TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat/Tetratricopeptide repeat, putative

Species:

Leishmania mexicana

UniProt:

E9ASY3_LEIMU

TriTrypDb:

LmxM.36.2070

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASY3

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0030544	Hsp70 protein binding	4	12
GO:0031072	heat shock protein binding	3	12
GO:0051879	Hsp90 protein binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.602
CLV_NRD_NRD_1	239	241	PF00675	0.418
CLV_PCSK_FUR_1	237	241	PF00082	0.428
CLV_PCSK_KEX2_1	128	130	PF00082	0.459
CLV_PCSK_KEX2_1	239	241	PF00082	0.484
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.350
CLV_PCSK_SKI1_1	140	144	PF00082	0.417
CLV_PCSK_SKI1_1	255	259	PF00082	0.485
CLV_PCSK_SKI1_1	4	8	PF00082	0.656
DEG_SPOP_SBC_1	192	196	PF00917	0.552
DOC_CKS1_1	213	218	PF01111	0.366
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.511
DOC_PP2B_LxvP_1	71	74	PF13499	0.431
DOC_USP7_MATH_1	186	190	PF00917	0.595
DOC_USP7_MATH_1	192	196	PF00917	0.762
DOC_USP7_UBL2_3	103	107	PF12436	0.461
DOC_WW_Pin1_4	178	183	PF00397	0.623
DOC_WW_Pin1_4	184	189	PF00397	0.806
DOC_WW_Pin1_4	212	217	PF00397	0.661
DOC_WW_Pin1_4	89	94	PF00397	0.470
LIG_14-3-3_CanoR_1	175	183	PF00244	0.554
LIG_14-3-3_CanoR_1	239	244	PF00244	0.658
LIG_14-3-3_CanoR_1	297	303	PF00244	0.538
LIG_14-3-3_CanoR_1	82	90	PF00244	0.420
LIG_CtBP_PxDLS_1	97	103	PF00389	0.377
LIG_deltaCOP1_diTrp_1	124	132	PF00928	0.217
LIG_FHA_1	304	310	PF00498	0.531
LIG_FHA_1	76	82	PF00498	0.421
LIG_FHA_2	23	29	PF00498	0.554
LIG_FHA_2	273	279	PF00498	0.503
LIG_IRF3_LxIS_1	309	314	PF10401	0.531
LIG_LIR_Nem_3	25	30	PF02991	0.491
LIG_LIR_Nem_3	315	321	PF02991	0.531
LIG_LIR_Nem_3	46	50	PF02991	0.335
LIG_MYND_1	188	192	PF01753	0.491
LIG_PTB_Apo_2	49	56	PF02174	0.329
LIG_PTB_Phospho_1	49	55	PF10480	0.416
LIG_SH2_CRK	67	71	PF00017	0.466
LIG_SH2_GRB2like	183	186	PF00017	0.621
LIG_SH2_NCK_1	302	306	PF00017	0.558
LIG_SH2_STAP1	67	71	PF00017	0.323
LIG_SH2_STAT5	89	92	PF00017	0.376
LIG_SH3_3	6	12	PF00018	0.473
LIG_TRAF2_1	207	210	PF00917	0.558
MOD_CDK_SPxxK_3	184	191	PF00069	0.562
MOD_CK1_1	194	200	PF00069	0.602
MOD_CK1_1	303	309	PF00069	0.556
MOD_CK1_1	83	89	PF00069	0.341
MOD_CK2_1	2	8	PF00069	0.489
MOD_CK2_1	225	231	PF00069	0.529
MOD_CK2_1	265	271	PF00069	0.543
MOD_GlcNHglycan	271	275	PF01048	0.576
MOD_GlcNHglycan	3	7	PF01048	0.652
MOD_GlcNHglycan	85	88	PF01048	0.364
MOD_GSK3_1	191	198	PF00069	0.623
MOD_N-GLC_1	184	189	PF02516	0.667
MOD_N-GLC_1	198	203	PF02516	0.447
MOD_N-GLC_1	83	88	PF02516	0.376
MOD_N-GLC_2	52	54	PF02516	0.327
MOD_NEK2_1	193	198	PF00069	0.543
MOD_NEK2_1	22	27	PF00069	0.500
MOD_NEK2_1	272	277	PF00069	0.479
MOD_NEK2_1	298	303	PF00069	0.634
MOD_PIKK_1	241	247	PF00454	0.530
MOD_PIKK_1	38	44	PF00454	0.453
MOD_PKA_1	239	245	PF00069	0.477
MOD_PKA_2	239	245	PF00069	0.612
MOD_PKA_2	298	304	PF00069	0.614
MOD_PKB_1	237	245	PF00069	0.597
MOD_ProDKin_1	178	184	PF00069	0.624
MOD_ProDKin_1	212	218	PF00069	0.658
MOD_ProDKin_1	89	95	PF00069	0.480
MOD_SUMO_for_1	207	210	PF00179	0.571
MOD_SUMO_for_1	264	267	PF00179	0.462
MOD_SUMO_rev_2	41	50	PF00179	0.420
MOD_SUMO_rev_2	8	17	PF00179	0.441
TRG_DiLeu_BaEn_4	209	215	PF01217	0.547
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.396
TRG_ENDOCYTIC_2	67	70	PF00928	0.465
TRG_ER_diArg_1	237	240	PF00400	0.435
TRG_ER_diArg_1	297	300	PF00400	0.426
TRG_ER_diArg_1	321	324	PF00400	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7A6	Leptomonas seymouri	56%	100%
A0A0S4IZ49	Bodo saltans	36%	100%
A0A1X0P800	Trypanosomatidae	40%	99%
A0A3Q8IKL8	Leishmania donovani	90%	100%
A0A422N1V8	Trypanosoma rangeli	39%	100%
A4HP75	Leishmania braziliensis	70%	94%
A4IDI0	Leishmania infantum	89%	100%
D0A371	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q1L5	Leishmania major	88%	100%
V5BKW9	Trypanosoma cruzi	39%	100%