Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AT07_LEIMU

TriTrypDb:

LmxM.36.2300

Length:

482

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AT07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT07

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.542
CLV_NRD_NRD_1	257	259	PF00675	0.500
CLV_NRD_NRD_1	55	57	PF00675	0.562
CLV_PCSK_KEX2_1	257	259	PF00082	0.500
CLV_PCSK_KEX2_1	55	57	PF00082	0.562
CLV_PCSK_SKI1_1	257	261	PF00082	0.504
CLV_PCSK_SKI1_1	472	476	PF00082	0.786
CLV_Separin_Metazoa	52	56	PF03568	0.367
DEG_Nend_UBRbox_2	1	3	PF02207	0.565
DOC_CKS1_1	350	355	PF01111	0.499
DOC_CYCLIN_RxL_1	95	105	PF00134	0.406
DOC_MAPK_gen_1	120	128	PF00069	0.704
DOC_MAPK_gen_1	257	265	PF00069	0.660
DOC_MAPK_MEF2A_6	122	130	PF00069	0.543
DOC_MAPK_MEF2A_6	46	53	PF00069	0.440
DOC_PP1_RVXF_1	250	256	PF00149	0.568
DOC_PP2B_LxvP_1	224	227	PF13499	0.532
DOC_PP4_FxxP_1	147	150	PF00568	0.688
DOC_USP7_MATH_1	167	171	PF00917	0.406
DOC_USP7_MATH_1	206	210	PF00917	0.449
DOC_USP7_MATH_1	215	219	PF00917	0.504
DOC_USP7_MATH_1	227	231	PF00917	0.412
DOC_USP7_MATH_1	85	89	PF00917	0.474
DOC_WW_Pin1_4	349	354	PF00397	0.537
DOC_WW_Pin1_4	454	459	PF00397	0.590
DOC_WW_Pin1_4	9	14	PF00397	0.459
LIG_14-3-3_CanoR_1	114	119	PF00244	0.701
LIG_14-3-3_CanoR_1	133	139	PF00244	0.524
LIG_14-3-3_CanoR_1	225	234	PF00244	0.418
LIG_14-3-3_CanoR_1	257	266	PF00244	0.704
LIG_14-3-3_CanoR_1	285	291	PF00244	0.355
LIG_14-3-3_CanoR_1	37	44	PF00244	0.526
LIG_14-3-3_CanoR_1	71	79	PF00244	0.506
LIG_Actin_RPEL_3	91	110	PF02755	0.470
LIG_Actin_WH2_2	17	34	PF00022	0.517
LIG_Actin_WH2_2	242	259	PF00022	0.554
LIG_Actin_WH2_2	269	287	PF00022	0.231
LIG_BIR_III_2	375	379	PF00653	0.429
LIG_BRCT_BRCA1_1	246	250	PF00533	0.435
LIG_BRCT_BRCA1_2	246	252	PF00533	0.406
LIG_FHA_1	103	109	PF00498	0.347
LIG_FHA_1	179	185	PF00498	0.523
LIG_FHA_1	196	202	PF00498	0.464
LIG_FHA_1	258	264	PF00498	0.730
LIG_FHA_1	398	404	PF00498	0.588
LIG_FHA_1	64	70	PF00498	0.454
LIG_FHA_1	90	96	PF00498	0.359
LIG_FHA_2	227	233	PF00498	0.477
LIG_FHA_2	350	356	PF00498	0.437
LIG_FHA_2	37	43	PF00498	0.500
LIG_FHA_2	384	390	PF00498	0.564
LIG_FHA_2	442	448	PF00498	0.575
LIG_GBD_Chelix_1	100	108	PF00786	0.470
LIG_GBD_Chelix_1	126	134	PF00786	0.345
LIG_GBD_Chelix_1	171	179	PF00786	0.470
LIG_LIR_Apic_2	145	150	PF02991	0.700
LIG_LIR_Gen_1	105	115	PF02991	0.547
LIG_LIR_Gen_1	16	24	PF02991	0.517
LIG_LIR_Gen_1	247	256	PF02991	0.524
LIG_LIR_Gen_1	59	69	PF02991	0.485
LIG_LIR_Gen_1	92	102	PF02991	0.355
LIG_LIR_Nem_3	105	109	PF02991	0.389
LIG_LIR_Nem_3	16	20	PF02991	0.523
LIG_LIR_Nem_3	247	253	PF02991	0.335
LIG_LIR_Nem_3	59	65	PF02991	0.531
LIG_LIR_Nem_3	92	97	PF02991	0.355
LIG_NRBOX	189	195	PF00104	0.495
LIG_NRBOX	95	101	PF00104	0.470
LIG_Pex14_1	282	286	PF04695	0.470
LIG_SH2_STAP1	17	21	PF00017	0.526
LIG_SH2_STAP1	234	238	PF00017	0.393
LIG_SH2_STAP1	286	290	PF00017	0.469
LIG_SH2_STAT5	267	270	PF00017	0.470
LIG_SH2_STAT5	300	303	PF00017	0.566
LIG_SH2_STAT5	359	362	PF00017	0.506
LIG_SH3_3	209	215	PF00018	0.439
LIG_SH3_3	347	353	PF00018	0.499
LIG_SUMO_SIM_anti_2	187	192	PF11976	0.446
LIG_SUMO_SIM_par_1	99	105	PF11976	0.406
