Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function DUF72, putative

Species:

Leishmania mexicana

UniProt:

E9ASY2_LEIMU

TriTrypDb:

LmxM.36.2060

Length:

506

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASY2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	374	378	PF00656	0.381
CLV_C14_Caspase3-7	409	413	PF00656	0.371
CLV_NRD_NRD_1	284	286	PF00675	0.443
CLV_NRD_NRD_1	287	289	PF00675	0.434
CLV_NRD_NRD_1	32	34	PF00675	0.466
CLV_NRD_NRD_1	469	471	PF00675	0.518
CLV_NRD_NRD_1	99	101	PF00675	0.428
CLV_PCSK_FUR_1	285	289	PF00082	0.336
CLV_PCSK_KEX2_1	284	286	PF00082	0.443
CLV_PCSK_KEX2_1	287	289	PF00082	0.434
CLV_PCSK_KEX2_1	32	34	PF00082	0.596
CLV_PCSK_KEX2_1	469	471	PF00082	0.799
CLV_PCSK_KEX2_1	487	489	PF00082	0.786
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.791
CLV_PCSK_SKI1_1	170	174	PF00082	0.683
CLV_PCSK_SKI1_1	313	317	PF00082	0.372
CLV_PCSK_SKI1_1	390	394	PF00082	0.357
CLV_PCSK_SKI1_1	93	97	PF00082	0.469
DEG_COP1_1	77	85	PF00400	0.546
DEG_Nend_Nbox_1	1	3	PF02207	0.631
DEG_SPOP_SBC_1	266	270	PF00917	0.351
DOC_ANK_TNKS_1	372	379	PF00023	0.272
DOC_CKS1_1	273	278	PF01111	0.176
DOC_MAPK_gen_1	284	295	PF00069	0.327
DOC_MAPK_gen_1	310	318	PF00069	0.363
DOC_MAPK_MEF2A_6	284	293	PF00069	0.304
DOC_PP2B_PxIxI_1	69	75	PF00149	0.430
DOC_PP4_FxxP_1	220	223	PF00568	0.401
DOC_PP4_FxxP_1	58	61	PF00568	0.511
DOC_USP7_MATH_1	13	17	PF00917	0.572
DOC_USP7_MATH_1	159	163	PF00917	0.720
DOC_USP7_MATH_1	266	270	PF00917	0.412
DOC_USP7_MATH_1	278	282	PF00917	0.256
DOC_USP7_MATH_1	443	447	PF00917	0.737
DOC_WW_Pin1_4	164	169	PF00397	0.644
DOC_WW_Pin1_4	269	274	PF00397	0.327
DOC_WW_Pin1_4	39	44	PF00397	0.466
DOC_WW_Pin1_4	437	442	PF00397	0.738
DOC_WW_Pin1_4	457	462	PF00397	0.769
DOC_WW_Pin1_4	480	485	PF00397	0.789
LIG_14-3-3_CanoR_1	138	143	PF00244	0.713
LIG_14-3-3_CanoR_1	17	21	PF00244	0.512
LIG_14-3-3_CanoR_1	170	175	PF00244	0.714
LIG_14-3-3_CanoR_1	296	301	PF00244	0.325
LIG_14-3-3_CanoR_1	444	452	PF00244	0.649
LIG_14-3-3_CanoR_1	469	474	PF00244	0.724
LIG_14-3-3_CanoR_1	90	96	PF00244	0.442
LIG_eIF4E_1	52	58	PF01652	0.440
LIG_EVH1_2	263	267	PF00568	0.176
LIG_FHA_1	142	148	PF00498	0.628
LIG_FHA_1	257	263	PF00498	0.397
LIG_FHA_1	303	309	PF00498	0.385
LIG_FHA_1	379	385	PF00498	0.348
LIG_FHA_1	387	393	PF00498	0.253
LIG_FHA_1	481	487	PF00498	0.537
LIG_FHA_1	61	67	PF00498	0.454
LIG_FHA_2	496	502	PF00498	0.753
LIG_HCF-1_HBM_1	107	110	PF13415	0.330
