UDENN domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASY5_LEIMU

TriTrypDb:

LmxM.36.2090

Length:

954

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005768	endosome	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0055037	recycling endosome	8	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASY5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005085	guanyl-nucleotide exchange factor activity	3	6
GO:0030234	enzyme regulator activity	2	6
GO:0030695	GTPase regulator activity	4	6
GO:0060589	nucleoside-triphosphatase regulator activity	3	6
GO:0098772	molecular function regulator activity	1	6
GO:0140677	molecular function activator activity	2	6
GO:0140678	molecular function inhibitor activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	605	609	PF00656	0.717
CLV_C14_Caspase3-7	700	704	PF00656	0.589
CLV_NRD_NRD_1	511	513	PF00675	0.527
CLV_NRD_NRD_1	551	553	PF00675	0.606
CLV_NRD_NRD_1	654	656	PF00675	0.534
CLV_NRD_NRD_1	663	665	PF00675	0.443
CLV_NRD_NRD_1	779	781	PF00675	0.395
CLV_PCSK_KEX2_1	243	245	PF00082	0.554
CLV_PCSK_KEX2_1	411	413	PF00082	0.442
CLV_PCSK_KEX2_1	551	553	PF00082	0.606
CLV_PCSK_KEX2_1	653	655	PF00082	0.521
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.545
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.442
CLV_PCSK_PC7_1	547	553	PF00082	0.569
CLV_PCSK_SKI1_1	47	51	PF00082	0.642
CLV_PCSK_SKI1_1	503	507	PF00082	0.438
CLV_PCSK_SKI1_1	513	517	PF00082	0.478
CLV_PCSK_SKI1_1	780	784	PF00082	0.346
DEG_APCC_DBOX_1	502	510	PF00400	0.623
DEG_COP1_1	86	94	PF00400	0.473
DEG_Nend_UBRbox_3	1	3	PF02207	0.411
DEG_SCF_FBW7_1	213	220	PF00400	0.408
DEG_SPOP_SBC_1	532	536	PF00917	0.702
DEG_SPOP_SBC_1	737	741	PF00917	0.691
DEG_SPOP_SBC_1	747	751	PF00917	0.642
DOC_CKS1_1	214	219	PF01111	0.407
DOC_CKS1_1	790	795	PF01111	0.405
DOC_CKS1_1	801	806	PF01111	0.294
DOC_CKS1_1	819	824	PF01111	0.387
DOC_CYCLIN_RxL_1	336	350	PF00134	0.620
DOC_CYCLIN_yClb5_NLxxxL_5	664	671	PF00134	0.630
DOC_CYCLIN_yCln2_LP_2	313	319	PF00134	0.405
DOC_MAPK_gen_1	336	346	PF00069	0.618
DOC_MAPK_MEF2A_6	289	296	PF00069	0.232
DOC_MAPK_MEF2A_6	485	492	PF00069	0.641
DOC_MAPK_MEF2A_6	708	715	PF00069	0.672
DOC_MAPK_MEF2A_6	897	904	PF00069	0.386
DOC_PP1_RVXF_1	241	248	PF00149	0.434
DOC_PP1_RVXF_1	25	31	PF00149	0.394
DOC_PP1_RVXF_1	340	347	PF00149	0.622
DOC_PP2B_LxvP_1	158	161	PF13499	0.359
DOC_PP2B_LxvP_1	313	316	PF13499	0.405
DOC_PP4_FxxP_1	214	217	PF00568	0.403
DOC_PP4_FxxP_1	30	33	PF00568	0.399
DOC_PP4_FxxP_1	65	68	PF00568	0.368
DOC_PP4_FxxP_1	790	793	PF00568	0.405
DOC_USP7_MATH_1	154	158	PF00917	0.389
DOC_USP7_MATH_1	217	221	PF00917	0.431
DOC_USP7_MATH_1	227	231	PF00917	0.552
DOC_USP7_MATH_1	261	265	PF00917	0.418
