.622
DOC_WW_Pin1_4	187	192	PF00397	0.656
DOC_WW_Pin1_4	193	198	PF00397	0.599
DOC_WW_Pin1_4	239	244	PF00397	0.801
DOC_WW_Pin1_4	245	250	PF00397	0.746
DOC_WW_Pin1_4	329	334	PF00397	0.547
DOC_WW_Pin1_4	392	397	PF00397	0.503
DOC_WW_Pin1_4	41	46	PF00397	0.644
DOC_WW_Pin1_4	412	417	PF00397	0.630
DOC_WW_Pin1_4	423	428	PF00397	0.572
DOC_WW_Pin1_4	481	486	PF00397	0.538
DOC_WW_Pin1_4	494	499	PF00397	0.624
DOC_WW_Pin1_4	506	511	PF00397	0.577
DOC_WW_Pin1_4	65	70	PF00397	0.840
DOC_WW_Pin1_4	71	76	PF00397	0.567
DOC_WW_Pin1_4	713	718	PF00397	0.431
DOC_WW_Pin1_4	777	782	PF00397	0.647
DOC_WW_Pin1_4	788	793	PF00397	0.627
DOC_WW_Pin1_4	8	13	PF00397	0.614
LIG_14-3-3_CanoR_1	100	104	PF00244	0.395
LIG_14-3-3_CanoR_1	362	371	PF00244	0.579
LIG_14-3-3_CanoR_1	412	416	PF00244	0.556
LIG_14-3-3_CanoR_1	459	466	PF00244	0.407
LIG_14-3-3_CanoR_1	643	649	PF00244	0.366
LIG_14-3-3_CanoR_1	869	873	PF00244	0.515
LIG_14-3-3_CanoR_1	907	917	PF00244	0.505
LIG_APCC_ABBA_1	857	862	PF00400	0.493
LIG_BIR_III_2	62	66	PF00653	0.551
LIG_BRCT_BRCA1_1	211	215	PF00533	0.436
LIG_BRCT_BRCA1_1	262	266	PF00533	0.476
LIG_BRCT_BRCA1_1	651	655	PF00533	0.424
LIG_Clathr_ClatBox_1	277	281	PF01394	0.371
LIG_deltaCOP1_diTrp_1	172	176	PF00928	0.563
LIG_eIF4E_1	296	302	PF01652	0.434
LIG_EVH1_2	491	495	PF00568	0.699
LIG_FHA_1	100	106	PF00498	0.570
LIG_FHA_1	194	200	PF00498	0.672
LIG_FHA_1	30	36	PF00498	0.674
LIG_FHA_1	366	372	PF00498	0.594
LIG_FHA_1	424	430	PF00498	0.565
LIG_FHA_1	572	578	PF00498	0.424
LIG_FHA_1	635	641	PF00498	0.350
LIG_FHA_1	851	857	PF00498	0.496
LIG_FHA_2	156	162	PF00498	0.645
LIG_FHA_2	167	173	PF00498	0.545
LIG_FHA_2	453	459	PF00498	0.565
LIG_FHA_2	524	530	PF00498	0.543
LIG_FHA_2	568	574	PF00498	0.518
LIG_FHA_2	761	767	PF00498	0.696
LIG_FHA_2	869	875	PF00498	0.450
LIG_FHA_2	925	931	PF00498	0.488
LIG_GBD_Chelix_1	615	623	PF00786	0.459
LIG_LIR_Apic_2	172	177	PF02991	0.514
LIG_LIR_Apic_2	493	498	PF02991	0.760
LIG_LIR_Apic_2	652	658	PF02991	0.370
LIG_LIR_Apic_2	926	932	PF02991	0.416
LIG_LIR_Gen_1	27	38	PF02991	0.643
LIG_LIR_Gen_1	355	364	PF02991	0.497
LIG_LIR_Gen_1	560	571	PF02991	0.408
LIG_LIR_Gen_1	579	587	PF02991	0.367
LIG_LIR_Gen_1	944	953	PF02991	0.489
LIG_LIR_Nem_3	27	33	PF02991	0.644
LIG_LIR_Nem_3	355	361	PF02991	0.557
LIG_LIR_Nem_3	442	448	PF02991	0.356
LIG_LIR_Nem_3	560	566	PF02991	0.376
LIG_LIR_Nem_3	579	583	PF02991	0.389
LIG_LIR_Nem_3	622	628	PF02991	0.389
LIG_LIR_Nem_3	647	653	PF02991	0.347
LIG_LIR_Nem_3	824	829	PF02991	0.541
