WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASX9_LEIMU

TriTrypDb:

LmxM.36.2035

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0000152	nuclear ubiquitin ligase complex	3	1
GO:0005680	anaphase-promoting complex	4	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

E9ASX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASX9

Function

Biological processes
Term	Name	Level	Count
GO:0009893	positive regulation of metabolic process	4	9
GO:0010604	positive regulation of macromolecule metabolic process	5	9
GO:0019222	regulation of metabolic process	3	9
GO:0031396	regulation of protein ubiquitination	8	8
GO:0031398	positive regulation of protein ubiquitination	9	8
GO:0031399	regulation of protein modification process	6	8
GO:0031401	positive regulation of protein modification process	7	8
GO:0043085	positive regulation of catalytic activity	4	8
GO:0044093	positive regulation of molecular function	3	8
GO:0048518	positive regulation of biological process	3	9
GO:0050789	regulation of biological process	2	9
GO:0050790	regulation of catalytic activity	3	8
GO:0051171	regulation of nitrogen compound metabolic process	4	9
GO:0051173	positive regulation of nitrogen compound metabolic process	5	9
GO:0051246	regulation of protein metabolic process	5	9
GO:0051247	positive regulation of protein metabolic process	6	9
GO:0051338	regulation of transferase activity	4	8
GO:0051347	positive regulation of transferase activity	5	8
GO:0051438	regulation of ubiquitin-protein transferase activity	5	8
GO:0051443	positive regulation of ubiquitin-protein transferase activity	6	8
GO:0060255	regulation of macromolecule metabolic process	4	9
GO:0065007	biological regulation	1	9
GO:0065009	regulation of molecular function	2	8
GO:0080090	regulation of primary metabolic process	4	9
GO:1903320	regulation of protein modification by small protein conjugation or removal	7	8
GO:1903322	positive regulation of protein modification by small protein conjugation or removal	8	8
GO:1904666	regulation of ubiquitin protein ligase activity	6	8
GO:1904668	positive regulation of ubiquitin protein ligase activity	7	8
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009896	positive regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030162	regulation of proteolysis	6	1
GO:0030163	protein catabolic process	4	1
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031331	positive regulation of cellular catabolic process	6	1
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	8	1
GO:0042176	regulation of protein catabolic process	5	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0045732	positive regulation of protein catabolic process	6	1