DOC_USP7_MATH_1	407	411	PF00917	0.760
DOC_USP7_MATH_1	540	544	PF00917	0.810
DOC_USP7_MATH_1	660	664	PF00917	0.603
DOC_USP7_MATH_1	728	732	PF00917	0.753
DOC_USP7_MATH_1	736	740	PF00917	0.708
DOC_USP7_MATH_1	74	78	PF00917	0.525
DOC_USP7_MATH_1	743	747	PF00917	0.684
DOC_WW_Pin1_4	144	149	PF00397	0.410
DOC_WW_Pin1_4	193	198	PF00397	0.436
DOC_WW_Pin1_4	213	218	PF00397	0.428
DOC_WW_Pin1_4	29	34	PF00397	0.469
DOC_WW_Pin1_4	296	301	PF00397	0.371
DOC_WW_Pin1_4	397	402	PF00397	0.655
DOC_WW_Pin1_4	403	408	PF00397	0.707
DOC_WW_Pin1_4	435	440	PF00397	0.833
DOC_WW_Pin1_4	536	541	PF00397	0.746
DOC_WW_Pin1_4	577	582	PF00397	0.769
DOC_WW_Pin1_4	6	11	PF00397	0.373
DOC_WW_Pin1_4	623	628	PF00397	0.749
DOC_WW_Pin1_4	724	729	PF00397	0.765
DOC_WW_Pin1_4	738	743	PF00397	0.762
DOC_WW_Pin1_4	789	794	PF00397	0.405
DOC_WW_Pin1_4	800	805	PF00397	0.298
DOC_WW_Pin1_4	818	823	PF00397	0.464
LIG_14-3-3_CanoR_1	202	208	PF00244	0.389
LIG_14-3-3_CanoR_1	226	235	PF00244	0.516
LIG_14-3-3_CanoR_1	236	242	PF00244	0.412
LIG_14-3-3_CanoR_1	324	330	PF00244	0.586
LIG_14-3-3_CanoR_1	464	471	PF00244	0.634
LIG_14-3-3_CanoR_1	485	491	PF00244	0.739
LIG_14-3-3_CanoR_1	495	500	PF00244	0.730
LIG_14-3-3_CanoR_1	708	714	PF00244	0.666
LIG_14-3-3_CanoR_1	723	728	PF00244	0.667
LIG_14-3-3_CanoR_1	780	790	PF00244	0.539
LIG_14-3-3_CanoR_1	800	804	PF00244	0.414
LIG_14-3-3_CanoR_1	844	848	PF00244	0.459
LIG_AP2alpha_1	825	829	PF02296	0.389
LIG_BRCT_BRCA1_1	16	20	PF00533	0.365
LIG_BRCT_BRCA1_1	584	588	PF00533	0.633
LIG_BRCT_BRCA1_1	677	681	PF00533	0.625
LIG_CtBP_PxDLS_1	4	8	PF00389	0.383
LIG_EH_1	357	361	PF12763	0.595
LIG_EH1_1	125	133	PF00400	0.366
LIG_EH1_1	307	315	PF00400	0.405
LIG_eIF4E_1	112	118	PF01652	0.364
LIG_FHA_1	148	154	PF00498	0.405
LIG_FHA_1	202	208	PF00498	0.389
LIG_FHA_1	416	422	PF00498	0.645
LIG_FHA_1	466	472	PF00498	0.829
LIG_FHA_1	487	493	PF00498	0.635
LIG_FHA_1	521	527	PF00498	0.718
LIG_FHA_1	687	693	PF00498	0.612
LIG_FHA_1	739	745	PF00498	0.738
LIG_FHA_1	761	767	PF00498	0.715
LIG_FHA_1	847	853	PF00498	0.375
LIG_FHA_1	925	931	PF00498	0.386
LIG_FHA_2	177	183	PF00498	0.361
LIG_FHA_2	64	70	PF00498	0.369
LIG_FHA_2	640	646	PF00498	0.640
LIG_FHA_2	88	94	PF00498	0.541
LIG_LIR_Apic_2	29	33	PF02991	0.400
LIG_LIR_Apic_2	787	793	PF02991	0.405
LIG_LIR_Gen_1	246	255	PF02991	0.487
LIG_LIR_Gen_1	281	292	PF02991	0.361
LIG_LIR_Gen_1	538	545	PF02991	0.636
LIG_LIR_Gen_1	56	67	PF02991	0.387
LIG_LIR_Gen_1	795	805	PF02991	0.469
LIG_LIR_Nem_3	164	169	PF02991	0.424
LIG_LIR_Nem_3	264	269	PF02991	0.287
LIG_LIR_Nem_3	281	287	PF02991	0.235
LIG_LIR_Nem_3	325	329	PF02991	0.579
LIG_LIR_Nem_3	332	337	PF02991	0.556
LIG_LIR_Nem_3	538	544	PF02991	0.672
LIG_LIR_Nem_3	56	62	PF02991	0.494
LIG_LIR_Nem_3	795	801	PF02991	0.459