LIG_MYND_1	734	738	PF01753	0.566
LIG_Pex14_1	817	821	PF04695	0.601
LIG_Pex14_2	434	438	PF04695	0.369
LIG_Pex14_2	685	689	PF04695	0.393
LIG_PTAP_UEV_1	261	266	PF05743	0.423
LIG_PTAP_UEV_1	780	785	PF05743	0.668
LIG_REV1ctd_RIR_1	858	864	PF16727	0.519
LIG_REV1ctd_RIR_1	944	953	PF16727	0.565
LIG_SH2_CRK	580	584	PF00017	0.378
LIG_SH2_CRK	589	593	PF00017	0.388
LIG_SH2_NCK_1	580	584	PF00017	0.378
LIG_SH2_SRC	358	361	PF00017	0.617
LIG_SH2_SRC	618	621	PF00017	0.566
LIG_SH2_SRC	798	801	PF00017	0.500
LIG_SH2_STAP1	634	638	PF00017	0.439
LIG_SH2_STAT3	296	299	PF00017	0.358
LIG_SH2_STAT5	136	139	PF00017	0.517
LIG_SH2_STAT5	219	222	PF00017	0.405
LIG_SH2_STAT5	292	295	PF00017	0.396
LIG_SH2_STAT5	296	299	PF00017	0.394
LIG_SH2_STAT5	358	361	PF00017	0.541
LIG_SH2_STAT5	511	514	PF00017	0.693
LIG_SH2_STAT5	554	557	PF00017	0.407
LIG_SH2_STAT5	600	603	PF00017	0.528
LIG_SH2_STAT5	618	621	PF00017	0.587
LIG_SH2_STAT5	728	731	PF00017	0.438
LIG_SH2_STAT5	798	801	PF00017	0.500
LIG_SH2_STAT5	821	824	PF00017	0.596
LIG_SH3_1	600	606	PF00018	0.566
LIG_SH3_1	775	781	PF00018	0.651
LIG_SH3_2	72	77	PF14604	0.629
LIG_SH3_3	188	194	PF00018	0.668
LIG_SH3_3	217	223	PF00018	0.415
LIG_SH3_3	238	244	PF00018	0.695
LIG_SH3_3	259	265	PF00018	0.471
LIG_SH3_3	297	303	PF00018	0.397
LIG_SH3_3	479	485	PF00018	0.518
LIG_SH3_3	495	501	PF00018	0.586
LIG_SH3_3	600	606	PF00018	0.557
LIG_SH3_3	66	72	PF00018	0.647
LIG_SH3_3	775	781	PF00018	0.651
LIG_SH3_3	794	800	PF00018	0.611
LIG_SH3_3	81	87	PF00018	0.353
LIG_SH3_3	853	859	PF00018	0.499
LIG_SUMO_SIM_anti_2	853	858	PF11976	0.484
LIG_SUMO_SIM_par_1	113	118	PF11976	0.407
LIG_SUMO_SIM_par_1	31	37	PF11976	0.697
LIG_SUMO_SIM_par_1	573	579	PF11976	0.466
LIG_SUMO_SIM_par_1	804	812	PF11976	0.491
LIG_SUMO_SIM_par_1	839	844	PF11976	0.520
LIG_TRAF2_1	830	833	PF00917	0.541
LIG_UBA3_1	1	7	PF00899	0.695
LIG_WW_3	904	908	PF00397	0.423
MOD_CDC14_SPxK_1	716	719	PF00782	0.436
MOD_CDK_SPK_2	423	428	PF00069	0.596
MOD_CDK_SPxK_1	71	77	PF00069	0.639
MOD_CDK_SPxK_1	713	719	PF00069	0.429
MOD_CDK_SPxxK_3	788	795	PF00069	0.522
MOD_CK1_1	11	17	PF00069	0.640
MOD_CK1_1	190	196	PF00069	0.717
MOD_CK1_1	252	258	PF00069	0.659
MOD_CK1_1	365	371	PF00069	0.659
MOD_CK1_1	374	380	PF00069	0.595
MOD_CK1_1	384	390	PF00069	0.478
MOD_CK1_1	394	400	PF00069	0.591
MOD_CK1_1	40	46	PF00069	0.648
MOD_CK1_1	414	420	PF00069	0.568
MOD_CK1_1	450	456	PF00069	0.564
MOD_CK1_1	502	508	PF00069	0.665
MOD_CK1_1	576	582	PF00069	0.388
MOD_CK1_1	68	74	PF00069	0.782
MOD_CK1_1	751	757	PF00069	0.634
