Putative endonuclease V

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endonuclease V, putative

Species:

Leishmania mexicana

UniProt:

E9AT10_LEIMU

TriTrypDb:

LmxM.36.2330

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AT10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT10

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006259	DNA metabolic process	4	9
GO:0006281	DNA repair	5	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0006950	response to stress	2	9
GO:0006974	DNA damage response	4	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0033554	cellular response to stress	3	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044260	obsolete cellular macromolecule metabolic process	3	9
GO:0046483	heterocycle metabolic process	3	9
GO:0050896	response to stimulus	1	9
GO:0051716	cellular response to stimulus	2	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004518	nuclease activity	4	9
GO:0004519	endonuclease activity	5	9
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003727	single-stranded RNA binding	5	1
GO:0004521	RNA endonuclease activity	5	1
GO:0004540	RNA nuclease activity	4	1
GO:0005488	binding	1	1
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.610
CLV_NRD_NRD_1	261	263	PF00675	0.317
CLV_NRD_NRD_1	49	51	PF00675	0.590
CLV_PCSK_KEX2_1	261	263	PF00082	0.317
CLV_PCSK_KEX2_1	48	50	PF00082	0.573
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.548
CLV_PCSK_SKI1_1	104	108	PF00082	0.601
CLV_PCSK_SKI1_1	282	286	PF00082	0.317
CLV_PCSK_SKI1_1	58	62	PF00082	0.524
DEG_Nend_UBRbox_2	1	3	PF02207	0.443
DEG_SPOP_SBC_1	305	309	PF00917	0.499
DOC_CYCLIN_RxL_1	311	322	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	115	118	PF00134	0.332
DOC_CYCLIN_yCln2_LP_2	141	147	PF00134	0.260
DOC_PP2B_LxvP_1	114	117	PF13499	0.311
DOC_PP2B_LxvP_1	273	276	PF13499	0.450
DOC_PP2B_LxvP_1	86	89	PF13499	0.488
DOC_PP4_FxxP_1	105	108	PF00568	0.344
DOC_USP7_MATH_1	157	161	PF00917	0.455
DOC_USP7_MATH_1	215	219	PF00917	0.450
DOC_USP7_MATH_1	305	309	PF00917	0.499
DOC_USP7_MATH_1	386	390	PF00917	0.684
DOC_USP7_MATH_1	392	396	PF00917	0.764
DOC_USP7_MATH_1	42	46	PF00917	0.426
DOC_WW_Pin1_4	140	145	PF00397	0.397
DOC_WW_Pin1_4	306	311	PF00397	0.472
DOC_WW_Pin1_4	320	325	PF00397	0.377
DOC_WW_Pin1_4	343	348	PF00397	0.450
LIG_14-3-3_CanoR_1	158	164	PF00244	0.357
LIG_14-3-3_CanoR_1	209	213	PF00244	0.517
LIG_BRCT_BRCA1_1	383	387	PF00533	0.495
LIG_Clathr_ClatBox_1	249	253	PF01394	0.436
LIG_deltaCOP1_diTrp_1	146	154	PF00928	0.351
LIG_FHA_1	81	87	PF00498	0.539
LIG_FHA_2	209	215	PF00498	0.517
LIG_FHA_2	295	301	PF00498	0.475
LIG_GBD_Chelix_1	265	273	PF00786	0.275