LIG_LIR_Apic_2	218	223	PF02991	0.433
LIG_LIR_Gen_1	243	254	PF02991	0.347
LIG_LIR_Gen_1	311	319	PF02991	0.337
LIG_LIR_Gen_1	324	335	PF02991	0.395
LIG_LIR_Gen_1	391	400	PF02991	0.433
LIG_LIR_Nem_3	243	249	PF02991	0.347
LIG_LIR_Nem_3	303	309	PF02991	0.322
LIG_LIR_Nem_3	311	317	PF02991	0.326
LIG_LIR_Nem_3	324	330	PF02991	0.433
LIG_LIR_Nem_3	352	356	PF02991	0.333
LIG_LIR_Nem_3	391	396	PF02991	0.313
LIG_MYND_1	215	219	PF01753	0.433
LIG_Pex14_1	54	58	PF04695	0.455
LIG_Rb_LxCxE_1	448	468	PF01857	0.492
LIG_SH2_CRK	112	116	PF00017	0.481
LIG_SH2_CRK	327	331	PF00017	0.351
LIG_SH2_CRK	353	357	PF00017	0.313
LIG_SH2_NCK_1	234	238	PF00017	0.256
LIG_SH2_PTP2	339	342	PF00017	0.357
LIG_SH2_SRC	368	371	PF00017	0.407
LIG_SH2_STAP1	181	185	PF00017	0.388
LIG_SH2_STAP1	327	331	PF00017	0.415
LIG_SH2_STAT5	181	184	PF00017	0.319
LIG_SH2_STAT5	339	342	PF00017	0.297
LIG_SH2_STAT5	368	371	PF00017	0.368
LIG_SH3_2	43	48	PF14604	0.550
LIG_SH3_3	112	118	PF00018	0.271
LIG_SH3_3	144	150	PF00018	0.622
LIG_SH3_3	165	171	PF00018	0.626
LIG_SH3_3	223	229	PF00018	0.340
LIG_SH3_3	270	276	PF00018	0.176
LIG_SH3_3	40	46	PF00018	0.480
LIG_SH3_3	64	70	PF00018	0.524
LIG_SUMO_SIM_anti_2	252	261	PF11976	0.351
LIG_SUMO_SIM_par_1	252	261	PF11976	0.351
LIG_TRAF2_1	250	253	PF00917	0.433
LIG_WRC_WIRS_1	309	314	PF05994	0.433
LIG_WW_3	441	445	PF00397	0.494
MOD_CDK_SPxK_1	164	170	PF00069	0.582
MOD_CDK_SPxxK_3	437	444	PF00069	0.755
MOD_CDK_SPxxK_3	480	487	PF00069	0.733
MOD_CK1_1	131	137	PF00069	0.509
MOD_CK1_1	141	147	PF00069	0.615
MOD_CK1_1	16	22	PF00069	0.773
MOD_CK1_1	269	275	PF00069	0.435
MOD_CK1_1	371	377	PF00069	0.455
MOD_CK1_1	47	53	PF00069	0.560
MOD_CK1_1	493	499	PF00069	0.672
MOD_CK1_1	6	12	PF00069	0.596
MOD_CK1_1	88	94	PF00069	0.534
MOD_CK2_1	247	253	PF00069	0.433
MOD_CMANNOS	121	124	PF00535	0.388
MOD_GlcNHglycan	13	16	PF01048	0.689
MOD_GlcNHglycan	162	165	PF01048	0.706
MOD_GlcNHglycan	18	21	PF01048	0.731
MOD_GlcNHglycan	234	237	PF01048	0.256
MOD_GlcNHglycan	269	272	PF01048	0.351
MOD_GlcNHglycan	280	283	PF01048	0.238
MOD_GlcNHglycan	374	377	PF01048	0.412
MOD_GlcNHglycan	381	384	PF01048	0.450
MOD_GlcNHglycan	408	411	PF01048	0.254
MOD_GlcNHglycan	445	448	PF01048	0.773
MOD_GlcNHglycan	495	498	PF01048	0.755
MOD_GlcNHglycan	5	8	PF01048	0.623
MOD_GSK3_1	11	18	PF00069	0.755
MOD_GSK3_1	160	167	PF00069	0.722
MOD_GSK3_1	228	235	PF00069	0.433
MOD_GSK3_1	265	272	PF00069	0.425
MOD_GSK3_1	368	375	PF00069	0.336
MOD_GSK3_1	433	440	PF00069	0.641
MOD_GSK3_1	489	496	PF00069	0.770
MOD_GSK3_1	81	88	PF00069	0.561
MOD_N-GLC_1	131	136	PF02516	0.677
MOD_N-GLC_1	396	401	PF02516	0.315
MOD_NEK2_1	179	184	PF00069	0.297
MOD_NEK2_1	232	237	PF00069	0.355
MOD_NEK2_1	256	261	PF00069	0.442
MOD_NEK2_1	267	272	PF00069	0.414
MOD_NEK2_1	308	313	PF00069	0.414
MOD_NEK2_1	424	429	PF00069	0.620
MOD_NEK2_1	62	67	PF00069	0.534
MOD_PIKK_1	21	27	PF00454	0.533
MOD_PIKK_1	247	253	PF00454	0.477
MOD_PIKK_1	325	331	PF00454	0.351
MOD_PIKK_1	94	100	PF00454	0.452
MOD_PK_1	143	149	PF00069	0.511
MOD_PKA_1	469	475	PF00069	0.512
MOD_PKA_2	128	134	PF00069	0.600
MOD_PKA_2	16	22	PF00069	0.545
MOD_PKA_2	240	246	PF00069	0.423
MOD_PKA_2	372	378	PF00069	0.176
MOD_PKA_2	443	449	PF00069	0.755
MOD_PKA_2	469	475	PF00069	0.735
MOD_PKA_2	47	53	PF00069	0.545
MOD_PKA_2	489	495	PF00069	0.493
MOD_PKB_1	488	496	PF00069	0.617
MOD_Plk_1	257	263	PF00069	0.425
MOD_Plk_1	302	308	PF00069	0.446
MOD_Plk_1	411	417	PF00069	0.383
MOD_Plk_1	88	94	PF00069	0.574
MOD_Plk_4	143	149	PF00069	0.469
MOD_Plk_4	34	40	PF00069	0.543
MOD_Plk_4	47	53	PF00069	0.441
MOD_Plk_4	6	12	PF00069	0.683
MOD_ProDKin_1	164	170	PF00069	0.644
MOD_ProDKin_1	269	275	PF00069	0.327
MOD_ProDKin_1	39	45	PF00069	0.465
MOD_ProDKin_1	437	443	PF00069	0.738
MOD_ProDKin_1	457	463	PF00069	0.768
MOD_ProDKin_1	480	486	PF00069	0.791
TRG_AP2beta_CARGO_1	303	313	PF09066	0.435
TRG_DiLeu_BaEn_1	252	257	PF01217	0.351
TRG_DiLeu_BaEn_1	304	309	PF01217	0.357
TRG_DiLeu_BaEn_2	390	396	PF01217	0.433
TRG_DiLeu_BaEn_4	252	258	PF01217	0.351
TRG_DiLeu_LyEn_5	212	217	PF01217	0.415
TRG_ENDOCYTIC_2	112	115	PF00928	0.456
TRG_ENDOCYTIC_2	246	249	PF00928	0.347
TRG_ENDOCYTIC_2	327	330	PF00928	0.415
TRG_ENDOCYTIC_2	339	342	PF00928	0.312
TRG_ENDOCYTIC_2	353	356	PF00928	0.313
TRG_ER_diArg_1	283	285	PF00400	0.407
TRG_ER_diArg_1	287	290	PF00400	0.382
TRG_ER_diArg_1	295	298	PF00400	0.323
TRG_ER_diArg_1	32	34	PF00400	0.666
TRG_NLS_Bipartite_1	469	491	PF00514	0.516
TRG_NLS_MonoExtN_4	484	491	PF00514	0.758
TRG_Pf-PMV_PEXEL_1	93	98	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILN3	Leptomonas seymouri	53%	100%
A0A0S4J806	Bodo saltans	37%	100%
A0A1X0P7Q2	Trypanosomatidae	43%	100%
A0A3Q8IG26	Leishmania donovani	87%	100%
A0A422N1S4	Trypanosoma rangeli	40%	100%
A4HP74	Leishmania braziliensis	72%	100%
A4IDH9	Leishmania infantum	88%	100%
D0A370	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4Q1L6	Leishmania major	88%	100%
V5BGE6	Trypanosoma cruzi	42%	100%