N-acetyltransferase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinetoplastid kinetochore protein 23, putative

Species:

Leishmania mexicana

UniProt:

E9ASY6_LEIMU

TriTrypDb:

LmxM.36.2100

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASY6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016407	acetyltransferase activity	5	9
GO:0016740	transferase activity	2	9
GO:0016746	acyltransferase activity	3	9
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.609
CLV_NRD_NRD_1	196	198	PF00675	0.502
CLV_NRD_NRD_1	332	334	PF00675	0.736
CLV_PCSK_KEX2_1	125	127	PF00082	0.612
CLV_PCSK_KEX2_1	198	200	PF00082	0.450
CLV_PCSK_KEX2_1	332	334	PF00082	0.698
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.575
CLV_PCSK_SKI1_1	184	188	PF00082	0.436
CLV_PCSK_SKI1_1	287	291	PF00082	0.437
CLV_PCSK_SKI1_1	350	354	PF00082	0.446
CLV_PCSK_SKI1_1	358	362	PF00082	0.380
CLV_PCSK_SKI1_1	58	62	PF00082	0.538
DEG_APCC_DBOX_1	349	357	PF00400	0.387
DEG_Nend_Nbox_1	1	3	PF02207	0.514
DEG_SPOP_SBC_1	113	117	PF00917	0.622
DOC_CYCLIN_yCln2_LP_2	361	367	PF00134	0.317
DOC_MAPK_gen_1	161	169	PF00069	0.381
DOC_MAPK_gen_1	291	299	PF00069	0.449
DOC_PP1_RVXF_1	294	300	PF00149	0.376
DOC_PP1_RVXF_1	56	63	PF00149	0.543
DOC_PP4_FxxP_1	174	177	PF00568	0.393
DOC_PP4_FxxP_1	50	53	PF00568	0.578
DOC_USP7_MATH_1	107	111	PF00917	0.758
DOC_USP7_MATH_1	113	117	PF00917	0.685
DOC_WW_Pin1_4	75	80	PF00397	0.687
DOC_WW_Pin1_4	98	103	PF00397	0.739
LIG_14-3-3_CanoR_1	12	18	PF00244	0.596
LIG_14-3-3_CanoR_1	125	133	PF00244	0.580
LIG_14-3-3_CanoR_1	184	189	PF00244	0.542
LIG_14-3-3_CanoR_1	209	217	PF00244	0.383
LIG_14-3-3_CanoR_1	7	11	PF00244	0.576
LIG_BRCT_BRCA1_1	170	174	PF00533	0.390
LIG_FHA_1	14	20	PF00498	0.457
LIG_FHA_1	211	217	PF00498	0.386
LIG_FHA_1	219	225	PF00498	0.426
LIG_FHA_2	134	140	PF00498	0.575
LIG_FHA_2	20	26	PF00498	0.466
LIG_FHA_2	288	294	PF00498	0.540
LIG_FHA_2	47	53	PF00498	0.400
LIG_LIR_Apic_2	171	177	PF02991	0.390
LIG_LIR_Apic_2	49	53	PF02991	0.570
LIG_LIR_Gen_1	229	239	PF02991	0.346
LIG_LIR_Gen_1	267	275	PF02991	0.355
LIG_LIR_Nem_3	139	144	PF02991	0.466
LIG_LIR_Nem_3	201	207	PF02991	0.385
LIG_LIR_Nem_3	267	271	PF02991	0.318
LIG_SH2_CRK	14	18	PF00017	0.472
LIG_SH2_STAP1	170	174	PF00017	0.276
LIG_SH2_STAP1	204	208	PF00017	0.299
LIG_SH2_STAP1	46	50	PF00017	0.445
LIG_SH2_STAT3	150	153	PF00017	0.479
LIG_SH2_STAT3	170	173	PF00017	0.295
LIG_SH2_STAT5	207	210	PF00017	0.302
LIG_SH2_STAT5	317	320	PF00017	0.382
LIG_SH3_3	174	180	PF00018	0.406
LIG_SH3_3	183	189	PF00018	0.391
LIG_SUMO_SIM_par_1	164	172	PF11976	0.493