LIG_TRAF2_1	312	315	PF00917	0.449
LIG_TRAF2_1	318	321	PF00917	0.402
LIG_TRAF2_1	460	463	PF00917	0.520
LIG_WW_1	14	17	PF00397	0.616
MOD_CDK_SPK_2	349	354	PF00069	0.618
MOD_CDK_SPxxK_3	349	356	PF00069	0.620
MOD_CK1_1	16	22	PF00069	0.589
MOD_CK1_1	216	222	PF00069	0.674
MOD_CK1_1	237	243	PF00069	0.419
MOD_CK1_1	453	459	PF00069	0.810
MOD_CK2_1	226	232	PF00069	0.574
MOD_CK2_1	349	355	PF00069	0.528
MOD_CK2_1	383	389	PF00069	0.704
MOD_CK2_1	441	447	PF00069	0.721
MOD_GlcNHglycan	151	154	PF01048	0.421
MOD_GlcNHglycan	165	168	PF01048	0.470
MOD_GlcNHglycan	239	242	PF01048	0.380
MOD_GlcNHglycan	409	412	PF01048	0.728
MOD_GlcNHglycan	421	424	PF01048	0.642
MOD_GlcNHglycan	85	88	PF01048	0.649
MOD_GSK3_1	157	164	PF00069	0.518
MOD_GSK3_1	216	223	PF00069	0.615
MOD_GSK3_1	233	240	PF00069	0.364
MOD_GSK3_1	290	297	PF00069	0.520
MOD_GSK3_1	316	323	PF00069	0.397
MOD_GSK3_1	379	386	PF00069	0.778
MOD_GSK3_1	403	410	PF00069	0.601
MOD_GSK3_1	446	453	PF00069	0.750
MOD_GSK3_1	5	12	PF00069	0.720
MOD_GSK3_1	79	86	PF00069	0.679
MOD_LATS_1	131	137	PF00433	0.411
MOD_N-GLC_1	157	162	PF02516	0.596
MOD_N-GLC_1	216	221	PF02516	0.615
MOD_N-GLC_1	245	250	PF02516	0.406
MOD_N-GLC_1	294	299	PF02516	0.606
MOD_N-GLC_1	79	84	PF02516	0.468
MOD_N-GLC_2	407	409	PF02516	0.598
MOD_NEK2_1	102	107	PF00069	0.483
MOD_NEK2_1	161	166	PF00069	0.533
MOD_NEK2_1	23	28	PF00069	0.635
MOD_NEK2_1	245	250	PF00069	0.508
MOD_NEK2_1	284	289	PF00069	0.521
MOD_NEK2_1	290	295	PF00069	0.463
MOD_NEK2_1	344	349	PF00069	0.679
MOD_NEK2_1	65	70	PF00069	0.613
MOD_NEK2_2	178	183	PF00069	0.390
MOD_PIKK_1	216	222	PF00454	0.537
MOD_PIKK_1	257	263	PF00454	0.624
MOD_PIKK_1	316	322	PF00454	0.512
MOD_PIKK_1	330	336	PF00454	0.542
MOD_PKA_1	257	263	PF00069	0.624
MOD_PKA_2	113	119	PF00069	0.631
MOD_PKA_2	257	263	PF00069	0.624
MOD_PKA_2	284	290	PF00069	0.342
MOD_PKA_2	36	42	PF00069	0.656
MOD_PKA_2	70	76	PF00069	0.618
MOD_Plk_1	157	163	PF00069	0.470
MOD_Plk_1	245	251	PF00069	0.406
MOD_Plk_1	294	300	PF00069	0.616
MOD_Plk_1	79	85	PF00069	0.504
MOD_Plk_1	89	95	PF00069	0.295
MOD_Plk_4	102	108	PF00069	0.451
MOD_Plk_4	157	163	PF00069	0.470
MOD_Plk_4	16	22	PF00069	0.653
MOD_Plk_4	234	240	PF00069	0.480
MOD_Plk_4	245	251	PF00069	0.321
MOD_Plk_4	272	278	PF00069	0.470
MOD_Plk_4	65	71	PF00069	0.654
MOD_Plk_4	79	85	PF00069	0.574
MOD_ProDKin_1	349	355	PF00069	0.671
MOD_ProDKin_1	454	460	PF00069	0.746
MOD_ProDKin_1	9	15	PF00069	0.556
TRG_DiLeu_BaEn_1	368	373	PF01217	0.496
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.611
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.496
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.470
TRG_DiLeu_LyEn_5	303	308	PF01217	0.629
TRG_ENDOCYTIC_2	17	20	PF00928	0.660
TRG_ENDOCYTIC_2	359	362	PF00928	0.628
TRG_ENDOCYTIC_2	62	65	PF00928	0.668
TRG_ER_diArg_1	119	122	PF00400	0.638
TRG_ER_diArg_1	256	258	PF00400	0.641
TRG_ER_diArg_1	356	359	PF00400	0.622
TRG_ER_diArg_1	54	56	PF00400	0.435
TRG_ER_FFAT_2	232	243	PF00635	0.231
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAV6	Leishmania donovani	85%	100%
A4HP98	Leishmania braziliensis	64%	100%
A4IDK4	Leishmania infantum	85%	100%
Q4Q1J1	Leishmania major	83%	99%