GO:0045862	positive regulation of proteolysis	7	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050794	regulation of cellular process	3	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0061136	regulation of proteasomal protein catabolic process	6	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901800	positive regulation of proteasomal protein catabolic process	7	1
GO:1903050	regulation of proteolysis involved in protein catabolic process	7	1
GO:1903052	positive regulation of proteolysis involved in protein catabolic process	8	1
GO:1905784	regulation of anaphase-promoting complex-dependent catabolic process	8	1
GO:1905786	positive regulation of anaphase-promoting complex-dependent catabolic process	9	1
GO:2000058	regulation of ubiquitin-dependent protein catabolic process	6	1
GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0008047	enzyme activator activity	3	9
GO:0010997	anaphase-promoting complex binding	3	9
GO:0030234	enzyme regulator activity	2	9
GO:0044877	protein-containing complex binding	2	9
GO:0055106	ubiquitin-protein transferase regulator activity	3	9
GO:0097027	ubiquitin-protein transferase activator activity	4	9
GO:0098772	molecular function regulator activity	1	9
GO:0140677	molecular function activator activity	2	9
GO:1990757	ubiquitin ligase activator activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.503
CLV_NRD_NRD_1	129	131	PF00675	0.554
CLV_NRD_NRD_1	293	295	PF00675	0.338
CLV_NRD_NRD_1	530	532	PF00675	0.591
CLV_NRD_NRD_1	546	548	PF00675	0.691
CLV_NRD_NRD_1	662	664	PF00675	0.692
CLV_PCSK_KEX2_1	129	131	PF00082	0.554
CLV_PCSK_KEX2_1	529	531	PF00082	0.658
CLV_PCSK_KEX2_1	545	547	PF00082	0.755
CLV_PCSK_KEX2_1	662	664	PF00082	0.656
CLV_PCSK_PC7_1	525	531	PF00082	0.595
CLV_PCSK_PC7_1	542	548	PF00082	0.556
CLV_PCSK_SKI1_1	129	133	PF00082	0.538
CLV_PCSK_SKI1_1	536	540	PF00082	0.639
CLV_PCSK_SKI1_1	616	620	PF00082	0.530
DEG_COP1_1	27	37	PF00400	0.512
DEG_Nend_UBRbox_1	1	4	PF02207	0.644
DEG_SCF_FBW7_1	104	110	PF00400	0.445
DEG_SPOP_SBC_1	196	200	PF00917	0.452
DEG_SPOP_SBC_1	220	224	PF00917	0.565
DEG_SPOP_SBC_1	266	270	PF00917	0.579
DEG_SPOP_SBC_1	41	45	PF00917	0.446
DEG_SPOP_SBC_1	411	415	PF00917	0.696
DOC_CKS1_1	104	109	PF01111	0.651
DOC_CKS1_1	679	684	PF01111	0.689
DOC_CYCLIN_RxL_1	202	213	PF00134	0.639
DOC_MAPK_MEF2A_6	245	253	PF00069	0.549
DOC_PP1_RVXF_1	164	171	PF00149	0.542
DOC_PP1_RVXF_1	342	349	PF00149	0.435
DOC_PP2B_LxvP_1	20	23	PF13499	0.659
DOC_PP2B_LxvP_1	32	35	PF13499	0.626
DOC_PP2B_LxvP_1	325	328	PF13499	0.538
DOC_PP2B_LxvP_1	416	419	PF13499	0.760
DOC_PP4_FxxP_1	170	173	PF00568	0.479
DOC_PP4_MxPP_1	172	175	PF00568	0.577
DOC_USP7_MATH_1	10	14	PF00917	0.769