LIG_LIR_Nem_3	802	808	PF02991	0.317
LIG_LIR_Nem_3	846	850	PF02991	0.452
LIG_PCNA_PIPBox_1	668	677	PF02747	0.621
LIG_PCNA_yPIPBox_3	664	675	PF02747	0.644
LIG_PDZ_Class_2	949	954	PF00595	0.423
LIG_Pex14_2	266	270	PF04695	0.389
LIG_Pex14_2	61	65	PF04695	0.357
LIG_Pex14_2	825	829	PF04695	0.389
LIG_PTB_Apo_2	295	302	PF02174	0.240
LIG_PTB_Apo_2	328	335	PF02174	0.605
LIG_PTB_Phospho_1	295	301	PF10480	0.240
LIG_SH2_CRK	59	63	PF00017	0.371
LIG_SH2_CRK	850	854	PF00017	0.374
LIG_SH2_GRB2like	125	128	PF00017	0.372
LIG_SH2_STAP1	203	207	PF00017	0.391
LIG_SH2_STAP1	854	858	PF00017	0.369
LIG_SH2_STAT3	112	115	PF00017	0.373
LIG_SH2_STAT3	866	869	PF00017	0.388
LIG_SH2_STAT5	112	115	PF00017	0.373
LIG_SH2_STAT5	166	169	PF00017	0.417
LIG_SH2_STAT5	178	181	PF00017	0.318
LIG_SH2_STAT5	203	206	PF00017	0.397
LIG_SH2_STAT5	326	329	PF00017	0.581
LIG_SH2_STAT5	64	67	PF00017	0.363
LIG_SH2_STAT5	674	677	PF00017	0.610
LIG_SH2_STAT5	805	808	PF00017	0.379
LIG_SH2_STAT5	866	869	PF00017	0.382
LIG_SH3_1	103	109	PF00018	0.417
LIG_SH3_3	103	109	PF00018	0.417
LIG_SH3_3	132	138	PF00018	0.360
LIG_SH3_3	28	34	PF00018	0.368
LIG_SH3_3	386	392	PF00018	0.645
LIG_SH3_3	436	442	PF00018	0.761
LIG_SH3_3	481	487	PF00018	0.736
LIG_SH3_3	578	584	PF00018	0.728
LIG_SH3_3	79	85	PF00018	0.534
LIG_SH3_3	798	804	PF00018	0.449
LIG_SUMO_SIM_anti_2	204	209	PF11976	0.393
LIG_SUMO_SIM_anti_2	291	297	PF11976	0.233
LIG_SUMO_SIM_anti_2	896	902	PF11976	0.391
LIG_SUMO_SIM_par_1	115	121	PF11976	0.354
LIG_SUMO_SIM_par_1	291	297	PF11976	0.233
LIG_SUMO_SIM_par_1	3	9	PF11976	0.382
LIG_SUMO_SIM_par_1	488	494	PF11976	0.635
LIG_SUMO_SIM_par_1	504	511	PF11976	0.609
LIG_SUMO_SIM_par_1	697	703	PF11976	0.632
LIG_TRAF2_1	453	456	PF00917	0.734
LIG_TYR_ITIM	123	128	PF00017	0.373
LIG_UBA3_1	946	953	PF00899	0.416
LIG_WRC_WIRS_1	362	367	PF05994	0.672
LIG_WRC_WIRS_1	496	501	PF05994	0.722
LIG_WW_3	438	442	PF00397	0.628
MOD_CDK_SPxK_1	435	441	PF00069	0.638
MOD_CK1_1	147	153	PF00069	0.425
MOD_CK1_1	225	231	PF00069	0.514
MOD_CK1_1	234	240	PF00069	0.345
MOD_CK1_1	3	9	PF00069	0.438
MOD_CK1_1	309	315	PF00069	0.347
MOD_CK1_1	325	331	PF00069	0.512
MOD_CK1_1	345	351	PF00069	0.473
MOD_CK1_1	410	416	PF00069	0.735
MOD_CK1_1	420	426	PF00069	0.675
MOD_CK1_1	435	441	PF00069	0.719
MOD_CK1_1	466	472	PF00069	0.760
MOD_CK1_1	473	479	PF00069	0.765
MOD_CK1_1	494	500	PF00069	0.796
MOD_CK1_1	517	523	PF00069	0.758
MOD_CK1_1	535	541	PF00069	0.635
MOD_CK1_1	543	549	PF00069	0.742
MOD_CK1_1	706	712	PF00069	0.518
MOD_CK1_1	726	732	PF00069	0.727
MOD_CK1_1	746	752	PF00069	0.777
MOD_CK1_1	770	776	PF00069	0.613
MOD_CK1_1	785	791	PF00069	0.251
MOD_CK1_1	839	845	PF00069	0.444
MOD_CK1_1	846	852	PF00069	0.425
MOD_CK1_1	925	931	PF00069	0.382
