Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AT04_LEIMU

TriTrypDb:

LmxM.36.2270

Length:

461

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AT04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT04

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.420
CLV_C14_Caspase3-7	256	260	PF00656	0.766
CLV_NRD_NRD_1	33	35	PF00675	0.627
CLV_NRD_NRD_1	338	340	PF00675	0.757
CLV_NRD_NRD_1	369	371	PF00675	0.491
CLV_PCSK_KEX2_1	33	35	PF00082	0.627
CLV_PCSK_KEX2_1	338	340	PF00082	0.728
CLV_PCSK_KEX2_1	369	371	PF00082	0.693
CLV_PCSK_SKI1_1	333	337	PF00082	0.603
CLV_PCSK_SKI1_1	5	9	PF00082	0.611
CLV_PCSK_SKI1_1	72	76	PF00082	0.512
CLV_Separin_Metazoa	69	73	PF03568	0.522
DEG_APCC_DBOX_1	71	79	PF00400	0.430
DEG_SCF_FBW7_1	178	185	PF00400	0.418
DEG_SPOP_SBC_1	212	216	PF00917	0.607
DOC_CYCLIN_yCln2_LP_2	130	136	PF00134	0.736
DOC_MAPK_gen_1	56	66	PF00069	0.339
DOC_MAPK_MEF2A_6	59	66	PF00069	0.539
DOC_PP1_RVXF_1	298	305	PF00149	0.466
DOC_PP1_RVXF_1	70	77	PF00149	0.394
DOC_PP2B_LxvP_1	207	210	PF13499	0.590
DOC_USP7_MATH_1	100	104	PF00917	0.682
DOC_USP7_MATH_1	212	216	PF00917	0.778
DOC_USP7_MATH_1	228	232	PF00917	0.518
DOC_USP7_MATH_1	312	316	PF00917	0.842
DOC_USP7_MATH_1	375	379	PF00917	0.514
DOC_WW_Pin1_4	178	183	PF00397	0.423
DOC_WW_Pin1_4	208	213	PF00397	0.764
DOC_WW_Pin1_4	226	231	PF00397	0.590
DOC_WW_Pin1_4	263	268	PF00397	0.665
DOC_WW_Pin1_4	308	313	PF00397	0.634
LIG_14-3-3_CanoR_1	126	131	PF00244	0.670
LIG_14-3-3_CanoR_1	206	210	PF00244	0.527
LIG_14-3-3_CanoR_1	394	398	PF00244	0.590
LIG_14-3-3_CanoR_1	56	62	PF00244	0.439
LIG_BIR_II_1	1	5	PF00653	0.646
LIG_BIR_III_3	1	5	PF00653	0.646
LIG_deltaCOP1_diTrp_1	350	356	PF00928	0.594
LIG_FHA_1	125	131	PF00498	0.669
LIG_FHA_1	144	150	PF00498	0.464
LIG_FHA_1	183	189	PF00498	0.413
LIG_FHA_1	263	269	PF00498	0.722
LIG_FHA_1	394	400	PF00498	0.671
LIG_FHA_1	53	59	PF00498	0.530
LIG_FHA_1	89	95	PF00498	0.719
LIG_FHA_2	251	257	PF00498	0.662
LIG_FHA_2	335	341	PF00498	0.746
LIG_FHA_2	41	47	PF00498	0.545
LIG_FHA_2	436	442	PF00498	0.532
LIG_LIR_Gen_1	125	136	PF02991	0.628
LIG_LIR_Gen_1	198	207	PF02991	0.679
LIG_LIR_Gen_1	350	360	PF02991	0.606
LIG_LIR_Gen_1	437	447	PF02991	0.716
LIG_LIR_Gen_1	60	67	PF02991	0.632
LIG_LIR_Gen_1	73	82	PF02991	0.387
LIG_LIR_Nem_3	198	202	PF02991	0.660
LIG_LIR_Nem_3	350	356	PF02991	0.594
LIG_LIR_Nem_3	437	442	PF02991	0.712
LIG_LIR_Nem_3	60	64	PF02991	0.640
LIG_PCNA_yPIPBox_3	63	75	PF02747	0.615
LIG_PDZ_Class_2	456	461	PF00595	0.620
LIG_Pex14_1	274	278	PF04695	0.541
LIG_RPA_C_Fungi	29	41	PF08784	0.634
LIG_SH2_NCK_1	439	443	PF00017	0.703
LIG_SH2_PTP2	292	295	PF00017	0.481
LIG_SH2_SRC	292	295	PF00017	0.474
LIG_SH2_SRC	439	442	PF00017	0.632
LIG_SH2_STAP1	199	203	PF00017	0.665
LIG_SH2_STAP1	439	443	PF00017	0.528
LIG_SH2_STAT5	128	131	PF00017	0.678
LIG_SH2_STAT5	292	295	PF00017	0.695
