SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NOL1/NOP2/sun family, putative

Species:

Leishmania mexicana

UniProt:

E9ASZ4_LEIMU

TriTrypDb:

LmxM.36.2170

Length:

762

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9ASZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASZ4

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	8
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009451	RNA modification	5	8
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0032259	methylation	2	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0043414	macromolecule methylation	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0008168	methyltransferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0000049	tRNA binding	5	3
GO:0008173	RNA methyltransferase activity	4	3
GO:0008175	tRNA methyltransferase activity	5	3
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	3
GO:0016427	tRNA (cytosine) methyltransferase activity	6	3
GO:0016428	tRNA (cytosine-5-)-methyltransferase activity	7	3
GO:0140098	catalytic activity, acting on RNA	3	3
GO:0140101	catalytic activity, acting on a tRNA	4	3
GO:0140640	catalytic activity, acting on a nucleic acid	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.254
CLV_C14_Caspase3-7	409	413	PF00656	0.531
CLV_C14_Caspase3-7	486	490	PF00656	0.477
CLV_C14_Caspase3-7	529	533	PF00656	0.463
CLV_C14_Caspase3-7	69	73	PF00656	0.679
CLV_NRD_NRD_1	15	17	PF00675	0.589
CLV_NRD_NRD_1	158	160	PF00675	0.425
CLV_NRD_NRD_1	321	323	PF00675	0.251
CLV_NRD_NRD_1	654	656	PF00675	0.520
CLV_PCSK_KEX2_1	15	17	PF00082	0.589
CLV_PCSK_KEX2_1	160	162	PF00082	0.434
CLV_PCSK_KEX2_1	253	255	PF00082	0.251
CLV_PCSK_KEX2_1	263	265	PF00082	0.251
CLV_PCSK_KEX2_1	513	515	PF00082	0.666
CLV_PCSK_KEX2_1	654	656	PF00082	0.520
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.453
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.251
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.251
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.666
CLV_PCSK_SKI1_1	19	23	PF00082	0.634
CLV_PCSK_SKI1_1	266	270	PF00082	0.251
CLV_PCSK_SKI1_1	393	397	PF00082	0.258
CLV_Separin_Metazoa	302	306	PF03568	0.471
DEG_APCC_DBOX_1	392	400	PF00400	0.458
DEG_APCC_DBOX_1	690	698	PF00400	0.378
DEG_SCF_FBW7_1	103	110	PF00400	0.518
DEG_SPOP_SBC_1	77	81	PF00917	0.596
DOC_CKS1_1	104	109	PF01111	0.520
DOC_CKS1_1	32	37	PF01111	0.652
DOC_CKS1_1	432	437	PF01111	0.451
DOC_CYCLIN_RxL_1	260	272	PF00134	0.346
DOC_CYCLIN_yCln2_LP_2	267	273	PF00134	0.451
DOC_MAPK_gen_1	253	259	PF00069	0.451
DOC_MAPK_gen_1	263	269	PF00069	0.451
DOC_MAPK_gen_1	382	389	PF00069	0.465
DOC_MAPK_gen_1	654	664	PF00069	0.391
DOC_MAPK_gen_1	691	699	PF00069	0.447
DOC_MAPK_gen_1	722	731	PF00069	0.356
DOC_MAPK_HePTP_8	652	664	PF00069	0.513
DOC_MAPK_MEF2A_6	212	220	PF00069	0.347
DOC_MAPK_MEF2A_6	341	348	PF00069	0.451
DOC_MAPK_MEF2A_6	655	664	PF00069	0.381
DOC_MAPK_MEF2A_6	722	731	PF00069	0.398
DOC_MAPK_NFAT4_5	724	732	PF00069	0.386
DOC_MIT_MIM_1	687	697	PF04212	0.533
DOC_PP1_RVXF_1	264	270	PF00149	0.451
DOC_PP1_RVXF_1	626	633	PF00149	0.460
DOC_PP2B_LxvP_1	429	432	PF13499	0.451
DOC_PP4_FxxP_1	104	107	PF00568	0.379
DOC_PP4_FxxP_1	418	421	PF00568	0.531
DOC_PP4_MxPP_1	188	191	PF00568	0.337
DOC_USP7_MATH_1	227	231	PF00917	0.502
DOC_USP7_MATH_1	283	287	PF00917	0.545
DOC_USP7_MATH_1	73	77	PF00917	0.680
DOC_USP7_MATH_1	78	82	PF00917	0.690
DOC_USP7_MATH_2	236	242	PF00917	0.390
DOC_USP7_UBL2_3	484	488	PF12436	0.685
DOC_USP7_UBL2_3	5	9	PF12436	0.624
DOC_USP7_UBL2_3	513	517	PF12436	0.738
DOC_WW_Pin1_4	103	108	PF00397	0.519
DOC_WW_Pin1_4	205	210	PF00397	0.366
DOC_WW_Pin1_4	230	235	PF00397	0.505
DOC_WW_Pin1_4	31	36	PF00397	0.660
DOC_WW_Pin1_4	329	334	PF00397	0.451
DOC_WW_Pin1_4	431	436	PF00397	0.451
DOC_WW_Pin1_4	594	599	PF00397	0.568
LIG_14-3-3_CanoR_1	359	369	PF00244	0.451
LIG_14-3-3_CanoR_1	640	649	PF00244	0.373
LIG_14-3-3_CanoR_1	654	662	PF00244	0.351
LIG_Actin_WH2_2	306	324	PF00022	0.482
LIG_Actin_WH2_2	339	357	PF00022	0.484
LIG_BIR_III_2	231	235	PF00653	0.584
LIG_BIR_III_4	412	416	PF00653	0.531
LIG_Clathr_ClatBox_1	703	707	PF01394	0.348
LIG_CSL_BTD_1	330	333	PF09270	0.451
LIG_eIF4E_1	239	245	PF01652	0.304
LIG_FHA_1	104	110	PF00498	0.399
LIG_FHA_1	115	121	PF00498	0.346
LIG_FHA_1	362	368	PF00498	0.507
LIG_FHA_1	517	523	PF00498	0.495
LIG_FHA_1	615	621	PF00498	0.430
LIG_FHA_2	21	27	PF00498	0.596
LIG_FHA_2	273	279	PF00498	0.451
LIG_FHA_2	407	413	PF00498	0.531
LIG_FHA_2	542	548	PF00498	0.742
LIG_FHA_2	67	73	PF00498	0.608
LIG_LIR_Apic_2	102	107	PF02991	0.402
LIG_LIR_Apic_2	571	576	PF02991	0.416
LIG_LIR_Gen_1	49	58	PF02991	0.447
LIG_LIR_Nem_3	140	144	PF02991	0.395
LIG_LIR_Nem_3	49	55	PF02991	0.382
LIG_LIR_Nem_3	571	575	PF02991	0.418
LIG_LIR_Nem_3	636	642	PF02991	0.307
LIG_MAD2	60	68	PF02301	0.495
LIG_PCNA_PIPBox_1	164	173	PF02747	0.428
LIG_PCNA_PIPBox_1	566	575	PF02747	0.491
LIG_PDZ_Class_3	757	762	PF00595	0.753
LIG_PTB_Apo_2	42	49	PF02174	0.535
LIG_SH2_CRK	52	56	PF00017	0.522
LIG_SH2_GRB2like	51	54	PF00017	0.250
LIG_SH2_NCK_1	438	442	PF00017	0.522
LIG_SH2_NCK_1	573	577	PF00017	0.433
LIG_SH2_SRC	573	576	PF00017	0.442
LIG_SH2_STAP1	438	442	PF00017	0.482
LIG_SH2_STAP1	717	721	PF00017	0.346
LIG_SH2_STAT5	170	173	PF00017	0.494
LIG_SH2_STAT5	281	284	PF00017	0.465
LIG_SH3_1	573	579	PF00018	0.427
LIG_SH3_3	29	35	PF00018	0.645
LIG_SH3_3	397	403	PF00018	0.502
LIG_SH3_3	429	435	PF00018	0.484
LIG_SH3_3	556	562	PF00018	0.359
LIG_SH3_3	573	579	PF00018	0.399
LIG_SH3_3	657	663	PF00018	0.471
LIG_SH3_3	744	750	PF00018	0.565
LIG_SUMO_SIM_anti_2	617	624	PF11976	0.415
LIG_SUMO_SIM_par_1	617	624	PF11976	0.386
LIG_SUMO_SIM_par_1	702	707	PF11976	0.373
LIG_TRAF2_1	181	184	PF00917	0.349
LIG_UBA3_1	216	224	PF00899	0.378
LIG_UBA3_1	327	334	PF00899	0.522
LIG_UBA3_1	703	710	PF00899	0.490
LIG_WRC_WIRS_1	8	13	PF05994	0.529
MOD_CDK_SPK_2	329	334	PF00069	0.451
MOD_CDK_SPxxK_3	205	212	PF00069	0.363
MOD_CK1_1	130	136	PF00069	0.297
MOD_CK1_1	20	26	PF00069	0.693
MOD_CK1_1	208	214	PF00069	0.359
MOD_CK1_1	230	236	PF00069	0.503
MOD_CK1_1	363	369	PF00069	0.450
MOD_CK1_1	600	606	PF00069	0.370
MOD_CK1_1	76	82	PF00069	0.735
MOD_CK2_1	131	137	PF00069	0.382
MOD_CK2_1	178	184	PF00069	0.343
MOD_CK2_1	329	335	PF00069	0.451
MOD_CK2_1	541	547	PF00069	0.742
MOD_CK2_1	689	695	PF00069	0.388
MOD_GlcNHglycan	19	22	PF01048	0.672
MOD_GlcNHglycan	315	318	PF01048	0.262
MOD_GlcNHglycan	439	442	PF01048	0.322
MOD_GlcNHglycan	522	525	PF01048	0.678
MOD_GlcNHglycan	623	626	PF01048	0.417
MOD_GlcNHglycan	644	647	PF01048	0.380
MOD_GlcNHglycan	75	78	PF01048	0.630
MOD_GlcNHglycan	87	91	PF01048	0.461
MOD_GSK3_1	103	110	PF00069	0.518
MOD_GSK3_1	127	134	PF00069	0.396
MOD_GSK3_1	17	24	PF00069	0.671
MOD_GSK3_1	172	179	PF00069	0.386
MOD_GSK3_1	313	320	PF00069	0.451
MOD_GSK3_1	497	504	PF00069	0.604
MOD_GSK3_1	516	523	PF00069	0.769
MOD_GSK3_1	62	69	PF00069	0.593
MOD_GSK3_1	681	688	PF00069	0.501
MOD_GSK3_1	73	80	PF00069	0.663
MOD_N-GLC_1	114	119	PF02516	0.377
MOD_NEK2_1	108	113	PF00069	0.447
MOD_NEK2_1	131	136	PF00069	0.320
MOD_NEK2_1	360	365	PF00069	0.481
MOD_NEK2_1	446	451	PF00069	0.555
MOD_NEK2_1	584	589	PF00069	0.475
MOD_NEK2_1	621	626	PF00069	0.397
MOD_NEK2_1	653	658	PF00069	0.487
MOD_NEK2_1	681	686	PF00069	0.352
MOD_NEK2_1	716	721	PF00069	0.203
MOD_NEK2_2	317	322	PF00069	0.463
MOD_PIKK_1	685	691	PF00454	0.454
MOD_PKA_1	516	522	PF00069	0.621
MOD_PKA_1	654	660	PF00069	0.515
MOD_PKA_2	501	507	PF00069	0.731
MOD_PKA_2	653	659	PF00069	0.474
MOD_Plk_1	131	137	PF00069	0.315
MOD_Plk_1	184	190	PF00069	0.353
MOD_Plk_1	283	289	PF00069	0.499
MOD_Plk_1	446	452	PF00069	0.555
MOD_Plk_4	131	137	PF00069	0.403
MOD_Plk_4	184	190	PF00069	0.342
MOD_Plk_4	501	507	PF00069	0.686
MOD_Plk_4	600	606	PF00069	0.359
MOD_Plk_4	662	668	PF00069	0.414
MOD_Plk_4	92	98	PF00069	0.447
MOD_ProDKin_1	103	109	PF00069	0.519
MOD_ProDKin_1	205	211	PF00069	0.365
MOD_ProDKin_1	230	236	PF00069	0.503
MOD_ProDKin_1	31	37	PF00069	0.658
MOD_ProDKin_1	329	335	PF00069	0.451
MOD_ProDKin_1	431	437	PF00069	0.451
MOD_ProDKin_1	594	600	PF00069	0.558
MOD_SUMO_for_1	483	486	PF00179	0.619
MOD_SUMO_for_1	512	515	PF00179	0.748
MOD_SUMO_rev_2	249	255	PF00179	0.451
MOD_SUMO_rev_2	481	490	PF00179	0.650
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.487
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.451
TRG_ENDOCYTIC_2	52	55	PF00928	0.401
TRG_ER_diArg_1	158	161	PF00400	0.420
TRG_ER_diArg_1	264	267	PF00400	0.451
TRG_ER_diArg_1	653	655	PF00400	0.518
TRG_ER_diArg_1	690	693	PF00400	0.425
TRG_ER_diArg_1	721	724	PF00400	0.350
TRG_NLS_Bipartite_1	253	267	PF00514	0.451
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	478	482	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	567	571	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZE7	Leptomonas seymouri	77%	98%
A0A1X0P7M3	Trypanosomatidae	59%	100%
A0A3Q8IJ07	Leishmania donovani	32%	100%
A0A3Q8INR5	Leishmania donovani	92%	99%
A0A3R7M922	Trypanosoma rangeli	29%	95%
A0A3R7NNX1	Trypanosoma rangeli	57%	100%
A4HP86	Leishmania braziliensis	85%	100%
A4IDJ1	Leishmania infantum	92%	99%
D0A386	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AHJ5	Leishmania infantum	33%	100%
O13935	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
P38205	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q08J23	Homo sapiens	31%	99%
Q1HFZ0	Mus musculus	31%	100%
Q28E61	Xenopus tropicalis	32%	95%
Q4Q1K4	Leishmania major	91%	100%
Q4V7N2	Xenopus laevis	34%	100%
Q5ZLV4	Gallus gallus	32%	96%
Q9HGQ2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
V5DCJ5	Trypanosoma cruzi	63%	100%