Vacuolar protein sorting-associated protein 45-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar protein sorting-associated protein 45- like protein

Species:

Leishmania mexicana

UniProt:

E9AT00_LEIMU

TriTrypDb:

LmxM.36.2230

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	2
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AT00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AT00

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	14
GO:0016192	vesicle-mediated transport	4	14
GO:0051179	localization	1	14
GO:0051234	establishment of localization	2	14
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.365
CLV_NRD_NRD_1	164	166	PF00675	0.297
CLV_PCSK_KEX2_1	149	151	PF00082	0.336
CLV_PCSK_KEX2_1	163	165	PF00082	0.311
CLV_PCSK_KEX2_1	333	335	PF00082	0.290
CLV_PCSK_KEX2_1	453	455	PF00082	0.291
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.290
CLV_PCSK_PC1ET2_1	453	455	PF00082	0.291
CLV_PCSK_SKI1_1	12	16	PF00082	0.329
CLV_PCSK_SKI1_1	125	129	PF00082	0.384
CLV_PCSK_SKI1_1	285	289	PF00082	0.403
CLV_PCSK_SKI1_1	311	315	PF00082	0.257
CLV_PCSK_SKI1_1	334	338	PF00082	0.399
CLV_PCSK_SKI1_1	433	437	PF00082	0.316
CLV_PCSK_SKI1_1	78	82	PF00082	0.351
DEG_APCC_DBOX_1	63	71	PF00400	0.351
DEG_Nend_UBRbox_3	1	3	PF02207	0.380
DEG_SCF_FBW7_1	213	219	PF00400	0.275
DEG_SPOP_SBC_1	475	479	PF00917	0.285
DOC_ANK_TNKS_1	148	155	PF00023	0.403
DOC_CKS1_1	130	135	PF01111	0.403
DOC_CKS1_1	213	218	PF01111	0.338
DOC_CYCLIN_RxL_1	331	340	PF00134	0.316
DOC_CYCLIN_yClb5_NLxxxL_5	49	57	PF00134	0.403
DOC_CYCLIN_yCln2_LP_2	217	223	PF00134	0.326
DOC_CYCLIN_yCln2_LP_2	238	244	PF00134	0.316
DOC_MAPK_gen_1	332	341	PF00069	0.291
DOC_MAPK_gen_1	433	441	PF00069	0.316
DOC_MAPK_gen_1	55	63	PF00069	0.305
DOC_MAPK_gen_1	81	89	PF00069	0.403
DOC_MAPK_MEF2A_6	200	207	PF00069	0.330
DOC_MAPK_MEF2A_6	332	341	PF00069	0.291
DOC_MAPK_MEF2A_6	490	498	PF00069	0.389
DOC_PP2B_LxvP_1	238	241	PF13499	0.351
DOC_USP7_MATH_1	366	370	PF00917	0.342
DOC_USP7_MATH_1	475	479	PF00917	0.241
DOC_WW_Pin1_4	129	134	PF00397	0.359
DOC_WW_Pin1_4	171	176	PF00397	0.403
DOC_WW_Pin1_4	212	217	PF00397	0.326
DOC_WW_Pin1_4	554	559	PF00397	0.452
LIG_14-3-3_CanoR_1	234	239	PF00244	0.325
LIG_14-3-3_CanoR_1	292	298	PF00244	0.326
LIG_14-3-3_CanoR_1	358	363	PF00244	0.308
LIG_14-3-3_CanoR_1	365	373	PF00244	0.284
LIG_14-3-3_CanoR_1	419	425	PF00244	0.406
LIG_Actin_RPEL_3	44	63	PF02755	0.403
LIG_Actin_WH2_2	437	455	PF00022	0.316
LIG_Actin_WH2_2	50	66	PF00022	0.369
LIG_APCC_ABBA_1	393	398	PF00400	0.316
LIG_Clathr_ClatBox_1	204	208	PF01394	0.326
LIG_FHA_1	200	206	PF00498	0.366
