LeishMANIAdb
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Choline transporter-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Choline transporter-like protein
Gene product:
Plasma-membrane choline transporter, putative
Species:
Leishmania mexicana
UniProt:
E9ASZ8_LEIMU
TriTrypDb:
LmxM.36.2210
Length:
510

Annotations

LeishMANIAdb annotations

Highly homologous to other eukaryotic choline transporters. The protein family expanded in parazitic kinetoplastids.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 23
NetGPI no yes: 0, no: 23
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 24
GO:0016020 membrane 2 24
GO:0110165 cellular anatomical entity 1 24
GO:0005737 cytoplasm 2 1
GO:0020016 ciliary pocket 2 1

Expansion

Sequence features

E9ASZ8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASZ8

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0009987 cellular process 1 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 24
GO:0022857 transmembrane transporter activity 2 24

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 321 323 PF00082 0.410
CLV_PCSK_KEX2_1 398 400 PF00082 0.239
CLV_PCSK_PC1ET2_1 321 323 PF00082 0.415
CLV_PCSK_PC1ET2_1 398 400 PF00082 0.259
CLV_PCSK_SKI1_1 322 326 PF00082 0.425
CLV_PCSK_SKI1_1 380 384 PF00082 0.321
DEG_MDM2_SWIB_1 200 208 PF02201 0.389
DEG_MDM2_SWIB_1 279 287 PF02201 0.340
DEG_MDM2_SWIB_1 99 106 PF02201 0.351
DEG_SPOP_SBC_1 323 327 PF00917 0.328
DEG_SPOP_SBC_1 348 352 PF00917 0.411
DOC_CKS1_1 286 291 PF01111 0.410
DOC_MAPK_MEF2A_6 185 194 PF00069 0.312
DOC_MAPK_MEF2A_6 230 239 PF00069 0.491
DOC_MAPK_MEF2A_6 380 388 PF00069 0.537
DOC_MAPK_NFAT4_5 230 238 PF00069 0.334
DOC_PP4_FxxP_1 123 126 PF00568 0.265
DOC_PP4_FxxP_1 461 464 PF00568 0.445
DOC_SPAK_OSR1_1 78 82 PF12202 0.486
DOC_USP7_MATH_1 142 146 PF00917 0.326
DOC_USP7_MATH_1 26 30 PF00917 0.609
DOC_USP7_MATH_1 464 468 PF00917 0.345
DOC_WW_Pin1_4 118 123 PF00397 0.466
DOC_WW_Pin1_4 285 290 PF00397 0.410
DOC_WW_Pin1_4 416 421 PF00397 0.246
LIG_14-3-3_CanoR_1 220 226 PF00244 0.492
LIG_14-3-3_CanoR_1 322 331 PF00244 0.251
LIG_Actin_WH2_2 205 222 PF00022 0.303
LIG_Actin_WH2_2 356 371 PF00022 0.376
LIG_BIR_II_1 1 5 PF00653 0.675
LIG_BIR_III_4 498 502 PF00653 0.625
LIG_BRCT_BRCA1_1 1 5 PF00533 0.578
LIG_BRCT_BRCA1_1 329 333 PF00533 0.251
LIG_BRCT_BRCA1_1 429 433 PF00533 0.403
LIG_BRCT_BRCA1_1 458 462 PF00533 0.442
LIG_deltaCOP1_diTrp_1 86 93 PF00928 0.453
LIG_EH1_1 271 279 PF00400 0.424
LIG_EH1_1 450 458 PF00400 0.341
LIG_eIF4E_1 412 418 PF01652 0.462
LIG_FHA_1 226 232 PF00498 0.490
LIG_FHA_1 286 292 PF00498 0.443
LIG_FHA_1 294 300 PF00498 0.263
LIG_FHA_1 398 404 PF00498 0.454
LIG_FHA_1 469 475 PF00498 0.467
LIG_FHA_1 66 72 PF00498 0.496
LIG_GBD_Chelix_1 452 460 PF00786 0.259
LIG_LIR_Apic_2 121 126 PF02991 0.270
LIG_LIR_Apic_2 459 464 PF02991 0.467
LIG_LIR_Gen_1 100 111 PF02991 0.303
LIG_LIR_Gen_1 171 181 PF02991 0.330
LIG_LIR_Gen_1 243 254 PF02991 0.341
LIG_LIR_Gen_1 430 440 PF02991 0.443
LIG_LIR_Gen_1 470 480 PF02991 0.495
LIG_LIR_Gen_1 489 499 PF02991 0.419
LIG_LIR_Gen_1 86 96 PF02991 0.451
LIG_LIR_LC3C_4 335 338 PF02991 0.285
LIG_LIR_Nem_3 100 106 PF02991 0.310
LIG_LIR_Nem_3 171 176 PF02991 0.317
LIG_LIR_Nem_3 243 249 PF02991 0.343
LIG_LIR_Nem_3 325 331 PF02991 0.306
LIG_LIR_Nem_3 376 381 PF02991 0.403
LIG_LIR_Nem_3 430 436 PF02991 0.381
LIG_LIR_Nem_3 459 465 PF02991 0.354
LIG_LIR_Nem_3 470 476 PF02991 0.409
LIG_LIR_Nem_3 489 494 PF02991 0.464
LIG_LIR_Nem_3 86 91 PF02991 0.449