LIG_GBD_Chelix_1	355	363	PF00786	0.317
LIG_LIR_Gen_1	143	152	PF02991	0.399
LIG_LIR_Gen_1	218	228	PF02991	0.517
LIG_LIR_Gen_1	231	241	PF02991	0.517
LIG_LIR_Nem_3	143	148	PF02991	0.441
LIG_LIR_Nem_3	218	223	PF02991	0.517
LIG_LIR_Nem_3	231	236	PF02991	0.456
LIG_LYPXL_yS_3	197	200	PF13949	0.450
LIG_MYND_1	313	317	PF01753	0.467
LIG_PROFILIN_1	5	11	PF00235	0.391
LIG_Rb_pABgroove_1	227	235	PF01858	0.471
LIG_SH2_PTP2	344	347	PF00017	0.499
LIG_SH2_STAT5	344	347	PF00017	0.499
LIG_SH2_STAT5	382	385	PF00017	0.590
LIG_SH2_STAT5	72	75	PF00017	0.447
LIG_SH3_1	4	10	PF00018	0.391
LIG_SH3_3	2	8	PF00018	0.397
LIG_SH3_3	254	260	PF00018	0.465
LIG_SH3_3	27	33	PF00018	0.419
LIG_SH3_3	307	313	PF00018	0.474
LIG_Sin3_3	356	363	PF02671	0.475
LIG_SUMO_SIM_par_1	248	253	PF11976	0.450
LIG_TRAF2_1	44	47	PF00917	0.425
MOD_CK1_1	140	146	PF00069	0.488
MOD_CK1_1	308	314	PF00069	0.492
MOD_CK1_1	322	328	PF00069	0.525
MOD_CK2_1	140	146	PF00069	0.366
MOD_CK2_1	208	214	PF00069	0.517
MOD_CK2_1	294	300	PF00069	0.516
MOD_GlcNHglycan	14	17	PF01048	0.659
MOD_GlcNHglycan	159	162	PF01048	0.444
MOD_GlcNHglycan	217	220	PF01048	0.251
MOD_GlcNHglycan	26	29	PF01048	0.709
MOD_GlcNHglycan	37	40	PF01048	0.763
MOD_GlcNHglycan	388	391	PF01048	0.427
MOD_GSK3_1	136	143	PF00069	0.552
MOD_GSK3_1	274	281	PF00069	0.517
MOD_GSK3_1	294	301	PF00069	0.575
MOD_GSK3_1	304	311	PF00069	0.550
MOD_GSK3_1	318	325	PF00069	0.390
MOD_GSK3_1	386	393	PF00069	0.562
MOD_N-GLC_1	80	85	PF02516	0.637
MOD_NEK2_1	110	115	PF00069	0.393
MOD_NEK2_1	232	237	PF00069	0.540
MOD_NEK2_1	240	245	PF00069	0.495
MOD_NEK2_1	318	323	PF00069	0.576
MOD_NEK2_1	359	364	PF00069	0.450
MOD_PIKK_1	240	246	PF00454	0.499
MOD_PIKK_1	322	328	PF00454	0.499
MOD_PKA_2	157	163	PF00069	0.299
MOD_PKA_2	208	214	PF00069	0.517
MOD_Plk_1	110	116	PF00069	0.422
MOD_Plk_1	131	137	PF00069	0.421
MOD_Plk_1	177	183	PF00069	0.450
MOD_Plk_4	110	116	PF00069	0.397
MOD_Plk_4	169	175	PF00069	0.564
MOD_Plk_4	202	208	PF00069	0.486
MOD_Plk_4	359	365	PF00069	0.467
MOD_ProDKin_1	140	146	PF00069	0.392
MOD_ProDKin_1	306	312	PF00069	0.472
MOD_ProDKin_1	320	326	PF00069	0.377
MOD_ProDKin_1	343	349	PF00069	0.450
TRG_DiLeu_BaEn_1	111	116	PF01217	0.291
TRG_DiLeu_BaLyEn_6	311	316	PF01217	0.494
TRG_ENDOCYTIC_2	197	200	PF00928	0.458
TRG_ER_diArg_1	260	262	PF00400	0.517
TRG_ER_diArg_1	364	367	PF00400	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILN9	Leptomonas seymouri	54%	100%
A0A1X0P8I3	Trypanosomatidae	41%	100%
A0A3S7XAV3	Leishmania donovani	86%	100%
A0A422NIX5	Trypanosoma rangeli	40%	100%
A4HPA1	Leishmania braziliensis	71%	100%
A4IDK7	Leishmania infantum	86%	100%
Q4Q1I8	Leishmania major	86%	100%