LIG_SH2_STAT5	35	38	PF00017	0.630
LIG_SH2_STAT5	458	461	PF00017	0.740
LIG_SH2_STAT5	61	64	PF00017	0.637
LIG_SH3_3	227	233	PF00018	0.724
LIG_SH3_3	316	322	PF00018	0.536
LIG_SUMO_SIM_par_1	134	139	PF11976	0.782
LIG_TRAF2_1	329	332	PF00917	0.699
LIG_TYR_ITIM	197	202	PF00017	0.659
MOD_CK1_1	122	128	PF00069	0.650
MOD_CK1_1	211	217	PF00069	0.824
MOD_CK1_1	22	28	PF00069	0.601
MOD_CK1_1	245	251	PF00069	0.721
MOD_CK1_1	257	263	PF00069	0.701
MOD_CK1_1	305	311	PF00069	0.642
MOD_CK1_1	315	321	PF00069	0.546
MOD_CK1_1	365	371	PF00069	0.744
MOD_CK2_1	13	19	PF00069	0.541
MOD_CK2_1	158	164	PF00069	0.582
MOD_CK2_1	250	256	PF00069	0.741
MOD_CK2_1	334	340	PF00069	0.754
MOD_CK2_1	370	376	PF00069	0.732
MOD_GlcNHglycan	121	124	PF01048	0.638
MOD_GlcNHglycan	15	18	PF01048	0.560
MOD_GlcNHglycan	21	24	PF01048	0.461
MOD_GlcNHglycan	223	226	PF01048	0.669
MOD_GlcNHglycan	261	264	PF01048	0.722
MOD_GlcNHglycan	314	317	PF01048	0.661
MOD_GlcNHglycan	36	39	PF01048	0.485
MOD_GlcNHglycan	364	367	PF01048	0.582
MOD_GlcNHglycan	376	380	PF01048	0.480
MOD_GlcNHglycan	408	411	PF01048	0.745
MOD_GlcNHglycan	412	415	PF01048	0.673
MOD_GSK3_1	122	129	PF00069	0.655
MOD_GSK3_1	13	20	PF00069	0.614
MOD_GSK3_1	178	185	PF00069	0.418
MOD_GSK3_1	208	215	PF00069	0.793
MOD_GSK3_1	250	257	PF00069	0.785
MOD_GSK3_1	258	265	PF00069	0.664
MOD_GSK3_1	304	311	PF00069	0.627
MOD_GSK3_1	360	367	PF00069	0.740
MOD_GSK3_1	398	405	PF00069	0.657
MOD_GSK3_1	406	413	PF00069	0.690
MOD_N-GLC_1	308	313	PF02516	0.613
MOD_N-GLC_1	410	415	PF02516	0.471
MOD_NEK2_1	121	126	PF00069	0.624
MOD_NEK2_1	205	210	PF00069	0.511
MOD_NEK2_1	242	247	PF00069	0.752
MOD_NEK2_1	302	307	PF00069	0.504
MOD_NEK2_1	360	365	PF00069	0.733
MOD_NEK2_1	398	403	PF00069	0.672
MOD_NEK2_1	406	411	PF00069	0.602
MOD_NEK2_1	435	440	PF00069	0.594
MOD_NEK2_1	50	55	PF00069	0.583
MOD_PIKK_1	176	182	PF00454	0.704
MOD_PIKK_1	98	104	PF00454	0.441
MOD_PKA_1	369	375	PF00069	0.468
MOD_PKA_2	205	211	PF00069	0.517
MOD_PKA_2	242	248	PF00069	0.679
MOD_PKA_2	369	375	PF00069	0.468
MOD_PKA_2	393	399	PF00069	0.596
MOD_Plk_4	116	122	PF00069	0.549
MOD_Plk_4	126	132	PF00069	0.470
MOD_Plk_4	242	248	PF00069	0.581
MOD_ProDKin_1	178	184	PF00069	0.419
MOD_ProDKin_1	208	214	PF00069	0.770
MOD_ProDKin_1	226	232	PF00069	0.586
MOD_ProDKin_1	263	269	PF00069	0.663
MOD_ProDKin_1	308	314	PF00069	0.636
TRG_DiLeu_BaEn_4	331	337	PF01217	0.695
TRG_ENDOCYTIC_2	128	131	PF00928	0.600
TRG_ENDOCYTIC_2	199	202	PF00928	0.663
TRG_ENDOCYTIC_2	292	295	PF00928	0.566
TRG_ENDOCYTIC_2	439	442	PF00928	0.710
TRG_ENDOCYTIC_2	61	64	PF00928	0.637
TRG_ER_diArg_1	33	35	PF00400	0.627
TRG_ER_diArg_1	369	371	PF00400	0.491
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAU2	Leishmania donovani	86%	100%
A4HP96	Leishmania braziliensis	68%	100%
A4IDK1	Leishmania infantum	86%	100%
Q4Q1J4	Leishmania major	85%	100%