LIG_MLH1_MIPbox_1 458 462 PF16413 0.285
LIG_PCNA_yPIPBox_3 361 373 PF02747 0.334
LIG_Pex14_2 200 204 PF04695 0.351
LIG_Pex14_2 279 283 PF04695 0.320
LIG_Pex14_2 409 413 PF04695 0.468
LIG_Pex14_2 84 88 PF04695 0.603
LIG_Pex14_2 99 103 PF04695 0.311
LIG_PTB_Apo_2 8 15 PF02174 0.546
LIG_Rb_LxCxE_1 365 376 PF01857 0.431
LIG_SH2_CRK 381 385 PF00017 0.462
LIG_SH2_CRK 491 495 PF00017 0.524
LIG_SH2_GRB2like 355 358 PF00017 0.438
LIG_SH2_GRB2like 377 380 PF00017 0.456
LIG_SH2_GRB2like 412 415 PF00017 0.462
LIG_SH2_PTP2 133 136 PF00017 0.334
LIG_SH2_PTP2 246 249 PF00017 0.424
LIG_SH2_PTP2 270 273 PF00017 0.198
LIG_SH2_SRC 355 358 PF00017 0.438
LIG_SH2_SRC 393 396 PF00017 0.477
LIG_SH2_STAP1 49 53 PF00017 0.501
LIG_SH2_STAT3 262 265 PF00017 0.210
LIG_SH2_STAT5 133 136 PF00017 0.269
LIG_SH2_STAT5 165 168 PF00017 0.387
LIG_SH2_STAT5 246 249 PF00017 0.344
LIG_SH2_STAT5 270 273 PF00017 0.344
LIG_SH2_STAT5 304 307 PF00017 0.303
LIG_SH2_STAT5 377 380 PF00017 0.446
LIG_SH2_STAT5 393 396 PF00017 0.446
LIG_SH2_STAT5 412 415 PF00017 0.462
LIG_SH3_3 123 129 PF00018 0.392
LIG_SH3_3 251 257 PF00018 0.390
LIG_SH3_3 309 315 PF00018 0.242
LIG_SUMO_SIM_par_1 148 154 PF11976 0.189
LIG_SUMO_SIM_par_1 274 280 PF11976 0.178
LIG_TYR_ITIM 131 136 PF00017 0.287
LIG_WRC_WIRS_1 241 246 PF05994 0.201
LIG_WRC_WIRS_1 317 322 PF05994 0.233
MOD_CK1_1 121 127 PF00069 0.462
MOD_CK1_1 145 151 PF00069 0.372
MOD_CK1_1 285 291 PF00069 0.466
MOD_CK1_1 327 333 PF00069 0.308
MOD_CK1_1 350 356 PF00069 0.522
MOD_CK1_1 467 473 PF00069 0.461
MOD_CK2_1 350 356 PF00069 0.438
MOD_CK2_1 389 395 PF00069 0.526
MOD_CK2_1 483 489 PF00069 0.518
MOD_GlcNHglycan 123 126 PF01048 0.643
MOD_GlcNHglycan 140 143 PF01048 0.190
MOD_GlcNHglycan 177 180 PF01048 0.324
MOD_GlcNHglycan 221 224 PF01048 0.245
MOD_GlcNHglycan 28 31 PF01048 0.534
MOD_GlcNHglycan 296 299 PF01048 0.337
MOD_GlcNHglycan 466 469 PF01048 0.234
MOD_GSK3_1 112 119 PF00069 0.305
MOD_GSK3_1 138 145 PF00069 0.423
MOD_GSK3_1 225 232 PF00069 0.489
MOD_GSK3_1 323 330 PF00069 0.296
MOD_GSK3_1 464 471 PF00069 0.295
MOD_GSK3_1 97 104 PF00069 0.324
MOD_N-GLC_1 499 504 PF02516 0.342
MOD_N-GLC_2 414 416 PF02516 0.337
MOD_NEK2_1 175 180 PF00069 0.350
MOD_NEK2_1 218 223 PF00069 0.473
MOD_NEK2_1 225 230 PF00069 0.459
MOD_NEK2_1 277 282 PF00069 0.268
MOD_NEK2_1 292 297 PF00069 0.225
MOD_NEK2_1 299 304 PF00069 0.375
MOD_NEK2_1 305 310 PF00069 0.281
MOD_NEK2_1 347 352 PF00069 0.494
MOD_NEK2_1 427 432 PF00069 0.292
MOD_NEK2_1 490 495 PF00069 0.510
MOD_NEK2_1 97 102 PF00069 0.187
MOD_NEK2_2 468 473 PF00069 0.464
MOD_PIKK_1 282 288 PF00454 0.278
MOD_PIKK_1 305 311 PF00454 0.139
MOD_PIKK_1 37 43 PF00454 0.713
MOD_PKA_2 219 225 PF00069 0.526
MOD_PKA_2 483 489 PF00069 0.595
MOD_Plk_4 142 148 PF00069 0.354
MOD_Plk_4 151 157 PF00069 0.284
MOD_Plk_4 168 174 PF00069 0.419
MOD_Plk_4 229 235 PF00069 0.446
MOD_Plk_4 299 305 PF00069 0.311
MOD_Plk_4 332 338 PF00069 0.298
MOD_Plk_4 389 395 PF00069 0.519
MOD_Plk_4 427 433 PF00069 0.372
MOD_Plk_4 456 462 PF00069 0.336
MOD_Plk_4 468 474 PF00069 0.410
MOD_Plk_4 57 63 PF00069 0.532
MOD_ProDKin_1 118 124 PF00069 0.464
MOD_ProDKin_1 285 291 PF00069 0.410
MOD_ProDKin_1 416 422 PF00069 0.246
TRG_DiLeu_BaLyEn_6 127 132 PF01217 0.242
TRG_DiLeu_BaLyEn_6 221 226 PF01217 0.519
TRG_ENDOCYTIC_2 133 136 PF00928 0.310
TRG_ENDOCYTIC_2 246 249 PF00928 0.404
TRG_ENDOCYTIC_2 270 273 PF00928 0.407
TRG_ENDOCYTIC_2 381 384 PF00928 0.448
TRG_ENDOCYTIC_2 491 494 PF00928 0.516
TRG_ER_diArg_1 208 211 PF00400 0.392
TRG_Pf-PMV_PEXEL_1 345 349 PF00026 0.312

