Guanylate kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

guanylate kinase-like protein

Species:

Leishmania mexicana

UniProt:

E9AT03_LEIMU

TriTrypDb:

LmxM.36.2260

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0005829	cytosol	2	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AT03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT03

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0044237	cellular metabolic process	2	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0004385	guanylate kinase activity	6	3
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	3
GO:0019205	nucleobase-containing compound kinase activity	5	3
GO:0050145	nucleoside monophosphate kinase activity	5	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.285
CLV_NRD_NRD_1	164	166	PF00675	0.428
CLV_NRD_NRD_1	181	183	PF00675	0.690
CLV_NRD_NRD_1	266	268	PF00675	0.386
CLV_NRD_NRD_1	60	62	PF00675	0.470
CLV_NRD_NRD_1	82	84	PF00675	0.320
CLV_PCSK_KEX2_1	164	166	PF00082	0.378
CLV_PCSK_KEX2_1	181	183	PF00082	0.621
CLV_PCSK_KEX2_1	242	244	PF00082	0.294
CLV_PCSK_KEX2_1	39	41	PF00082	0.534
CLV_PCSK_KEX2_1	60	62	PF00082	0.445
CLV_PCSK_KEX2_1	82	84	PF00082	0.424
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.188
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.390
CLV_PCSK_SKI1_1	138	142	PF00082	0.428
CLV_PCSK_SKI1_1	149	153	PF00082	0.372
CLV_PCSK_SKI1_1	175	179	PF00082	0.525
CLV_PCSK_SKI1_1	226	230	PF00082	0.188
CLV_Separin_Metazoa	314	318	PF03568	0.402
DEG_APCC_KENBOX_2	289	293	PF00400	0.305
DEG_COP1_1	212	221	PF00400	0.188
DEG_SCF_FBW7_1	114	120	PF00400	0.188
DEG_SPOP_SBC_1	117	121	PF00917	0.454
DOC_CKS1_1	114	119	PF01111	0.188
DOC_CKS1_1	201	206	PF01111	0.628
DOC_MAPK_gen_1	242	252	PF00069	0.358
DOC_MAPK_gen_1	39	47	PF00069	0.487
DOC_MAPK_HePTP_8	240	252	PF00069	0.305
DOC_MAPK_HePTP_8	36	48	PF00069	0.503
DOC_MAPK_MEF2A_6	243	252	PF00069	0.341
DOC_MAPK_MEF2A_6	39	48	PF00069	0.459
DOC_MAPK_MEF2A_6	6	14	PF00069	0.441
DOC_PP4_FxxP_1	251	254	PF00568	0.447
DOC_PP4_FxxP_1	47	50	PF00568	0.335
DOC_USP7_MATH_1	10	14	PF00917	0.742
DOC_USP7_MATH_1	117	121	PF00917	0.419
DOC_USP7_MATH_1	207	211	PF00917	0.777
DOC_USP7_MATH_1	219	223	PF00917	0.478
DOC_WW_Pin1_4	113	118	PF00397	0.378
DOC_WW_Pin1_4	120	125	PF00397	0.466
DOC_WW_Pin1_4	200	205	PF00397	0.682
DOC_WW_Pin1_4	230	235	PF00397	0.476
LIG_14-3-3_CanoR_1	175	180	PF00244	0.617
LIG_14-3-3_CanoR_1	181	186	PF00244	0.753
LIG_14-3-3_CanoR_1	205	210	PF00244	0.609
LIG_14-3-3_CanoR_1	267	275	PF00244	0.428
LIG_BIR_II_1	1	5	PF00653	0.704
LIG_deltaCOP1_diTrp_1	65	72	PF00928	0.447
LIG_FHA_1	121	127	PF00498	0.460
LIG_FHA_1	153	159	PF00498	0.374
LIG_FHA_1	235	241	PF00498	0.409
LIG_FHA_1	27	33	PF00498	0.720
LIG_FHA_2	267	273	PF00498	0.466
LIG_FHA_2	66	72	PF00498	0.419
LIG_FHA_2	93	99	PF00498	0.480
LIG_LIR_Apic_2	233	239	PF02991	0.383
LIG_LIR_Gen_1	110	117	PF02991	0.203
LIG_LIR_Gen_1	306	316	PF02991	0.422
LIG_LIR_Gen_1	97	105	PF02991	0.385
LIG_LIR_Nem_3	110	114	PF02991	0.226
LIG_LIR_Nem_3	294	299	PF02991	0.359
LIG_LIR_Nem_3	306	312	PF02991	0.349
LIG_LIR_Nem_3	65	69	PF02991	0.422
LIG_LIR_Nem_3	97	102	PF02991	0.368
LIG_PDZ_Class_1	322	327	PF00595	0.555
LIG_Pex14_1	66	70	PF04695	0.335
LIG_SH2_CRK	111	115	PF00017	0.355
LIG_SH2_CRK	236	240	PF00017	0.383
LIG_SH2_CRK	309	313	PF00017	0.466
LIG_SH2_STAP1	111	115	PF00017	0.188
LIG_SH2_STAT5	115	118	PF00017	0.188
LIG_SH2_STAT5	166	169	PF00017	0.410
LIG_SH2_STAT5	236	239	PF00017	0.188
LIG_SH2_STAT5	299	302	PF00017	0.434
LIG_SH2_STAT5	92	95	PF00017	0.402
LIG_SH3_3	228	234	PF00018	0.407
LIG_SUMO_SIM_par_1	197	203	PF11976	0.754
LIG_SUMO_SIM_par_1	319	326	PF11976	0.592
LIG_TRAF2_1	95	98	PF00917	0.447
LIG_TYR_ITIM	109	114	PF00017	0.355
LIG_TYR_ITIM	307	312	PF00017	0.434
MOD_CDK_SPK_2	200	205	PF00069	0.628
MOD_CK1_1	120	126	PF00069	0.428
MOD_CK1_1	2	8	PF00069	0.438
MOD_CK1_1	222	228	PF00069	0.496
MOD_CK1_1	232	238	PF00069	0.454
MOD_CK1_1	75	81	PF00069	0.334
MOD_CK2_1	266	272	PF00069	0.428
MOD_CK2_1	65	71	PF00069	0.442
MOD_CK2_1	92	98	PF00069	0.408
MOD_CMANNOS	285	288	PF00535	0.356
MOD_GlcNHglycan	50	53	PF01048	0.335
MOD_GSK3_1	109	116	PF00069	0.352
MOD_GSK3_1	120	127	PF00069	0.383
MOD_GSK3_1	217	224	PF00069	0.490
MOD_GSK3_1	226	233	PF00069	0.447
MOD_GSK3_1	70	77	PF00069	0.334
MOD_N-GLC_1	222	227	PF02516	0.475
MOD_N-GLC_1	291	296	PF02516	0.417
MOD_N-GLC_1	301	306	PF02516	0.327
MOD_NEK2_1	133	138	PF00069	0.426
MOD_NEK2_1	199	204	PF00069	0.707
MOD_NEK2_1	32	37	PF00069	0.675
MOD_NEK2_1	322	327	PF00069	0.663
MOD_NEK2_1	70	75	PF00069	0.341
MOD_PK_1	205	211	PF00069	0.609
MOD_PKA_1	181	187	PF00069	0.460
MOD_PKA_2	180	186	PF00069	0.566
MOD_PKA_2	266	272	PF00069	0.335
MOD_Plk_1	109	115	PF00069	0.447
MOD_Plk_1	226	232	PF00069	0.460
MOD_Plk_1	271	277	PF00069	0.373
MOD_Plk_1	291	297	PF00069	0.150
MOD_Plk_1	301	307	PF00069	0.327
MOD_Plk_1	70	76	PF00069	0.451
MOD_Plk_2-3	266	272	PF00069	0.408
MOD_Plk_2-3	291	297	PF00069	0.480
MOD_Plk_2-3	65	71	PF00069	0.402
MOD_Plk_4	10	16	PF00069	0.448
MOD_Plk_4	140	146	PF00069	0.454
MOD_Plk_4	175	181	PF00069	0.470
MOD_Plk_4	291	297	PF00069	0.459
MOD_Plk_4	54	60	PF00069	0.335
MOD_Plk_4	65	71	PF00069	0.335
MOD_ProDKin_1	113	119	PF00069	0.378
MOD_ProDKin_1	120	126	PF00069	0.466
MOD_ProDKin_1	200	206	PF00069	0.683
MOD_ProDKin_1	230	236	PF00069	0.476
MOD_SUMO_rev_2	261	269	PF00179	0.447
TRG_DiLeu_BaEn_1	98	103	PF01217	0.447
TRG_ENDOCYTIC_2	111	114	PF00928	0.355
TRG_ENDOCYTIC_2	309	312	PF00928	0.438
TRG_ENDOCYTIC_2	91	94	PF00928	0.355
TRG_ER_diArg_1	147	150	PF00400	0.383
TRG_ER_diArg_1	163	165	PF00400	0.447
TRG_ER_diArg_1	180	182	PF00400	0.669
TRG_ER_diArg_1	59	61	PF00400	0.402
TRG_ER_diArg_1	81	83	PF00400	0.429
TRG_Pf-PMV_PEXEL_1	60	65	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I117	Leptomonas seymouri	52%	100%
A0A1X0P7T4	Trypanosomatidae	31%	100%
A0A3R7LXR6	Trypanosoma rangeli	32%	100%
A0A3S7XAW4	Leishmania donovani	86%	99%
A4HP95	Leishmania braziliensis	73%	100%
A4IDK0	Leishmania infantum	87%	99%
D0A398	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4Q1J5	Leishmania major	85%	100%
V5BBU2	Trypanosoma cruzi	32%	100%