TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

bardet-biedl syndrome 4 protein

Species:

Leishmania mexicana

UniProt:

E9AT05_LEIMU

TriTrypDb:

LmxM.36.2280

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	11
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0031253	cell projection membrane	4	11
GO:0060170	ciliary membrane	5	11
GO:0098588	bounding membrane of organelle	4	11
GO:0098590	plasma membrane region	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0012506	vesicle membrane	4	1
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0032991	protein-containing complex	1	1
GO:0034464	BBSome	2	1
GO:0035869	ciliary transition zone	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

E9AT05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT05

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006826	iron ion transport	8	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030001	metal ion transport	6	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0033572	transferrin transport	5	1
GO:0044782	cilium organization	5	1
GO:0045184	establishment of protein localization	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0060271	cilium assembly	6	1
GO:0061512	protein localization to cilium	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070925	organelle assembly	5	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030276	clathrin binding	3	1
GO:0032050	clathrin heavy chain binding	4	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.435
CLV_NRD_NRD_1	183	185	PF00675	0.538
CLV_NRD_NRD_1	187	189	PF00675	0.445
CLV_NRD_NRD_1	328	330	PF00675	0.325
CLV_NRD_NRD_1	444	446	PF00675	0.590
CLV_NRD_NRD_1	64	66	PF00675	0.343
CLV_PCSK_FUR_1	62	66	PF00082	0.358
CLV_PCSK_KEX2_1	107	109	PF00082	0.317
CLV_PCSK_KEX2_1	183	185	PF00082	0.405
CLV_PCSK_KEX2_1	187	189	PF00082	0.360
CLV_PCSK_KEX2_1	444	446	PF00082	0.590
CLV_PCSK_KEX2_1	64	66	PF00082	0.343
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.359
CLV_PCSK_PC7_1	183	189	PF00082	0.351
CLV_PCSK_SKI1_1	103	107	PF00082	0.288
CLV_PCSK_SKI1_1	161	165	PF00082	0.429
CLV_PCSK_SKI1_1	21	25	PF00082	0.507
CLV_PCSK_SKI1_1	211	215	PF00082	0.418
CLV_PCSK_SKI1_1	262	266	PF00082	0.343
CLV_PCSK_SKI1_1	318	322	PF00082	0.538
CLV_PCSK_SKI1_1	330	334	PF00082	0.377
DEG_APCC_DBOX_1	64	72	PF00400	0.459
DEG_MDM2_SWIB_1	432	439	PF02201	0.479
DEG_Nend_UBRbox_3	1	3	PF02207	0.692
DEG_SPOP_SBC_1	469	473	PF00917	0.714
DOC_CKS1_1	438	443	PF01111	0.476
DOC_CYCLIN_RxL_1	100	110	PF00134	0.318
DOC_CYCLIN_yCln2_LP_2	462	465	PF00134	0.361
DOC_MAPK_gen_1	62	71	PF00069	0.473
DOC_PP2B_LxvP_1	461	464	PF13499	0.580
DOC_PP4_FxxP_1	333	336	PF00568	0.455
DOC_USP7_MATH_1	276	280	PF00917	0.318
DOC_USP7_MATH_1	302	306	PF00917	0.384
DOC_USP7_MATH_1	477	481	PF00917	0.674
DOC_USP7_UBL2_3	103	107	PF12436	0.332
DOC_WW_Pin1_4	124	129	PF00397	0.437
DOC_WW_Pin1_4	230	235	PF00397	0.252
DOC_WW_Pin1_4	31	36	PF00397	0.618
DOC_WW_Pin1_4	437	442	PF00397	0.472
LIG_14-3-3_CanoR_1	354	362	PF00244	0.414
LIG_14-3-3_CanoR_1	430	436	PF00244	0.444
LIG_Actin_WH2_2	313	331	PF00022	0.376
LIG_APCC_ABBA_1	223	228	PF00400	0.296
LIG_APCC_ABBA_1	366	371	PF00400	0.357
LIG_FHA_1	120	126	PF00498	0.401
LIG_FHA_2	233	239	PF00498	0.390
LIG_FHA_2	267	273	PF00498	0.443
LIG_LIR_Apic_2	331	336	PF02991	0.438
LIG_LIR_Gen_1	203	214	PF02991	0.429
LIG_LIR_Gen_1	305	316	PF02991	0.369
LIG_LIR_Gen_1	321	328	PF02991	0.462
LIG_LIR_Gen_1	434	441	PF02991	0.368
LIG_LIR_Nem_3	173	178	PF02991	0.447
LIG_LIR_Nem_3	203	209	PF02991	0.430
LIG_LIR_Nem_3	292	297	PF02991	0.384
LIG_LIR_Nem_3	305	311	PF02991	0.384
LIG_LIR_Nem_3	321	325	PF02991	0.465
LIG_LIR_Nem_3	404	409	PF02991	0.459
LIG_LIR_Nem_3	427	432	PF02991	0.386
LIG_LIR_Nem_3	434	439	PF02991	0.454
LIG_LIR_Nem_3	95	101	PF02991	0.325
LIG_NRBOX	457	463	PF00104	0.433
LIG_NRBOX	67	73	PF00104	0.391
LIG_PCNA_TLS_4	187	194	PF02747	0.340
LIG_Pex14_1	170	174	PF04695	0.287
LIG_Pex14_1	339	343	PF04695	0.288
LIG_Pex14_2	333	337	PF04695	0.430
LIG_Pex14_2	432	436	PF04695	0.346
LIG_SH2_CRK	294	298	PF00017	0.384
LIG_SH2_CRK	322	326	PF00017	0.437
LIG_SH2_GRB2like	409	412	PF00017	0.419
LIG_SH2_GRB2like	78	81	PF00017	0.397
LIG_SH2_NCK_1	322	326	PF00017	0.437
LIG_SH2_PTP2	175	178	PF00017	0.426
LIG_SH2_SRC	226	229	PF00017	0.384
LIG_SH2_SRC	396	399	PF00017	0.440
LIG_SH2_STAP1	219	223	PF00017	0.296
LIG_SH2_STAP1	226	230	PF00017	0.296
LIG_SH2_STAP1	287	291	PF00017	0.384
LIG_SH2_STAP1	322	326	PF00017	0.437
LIG_SH2_STAP1	396	400	PF00017	0.358
LIG_SH2_STAP1	412	416	PF00017	0.365
LIG_SH2_STAP1	78	82	PF00017	0.327
LIG_SH2_STAP1	98	102	PF00017	0.228
LIG_SH2_STAT3	247	250	PF00017	0.328
LIG_SH2_STAT3	73	76	PF00017	0.332
LIG_SH2_STAT5	101	104	PF00017	0.318
LIG_SH2_STAT5	175	178	PF00017	0.353
LIG_SH2_STAT5	206	209	PF00017	0.397
LIG_SH2_STAT5	247	250	PF00017	0.289
LIG_SH2_STAT5	259	262	PF00017	0.229
LIG_SH2_STAT5	355	358	PF00017	0.338
LIG_SH2_STAT5	409	412	PF00017	0.328
LIG_SH2_STAT5	73	76	PF00017	0.363
LIG_SH3_3	231	237	PF00018	0.323
LIG_SH3_3	462	468	PF00018	0.671
LIG_SUMO_SIM_anti_2	114	122	PF11976	0.453
