Serine/threonine-protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9ASY1_LEIMU

TriTrypDb:

LmxM.36.2050

Length:

913

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASY1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004722	protein serine/threonine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0017018	myosin phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.661
CLV_C14_Caspase3-7	687	691	PF00656	0.710
CLV_NRD_NRD_1	147	149	PF00675	0.489
CLV_NRD_NRD_1	185	187	PF00675	0.372
CLV_NRD_NRD_1	499	501	PF00675	0.276
CLV_NRD_NRD_1	663	665	PF00675	0.740
CLV_NRD_NRD_1	794	796	PF00675	0.355
CLV_NRD_NRD_1	88	90	PF00675	0.651
CLV_PCSK_KEX2_1	403	405	PF00082	0.310
CLV_PCSK_KEX2_1	499	501	PF00082	0.276
CLV_PCSK_KEX2_1	663	665	PF00082	0.740
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.310
CLV_PCSK_SKI1_1	166	170	PF00082	0.487
CLV_PCSK_SKI1_1	186	190	PF00082	0.275
CLV_PCSK_SKI1_1	220	224	PF00082	0.312
CLV_PCSK_SKI1_1	298	302	PF00082	0.423
CLV_PCSK_SKI1_1	365	369	PF00082	0.335
CLV_PCSK_SKI1_1	443	447	PF00082	0.214
CLV_PCSK_SKI1_1	47	51	PF00082	0.598
CLV_PCSK_SKI1_1	651	655	PF00082	0.616
CLV_PCSK_SKI1_1	656	660	PF00082	0.651
CLV_PCSK_SKI1_1	856	860	PF00082	0.369
CLV_Separin_Metazoa	339	343	PF03568	0.560
DEG_APCC_DBOX_1	185	193	PF00400	0.399
DEG_APCC_DBOX_1	364	372	PF00400	0.335
DEG_SPOP_SBC_1	701	705	PF00917	0.639
DOC_ANK_TNKS_1	270	277	PF00023	0.666
DOC_ANK_TNKS_1	60	67	PF00023	0.531
DOC_CKS1_1	137	142	PF01111	0.680
DOC_CYCLIN_RxL_1	437	449	PF00134	0.214
DOC_CYCLIN_yClb1_LxF_4	832	838	PF00134	0.384
DOC_CYCLIN_yCln2_LP_2	223	229	PF00134	0.431
DOC_MAPK_gen_1	148	155	PF00069	0.414
DOC_MAPK_gen_1	230	237	PF00069	0.395
DOC_MAPK_gen_1	301	310	PF00069	0.555
DOC_MAPK_gen_1	721	731	PF00069	0.503
DOC_MAPK_gen_1	870	878	PF00069	0.396
DOC_MAPK_MEF2A_6	230	237	PF00069	0.395
DOC_MAPK_MEF2A_6	301	310	PF00069	0.555
DOC_MAPK_MEF2A_6	342	349	PF00069	0.420
DOC_MAPK_NFAT4_5	230	238	PF00069	0.516
DOC_MAPK_RevD_3	135	149	PF00069	0.497
DOC_PP2B_LxvP_1	102	105	PF13499	0.791
DOC_PP2B_LxvP_1	710	713	PF13499	0.690
DOC_PP4_FxxP_1	719	722	PF00568	0.640
DOC_PP4_FxxP_1	861	864	PF00568	0.371
DOC_USP7_MATH_1	28	32	PF00917	0.649
DOC_USP7_MATH_1	377	381	PF00917	0.428
DOC_USP7_MATH_1	385	389	PF00917	0.345
DOC_USP7_MATH_1	393	397	PF00917	0.262
DOC_USP7_MATH_1	538	542	PF00917	0.586
DOC_USP7_MATH_1	59	63	PF00917	0.743
DOC_USP7_MATH_1	598	602	PF00917	0.546
DOC_USP7_MATH_1	626	630	PF00917	0.618
DOC_USP7_MATH_1	658	662	PF00917	0.603
DOC_USP7_MATH_1	672	676	PF00917	0.600
DOC_USP7_MATH_1	695	699	PF00917	0.665
DOC_USP7_MATH_1	701	705	PF00917	0.807
DOC_USP7_MATH_1	715	719	PF00917	0.658
DOC_USP7_MATH_1	72	76	PF00917	0.580
DOC_USP7_MATH_1	771	775	PF00917	0.605