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9D8 Leptomonas seymouri 63% 100%
A0A0N1PA24 Leptomonas seymouri 30% 86%
A0A0S4IW21 Bodo saltans 36% 94%
A0A0S4KHP0 Bodo saltans 43% 100%
A0A1X0P8J3 Trypanosomatidae 47% 100%
A0A3Q8I9V7 Leishmania donovani 36% 84%
A0A3R7MAJ2 Trypanosoma rangeli 32% 100%
A0A3S5IRA1 Trypanosoma rangeli 45% 100%
A0A3S7XAV8 Leishmania donovani 88% 100%
A4H7J7 Leishmania braziliensis 36% 84%
A4HP90 Leishmania braziliensis 74% 100%
A4HVY0 Leishmania infantum 36% 84%
A4IDJ5 Leishmania infantum 88% 100%
A5PMW0 Danio rerio 26% 73%
B0JZD0 Xenopus tropicalis 25% 71%
D0A390 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
D0A391 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
D0A392 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
D0A393 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 99%
E9APN1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 84%
P0CM92 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 29% 93%
P0CM93 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 29% 93%
Q12412 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 95%
Q20026 Caenorhabditis elegans 23% 66%
Q4I8E9 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 27% 95%
Q4PIP8 Ustilago maydis (strain 521 / FGSC 9021) 29% 96%
Q4Q1K0 Leishmania major 87% 100%
Q4QFU7 Leishmania major 37% 84%
Q4WYG7 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 27% 95%
Q53GD3 Homo sapiens 24% 72%
Q54IJ2 Dictyostelium discoideum 24% 93%
Q5AB93 Candida albicans (strain SC5314 / ATCC MYA-2876) 28% 98%
Q6BIV4 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 29% 99%
Q6C938 Yarrowia lipolytica (strain CLIB 122 / E 150) 28% 89%
Q6CY85 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 26% 92%
Q6FLC9 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 29% 92%
Q6GN42 Xenopus laevis 23% 72%
Q75EG5 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 26% 92%
Q7T2B0 Danio rerio 24% 71%
Q870V7 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 28% 92%
V5AWF7 Trypanosoma cruzi 46% 100%
V5BMB4 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS