Putative COP-coated vesicle membrane protein erv25

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transmembrane emp24 domain-containing protein

Species:

Leishmania mexicana

UniProt:

E9ASZ2_LEIMU

TriTrypDb:

LmxM.36.2150

Length:

268

Annotations

LeishMANIAdb annotations

Conserved eukaryotic protein. Probable receptor for ER-Golgi trafficking of GPI-anchored proteins. Related to metazoan Tmed10.. Localization: ER (by homology) / Golgi (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 0
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	1
GO:0005794	Golgi apparatus	5	1
GO:0016020	membrane	2	11
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1

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Expansion

Sequence features

E9ASZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASZ2

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	87	91	PF00656	0.363
CLV_NRD_NRD_1	166	168	PF00675	0.600
CLV_NRD_NRD_1	262	264	PF00675	0.494
CLV_PCSK_KEX2_1	165	167	PF00082	0.521
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.521
CLV_PCSK_SKI1_1	185	189	PF00082	0.545
CLV_PCSK_SKI1_1	20	24	PF00082	0.716
CLV_PCSK_SKI1_1	256	260	PF00082	0.328
DEG_APCC_DBOX_1	19	27	PF00400	0.384
DEG_APCC_DBOX_1	190	198	PF00400	0.399

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7A9	Leptomonas seymouri	57%	100%
A0A1X0P7Z0	Trypanosomatidae	33%	100%
A0A3S7XAW3	Leishmania donovani	95%	100%
A0A422N537	Trypanosoma rangeli	26%	100%
A4HP84	Leishmania braziliensis	82%	100%
A4IDI9	Leishmania infantum	95%	100%
D0A380	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B4J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	76%
Q4Q1K6	Leishmania major	91%	100%
V5BBT5	Trypanosoma cruzi	34%	100%

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