LIG_TRAF2_1	153	156	PF00917	0.365
LIG_TRAF2_1	421	424	PF00917	0.412
LIG_TYR_ITSM	290	297	PF00017	0.301
MOD_CDC14_SPxK_1	34	37	PF00782	0.569
MOD_CDK_SPxK_1	31	37	PF00069	0.574
MOD_CDK_SPxxK_3	437	444	PF00069	0.475
MOD_CK1_1	39	45	PF00069	0.574
MOD_CK2_1	109	115	PF00069	0.421
MOD_CK2_1	418	424	PF00069	0.397
MOD_Cter_Amidation	316	319	PF01082	0.449
MOD_GlcNHglycan	283	286	PF01048	0.394
MOD_GlcNHglycan	356	359	PF01048	0.335
MOD_GlcNHglycan	39	42	PF01048	0.536
MOD_GlcNHglycan	420	423	PF01048	0.265
MOD_GSK3_1	109	116	PF00069	0.385
MOD_GSK3_1	12	19	PF00069	0.479
MOD_GSK3_1	228	235	PF00069	0.409
MOD_GSK3_1	262	269	PF00069	0.342
MOD_GSK3_1	39	46	PF00069	0.605
MOD_N-GLC_2	391	393	PF02516	0.349
MOD_NEK2_1	109	114	PF00069	0.379
MOD_NEK2_1	119	124	PF00069	0.335
MOD_NEK2_1	193	198	PF00069	0.343
MOD_NEK2_1	28	33	PF00069	0.654
MOD_NEK2_1	328	333	PF00069	0.452
MOD_NEK2_2	412	417	PF00069	0.368
MOD_PIKK_1	132	138	PF00454	0.412
MOD_PIKK_1	302	308	PF00454	0.389
MOD_PKA_1	318	324	PF00069	0.391
MOD_PKA_2	266	272	PF00069	0.301
MOD_PKA_2	328	334	PF00069	0.425
MOD_PKA_2	36	42	PF00069	0.728
MOD_PKA_2	89	95	PF00069	0.491
MOD_Plk_1	202	208	PF00069	0.258
MOD_Plk_1	302	308	PF00069	0.354
MOD_Plk_1	445	451	PF00069	0.515
MOD_Plk_4	202	208	PF00069	0.200
MOD_Plk_4	276	282	PF00069	0.318
MOD_Plk_4	328	334	PF00069	0.432
MOD_Plk_4	412	418	PF00069	0.444
MOD_Plk_4	446	452	PF00069	0.594
MOD_ProDKin_1	124	130	PF00069	0.432
MOD_ProDKin_1	230	236	PF00069	0.252
MOD_ProDKin_1	31	37	PF00069	0.618
MOD_ProDKin_1	437	443	PF00069	0.474
TRG_DiLeu_BaEn_1	115	120	PF01217	0.441
TRG_DiLeu_BaEn_1	446	451	PF01217	0.511
TRG_DiLeu_BaEn_4	227	233	PF01217	0.219
TRG_ENDOCYTIC_2	175	178	PF00928	0.297
TRG_ENDOCYTIC_2	206	209	PF00928	0.418
TRG_ENDOCYTIC_2	294	297	PF00928	0.384
TRG_ENDOCYTIC_2	322	325	PF00928	0.430
TRG_ER_diArg_1	186	188	PF00400	0.464
TRG_NES_CRM1_1	115	129	PF08389	0.462
TRG_NES_CRM1_1	238	250	PF08389	0.270
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PED7	Leptomonas seymouri	66%	100%
A0A1X0P7L4	Trypanosomatidae	46%	87%
A0A3Q8IH89	Leishmania donovani	93%	100%
A0A3R7MGH4	Trypanosoma rangeli	49%	100%
A1Z8E9	Drosophila melanogaster	31%	100%
A4HP97	Leishmania braziliensis	82%	100%
A4IDK2	Leishmania infantum	93%	100%
D0A3A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
Q1JQ97	Bos taurus	42%	95%
Q28G25	Xenopus tropicalis	42%	96%
Q4Q1J3	Leishmania major	92%	100%
Q5CZ52	Caenorhabditis elegans	27%	100%
Q8C1Z7	Mus musculus	43%	95%
Q96RK4	Homo sapiens	44%	95%
V5DCK5	Trypanosoma cruzi	46%	100%