Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASX6_LEIMU

TriTrypDb:

LmxM.36.2010

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASX6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.414
CLV_NRD_NRD_1	119	121	PF00675	0.511
CLV_NRD_NRD_1	137	139	PF00675	0.374
CLV_NRD_NRD_1	257	259	PF00675	0.441
CLV_NRD_NRD_1	354	356	PF00675	0.469
CLV_PCSK_KEX2_1	119	121	PF00082	0.446
CLV_PCSK_KEX2_1	137	139	PF00082	0.403
CLV_PCSK_KEX2_1	257	259	PF00082	0.448
CLV_PCSK_SKI1_1	226	230	PF00082	0.466
CLV_PCSK_SKI1_1	355	359	PF00082	0.485
DEG_APCC_DBOX_1	118	126	PF00400	0.407
DEG_APCC_DBOX_1	249	257	PF00400	0.480
DEG_Nend_UBRbox_1	1	4	PF02207	0.606
DOC_CYCLIN_RxL_1	315	326	PF00134	0.415
DOC_MAPK_gen_1	73	80	PF00069	0.490
DOC_MAPK_MEF2A_6	73	80	PF00069	0.602
DOC_MAPK_NFAT4_5	73	81	PF00069	0.490
DOC_USP7_MATH_1	203	207	PF00917	0.560
DOC_USP7_MATH_1	235	239	PF00917	0.555
DOC_USP7_MATH_1	39	43	PF00917	0.643
DOC_USP7_MATH_1	48	52	PF00917	0.559
DOC_USP7_MATH_1	69	73	PF00917	0.508
DOC_WW_Pin1_4	35	40	PF00397	0.540
DOC_WW_Pin1_4	91	96	PF00397	0.598
LIG_14-3-3_CanoR_1	58	63	PF00244	0.577
LIG_14-3-3_CanoR_1	73	79	PF00244	0.727
LIG_Actin_WH2_2	115	132	PF00022	0.455
LIG_Actin_WH2_2	242	259	PF00022	0.478
LIG_BRCT_BRCA1_1	41	45	PF00533	0.615
LIG_deltaCOP1_diTrp_1	149	153	PF00928	0.461
LIG_FHA_1	100	106	PF00498	0.646
LIG_FHA_1	124	130	PF00498	0.494
LIG_FHA_1	275	281	PF00498	0.383
LIG_FHA_1	331	337	PF00498	0.513
LIG_FHA_2	239	245	PF00498	0.502
LIG_GBD_Chelix_1	245	253	PF00786	0.340
LIG_LIR_Gen_1	149	156	PF02991	0.476
LIG_LIR_Gen_1	333	343	PF02991	0.508
LIG_LIR_Nem_3	149	153	PF02991	0.614
LIG_LIR_Nem_3	333	338	PF02991	0.529
LIG_PCNA_PIPBox_1	282	291	PF02747	0.479
LIG_PCNA_yPIPBox_3	282	292	PF02747	0.431
LIG_Rb_LxCxE_1	170	189	PF01857	0.434
LIG_SH2_CRK	347	351	PF00017	0.407
LIG_SH2_STAT5	288	291	PF00017	0.494
LIG_SH2_STAT5	297	300	PF00017	0.469
LIG_SH3_3	306	312	PF00018	0.426
LIG_SH3_3	333	339	PF00018	0.418
LIG_SH3_3	41	47	PF00018	0.632
LIG_SH3_3	63	69	PF00018	0.733
LIG_SH3_3	8	14	PF00018	0.614
LIG_SUMO_SIM_par_1	87	94	PF11976	0.585
LIG_TRAF2_1	266	269	PF00917	0.503
LIG_TRFH_1	335	339	PF08558	0.488
LIG_TRFH_1	347	351	PF08558	0.407
LIG_UBA3_1	218	226	PF00899	0.321
MOD_CDK_SPxK_1	91	97	PF00069	0.476
MOD_CK1_1	100	106	PF00069	0.580
MOD_CK1_1	154	160	PF00069	0.432
MOD_CK1_1	238	244	PF00069	0.546
MOD_CK1_1	38	44	PF00069	0.605
MOD_CK1_1	74	80	PF00069	0.573
MOD_CK2_1	217	223	PF00069	0.431
MOD_CK2_1	238	244	PF00069	0.513
MOD_CK2_1	263	269	PF00069	0.603
MOD_GlcNHglycan	237	240	PF01048	0.569
MOD_GlcNHglycan	258	261	PF01048	0.490
MOD_GlcNHglycan	26	29	PF01048	0.527
MOD_GlcNHglycan	41	44	PF01048	0.609
MOD_GlcNHglycan	99	102	PF01048	0.510
MOD_GSK3_1	163	170	PF00069	0.518
MOD_GSK3_1	231	238	PF00069	0.514
MOD_GSK3_1	35	42	PF00069	0.662
MOD_GSK3_1	97	104	PF00069	0.602
MOD_N-GLC_1	106	111	PF02516	0.718
MOD_N-GLC_1	154	159	PF02516	0.414
MOD_N-GLC_1	280	285	PF02516	0.353
MOD_N-GLC_1	6	11	PF02516	0.609
MOD_NEK2_1	271	276	PF00069	0.479
MOD_PIKK_1	228	234	PF00454	0.492
MOD_PIKK_1	271	277	PF00454	0.489
MOD_PIKK_1	324	330	PF00454	0.553
MOD_PKA_2	256	262	PF00069	0.542
MOD_PKA_2	74	80	PF00069	0.545
MOD_PKB_1	97	105	PF00069	0.636
MOD_Plk_1	6	12	PF00069	0.498
MOD_ProDKin_1	35	41	PF00069	0.542
MOD_ProDKin_1	91	97	PF00069	0.600
MOD_SUMO_rev_2	123	132	PF00179	0.549
MOD_SUMO_rev_2	206	216	PF00179	0.603
MOD_SUMO_rev_2	262	272	PF00179	0.501
MOD_SUMO_rev_2	352	358	PF00179	0.332
MOD_SUMO_rev_2	360	366	PF00179	0.475
TRG_DiLeu_BaEn_2	330	336	PF01217	0.515
TRG_ENDOCYTIC_2	347	350	PF00928	0.410
TRG_ER_diArg_1	118	120	PF00400	0.523
TRG_ER_diArg_1	256	258	PF00400	0.457
TRG_ER_diArg_1	57	60	PF00400	0.627
TRG_ER_diArg_1	73	76	PF00400	0.514
TRG_ER_diArg_1	96	99	PF00400	0.637
TRG_ER_diLys_1	365	370	PF00400	0.511
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6L0	Leptomonas seymouri	48%	100%
A0A3Q8INP8	Leishmania donovani	88%	100%
A4HP68	Leishmania braziliensis	73%	100%
A4IDH3	Leishmania infantum	88%	100%
D0A360	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
Q4Q1M2	Leishmania major	87%	99%