DOC_USP7_MATH_1	196	200	PF00917	0.597
DOC_USP7_MATH_1	266	270	PF00917	0.713
DOC_USP7_MATH_1	273	277	PF00917	0.707
DOC_USP7_MATH_1	306	310	PF00917	0.525
DOC_USP7_MATH_1	312	316	PF00917	0.525
DOC_USP7_MATH_1	35	39	PF00917	0.775
DOC_USP7_MATH_1	405	409	PF00917	0.581
DOC_USP7_MATH_1	41	45	PF00917	0.712
DOC_USP7_MATH_1	411	415	PF00917	0.700
DOC_USP7_MATH_1	458	462	PF00917	0.752
DOC_USP7_MATH_1	501	505	PF00917	0.772
DOC_USP7_MATH_1	512	516	PF00917	0.633
DOC_USP7_MATH_1	557	561	PF00917	0.513
DOC_USP7_MATH_1	589	593	PF00917	0.557
DOC_WW_Pin1_4	103	108	PF00397	0.693
DOC_WW_Pin1_4	12	17	PF00397	0.751
DOC_WW_Pin1_4	192	197	PF00397	0.765
DOC_WW_Pin1_4	349	354	PF00397	0.573
DOC_WW_Pin1_4	407	412	PF00397	0.641
DOC_WW_Pin1_4	414	419	PF00397	0.636
DOC_WW_Pin1_4	483	488	PF00397	0.789
DOC_WW_Pin1_4	624	629	PF00397	0.542
DOC_WW_Pin1_4	678	683	PF00397	0.691
LIG_14-3-3_CanoR_1	129	136	PF00244	0.476
LIG_14-3-3_CanoR_1	21	27	PF00244	0.755
LIG_14-3-3_CanoR_1	267	272	PF00244	0.721
LIG_14-3-3_CanoR_1	288	293	PF00244	0.602
LIG_14-3-3_CanoR_1	298	303	PF00244	0.525
LIG_14-3-3_CanoR_1	330	336	PF00244	0.535
LIG_14-3-3_CanoR_1	40	48	PF00244	0.410
LIG_14-3-3_CanoR_1	450	456	PF00244	0.762
LIG_14-3-3_CanoR_1	50	56	PF00244	0.534
LIG_14-3-3_CanoR_1	96	104	PF00244	0.613
LIG_Clathr_ClatBox_1	239	243	PF01394	0.400
LIG_eIF4E_1	534	540	PF01652	0.727
LIG_FHA_1	15	21	PF00498	0.743
LIG_FHA_1	175	181	PF00498	0.586
LIG_FHA_1	305	311	PF00498	0.560
LIG_FHA_1	332	338	PF00498	0.578
LIG_FHA_1	367	373	PF00498	0.510
LIG_FHA_1	388	394	PF00498	0.443
LIG_FHA_1	483	489	PF00498	0.615
LIG_FHA_1	67	73	PF00498	0.481
LIG_FHA_1	679	685	PF00498	0.646
LIG_FHA_1	99	105	PF00498	0.606
LIG_FHA_2	22	28	PF00498	0.739
LIG_FHA_2	253	259	PF00498	0.679
LIG_FHA_2	31	37	PF00498	0.745
LIG_FHA_2	570	576	PF00498	0.539
LIG_FHA_2	669	675	PF00498	0.494
LIG_Integrin_RGD_1	159	161	PF01839	0.604
LIG_LIR_Apic_2	167	173	PF02991	0.486
LIG_LIR_Gen_1	352	362	PF02991	0.462
LIG_LIR_Gen_1	476	484	PF02991	0.697
LIG_LIR_Gen_1	52	63	PF02991	0.480
LIG_LIR_Nem_3	352	357	PF02991	0.454
LIG_LIR_Nem_3	52	58	PF02991	0.488
LIG_LIR_Nem_3	643	649	PF02991	0.476
LIG_LYPXL_yS_3	421	424	PF13949	0.683
LIG_OCRL_FandH_1	291	303	PF00620	0.415
LIG_PCNA_PIPBox_1	329	338	PF02747	0.517
LIG_Pex14_1	604	608	PF04695	0.614
LIG_Pex14_2	498	502	PF04695	0.676
LIG_Pex14_2	646	650	PF04695	0.433
LIG_SH2_CRK	354	358	PF00017	0.252
LIG_SH2_CRK	55	59	PF00017	0.474
LIG_SH2_CRK	608	612	PF00017	0.617
LIG_SH2_CRK	633	637	PF00017	0.508
LIG_SH2_NCK_1	608	612	PF00017	0.617
LIG_SH2_NCK_1	633	637	PF00017	0.562
LIG_SH2_STAP1	354	358	PF00017	0.258
LIG_SH2_STAP1	633	637	PF00017	0.508
LIG_SH2_STAP1	68	72	PF00017	0.440
LIG_SH2_STAT5	179	182	PF00017	0.600
LIG_SH2_STAT5	534	537	PF00017	0.728
LIG_SH2_STAT5	55	58	PF00017	0.470
LIG_SH2_STAT5	68	71	PF00017	0.445
LIG_SH3_3	16	22	PF00018	0.748
LIG_SH3_3	170	176	PF00018	0.572
LIG_SH3_3	325	331	PF00018	0.546
LIG_SH3_3	347	353	PF00018	0.423
LIG_SH3_3	416	422	PF00018	0.700
LIG_SH3_3	481	487	PF00018	0.716
LIG_SH3_3	571	577	PF00018	0.513
LIG_SH3_3	89	95	PF00018	0.510
LIG_SUMO_SIM_par_1	238	243	PF11976	0.492
LIG_TRAF2_1	109	112	PF00917	0.498
LIG_TRAF2_1	671	674	PF00917	0.695
LIG_TRAF2_1	82	85	PF00917	0.595
LIG_WRC_WIRS_1	332	337	PF05994	0.522
LIG_WRC_WIRS_1	378	383	PF05994	0.299
LIG_WW_1	418	421	PF00397	0.557
MOD_CDK_SPxxK_3	678	685	PF00069	0.692
MOD_CK1_1	195	201	PF00069	0.712
MOD_CK1_1	212	218	PF00069	0.321
MOD_CK1_1	231	237	PF00069	0.324
MOD_CK1_1	25	31	PF00069	0.772
MOD_CK1_1	274	280	PF00069	0.688
MOD_CK1_1	39	45	PF00069	0.628
MOD_CK1_1	410	416	PF00069	0.645
MOD_CK1_1	451	457	PF00069	0.753
MOD_CK1_1	486	492	PF00069	0.759
MOD_CK1_1	504	510	PF00069	0.609
MOD_CK1_1	592	598	PF00069	0.555
MOD_CK1_1	654	660	PF00069	0.579
MOD_CK1_1	669	675	PF00069	0.562
MOD_CK1_1	70	76	PF00069	0.417
MOD_CK2_1	21	27	PF00069	0.739
MOD_CK2_1	252	258	PF00069	0.613
MOD_CK2_1	370	376	PF00069	0.542
MOD_CK2_1	474	480	PF00069	0.764
MOD_CK2_1	668	674	PF00069	0.609
MOD_GlcNHglycan	121	124	PF01048	0.764
MOD_GlcNHglycan	125	128	PF01048	0.644
MOD_GlcNHglycan	230	233	PF01048	0.552
MOD_GlcNHglycan	276	279	PF01048	0.723
MOD_GlcNHglycan	314	317	PF01048	0.339
MOD_GlcNHglycan	325	328	PF01048	0.520
MOD_GlcNHglycan	360	363	PF01048	0.505
MOD_GlcNHglycan	371	375	PF01048	0.417
MOD_GlcNHglycan	438	441	PF01048	0.745
MOD_GlcNHglycan	456	459	PF01048	0.750
MOD_GlcNHglycan	462	465	PF01048	0.755
MOD_GlcNHglycan	467	470	PF01048	0.708
MOD_GlcNHglycan	488	491	PF01048	0.807
MOD_GlcNHglycan	509	512	PF01048	0.730
MOD_GlcNHglycan	514	517	PF01048	0.652
MOD_GlcNHglycan	58	61	PF01048	0.501
MOD_GlcNHglycan	668	671	PF01048	0.708
MOD_GSK3_1	119	126	PF00069	0.673
MOD_GSK3_1	160	167	PF00069	0.565
MOD_GSK3_1	174	181	PF00069	0.471
MOD_GSK3_1	192	199	PF00069	0.526
MOD_GSK3_1	208	215	PF00069	0.520
MOD_GSK3_1	21	28	PF00069	0.606
MOD_GSK3_1	267	274	PF00069	0.672
MOD_GSK3_1	277	284	PF00069	0.464
MOD_GSK3_1	300	307	PF00069	0.538
MOD_GSK3_1	310	317	PF00069	0.490
MOD_GSK3_1	35	42	PF00069	0.588
MOD_GSK3_1	366	373	PF00069	0.485
MOD_GSK3_1	407	414	PF00069	0.683
MOD_GSK3_1	450	457	PF00069	0.741
MOD_GSK3_1	46	53	PF00069	0.484
MOD_GSK3_1	465	472	PF00069	0.587
MOD_GSK3_1	482	489	PF00069	0.612
MOD_GSK3_1	500	507	PF00069	0.654
MOD_GSK3_1	557	564	PF00069	0.702
MOD_GSK3_1	565	572	PF00069	0.780
MOD_GSK3_1	6	13	PF00069	0.738
MOD_GSK3_1	650	657	PF00069	0.536
MOD_GSK3_1	66	73	PF00069	0.258
MOD_GSK3_1	98	105	PF00069	0.577
MOD_LATS_1	296	302	PF00433	0.598
MOD_LATS_1	94	100	PF00433	0.612
MOD_N-GLC_1	271	276	PF02516	0.474
MOD_N-GLC_1	304	309	PF02516	0.301
MOD_NEK2_1	139	144	PF00069	0.463
MOD_NEK2_1	146	151	PF00069	0.410
MOD_NEK2_1	164	169	PF00069	0.399
MOD_NEK2_1	209	214	PF00069	0.490
MOD_NEK2_1	30	35	PF00069	0.765
MOD_NEK2_1	310	315	PF00069	0.552
MOD_NEK2_1	379	384	PF00069	0.514
MOD_NEK2_1	51	56	PF00069	0.542
MOD_NEK2_1	582	587	PF00069	0.796
MOD_NEK2_1	67	72	PF00069	0.345
MOD_PIKK_1	10	16	PF00454	0.713
MOD_PIKK_1	387	393	PF00454	0.453
MOD_PIKK_1	569	575	PF00454	0.703
MOD_PIKK_1	622	628	PF00454	0.373
MOD_PIKK_1	669	675	PF00454	0.695
MOD_PK_1	267	273	PF00069	0.694
MOD_PK_1	298	304	PF00069	0.560
MOD_PKA_1	129	135	PF00069	0.526
MOD_PKA_1	546	552	PF00069	0.698
MOD_PKA_2	102	108	PF00069	0.602
MOD_PKA_2	129	135	PF00069	0.496
MOD_PKA_2	266	272	PF00069	0.708
MOD_PKA_2	281	287	PF00069	0.449
MOD_PKA_2	39	45	PF00069	0.616
MOD_PKA_2	449	455	PF00069	0.712
MOD_PKA_2	49	55	PF00069	0.498
MOD_PKA_2	546	552	PF00069	0.716
MOD_PKA_2	557	563	PF00069	0.770
MOD_PKA_2	582	588	PF00069	0.718
MOD_PKB_1	545	553	PF00069	0.583
MOD_Plk_1	140	146	PF00069	0.505
MOD_Plk_1	257	263	PF00069	0.526
MOD_Plk_1	271	277	PF00069	0.712
MOD_Plk_1	339	345	PF00069	0.504
MOD_Plk_1	569	575	PF00069	0.699
MOD_Plk_1	583	589	PF00069	0.798
MOD_Plk_1	654	660	PF00069	0.641
MOD_Plk_2-3	561	567	PF00069	0.791
MOD_Plk_4	179	185	PF00069	0.568
MOD_Plk_4	25	31	PF00069	0.765
MOD_Plk_4	288	294	PF00069	0.567
MOD_Plk_4	306	312	PF00069	0.400
MOD_Plk_4	331	337	PF00069	0.522
MOD_Plk_4	42	48	PF00069	0.606
MOD_Plk_4	469	475	PF00069	0.806
MOD_ProDKin_1	103	109	PF00069	0.702
MOD_ProDKin_1	12	18	PF00069	0.753
MOD_ProDKin_1	192	198	PF00069	0.763
MOD_ProDKin_1	349	355	PF00069	0.570
MOD_ProDKin_1	407	413	PF00069	0.646
MOD_ProDKin_1	414	420	PF00069	0.636
MOD_ProDKin_1	483	489	PF00069	0.792
MOD_ProDKin_1	624	630	PF00069	0.540
MOD_ProDKin_1	678	684	PF00069	0.690
TRG_DiLeu_BaEn_1	674	679	PF01217	0.687
TRG_DiLeu_BaEn_2	140	146	PF01217	0.505
TRG_DiLeu_BaLyEn_6	614	619	PF01217	0.552
TRG_ENDOCYTIC_2	354	357	PF00928	0.443
TRG_ENDOCYTIC_2	421	424	PF00928	0.683
TRG_ENDOCYTIC_2	55	58	PF00928	0.470
TRG_ENDOCYTIC_2	633	636	PF00928	0.508
TRG_ER_diArg_1	128	130	PF00400	0.595
TRG_ER_diArg_1	529	531	PF00400	0.657
TRG_ER_diArg_1	545	547	PF00400	0.754
TRG_ER_diArg_1	614	617	PF00400	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZD9	Leptomonas seymouri	57%	89%
A0A1X0P7P5	Trypanosomatidae	33%	100%
A0A3S7XAS2	Leishmania donovani	91%	100%
A4HP71	Leishmania braziliensis	79%	100%
A4IDH6	Leishmania infantum	91%	100%
D0A364	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4Q1L9	Leishmania major	92%	100%