MOD_CK1_1	758	764	PF00069	0.561
MOD_CK1_1	779	785	PF00069	0.535
MOD_CK1_1	788	794	PF00069	0.517
MOD_CK1_1	807	813	PF00069	0.540
MOD_CK1_1	879	885	PF00069	0.577
MOD_CK2_1	155	161	PF00069	0.626
MOD_CK2_1	344	350	PF00069	0.599
MOD_CK2_1	452	458	PF00069	0.571
MOD_CK2_1	523	529	PF00069	0.555
MOD_CK2_1	760	766	PF00069	0.693
MOD_CK2_1	827	833	PF00069	0.559
MOD_CK2_1	868	874	PF00069	0.441
MOD_CK2_1	890	896	PF00069	0.695
MOD_CK2_1	924	930	PF00069	0.495
MOD_Cter_Amidation	793	796	PF01082	0.702
MOD_DYRK1A_RPxSP_1	412	416	PF00069	0.556
MOD_DYRK1A_RPxSP_1	777	781	PF00069	0.646
MOD_GlcNHglycan	13	16	PF01048	0.676
MOD_GlcNHglycan	199	202	PF01048	0.598
MOD_GlcNHglycan	211	214	PF01048	0.619
MOD_GlcNHglycan	225	228	PF01048	0.468
MOD_GlcNHglycan	252	255	PF01048	0.646
MOD_GlcNHglycan	262	265	PF01048	0.483
MOD_GlcNHglycan	312	316	PF01048	0.497
MOD_GlcNHglycan	376	379	PF01048	0.619
MOD_GlcNHglycan	383	386	PF01048	0.641
MOD_GlcNHglycan	408	411	PF01048	0.580
MOD_GlcNHglycan	417	420	PF01048	0.639
MOD_GlcNHglycan	460	463	PF01048	0.350
MOD_GlcNHglycan	50	53	PF01048	0.685
MOD_GlcNHglycan	502	505	PF01048	0.667
MOD_GlcNHglycan	537	540	PF01048	0.566
MOD_GlcNHglycan	729	732	PF01048	0.422
MOD_GlcNHglycan	750	753	PF01048	0.648
MOD_GlcNHglycan	885	888	PF01048	0.661
MOD_GSK3_1	11	18	PF00069	0.643
MOD_GSK3_1	149	156	PF00069	0.590
MOD_GSK3_1	189	196	PF00069	0.684
MOD_GSK3_1	239	246	PF00069	0.779
MOD_GSK3_1	249	256	PF00069	0.647
MOD_GSK3_1	37	44	PF00069	0.706
MOD_GSK3_1	370	377	PF00069	0.548
MOD_GSK3_1	406	413	PF00069	0.690
MOD_GSK3_1	447	454	PF00069	0.517
MOD_GSK3_1	486	493	PF00069	0.633
MOD_GSK3_1	500	507	PF00069	0.575
MOD_GSK3_1	553	560	PF00069	0.361
MOD_GSK3_1	567	574	PF00069	0.417
MOD_GSK3_1	748	755	PF00069	0.608
MOD_GSK3_1	765	772	PF00069	0.540
MOD_GSK3_1	782	789	PF00069	0.739
MOD_GSK3_1	804	811	PF00069	0.569
MOD_GSK3_1	879	886	PF00069	0.655
MOD_GSK3_1	89	96	PF00069	0.401
MOD_N-GLC_1	149	154	PF02516	0.506
MOD_N-GLC_1	239	244	PF02516	0.686
MOD_N-GLC_1	47	52	PF02516	0.710
MOD_N-GLC_1	748	753	PF02516	0.633
MOD_N-GLC_1	890	895	PF02516	0.694
MOD_NEK2_1	209	214	PF00069	0.462
MOD_NEK2_1	288	293	PF00069	0.279
MOD_NEK2_1	370	375	PF00069	0.516
MOD_NEK2_1	405	410	PF00069	0.650
MOD_NEK2_1	447	452	PF00069	0.488
MOD_NEK2_1	523	528	PF00069	0.634
MOD_NEK2_1	552	557	PF00069	0.395
MOD_NEK2_1	619	624	PF00069	0.458
MOD_NEK2_1	727	732	PF00069	0.515
MOD_NEK2_1	809	814	PF00069	0.620
MOD_NEK2_1	98	103	PF00069	0.492
MOD_NEK2_2	644	649	PF00069	0.364
MOD_PIKK_1	511	517	PF00454	0.498
MOD_PKA_1	260	266	PF00069	0.519
MOD_PKA_1	362	368	PF00069	0.639
MOD_PKA_2	209	215	PF00069	0.483
MOD_PKA_2	260	266	PF00069	0.657
MOD_PKA_2	362	368	PF00069	0.572
MOD_PKA_2	411	417	PF00069	0.688
MOD_PKA_2	458	464	PF00069	0.422
MOD_PKA_2	776	782	PF00069	0.543
MOD_PKA_2	868	874	PF00069	0.465
MOD_PKA_2	99	105	PF00069	0.403
MOD_PKB_1	825	833	PF00069	0.578
MOD_Plk_1	619	625	PF00069	0.560
MOD_Plk_1	634	640	PF00069	0.266
MOD_Plk_1	786	792	PF00069	0.597
MOD_Plk_1	98	104	PF00069	0.409
MOD_Plk_2-3	354	360	PF00069	0.537
MOD_Plk_2-3	37	43	PF00069	0.664
MOD_Plk_4	288	294	PF00069	0.403
MOD_Plk_4	344	350	PF00069	0.525
MOD_Plk_4	354	360	PF00069	0.568
MOD_Plk_4	619	625	PF00069	0.444
MOD_Plk_4	804	810	PF00069	0.541
MOD_Plk_4	863	869	PF00069	0.461
MOD_ProDKin_1	15	21	PF00069	0.647
MOD_ProDKin_1	166	172	PF00069	0.618
MOD_ProDKin_1	187	193	PF00069	0.659
MOD_ProDKin_1	239	245	PF00069	0.801
MOD_ProDKin_1	329	335	PF00069	0.543
MOD_ProDKin_1	392	398	PF00069	0.503
MOD_ProDKin_1	41	47	PF00069	0.645
MOD_ProDKin_1	412	418	PF00069	0.632
MOD_ProDKin_1	423	429	PF00069	0.564
MOD_ProDKin_1	481	487	PF00069	0.547
MOD_ProDKin_1	494	500	PF00069	0.621
MOD_ProDKin_1	506	512	PF00069	0.576
MOD_ProDKin_1	65	71	PF00069	0.837
MOD_ProDKin_1	713	719	PF00069	0.438
MOD_ProDKin_1	777	783	PF00069	0.644
MOD_ProDKin_1	788	794	PF00069	0.626
MOD_ProDKin_1	8	14	PF00069	0.616
MOD_SUMO_for_1	948	951	PF00179	0.527
MOD_SUMO_rev_2	232	241	PF00179	0.547
MOD_SUMO_rev_2	347	353	PF00179	0.582
TRG_DiLeu_BaLyEn_6	425	430	PF01217	0.535
TRG_ENDOCYTIC_2	125	128	PF00928	0.416
TRG_ENDOCYTIC_2	136	139	PF00928	0.475
TRG_ENDOCYTIC_2	346	349	PF00928	0.527
TRG_ENDOCYTIC_2	358	361	PF00928	0.541
TRG_ENDOCYTIC_2	437	440	PF00928	0.334
TRG_ENDOCYTIC_2	563	566	PF00928	0.493
TRG_ENDOCYTIC_2	580	583	PF00928	0.386
TRG_ENDOCYTIC_2	589	592	PF00928	0.387
TRG_ER_diArg_1	260	262	PF00400	0.490
TRG_ER_diArg_1	361	363	PF00400	0.521
TRG_ER_diArg_1	471	474	PF00400	0.453
TRG_ER_diArg_1	608	610	PF00400	0.454
TRG_ER_diArg_1	708	711	PF00400	0.409
TRG_ER_diArg_1	773	776	PF00400	0.668
TRG_ER_diArg_1	795	797	PF00400	0.691
TRG_NLS_MonoExtC_3	772	777	PF00514	0.659
TRG_NLS_MonoExtN_4	773	778	PF00514	0.733
TRG_Pf-PMV_PEXEL_1	651	656	PF00026	0.249

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R8	Leptomonas seymouri	55%	100%
A0A3Q8IKQ0	Leishmania donovani	90%	100%
A4HPA4	Leishmania braziliensis	81%	99%
A4IDL1	Leishmania infantum	90%	100%
Q4Q1I4	Leishmania major	91%	100%