Protein-tyrosine phosphatase 1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein-tyrosine phosphatase 1-like protein

Species:

Leishmania mexicana

UniProt:

E9ASZ5_LEIMU

TriTrypDb:

LmxM.36.2180

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASZ5

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004725	protein tyrosine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	397	401	PF00656	0.301
CLV_C14_Caspase3-7	406	410	PF00656	0.237
CLV_C14_Caspase3-7	75	79	PF00656	0.487
CLV_NRD_NRD_1	201	203	PF00675	0.264
CLV_NRD_NRD_1	323	325	PF00675	0.345
CLV_NRD_NRD_1	454	456	PF00675	0.284
CLV_NRD_NRD_1	460	462	PF00675	0.286
CLV_NRD_NRD_1	489	491	PF00675	0.455
CLV_PCSK_KEX2_1	195	197	PF00082	0.515
CLV_PCSK_KEX2_1	201	203	PF00082	0.276
CLV_PCSK_KEX2_1	323	325	PF00082	0.345
CLV_PCSK_KEX2_1	454	456	PF00082	0.345
CLV_PCSK_KEX2_1	83	85	PF00082	0.417
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.442
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.417
CLV_PCSK_SKI1_1	195	199	PF00082	0.454
CLV_PCSK_SKI1_1	455	459	PF00082	0.284
CLV_PCSK_SKI1_1	513	517	PF00082	0.468
CLV_PCSK_SKI1_1	519	523	PF00082	0.456
CLV_Separin_Metazoa	320	324	PF03568	0.345
DEG_SPOP_SBC_1	15	19	PF00917	0.511
DOC_CKS1_1	375	380	PF01111	0.181
DOC_CKS1_1	39	44	PF01111	0.488
DOC_CYCLIN_RxL_1	192	200	PF00134	0.434
DOC_CYCLIN_yCln2_LP_2	415	421	PF00134	0.345
DOC_MAPK_MEF2A_6	414	421	PF00069	0.284
DOC_MAPK_MEF2A_6	470	479	PF00069	0.280
DOC_MAPK_RevD_3	475	491	PF00069	0.393
DOC_PP1_RVXF_1	178	185	PF00149	0.370
DOC_PP2B_LxvP_1	415	418	PF13499	0.345
DOC_USP7_MATH_1	15	19	PF00917	0.602
DOC_USP7_MATH_1	178	182	PF00917	0.534
DOC_USP7_MATH_1	207	211	PF00917	0.181
DOC_USP7_MATH_1	26	30	PF00917	0.620
DOC_USP7_MATH_1	288	292	PF00917	0.284
DOC_USP7_MATH_1	33	37	PF00917	0.549
DOC_USP7_MATH_1	394	398	PF00917	0.253
DOC_USP7_MATH_1	79	83	PF00917	0.531
DOC_WW_Pin1_4	165	170	PF00397	0.744
DOC_WW_Pin1_4	174	179	PF00397	0.504
DOC_WW_Pin1_4	222	227	PF00397	0.181
DOC_WW_Pin1_4	328	333	PF00397	0.181
DOC_WW_Pin1_4	374	379	PF00397	0.224
DOC_WW_Pin1_4	38	43	PF00397	0.778
DOC_WW_Pin1_4	388	393	PF00397	0.198
DOC_WW_Pin1_4	413	418	PF00397	0.345
LIG_14-3-3_CanoR_1	150	155	PF00244	0.550
LIG_14-3-3_CanoR_1	162	169	PF00244	0.575
LIG_14-3-3_CanoR_1	20	25	PF00244	0.622
LIG_14-3-3_CanoR_1	490	498	PF00244	0.434
LIG_AP_GAE_1	105	111	PF02883	0.434
LIG_APCC_ABBA_1	303	308	PF00400	0.280
LIG_BIR_II_1	1	5	PF00653	0.651
LIG_BRCT_BRCA1_1	180	184	PF00533	0.365
LIG_eIF4E_1	229	235	PF01652	0.181
LIG_FHA_1	216	222	PF00498	0.471
LIG_FHA_1	265	271	PF00498	0.345
LIG_FHA_1	316	322	PF00498	0.290
LIG_FHA_1	414	420	PF00498	0.383
LIG_FHA_1	428	434	PF00498	0.252
LIG_FHA_1	68	74	PF00498	0.588
LIG_FHA_2	235	241	PF00498	0.312
LIG_FHA_2	271	277	PF00498	0.298