LIG_FHA_1	213	219	PF00498	0.229
LIG_FHA_1	235	241	PF00498	0.403
LIG_FHA_1	29	35	PF00498	0.331
LIG_FHA_1	292	298	PF00498	0.354
LIG_FHA_1	308	314	PF00498	0.311
LIG_FHA_1	322	328	PF00498	0.389
LIG_FHA_1	419	425	PF00498	0.273
LIG_FHA_2	294	300	PF00498	0.272
LIG_FHA_2	366	372	PF00498	0.470
LIG_FHA_2	435	441	PF00498	0.307
LIG_FHA_2	444	450	PF00498	0.253
LIG_FHA_2	501	507	PF00498	0.367
LIG_FHA_2	91	97	PF00498	0.275
LIG_GBD_Chelix_1	151	159	PF00786	0.403
LIG_GBD_Chelix_1	180	188	PF00786	0.210
LIG_LIR_Gen_1	115	123	PF02991	0.307
LIG_LIR_Gen_1	222	231	PF02991	0.328
LIG_LIR_Gen_1	353	363	PF02991	0.251
LIG_LIR_Gen_1	402	411	PF02991	0.403
LIG_LIR_Gen_1	437	445	PF02991	0.351
LIG_LIR_Gen_1	546	556	PF02991	0.291
LIG_LIR_Gen_1	84	92	PF02991	0.434
LIG_LIR_Nem_3	115	120	PF02991	0.307
LIG_LIR_Nem_3	353	359	PF02991	0.251
LIG_LIR_Nem_3	402	407	PF02991	0.403
LIG_LIR_Nem_3	437	441	PF02991	0.351
LIG_LIR_Nem_3	466	472	PF02991	0.295
LIG_LIR_Nem_3	546	552	PF02991	0.316
LIG_LIR_Nem_3	84	88	PF02991	0.398
LIG_LYPXL_yS_3	469	472	PF13949	0.291
LIG_MYND_1	216	220	PF01753	0.346
LIG_PCNA_yPIPBox_3	136	150	PF02747	0.316
LIG_PCNA_yPIPBox_3	49	57	PF02747	0.422
LIG_PTB_Apo_2	261	268	PF02174	0.316
LIG_SH2_CRK	195	199	PF00017	0.403
LIG_SH2_CRK	404	408	PF00017	0.403
LIG_SH2_NCK_1	384	388	PF00017	0.331
LIG_SH2_PTP2	60	63	PF00017	0.403
LIG_SH2_SRC	195	198	PF00017	0.403
LIG_SH2_STAP1	404	408	PF00017	0.403
LIG_SH2_STAT3	280	283	PF00017	0.403
LIG_SH2_STAT3	460	463	PF00017	0.422
LIG_SH2_STAT3	471	474	PF00017	0.446
LIG_SH2_STAT5	252	255	PF00017	0.272
LIG_SH2_STAT5	280	283	PF00017	0.291
LIG_SH2_STAT5	326	329	PF00017	0.403
LIG_SH2_STAT5	39	42	PF00017	0.414
LIG_SH2_STAT5	396	399	PF00017	0.367
LIG_SH2_STAT5	445	448	PF00017	0.291
LIG_SH2_STAT5	471	474	PF00017	0.291
LIG_SH2_STAT5	502	505	PF00017	0.387
LIG_SH2_STAT5	60	63	PF00017	0.397
LIG_SH3_3	210	216	PF00018	0.399
LIG_SUMO_SIM_anti_2	201	208	PF11976	0.332
LIG_SUMO_SIM_anti_2	338	343	PF11976	0.367
LIG_SUMO_SIM_par_1	12	18	PF11976	0.272
LIG_SUMO_SIM_par_1	201	208	PF11976	0.324
LIG_SUMO_SIM_par_1	335	340	PF11976	0.291
LIG_TRAF2_1	247	250	PF00917	0.346
LIG_TRAF2_1	296	299	PF00917	0.403
LIG_TRAF2_1	368	371	PF00917	0.275
LIG_TRAF2_1	503	506	PF00917	0.316
LIG_TYR_ITAM	401	417	PF00017	0.275
LIG_UBA3_1	378	386	PF00899	0.304
LIG_WRC_WIRS_1	139	144	PF05994	0.316
LIG_WRC_WIRS_1	359	364	PF05994	0.328
LIG_WRC_WIRS_1	435	440	PF05994	0.316
MOD_CK1_1	137	143	PF00069	0.401
MOD_CK1_1	350	356	PF00069	0.339
MOD_CK1_1	364	370	PF00069	0.287
MOD_CK1_1	43	49	PF00069	0.474
MOD_CK1_1	66	72	PF00069	0.429
MOD_CK2_1	105	111	PF00069	0.286
MOD_CK2_1	26	32	PF00069	0.404
MOD_CK2_1	293	299	PF00069	0.315
MOD_CK2_1	337	343	PF00069	0.319
MOD_CK2_1	365	371	PF00069	0.275
MOD_CK2_1	443	449	PF00069	0.291
MOD_CK2_1	500	506	PF00069	0.367
MOD_CK2_1	65	71	PF00069	0.274
MOD_CK2_1	90	96	PF00069	0.453
MOD_GlcNHglycan	143	146	PF01048	0.268
MOD_GlcNHglycan	327	330	PF01048	0.287
MOD_GlcNHglycan	45	48	PF01048	0.403
MOD_GlcNHglycan	460	463	PF01048	0.291
MOD_GlcNHglycan	478	481	PF01048	0.291
MOD_GlcNHglycan	93	96	PF01048	0.337
MOD_GSK3_1	134	141	PF00069	0.409
MOD_GSK3_1	212	219	PF00069	0.271
MOD_GSK3_1	307	314	PF00069	0.313
MOD_GSK3_1	315	322	PF00069	0.343
MOD_GSK3_1	346	353	PF00069	0.303
MOD_GSK3_1	354	361	PF00069	0.305
MOD_GSK3_1	530	537	PF00069	0.414
MOD_N-GLC_1	311	316	PF02516	0.161
MOD_NEK2_1	138	143	PF00069	0.360
MOD_NEK2_1	23	28	PF00069	0.286
MOD_NEK2_1	313	318	PF00069	0.291
MOD_NEK2_1	337	342	PF00069	0.259
MOD_NEK2_1	40	45	PF00069	0.228
MOD_NEK2_1	406	411	PF00069	0.449
MOD_NEK2_1	425	430	PF00069	0.325
MOD_NEK2_1	452	457	PF00069	0.316
MOD_NEK2_1	492	497	PF00069	0.459
MOD_NEK2_2	530	535	PF00069	0.316
MOD_PIKK_1	143	149	PF00454	0.432
MOD_PIKK_1	26	32	PF00454	0.314
MOD_PIKK_1	366	372	PF00454	0.403
MOD_PIKK_1	388	394	PF00454	0.414
MOD_PIKK_1	443	449	PF00454	0.346
MOD_PKA_2	199	205	PF00069	0.299
MOD_PKA_2	291	297	PF00069	0.326
MOD_PKA_2	364	370	PF00069	0.337
MOD_PKA_2	418	424	PF00069	0.355
MOD_PKA_2	63	69	PF00069	0.432
MOD_Plk_1	337	343	PF00069	0.339
MOD_Plk_1	371	377	PF00069	0.403
MOD_Plk_1	492	498	PF00069	0.223
MOD_Plk_2-3	105	111	PF00069	0.403
MOD_Plk_4	105	111	PF00069	0.342
MOD_Plk_4	134	140	PF00069	0.368
MOD_Plk_4	154	160	PF00069	0.275
MOD_Plk_4	199	205	PF00069	0.330
MOD_Plk_4	322	328	PF00069	0.303
MOD_Plk_4	434	440	PF00069	0.310
MOD_Plk_4	492	498	PF00069	0.350
MOD_Plk_4	545	551	PF00069	0.358
MOD_ProDKin_1	129	135	PF00069	0.359
MOD_ProDKin_1	171	177	PF00069	0.403
MOD_ProDKin_1	212	218	PF00069	0.326
MOD_SUMO_rev_2	298	303	PF00179	0.443
TRG_DiLeu_BaEn_1	505	510	PF01217	0.316
TRG_DiLeu_BaEn_3	298	304	PF01217	0.403
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.326
TRG_DiLeu_BaLyEn_6	548	553	PF01217	0.161
TRG_ENDOCYTIC_2	223	226	PF00928	0.310
TRG_ENDOCYTIC_2	404	407	PF00928	0.351
TRG_ENDOCYTIC_2	414	417	PF00928	0.351
TRG_ENDOCYTIC_2	469	472	PF00928	0.291
TRG_ENDOCYTIC_2	60	63	PF00928	0.418
TRG_ENDOCYTIC_2	85	88	PF00928	0.423
TRG_ER_diArg_1	148	150	PF00400	0.348
TRG_ER_diArg_1	163	165	PF00400	0.231
TRG_ER_diArg_1	166	169	PF00400	0.217
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	3	8	PF00026	0.350
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.291
TRG_Pf-PMV_PEXEL_1	551	555	PF00026	0.250