MOD_CK2_1	450	456	PF00069	0.774
MOD_CK2_1	564	570	PF00069	0.678
MOD_CK2_1	587	593	PF00069	0.677
MOD_CK2_1	639	645	PF00069	0.640
MOD_CK2_1	87	93	PF00069	0.565
MOD_CK2_1	890	896	PF00069	0.379
MOD_DYRK1A_RPxSP_1	800	804	PF00069	0.271
MOD_GlcNHglycan	173	176	PF01048	0.610
MOD_GlcNHglycan	236	239	PF01048	0.672
MOD_GlcNHglycan	259	262	PF01048	0.637
MOD_GlcNHglycan	303	306	PF01048	0.405
MOD_GlcNHglycan	318	322	PF01048	0.272
MOD_GlcNHglycan	392	395	PF01048	0.622
MOD_GlcNHglycan	412	415	PF01048	0.552
MOD_GlcNHglycan	433	437	PF01048	0.499
MOD_GlcNHglycan	452	455	PF01048	0.640
MOD_GlcNHglycan	458	461	PF01048	0.559
MOD_GlcNHglycan	472	475	PF01048	0.440
MOD_GlcNHglycan	476	479	PF01048	0.588
MOD_GlcNHglycan	517	520	PF01048	0.577
MOD_GlcNHglycan	548	551	PF01048	0.585
MOD_GlcNHglycan	566	569	PF01048	0.498
MOD_GlcNHglycan	618	621	PF01048	0.460
MOD_GlcNHglycan	629	633	PF01048	0.370
MOD_GlcNHglycan	730	733	PF01048	0.479
MOD_GlcNHglycan	745	748	PF01048	0.562
MOD_GlcNHglycan	750	753	PF01048	0.533
MOD_GlcNHglycan	924	927	PF01048	0.591
MOD_GSK3_1	213	220	PF00069	0.408
MOD_GSK3_1	221	228	PF00069	0.431
MOD_GSK3_1	257	264	PF00069	0.524
MOD_GSK3_1	379	386	PF00069	0.658
MOD_GSK3_1	399	406	PF00069	0.716
MOD_GSK3_1	410	417	PF00069	0.687
MOD_GSK3_1	463	470	PF00069	0.785
MOD_GSK3_1	491	498	PF00069	0.773
MOD_GSK3_1	514	521	PF00069	0.755
MOD_GSK3_1	531	538	PF00069	0.639
MOD_GSK3_1	539	546	PF00069	0.710
MOD_GSK3_1	582	589	PF00069	0.747
MOD_GSK3_1	630	637	PF00069	0.638
MOD_GSK3_1	639	646	PF00069	0.600
MOD_GSK3_1	703	710	PF00069	0.677
MOD_GSK3_1	724	731	PF00069	0.691
MOD_GSK3_1	738	745	PF00069	0.851
MOD_GSK3_1	74	81	PF00069	0.519
MOD_GSK3_1	746	753	PF00069	0.771
MOD_GSK3_1	760	767	PF00069	0.608
MOD_GSK3_1	781	788	PF00069	0.395
MOD_GSK3_1	799	806	PF00069	0.274
MOD_GSK3_1	83	90	PF00069	0.504
MOD_GSK3_1	839	846	PF00069	0.484
MOD_GSK3_1	886	893	PF00069	0.437
MOD_GSK3_1	921	928	PF00069	0.434
MOD_LATS_1	448	454	PF00433	0.744
MOD_LATS_1	601	607	PF00433	0.689
MOD_N-GLC_1	377	382	PF02516	0.494
MOD_N-GLC_1	383	388	PF02516	0.526
MOD_N-GLC_1	747	752	PF02516	0.480
MOD_N-GLC_1	912	917	PF02516	0.630
MOD_NEK2_1	294	299	PF00069	0.369
MOD_NEK2_1	319	324	PF00069	0.581
MOD_NEK2_1	361	366	PF00069	0.594
MOD_NEK2_1	421	426	PF00069	0.720
MOD_NEK2_1	5	10	PF00069	0.465
MOD_NEK2_1	63	68	PF00069	0.364
MOD_NEK2_1	630	635	PF00069	0.636
MOD_NEK2_1	675	680	PF00069	0.622
MOD_NEK2_1	713	718	PF00069	0.749
MOD_NEK2_1	78	83	PF00069	0.573
MOD_NEK2_1	782	787	PF00069	0.405
MOD_NEK2_1	815	820	PF00069	0.371
MOD_NEK2_1	904	909	PF00069	0.385
MOD_NEK2_1	921	926	PF00069	0.270
MOD_NEK2_2	14	19	PF00069	0.271
MOD_PIKK_1	176	182	PF00454	0.416
MOD_PIKK_1	217	223	PF00454	0.443
MOD_PIKK_1	556	562	PF00454	0.653
