Short chain dehydrogenase family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT11_LEIMU

TriTrypDb:

LmxM.36.2340

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AT11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	82	86	PF00656	0.605
CLV_NRD_NRD_1	192	194	PF00675	0.312
CLV_NRD_NRD_1	44	46	PF00675	0.339
CLV_PCSK_KEX2_1	141	143	PF00082	0.368
CLV_PCSK_KEX2_1	192	194	PF00082	0.312
CLV_PCSK_KEX2_1	347	349	PF00082	0.416
CLV_PCSK_KEX2_1	44	46	PF00082	0.354
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.368
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.425
CLV_PCSK_SKI1_1	119	123	PF00082	0.257
CLV_PCSK_SKI1_1	167	171	PF00082	0.293
DEG_APCC_DBOX_1	166	174	PF00400	0.479
DEG_APCC_DBOX_1	272	280	PF00400	0.559
DEG_Nend_Nbox_1	1	3	PF02207	0.346
DEG_SCF_FBW7_1	309	315	PF00400	0.719
DOC_CKS1_1	309	314	PF01111	0.811
DOC_CKS1_1	401	406	PF01111	0.511
DOC_CYCLIN_yClb5_NLxxxL_5	154	163	PF00134	0.538
DOC_CYCLIN_yCln2_LP_2	124	130	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	159	165	PF00134	0.538
DOC_MAPK_gen_1	270	279	PF00069	0.587
DOC_MAPK_gen_1	44	50	PF00069	0.574
DOC_MAPK_MEF2A_6	167	174	PF00069	0.558
DOC_MAPK_NFAT4_5	167	175	PF00069	0.568
DOC_PP1_RVXF_1	393	400	PF00149	0.436
DOC_PP1_RVXF_1	54	61	PF00149	0.524
DOC_USP7_MATH_1	147	151	PF00917	0.501
DOC_USP7_MATH_1	176	180	PF00917	0.512
DOC_USP7_MATH_1	260	264	PF00917	0.744
DOC_USP7_MATH_1	288	292	PF00917	0.601
DOC_USP7_MATH_1	312	316	PF00917	0.750
DOC_USP7_MATH_1	95	99	PF00917	0.694
DOC_WW_Pin1_4	158	163	PF00397	0.568
DOC_WW_Pin1_4	172	177	PF00397	0.403
DOC_WW_Pin1_4	212	217	PF00397	0.485
DOC_WW_Pin1_4	294	299	PF00397	0.677
DOC_WW_Pin1_4	305	310	PF00397	0.729
DOC_WW_Pin1_4	315	320	PF00397	0.715
DOC_WW_Pin1_4	400	405	PF00397	0.462
LIG_14-3-3_CanoR_1	273	277	PF00244	0.527
LIG_14-3-3_CanoR_1	305	309	PF00244	0.662
LIG_14-3-3_CanoR_1	330	337	PF00244	0.713
LIG_Actin_WH2_2	63	78	PF00022	0.619
LIG_BIR_III_4	85	89	PF00653	0.570
LIG_BRCT_BRCA1_1	100	104	PF00533	0.525
LIG_DCNL_PONY_1	1	4	PF03556	0.378
LIG_FHA_1	106	112	PF00498	0.479
LIG_FHA_1	155	161	PF00498	0.544
LIG_FHA_1	272	278	PF00498	0.582
LIG_FHA_1	30	36	PF00498	0.499
LIG_FHA_1	376	382	PF00498	0.406
LIG_Integrin_RGD_1	193	195	PF01839	0.312
LIG_LIR_Apic_2	281	287	PF02991	0.686
LIG_LIR_Gen_1	101	111	PF02991	0.568
LIG_LIR_Gen_1	195	203	PF02991	0.540
LIG_LIR_Gen_1	339	345	PF02991	0.540
LIG_LIR_Gen_1	61	70	PF02991	0.555
LIG_LIR_Nem_3	195	199	PF02991	0.511
LIG_LIR_Nem_3	221	226	PF02991	0.467
LIG_LIR_Nem_3	339	344	PF02991	0.629
LIG_LIR_Nem_3	379	385	PF02991	0.359
LIG_LIR_Nem_3	61	65	PF02991	0.559
LIG_LYPXL_S_1	381	385	PF13949	0.462
LIG_LYPXL_yS_3	382	385	PF13949	0.462
LIG_REV1ctd_RIR_1	18	24	PF16727	0.475
LIG_SH2_CRK	196	200	PF00017	0.538
LIG_SH2_CRK	284	288	PF00017	0.683
LIG_SH2_CRK	341	345	PF00017	0.579
LIG_SH2_CRK	62	66	PF00017	0.593
LIG_SH2_STAP1	196	200	PF00017	0.538
LIG_SH2_STAP1	341	345	PF00017	0.618
LIG_SH2_STAP1	372	376	PF00017	0.496
LIG_SH2_STAT5	209	212	PF00017	0.538
LIG_SH2_STAT5	341	344	PF00017	0.636