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7D5	Leptomonas seymouri	31%	91%
A0A0N0P7P1	Leptomonas seymouri	80%	93%
A0A0N1HUY7	Leptomonas seymouri	22%	77%
A0A0S4JI94	Bodo saltans	32%	85%
A0A1X0P7Y3	Trypanosomatidae	55%	93%
A0A1X0P895	Trypanosomatidae	32%	91%
A0A3Q8IG36	Leishmania donovani	97%	100%
A0A3R7NER3	Trypanosoma rangeli	55%	100%
A0A3S7XAA1	Leishmania donovani	32%	91%
A0A422P2E3	Trypanosoma rangeli	31%	91%
A4HNQ4	Leishmania braziliensis	33%	100%
A4HP92	Leishmania braziliensis	88%	100%
A4ICU1	Leishmania infantum	33%	91%
A4IDJ7	Leishmania infantum	97%	100%
C9ZX51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	20%	87%
D0A395	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	95%
E9ASG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AYK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	20%	76%
O08599	Mus musculus	21%	94%
O08700	Rattus norvegicus	33%	98%
O18637	Drosophila virilis	21%	85%
O49048	Arabidopsis thaliana	30%	98%
O74534	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	87%
O94590	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	81%
P34815	Caenorhabditis elegans	21%	83%
P38932	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	97%
P61763	Bos taurus	21%	94%
P61764	Homo sapiens	21%	94%
P61765	Rattus norvegicus	21%	94%
P97390	Mus musculus	33%	98%
Q07327	Drosophila melanogaster	22%	94%
Q09805	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q15833	Homo sapiens	22%	94%
Q28288	Canis lupus familiaris	23%	94%
Q4Q1J8	Leishmania major	96%	100%
Q4Q232	Leishmania major	33%	100%
Q54GE3	Dictyostelium discoideum	30%	99%
Q54QC8	Dictyostelium discoideum	22%	93%
Q5R6D2	Pongo abelii	21%	94%
Q5VNU3	Oryza sativa subsp. japonica	21%	85%
Q62753	Rattus norvegicus	23%	94%
Q64324	Mus musculus	23%	94%
Q6R748	Gallus gallus	21%	94%
Q7XWP3	Oryza sativa subsp. japonica	20%	84%
Q851W1	Oryza sativa subsp. japonica	25%	90%
Q9C5P7	Arabidopsis thaliana	20%	83%
Q9C5X3	Arabidopsis thaliana	23%	84%
Q9NRW7	Homo sapiens	33%	98%
Q9SL48	Arabidopsis thaliana	20%	89%
Q9Y1I2	Drosophila melanogaster	22%	91%
V5BV59	Trypanosoma cruzi	32%	90%
V5DCK0	Trypanosoma cruzi	55%	98%