MOD_PIKK_1	686	692	PF00454	0.618
MOD_PIKK_1	703	709	PF00454	0.517
MOD_PIKK_1	76	82	PF00454	0.546
MOD_PIKK_1	839	845	PF00454	0.446
MOD_PKA_2	201	207	PF00069	0.393
MOD_PKA_2	221	227	PF00069	0.526
MOD_PKA_2	228	234	PF00069	0.402
MOD_PKA_2	257	263	PF00069	0.454
MOD_PKA_2	335	341	PF00069	0.615
MOD_PKA_2	463	469	PF00069	0.673
MOD_PKA_2	494	500	PF00069	0.714
MOD_PKA_2	546	552	PF00069	0.745
MOD_PKA_2	593	599	PF00069	0.735
MOD_PKA_2	707	713	PF00069	0.656
MOD_PKA_2	799	805	PF00069	0.409
MOD_PKA_2	833	839	PF00069	0.444
MOD_PKA_2	843	849	PF00069	0.405
MOD_Plk_1	377	383	PF00069	0.708
MOD_Plk_1	675	681	PF00069	0.620
MOD_Plk_1	686	692	PF00069	0.537
MOD_Plk_1	912	918	PF00069	0.426
MOD_Plk_2-3	35	41	PF00069	0.368
MOD_Plk_4	154	160	PF00069	0.392
MOD_Plk_4	203	209	PF00069	0.400
MOD_Plk_4	309	315	PF00069	0.405
MOD_Plk_4	367	373	PF00069	0.654
MOD_Plk_4	486	492	PF00069	0.737
MOD_Plk_4	630	636	PF00069	0.631
MOD_Plk_4	697	703	PF00069	0.632
MOD_Plk_4	815	821	PF00069	0.338
MOD_Plk_4	836	842	PF00069	0.371
MOD_Plk_4	925	931	PF00069	0.382
MOD_ProDKin_1	144	150	PF00069	0.415
MOD_ProDKin_1	193	199	PF00069	0.434
MOD_ProDKin_1	213	219	PF00069	0.430
MOD_ProDKin_1	29	35	PF00069	0.474
MOD_ProDKin_1	296	302	PF00069	0.371
MOD_ProDKin_1	397	403	PF00069	0.654
MOD_ProDKin_1	435	441	PF00069	0.836
MOD_ProDKin_1	536	542	PF00069	0.748
MOD_ProDKin_1	577	583	PF00069	0.768
MOD_ProDKin_1	6	12	PF00069	0.359
MOD_ProDKin_1	623	629	PF00069	0.748
MOD_ProDKin_1	724	730	PF00069	0.766
MOD_ProDKin_1	738	744	PF00069	0.763
MOD_ProDKin_1	789	795	PF00069	0.405
MOD_ProDKin_1	800	806	PF00069	0.295
MOD_ProDKin_1	818	824	PF00069	0.464
MOD_SUMO_for_1	26	29	PF00179	0.398
MOD_SUMO_rev_2	35	43	PF00179	0.400
TRG_DiLeu_BaEn_3	686	692	PF01217	0.584
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.380
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.232
TRG_ENDOCYTIC_2	125	128	PF00928	0.372
TRG_ENDOCYTIC_2	166	169	PF00928	0.417
TRG_ENDOCYTIC_2	326	329	PF00928	0.581
TRG_ENDOCYTIC_2	59	62	PF00928	0.375
TRG_ENDOCYTIC_2	64	67	PF00928	0.322
TRG_ENDOCYTIC_2	805	808	PF00928	0.379
TRG_ENDOCYTIC_2	850	853	PF00928	0.379
TRG_ENDOCYTIC_2	854	857	PF00928	0.341
TRG_ER_diArg_1	255	258	PF00400	0.495
TRG_ER_diArg_1	551	553	PF00400	0.784
TRG_ER_diArg_1	653	655	PF00400	0.647
TRG_NES_CRM1_1	690	705	PF08389	0.628
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	503	508	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	813	817	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	910	914	PF00026	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IK61	Leishmania donovani	89%	100%
A4HP77	Leishmania braziliensis	75%	100%
A4IDI2	Leishmania infantum	89%	100%
Q4Q1L3	Leishmania major	88%	100%