DOC_USP7_MATH_1	780	784	PF00917	0.634
DOC_USP7_MATH_1	787	791	PF00917	0.632
DOC_USP7_UBL2_3	415	419	PF12436	0.331
DOC_USP7_UBL2_3	656	660	PF12436	0.665
DOC_USP7_UBL2_3	9	13	PF12436	0.658
DOC_WW_Pin1_4	106	111	PF00397	0.664
DOC_WW_Pin1_4	136	141	PF00397	0.734
DOC_WW_Pin1_4	26	31	PF00397	0.760
DOC_WW_Pin1_4	285	290	PF00397	0.618
DOC_WW_Pin1_4	468	473	PF00397	0.335
DOC_WW_Pin1_4	534	539	PF00397	0.662
DOC_WW_Pin1_4	575	580	PF00397	0.742
DOC_WW_Pin1_4	674	679	PF00397	0.632
DOC_WW_Pin1_4	682	687	PF00397	0.663
DOC_WW_Pin1_4	705	710	PF00397	0.653
DOC_WW_Pin1_4	736	741	PF00397	0.401
DOC_WW_Pin1_4	79	84	PF00397	0.596
LIG_14-3-3_CanoR_1	148	156	PF00244	0.468
LIG_14-3-3_CanoR_1	404	412	PF00244	0.256
LIG_14-3-3_CanoR_1	453	459	PF00244	0.469
LIG_14-3-3_CanoR_1	786	792	PF00244	0.530
LIG_14-3-3_CanoR_1	795	803	PF00244	0.384
LIG_14-3-3_CanoR_1	856	861	PF00244	0.488
LIG_14-3-3_CanoR_1	89	95	PF00244	0.709
LIG_14-3-3_CterR_2	910	913	PF00244	0.693
LIG_Actin_WH2_2	256	273	PF00022	0.599
LIG_APCC_ABBA_1	165	170	PF00400	0.303
LIG_APCC_ABBA_1	738	743	PF00400	0.539
LIG_BRCT_BRCA1_1	707	711	PF00533	0.607
LIG_EVH1_1	102	106	PF00568	0.644
LIG_EVH1_2	908	912	PF00568	0.627
LIG_FHA_1	111	117	PF00498	0.677
LIG_FHA_1	210	216	PF00498	0.541
LIG_FHA_1	27	33	PF00498	0.744
LIG_FHA_1	44	50	PF00498	0.566
LIG_FHA_1	464	470	PF00498	0.336
LIG_FHA_1	472	478	PF00498	0.363
LIG_FHA_1	723	729	PF00498	0.445
LIG_FHA_1	815	821	PF00498	0.436
LIG_FHA_1	830	836	PF00498	0.393
LIG_FHA_2	129	135	PF00498	0.685
LIG_FHA_2	15	21	PF00498	0.647
LIG_FHA_2	31	37	PF00498	0.699
LIG_FHA_2	324	330	PF00498	0.266
LIG_FHA_2	561	567	PF00498	0.632
LIG_FHA_2	575	581	PF00498	0.534
LIG_FHA_2	685	691	PF00498	0.704
LIG_FHA_2	701	707	PF00498	0.502
LIG_FHA_2	765	771	PF00498	0.395
LIG_LIR_Apic_2	718	722	PF02991	0.630
LIG_LIR_Apic_2	765	771	PF02991	0.395
LIG_LIR_Apic_2	859	864	PF02991	0.370
LIG_LIR_Gen_1	159	169	PF02991	0.446
LIG_LIR_Gen_1	257	268	PF02991	0.411
LIG_LIR_Gen_1	332	341	PF02991	0.459
LIG_LIR_Nem_3	159	165	PF02991	0.451
LIG_LIR_Nem_3	257	263	PF02991	0.636
LIG_LIR_Nem_3	3	7	PF02991	0.693
LIG_LIR_Nem_3	332	337	PF02991	0.445
LIG_LIR_Nem_3	487	493	PF02991	0.327
LIG_LIR_Nem_3	743	749	PF02991	0.540
LIG_LYPXL_yS_3	501	504	PF13949	0.335
LIG_MYND_1	268	272	PF01753	0.690
LIG_MYND_1	83	87	PF01753	0.697
LIG_NRBOX	218	224	PF00104	0.422
LIG_Pex14_2	209	213	PF04695	0.431
LIG_SH2_CRK	314	318	PF00017	0.507
LIG_SH2_NCK_1	609	613	PF00017	0.523
LIG_SH2_SRC	609	612	PF00017	0.512
LIG_SH2_STAP1	94	98	PF00017	0.638
LIG_SH2_STAT5	323	326	PF00017	0.414
LIG_SH2_STAT5	444	447	PF00017	0.335
LIG_SH2_STAT5	450	453	PF00017	0.335
LIG_SH2_STAT5	836	839	PF00017	0.472
LIG_SH2_STAT5	866	869	PF00017	0.427
LIG_SH3_2	438	443	PF14604	0.214