LIG_FHA_2	404	410	PF00498	0.290
LIG_LIR_Gen_1	255	262	PF02991	0.345
LIG_LIR_Gen_1	358	368	PF02991	0.280
LIG_LIR_Gen_1	472	482	PF02991	0.321
LIG_LIR_Gen_1	98	109	PF02991	0.363
LIG_LIR_Nem_3	105	111	PF02991	0.306
LIG_LIR_Nem_3	255	260	PF02991	0.458
LIG_LIR_Nem_3	358	364	PF02991	0.280
LIG_LIR_Nem_3	387	393	PF02991	0.191
LIG_LIR_Nem_3	472	477	PF02991	0.321
LIG_LIR_Nem_3	89	93	PF02991	0.428
LIG_LIR_Nem_3	98	104	PF02991	0.328
LIG_MYND_1	11	15	PF01753	0.508
LIG_NRP_CendR_1	522	523	PF00754	0.535
LIG_PCNA_PIPBox_1	251	260	PF02747	0.345
LIG_PTB_Apo_2	84	91	PF02174	0.403
LIG_SH2_CRK	344	348	PF00017	0.345
LIG_SH2_CRK	390	394	PF00017	0.184
LIG_SH2_CRK	437	441	PF00017	0.280
LIG_SH2_CRK	474	478	PF00017	0.280
LIG_SH2_CRK	93	97	PF00017	0.420
LIG_SH2_GRB2like	135	138	PF00017	0.409
LIG_SH2_GRB2like	229	232	PF00017	0.280
LIG_SH2_NCK_1	390	394	PF00017	0.184
LIG_SH2_PTP2	135	138	PF00017	0.409
LIG_SH2_PTP2	327	330	PF00017	0.345
LIG_SH2_SRC	135	138	PF00017	0.409
LIG_SH2_SRC	229	232	PF00017	0.345
LIG_SH2_SRC	344	347	PF00017	0.345
LIG_SH2_STAP1	262	266	PF00017	0.345
LIG_SH2_STAP1	313	317	PF00017	0.280
LIG_SH2_STAT5	135	138	PF00017	0.409
LIG_SH2_STAT5	229	232	PF00017	0.280
LIG_SH2_STAT5	313	316	PF00017	0.280
LIG_SH2_STAT5	327	330	PF00017	0.280
LIG_SH2_STAT5	346	349	PF00017	0.168
LIG_SH2_STAT5	371	374	PF00017	0.279
LIG_SH2_STAT5	437	440	PF00017	0.280
LIG_SH2_STAT5	59	62	PF00017	0.569
LIG_SH3_3	319	325	PF00018	0.340
LIG_SH3_3	344	350	PF00018	0.345
LIG_SH3_3	36	42	PF00018	0.492
LIG_SH3_3	369	375	PF00018	0.296
LIG_SH3_3	379	385	PF00018	0.301
LIG_SH3_3	5	11	PF00018	0.617
LIG_SUMO_SIM_anti_2	255	263	PF11976	0.345
LIG_SUMO_SIM_anti_2	265	270	PF11976	0.252
LIG_SUMO_SIM_par_1	267	274	PF11976	0.284
LIG_TRAF2_1	140	143	PF00917	0.363
LIG_TRAF2_1	249	252	PF00917	0.345
LIG_TRAF2_1	360	363	PF00917	0.280
LIG_TRAF2_1	96	99	PF00917	0.544
LIG_TYR_ITIM	342	347	PF00017	0.345
LIG_WRC_WIRS_1	297	302	PF05994	0.279
MOD_CDK_SPxK_1	174	180	PF00069	0.546
MOD_CK1_1	161	167	PF00069	0.619
MOD_CK1_1	168	174	PF00069	0.573
MOD_CK1_1	18	24	PF00069	0.632
MOD_CK1_1	29	35	PF00069	0.532
MOD_CK1_1	299	305	PF00069	0.301
MOD_CK1_1	331	337	PF00069	0.345
MOD_CK1_1	357	363	PF00069	0.280
MOD_CK1_1	6	12	PF00069	0.590
MOD_CK1_1	69	75	PF00069	0.624
MOD_CK2_1	18	24	PF00069	0.633
MOD_CK2_1	234	240	PF00069	0.301
MOD_CK2_1	270	276	PF00069	0.280
MOD_CK2_1	357	363	PF00069	0.280
MOD_CK2_1	79	85	PF00069	0.488
MOD_Cter_Amidation	193	196	PF01082	0.371
MOD_GlcNHglycan	165	168	PF01048	0.588
MOD_GlcNHglycan	173	176	PF01048	0.528
MOD_GlcNHglycan	289	293	PF01048	0.293
MOD_GlcNHglycan	31	34	PF01048	0.629
MOD_GlcNHglycan	35	38	PF01048	0.596
MOD_GlcNHglycan	386	389	PF01048	0.311
MOD_GlcNHglycan	396	399	PF01048	0.224
MOD_GlcNHglycan	423	426	PF01048	0.262