LIG_SH2_STAT5	370	373	PF00017	0.577
LIG_SH3_3	295	301	PF00018	0.641
LIG_SH3_3	306	312	PF00018	0.721
LIG_SH3_3	377	383	PF00018	0.411
LIG_SUMO_SIM_anti_2	161	167	PF11976	0.568
LIG_SUMO_SIM_par_1	107	113	PF11976	0.503
LIG_SUMO_SIM_par_1	170	175	PF11976	0.568
LIG_SUMO_SIM_par_1	198	204	PF11976	0.528
LIG_SUMO_SIM_par_1	31	36	PF11976	0.508
LIG_TYR_ITIM	380	385	PF00017	0.442
MOD_CK1_1	177	183	PF00069	0.425
MOD_CK1_1	212	218	PF00069	0.326
MOD_CK1_1	29	35	PF00069	0.444
MOD_CK1_1	307	313	PF00069	0.708
MOD_CK1_1	315	321	PF00069	0.767
MOD_CK1_1	98	104	PF00069	0.538
MOD_CK2_1	228	234	PF00069	0.462
MOD_CMANNOS	12	15	PF00535	0.321
MOD_Cter_Amidation	42	45	PF01082	0.435
MOD_DYRK1A_RPxSP_1	305	309	PF00069	0.712
MOD_GlcNHglycan	100	103	PF01048	0.571
MOD_GlcNHglycan	148	152	PF01048	0.451
MOD_GlcNHglycan	203	206	PF01048	0.385
MOD_GlcNHglycan	248	251	PF01048	0.700
MOD_GlcNHglycan	28	31	PF01048	0.530
MOD_GlcNHglycan	314	317	PF01048	0.760
MOD_GlcNHglycan	334	337	PF01048	0.579
MOD_GlcNHglycan	373	376	PF01048	0.385
MOD_GSK3_1	105	112	PF00069	0.399
MOD_GSK3_1	154	161	PF00069	0.475
MOD_GSK3_1	172	179	PF00069	0.244
MOD_GSK3_1	242	249	PF00069	0.636
MOD_GSK3_1	29	36	PF00069	0.394
MOD_GSK3_1	300	307	PF00069	0.712
MOD_GSK3_1	308	315	PF00069	0.755
MOD_GSK3_1	371	378	PF00069	0.421
MOD_N-GLC_1	177	182	PF02516	0.447
MOD_N-GLC_1	207	212	PF02516	0.418
MOD_NEK2_1	154	159	PF00069	0.460
MOD_NEK2_1	228	233	PF00069	0.361
MOD_NEK2_2	95	100	PF00069	0.597
MOD_PIKK_1	218	224	PF00454	0.356
MOD_PIKK_1	339	345	PF00454	0.541
MOD_PKA_2	272	278	PF00069	0.407
MOD_PKA_2	304	310	PF00069	0.595
MOD_PKA_2	337	343	PF00069	0.573
MOD_PKB_1	24	32	PF00069	0.541
MOD_Plk_1	177	183	PF00069	0.233
MOD_Plk_1	207	213	PF00069	0.385
MOD_Plk_4	198	204	PF00069	0.385
MOD_Plk_4	272	278	PF00069	0.383
MOD_Plk_4	289	295	PF00069	0.550
MOD_Plk_4	29	35	PF00069	0.357
MOD_Plk_4	376	382	PF00069	0.341
MOD_Plk_4	7	13	PF00069	0.357
MOD_ProDKin_1	158	164	PF00069	0.462
MOD_ProDKin_1	172	178	PF00069	0.231
MOD_ProDKin_1	212	218	PF00069	0.346
MOD_ProDKin_1	294	300	PF00069	0.619
MOD_ProDKin_1	305	311	PF00069	0.688
MOD_ProDKin_1	315	321	PF00069	0.666
MOD_ProDKin_1	400	406	PF00069	0.601
MOD_SUMO_rev_2	249	258	PF00179	0.751
TRG_DiLeu_BaLyEn_6	168	173	PF01217	0.371
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.364
TRG_DiLeu_BaLyEn_6	392	397	PF01217	0.444
TRG_ENDOCYTIC_2	196	199	PF00928	0.378
TRG_ENDOCYTIC_2	341	344	PF00928	0.425
TRG_ENDOCYTIC_2	382	385	PF00928	0.418
TRG_ENDOCYTIC_2	62	65	PF00928	0.498
TRG_ER_diArg_1	23	26	PF00400	0.412
TRG_ER_diArg_1	44	46	PF00400	0.420
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7B0	Leptomonas seymouri	49%	100%
A0A1X0P7L9	Trypanosomatidae	28%	100%
A0A3Q8IQZ6	Leishmania donovani	91%	100%
A4HPA2	Leishmania braziliensis	76%	99%
A4IDK8	Leishmania infantum	91%	100%
D0A3A6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4Q1I7	Leishmania major	90%	100%
Q7TQA3	Mus musculus	24%	100%
Q8N3Y7	Homo sapiens	23%	100%
V5DCK9	Trypanosoma cruzi	28%	100%