LIG_SH3_2	84	89	PF14604	0.632
LIG_SH3_3	100	106	PF00018	0.592
LIG_SH3_3	134	140	PF00018	0.687
LIG_SH3_3	150	156	PF00018	0.420
LIG_SH3_3	347	353	PF00018	0.522
LIG_SH3_3	435	441	PF00018	0.453
LIG_SH3_3	646	652	PF00018	0.521
LIG_SH3_3	706	712	PF00018	0.694
LIG_SH3_3	80	86	PF00018	0.811
LIG_SH3_3	903	909	PF00018	0.632
LIG_SUMO_SIM_par_1	856	862	PF11976	0.367
LIG_SUMO_SIM_par_1	874	879	PF11976	0.366
LIG_TRAF2_1	326	329	PF00917	0.399
LIG_TRAF2_1	518	521	PF00917	0.636
LIG_TRAF2_1	98	101	PF00917	0.714
LIG_WRC_WIRS_1	1	6	PF05994	0.632
LIG_WW_1	441	444	PF00397	0.389
LIG_WW_2	83	86	PF00397	0.621
LIG_WW_3	440	444	PF00397	0.214
LIG_WW_3	907	911	PF00397	0.677
MOD_CDC14_SPxK_1	677	680	PF00782	0.521
MOD_CDK_SPK_2	136	141	PF00069	0.585
MOD_CDK_SPxK_1	674	680	PF00069	0.523
MOD_CK1_1	151	157	PF00069	0.618
MOD_CK1_1	200	206	PF00069	0.430
MOD_CK1_1	38	44	PF00069	0.693
MOD_CK1_1	388	394	PF00069	0.366
MOD_CK1_1	414	420	PF00069	0.428
MOD_CK1_1	471	477	PF00069	0.314
MOD_CK1_1	52	58	PF00069	0.802
MOD_CK1_1	533	539	PF00069	0.596
MOD_CK1_1	548	554	PF00069	0.619
MOD_CK1_1	671	677	PF00069	0.651
MOD_CK1_1	697	703	PF00069	0.662
MOD_CK1_1	705	711	PF00069	0.654
MOD_CK1_1	769	775	PF00069	0.455
MOD_CK1_1	799	805	PF00069	0.381
MOD_CK2_1	30	36	PF00069	0.660
MOD_CK2_1	323	329	PF00069	0.394
MOD_CK2_1	515	521	PF00069	0.646
MOD_CK2_1	555	561	PF00069	0.643
MOD_CK2_1	626	632	PF00069	0.617
MOD_CK2_1	667	673	PF00069	0.821
MOD_CK2_1	700	706	PF00069	0.664
MOD_CK2_1	90	96	PF00069	0.703
MOD_Cter_Amidation	661	664	PF01082	0.519
MOD_Cter_Amidation	7	10	PF01082	0.772
MOD_GlcNHglycan	118	121	PF01048	0.625
MOD_GlcNHglycan	199	202	PF01048	0.406
MOD_GlcNHglycan	407	410	PF01048	0.320
MOD_GlcNHglycan	427	430	PF01048	0.246
MOD_GlcNHglycan	43	46	PF01048	0.827
MOD_GlcNHglycan	532	535	PF01048	0.569
MOD_GlcNHglycan	660	663	PF01048	0.604
MOD_GlcNHglycan	670	673	PF01048	0.575
MOD_GlcNHglycan	713	716	PF01048	0.725
MOD_GlcNHglycan	74	77	PF01048	0.799
MOD_GlcNHglycan	773	776	PF01048	0.539
MOD_GlcNHglycan	798	801	PF01048	0.433
MOD_GlcNHglycan	861	864	PF01048	0.377
MOD_GlcNHglycan	96	99	PF01048	0.775
MOD_GSK3_1	106	113	PF00069	0.558
MOD_GSK3_1	123	130	PF00069	0.621
MOD_GSK3_1	135	142	PF00069	0.503
MOD_GSK3_1	14	21	PF00069	0.649
MOD_GSK3_1	254	261	PF00069	0.568
MOD_GSK3_1	26	33	PF00069	0.755
MOD_GSK3_1	388	395	PF00069	0.342
MOD_GSK3_1	410	417	PF00069	0.316
MOD_GSK3_1	512	519	PF00069	0.634
MOD_GSK3_1	530	537	PF00069	0.706
MOD_GSK3_1	556	563	PF00069	0.625
MOD_GSK3_1	658	665	PF00069	0.675
MOD_GSK3_1	667	674	PF00069	0.725
MOD_GSK3_1	682	689	PF00069	0.604
MOD_GSK3_1	693	700	PF00069	0.684
MOD_GSK3_1	701	708	PF00069	0.679
MOD_GSK3_1	711	718	PF00069	0.768
MOD_GSK3_1	72	79	PF00069	0.800
MOD_GSK3_1	766	773	PF00069	0.410