LIG_SUMO_SIM_par_1	184	190	PF11976	0.612
LIG_TRAF2_1	136	139	PF00917	0.572
LIG_TRAF2_1	212	215	PF00917	0.429
LIG_TRAF2_1	3	6	PF00917	0.599
LIG_TRAF2_1	35	38	PF00917	0.487
MOD_CK1_1	106	112	PF00069	0.702
MOD_CK1_1	115	121	PF00069	0.578
MOD_CK1_1	190	196	PF00069	0.544
MOD_CK1_1	98	104	PF00069	0.753
MOD_CK2_1	133	139	PF00069	0.570
MOD_CK2_1	156	162	PF00069	0.416
MOD_CK2_1	287	293	PF00069	0.425
MOD_CK2_1	91	97	PF00069	0.794
MOD_GlcNHglycan	200	203	PF01048	0.506
MOD_GlcNHglycan	271	274	PF01048	0.327
MOD_GlcNHglycan	327	330	PF01048	0.728
MOD_GlcNHglycan	340	343	PF01048	0.624
MOD_GlcNHglycan	93	96	PF01048	0.770
MOD_GlcNHglycan	97	100	PF01048	0.802
MOD_GSK3_1	103	110	PF00069	0.675
MOD_GSK3_1	187	194	PF00069	0.634
MOD_GSK3_1	198	205	PF00069	0.543
MOD_GSK3_1	91	98	PF00069	0.690
MOD_N-GLC_1	19	24	PF02516	0.380
MOD_N-GLC_1	190	195	PF02516	0.395
MOD_N-GLC_1	323	328	PF02516	0.544
MOD_NEK2_1	112	117	PF00069	0.662
MOD_NEK2_1	132	137	PF00069	0.480
MOD_NEK2_1	169	174	PF00069	0.470
MOD_NEK2_1	19	24	PF00069	0.561
MOD_NEK2_1	237	242	PF00069	0.321
MOD_NEK2_1	345	350	PF00069	0.510
MOD_NEK2_1	67	72	PF00069	0.606
MOD_NEK2_2	13	18	PF00069	0.601
MOD_PIKK_1	169	175	PF00454	0.438
MOD_PIKK_1	19	25	PF00454	0.600
MOD_PIKK_1	210	216	PF00454	0.431
MOD_PKA_1	198	204	PF00069	0.528
MOD_PKA_2	124	130	PF00069	0.575
MOD_PKA_2	133	139	PF00069	0.585
MOD_PKA_2	198	204	PF00069	0.530
MOD_PKA_2	6	12	PF00069	0.602
MOD_Plk_1	19	25	PF00069	0.582
MOD_Plk_4	107	113	PF00069	0.664
MOD_Plk_4	202	208	PF00069	0.313
MOD_Plk_4	310	316	PF00069	0.499
MOD_Plk_4	46	52	PF00069	0.498
MOD_Plk_4	6	12	PF00069	0.591
MOD_ProDKin_1	75	81	PF00069	0.690
MOD_ProDKin_1	98	104	PF00069	0.737
TRG_DiLeu_BaEn_1	6	11	PF01217	0.475
TRG_DiLeu_BaEn_4	164	170	PF01217	0.500
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.562
TRG_DiLeu_BaLyEn_6	248	253	PF01217	0.336
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.487
TRG_ENDOCYTIC_2	14	17	PF00928	0.452
TRG_ENDOCYTIC_2	286	289	PF00928	0.351
TRG_ER_diArg_1	124	126	PF00400	0.698
TRG_ER_diArg_1	197	200	PF00400	0.472
TRG_ER_diArg_1	332	334	PF00400	0.666
TRG_NLS_MonoExtN_4	195	201	PF00514	0.596
TRG_Pf-PMV_PEXEL_1	209	214	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9D4	Leptomonas seymouri	69%	99%
A0A0S4IZI8	Bodo saltans	38%	86%
A0A1X0P7V3	Trypanosomatidae	45%	100%
A0A3R7K298	Trypanosoma rangeli	46%	100%
A0A3S7XAU7	Leishmania donovani	94%	100%
A4HP78	Leishmania braziliensis	87%	100%
A4IDI3	Leishmania infantum	94%	100%
D0A374	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
Q4Q1L2	Leishmania major	91%	100%
V5DCI4	Trypanosoma cruzi	45%	100%