MOD_GlcNHglycan	48	51	PF01048	0.544
MOD_GlcNHglycan	492	495	PF01048	0.443
MOD_GlcNHglycan	55	58	PF01048	0.565
MOD_GSK3_1	14	21	PF00069	0.646
MOD_GSK3_1	146	153	PF00069	0.542
MOD_GSK3_1	154	161	PF00069	0.599
MOD_GSK3_1	163	170	PF00069	0.516
MOD_GSK3_1	174	181	PF00069	0.447
MOD_GSK3_1	215	222	PF00069	0.240
MOD_GSK3_1	260	267	PF00069	0.364
MOD_GSK3_1	29	36	PF00069	0.490
MOD_GSK3_1	311	318	PF00069	0.290
MOD_GSK3_1	37	44	PF00069	0.669
MOD_GSK3_1	384	391	PF00069	0.425
MOD_GSK3_1	399	406	PF00069	0.217
MOD_GSK3_1	53	60	PF00069	0.536
MOD_GSK3_1	68	75	PF00069	0.490
MOD_N-GLC_1	121	126	PF02516	0.359
MOD_N-GLC_1	15	20	PF02516	0.651
MOD_N-GLC_1	26	31	PF02516	0.573
MOD_N-GLC_1	449	454	PF02516	0.345
MOD_NEK2_1	123	128	PF00069	0.394
MOD_NEK2_1	163	168	PF00069	0.632
MOD_NEK2_1	197	202	PF00069	0.283
MOD_NEK2_1	234	239	PF00069	0.356
MOD_NEK2_1	243	248	PF00069	0.276
MOD_NEK2_1	448	453	PF00069	0.353
MOD_NEK2_1	66	71	PF00069	0.592
MOD_PIKK_1	243	249	PF00454	0.280
MOD_PIKK_1	331	337	PF00454	0.301
MOD_PIKK_1	43	49	PF00454	0.620
MOD_PK_1	150	156	PF00069	0.463
MOD_PKA_1	490	496	PF00069	0.448
MOD_PKA_2	161	167	PF00069	0.582
MOD_PKA_2	19	25	PF00069	0.539
MOD_PKA_2	207	213	PF00069	0.195
MOD_PKA_2	6	12	PF00069	0.612
MOD_Plk_1	111	117	PF00069	0.402
MOD_Plk_1	141	147	PF00069	0.391
MOD_Plk_1	235	241	PF00069	0.345
MOD_Plk_1	26	32	PF00069	0.590
MOD_Plk_1	264	270	PF00069	0.459
MOD_Plk_1	3	9	PF00069	0.653
MOD_Plk_1	449	455	PF00069	0.352
MOD_Plk_2-3	311	317	PF00069	0.254
MOD_Plk_4	141	147	PF00069	0.358
MOD_Plk_4	26	32	PF00069	0.505
MOD_Plk_4	264	270	PF00069	0.344
MOD_Plk_4	429	435	PF00069	0.280
MOD_Plk_4	72	78	PF00069	0.469
MOD_ProDKin_1	165	171	PF00069	0.742
MOD_ProDKin_1	174	180	PF00069	0.499
MOD_ProDKin_1	222	228	PF00069	0.181
MOD_ProDKin_1	328	334	PF00069	0.181
MOD_ProDKin_1	374	380	PF00069	0.224
MOD_ProDKin_1	38	44	PF00069	0.778
MOD_ProDKin_1	388	394	PF00069	0.198
MOD_ProDKin_1	413	419	PF00069	0.345
TRG_DiLeu_BaEn_1	99	104	PF01217	0.365
TRG_DiLeu_BaEn_2	275	281	PF01217	0.345
TRG_DiLeu_BaEn_2	471	477	PF01217	0.280
TRG_DiLeu_BaEn_3	362	368	PF01217	0.280
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.426
TRG_ENDOCYTIC_2	135	138	PF00928	0.409
TRG_ENDOCYTIC_2	344	347	PF00928	0.345
TRG_ENDOCYTIC_2	390	393	PF00928	0.184
TRG_ENDOCYTIC_2	437	440	PF00928	0.280
TRG_ENDOCYTIC_2	474	477	PF00928	0.280
TRG_ENDOCYTIC_2	478	481	PF00928	0.280
TRG_ER_diArg_1	322	324	PF00400	0.345
TRG_ER_diArg_1	453	455	PF00400	0.345
TRG_NES_CRM1_1	295	309	PF08389	0.235

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILN6	Leptomonas seymouri	46%	100%
A0A3S7XAX7	Leishmania donovani	88%	100%
A4HP87	Leishmania braziliensis	76%	100%
A4IDJ2	Leishmania infantum	88%	100%
P34138	Dictyostelium discoideum	24%	100%
Q4Q1K3	Leishmania major	89%	100%