MOD_GSK3_1	778	785	PF00069	0.656
MOD_GSK3_1	825	832	PF00069	0.304
MOD_GSK3_1	90	97	PF00069	0.634
MOD_N-GLC_1	556	561	PF02516	0.704
MOD_N-GLC_1	667	672	PF02516	0.805
MOD_N-GLC_1	715	720	PF02516	0.519
MOD_N-GLC_1	72	77	PF02516	0.537
MOD_N-GLC_1	787	792	PF02516	0.631
MOD_N-GLC_2	865	867	PF02516	0.410
MOD_NEK2_1	116	121	PF00069	0.714
MOD_NEK2_1	127	132	PF00069	0.610
MOD_NEK2_1	386	391	PF00069	0.221
MOD_NEK2_1	463	468	PF00069	0.342
MOD_NEK2_1	829	834	PF00069	0.413
MOD_PIKK_1	180	186	PF00454	0.380
MOD_PIKK_1	398	404	PF00454	0.427
MOD_PIKK_1	436	442	PF00454	0.294
MOD_PIKK_1	512	518	PF00454	0.617
MOD_PIKK_1	787	793	PF00454	0.655
MOD_PK_1	178	184	PF00069	0.545
MOD_PK_1	403	409	PF00069	0.310
MOD_PKA_1	14	20	PF00069	0.624
MOD_PKA_1	148	154	PF00069	0.427
MOD_PKA_1	403	409	PF00069	0.310
MOD_PKA_1	415	421	PF00069	0.208
MOD_PKA_2	403	409	PF00069	0.349
MOD_PKA_2	436	442	PF00069	0.444
MOD_PKA_2	662	668	PF00069	0.755
MOD_PKA_2	693	699	PF00069	0.664
MOD_PKA_2	814	820	PF00069	0.453
MOD_Plk_1	151	157	PF00069	0.487
MOD_Plk_1	195	201	PF00069	0.457
MOD_Plk_1	556	562	PF00069	0.712
MOD_Plk_1	715	721	PF00069	0.497
MOD_Plk_1	742	748	PF00069	0.543
MOD_Plk_1	764	770	PF00069	0.409
MOD_Plk_1	823	829	PF00069	0.394
MOD_Plk_4	313	319	PF00069	0.451
MOD_Plk_4	471	477	PF00069	0.335
MOD_Plk_4	856	862	PF00069	0.370
MOD_ProDKin_1	106	112	PF00069	0.664
MOD_ProDKin_1	136	142	PF00069	0.734
MOD_ProDKin_1	26	32	PF00069	0.762
MOD_ProDKin_1	285	291	PF00069	0.619
MOD_ProDKin_1	468	474	PF00069	0.335
MOD_ProDKin_1	534	540	PF00069	0.664
MOD_ProDKin_1	575	581	PF00069	0.740
MOD_ProDKin_1	674	680	PF00069	0.636
MOD_ProDKin_1	682	688	PF00069	0.665
MOD_ProDKin_1	705	711	PF00069	0.652
MOD_ProDKin_1	736	742	PF00069	0.402
MOD_ProDKin_1	79	85	PF00069	0.730
MOD_SUMO_for_1	177	180	PF00179	0.413
MOD_SUMO_for_1	300	303	PF00179	0.576
MOD_SUMO_rev_2	36	44	PF00179	0.639
MOD_SUMO_rev_2	890	898	PF00179	0.599
TRG_DiLeu_BaLyEn_6	853	858	PF01217	0.392
TRG_ENDOCYTIC_2	314	317	PF00928	0.386
TRG_ENDOCYTIC_2	444	447	PF00928	0.335
TRG_ENDOCYTIC_2	491	494	PF00928	0.354
TRG_ENDOCYTIC_2	501	504	PF00928	0.354
TRG_ENDOCYTIC_2	609	612	PF00928	0.512
TRG_ENDOCYTIC_2	836	839	PF00928	0.472
TRG_ENDOCYTIC_2	866	869	PF00928	0.427
TRG_ER_diArg_1	229	232	PF00400	0.404
TRG_ER_diArg_1	499	501	PF00400	0.279
TRG_NES_CRM1_1	157	170	PF08389	0.318
TRG_NLS_MonoExtC_3	13	19	PF00514	0.686
TRG_NLS_MonoExtN_4	11	18	PF00514	0.683
TRG_NLS_MonoExtN_4	721	727	PF00514	0.644
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	220	225	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N5	Leptomonas seymouri	47%	95%
A0A3S7XAZ4	Leishmania donovani	86%	100%
A4HP73	Leishmania braziliensis	65%	97%
A4IDH8	Leishmania infantum	86%	100%
Q4Q1L7	Leishmania major	82%	98%