LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
serine/threonine protein kinase, putative
Species:
Leishmania mexicana
UniProt:
E9AT06_LEIMU
TriTrypDb:
LmxM.36.2290
Length:
481

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 19
NetGPI no yes: 0, no: 19
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AT06
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT06

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 20
GO:0006793 phosphorus metabolic process 3 20
GO:0006796 phosphate-containing compound metabolic process 4 20
GO:0006807 nitrogen compound metabolic process 2 20
GO:0008152 metabolic process 1 20
GO:0009987 cellular process 1 20
GO:0016310 phosphorylation 5 20
GO:0019538 protein metabolic process 3 20
GO:0036211 protein modification process 4 20
GO:0043170 macromolecule metabolic process 3 20
GO:0043412 macromolecule modification 4 20
GO:0044237 cellular metabolic process 2 20
GO:0044238 primary metabolic process 2 20
GO:0071704 organic substance metabolic process 2 20
GO:1901564 organonitrogen compound metabolic process 3 20
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 20
GO:0003824 catalytic activity 1 20
GO:0004672 protein kinase activity 3 20
GO:0004674 protein serine/threonine kinase activity 4 19
GO:0005488 binding 1 20
GO:0005524 ATP binding 5 20
GO:0016301 kinase activity 4 20
GO:0016740 transferase activity 2 20
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 20
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 20
GO:0017076 purine nucleotide binding 4 20
GO:0030554 adenyl nucleotide binding 5 20
GO:0032553 ribonucleotide binding 3 20
GO:0032555 purine ribonucleotide binding 4 20
GO:0032559 adenyl ribonucleotide binding 5 20
GO:0035639 purine ribonucleoside triphosphate binding 4 20
GO:0036094 small molecule binding 2 20
GO:0043167 ion binding 2 20
GO:0043168 anion binding 3 20
GO:0097159 organic cyclic compound binding 2 20
GO:0097367 carbohydrate derivative binding 2 20
GO:0140096 catalytic activity, acting on a protein 2 20
GO:1901265 nucleoside phosphate binding 3 20
GO:1901363 heterocyclic compound binding 2 20

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 129 131 PF00675 0.562
CLV_NRD_NRD_1 215 217 PF00675 0.325
CLV_NRD_NRD_1 220 222 PF00675 0.296
CLV_NRD_NRD_1 397 399 PF00675 0.367
CLV_NRD_NRD_1 423 425 PF00675 0.484
CLV_PCSK_KEX2_1 129 131 PF00082 0.620
CLV_PCSK_KEX2_1 215 217 PF00082 0.248
CLV_PCSK_KEX2_1 219 221 PF00082 0.231
CLV_PCSK_KEX2_1 397 399 PF00082 0.431
CLV_PCSK_KEX2_1 423 425 PF00082 0.480
CLV_PCSK_PC7_1 125 131 PF00082 0.428
CLV_PCSK_PC7_1 215 221 PF00082 0.215
CLV_PCSK_SKI1_1 380 384 PF00082 0.362
DEG_APCC_DBOX_1 389 397 PF00400 0.337
DEG_Nend_UBRbox_1 1 4 PF02207 0.495
DOC_CYCLIN_yCln2_LP_2 329 335 PF00134 0.335
DOC_CYCLIN_yCln2_LP_2 50 56 PF00134 0.480
DOC_MAPK_gen_1 464 474 PF00069 0.577
DOC_PP4_FxxP_1 7 10 PF00568 0.464
DOC_USP7_MATH_1 34 38 PF00917 0.574
DOC_USP7_MATH_1 433 437 PF00917 0.600
DOC_WW_Pin1_4 182 187 PF00397 0.472
DOC_WW_Pin1_4 223 228 PF00397 0.253
DOC_WW_Pin1_4 293 298 PF00397 0.343
DOC_WW_Pin1_4 45 50 PF00397 0.585
DOC_WW_Pin1_4 56 61 PF00397 0.511
LIG_14-3-3_CanoR_1 288 297 PF00244 0.211
LIG_14-3-3_CanoR_1 309 313 PF00244 0.284
LIG_14-3-3_CanoR_1 397 406 PF00244 0.348
LIG_BIR_III_4 66 70 PF00653 0.467
LIG_Clathr_ClatBox_1 203 207 PF01394 0.359
LIG_Clathr_ClatBox_1 368 372 PF01394 0.273
LIG_eIF4E_1 95 101 PF01652 0.463
LIG_FHA_1 229 235 PF00498 0.371
LIG_FHA_1 265 271 PF00498 0.331
LIG_FHA_1 280 286 PF00498 0.262
LIG_FHA_1 377 383 PF00498 0.210
LIG_FHA_1 475 481 PF00498 0.512
LIG_FHA_2 227 233 PF00498 0.311
LIG_FHA_2 335 341 PF00498 0.363
LIG_Integrin_RGD_1 306 308 PF01839 0.208
LIG_LIR_Apic_2 296 302 PF02991 0.319
LIG_LIR_Apic_2 5 10 PF02991 0.466
LIG_LIR_Gen_1 232 243 PF02991 0.373
LIG_LIR_Gen_1 349 357 PF02991 0.214
LIG_LIR_Gen_1 363 373 PF02991 0.246
LIG_LIR_Gen_1 413 422 PF02991 0.313
LIG_LIR_Nem_3 232 238 PF02991 0.378
LIG_LIR_Nem_3 349 353 PF02991 0.341
LIG_LIR_Nem_3 363 369 PF02991 0.263
LIG_LIR_Nem_3 413 418 PF02991 0.313
LIG_MYND_1 56 60 PF01753 0.506
LIG_NRBOX 322 328 PF00104 0.205
LIG_Pex14_1 441 445 PF04695 0.518
LIG_Pex14_2 437 441 PF04695 0.655
LIG_PTB_Apo_2 344 351 PF02174 0.184
LIG_PTB_Phospho_1 344 350 PF10480 0.184
LIG_SH2_CRK 350 354 PF00017 0.208
LIG_SH2_CRK 366 370 PF00017 0.208
LIG_SH2_CRK 95 99 PF00017 0.278
LIG_SH2_GRB2like 357 360 PF00017 0.219
LIG_SH2_SRC 445 448 PF00017 0.460
LIG_SH2_STAP1 324 328 PF00017 0.455
LIG_SH2_STAP1 357 361 PF00017 0.411
LIG_SH2_STAT5 208 211 PF00017 0.287
LIG_SH2_STAT5 281 284 PF00017 0.184
LIG_SH2_STAT5 299 302 PF00017 0.313
LIG_SH2_STAT5 388 391 PF00017 0.315
LIG_SH2_STAT5 99 102 PF00017 0.480
LIG_SH3_3 150 156 PF00018 0.466
LIG_SH3_3 161 167 PF00018 0.440
LIG_SH3_3 462 468 PF00018 0.546
LIG_SH3_3 50 56 PF00018 0.660
LIG_SUMO_SIM_anti_2 201 207 PF11976 0.259
LIG_SUMO_SIM_par_1 325 330 PF11976 0.208
LIG_SUMO_SIM_par_1 367 372 PF11976 0.274
LIG_TRAF2_1 156 159 PF00917 0.430
LIG_TRAF2_1 407 410 PF00917 0.338
LIG_TRFH_1 298 302 PF08558 0.313
LIG_TYR_ITAM 347 369 PF00017 0.184
LIG_TYR_ITIM 322 327 PF00017 0.317
LIG_TYR_ITIM 364 369 PF00017 0.208
MOD_CK1_1 139 145 PF00069 0.484
MOD_CK1_1 311 317 PF00069 0.273
MOD_CK1_1 400 406 PF00069 0.452
MOD_CK1_1 5 11 PF00069 0.457
MOD_CK1_1 74 80 PF00069 0.593
MOD_CK2_1 226 232 PF00069 0.256
MOD_CK2_1 334 340 PF00069 0.232
MOD_CK2_1 404 410 PF00069 0.620
MOD_GlcNHglycan 141 144 PF01048 0.473
MOD_GlcNHglycan 418 421 PF01048 0.550
MOD_GlcNHglycan 427 430 PF01048 0.483
MOD_GlcNHglycan 453 456 PF01048 0.772
MOD_GSK3_1 279 286 PF00069 0.334
MOD_GSK3_1 289 296 PF00069 0.302
MOD_GSK3_1 311 318 PF00069 0.168
MOD_GSK3_1 400 407 PF00069 0.589
MOD_GSK3_1 410 417 PF00069 0.427
MOD_GSK3_1 441 448 PF00069 0.520
MOD_GSK3_1 5 12 PF00069 0.489
MOD_GSK3_1 71 78 PF00069 0.550
MOD_N-GLC_1 404 409 PF02516 0.358
MOD_N-GLC_2 479 481 PF02516 0.453
MOD_NEK2_1 263 268 PF00069 0.307
MOD_NEK2_1 327 332 PF00069 0.284
MOD_NEK2_1 414 419 PF00069 0.555
MOD_NEK2_1 73 78 PF00069 0.580
MOD_NEK2_2 36 41 PF00069 0.459
MOD_PK_1 2 8 PF00069 0.478
MOD_PK_1 71 77 PF00069 0.449
MOD_PKA_1 279 285 PF00069 0.189
MOD_PKA_1 397 403 PF00069 0.324
MOD_PKA_2 308 314 PF00069 0.364
MOD_PKA_2 375 381 PF00069 0.330
MOD_PKA_2 397 403 PF00069 0.324
MOD_Plk_1 400 406 PF00069 0.395
MOD_Plk_1 71 77 PF00069 0.490
MOD_Plk_4 2 8 PF00069 0.504
MOD_Plk_4 352 358 PF00069 0.181
MOD_Plk_4 410 416 PF00069 0.353
MOD_Plk_4 9 15 PF00069 0.419
MOD_ProDKin_1 182 188 PF00069 0.472
MOD_ProDKin_1 223 229 PF00069 0.253
MOD_ProDKin_1 293 299 PF00069 0.343
MOD_ProDKin_1 45 51 PF00069 0.583
MOD_ProDKin_1 56 62 PF00069 0.510
MOD_SUMO_for_1 257 260 PF00179 0.208
MOD_SUMO_for_1 312 315 PF00179 0.208
MOD_SUMO_rev_2 403 413 PF00179 0.395
TRG_ENDOCYTIC_2 116 119 PF00928 0.371
TRG_ENDOCYTIC_2 324 327 PF00928 0.389
TRG_ENDOCYTIC_2 350 353 PF00928 0.208
TRG_ENDOCYTIC_2 366 369 PF00928 0.230
TRG_ENDOCYTIC_2 95 98 PF00928 0.303
TRG_ER_diArg_1 214 216 PF00400 0.248
TRG_ER_diArg_1 218 221 PF00400 0.231
TRG_ER_diArg_1 396 398 PF00400 0.357
TRG_ER_diArg_1 422 424 PF00400 0.471
TRG_ER_diArg_1 55 58 PF00400 0.487
TRG_Pf-PMV_PEXEL_1 380 384 PF00026 0.410
TRG_Pf-PMV_PEXEL_1 397 401 PF00026 0.308

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9A0 Leptomonas seymouri 28% 74%
A0A0S4IRZ7 Bodo saltans 30% 98%
A0A1X0NIA0 Trypanosomatidae 35% 100%
A0A1X0NUB2 Trypanosomatidae 29% 83%
A0A3Q8IAQ1 Leishmania donovani 41% 100%
A0A3Q8IFK8 Leishmania donovani 35% 100%
A0A3S7XAX0 Leishmania donovani 89% 100%
A0A422P4V9 Trypanosoma rangeli 26% 100%
A4H7V0 Leishmania braziliensis 25% 67%
A4HCE6 Leishmania braziliensis 39% 100%
A4HI35 Leishmania braziliensis 25% 94%
A4HJT5 Leishmania braziliensis 39% 100%
A4HZW8 Leishmania infantum 41% 100%
A4I7A1 Leishmania infantum 35% 100%
A4IDK3 Leishmania infantum 90% 100%
A5GFW1 Sus scrofa 27% 100%
C9ZTU6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 88%
D0A7M4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 70%
D0AA64 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 84%
E9APX7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 67%
E9AVS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B2V8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 73%
E9B436 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B6S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B6S9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
O00141 Homo sapiens 27% 100%
O14965 Homo sapiens 27% 100%
O59790 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 100%
P28178 Dictyostelium discoideum 27% 100%
P59241 Rattus norvegicus 27% 100%
P97477 Mus musculus 26% 100%
Q10056 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 24% 82%
Q2TA06 Bos taurus 27% 100%
Q4Q1J2 Leishmania major 88% 99%
Q4Q5W2 Leishmania major 40% 100%
Q4Q7M5 Leishmania major 25% 94%
Q4QBQ2 Leishmania major 40% 100%
Q4QFK4 Leishmania major 25% 77%
Q4R633 Macaca fascicularis 27% 100%
Q5Q0U5 Fundulus heteroclitus 28% 100%
Q6U1I9 Gallus gallus 27% 100%
Q869W6 Dictyostelium discoideum 29% 100%
Q8NG66 Homo sapiens 29% 75%
Q91820 Xenopus laevis 26% 100%
Q9NAH6 Caenorhabditis elegans 25% 87%
V5B9Y9 Trypanosoma cruzi 24% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS