Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania mexicana

UniProt:

E9ASX2_LEIMU

TriTrypDb:

LmxM.36.1970

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASX2

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	11
GO:0070988	demethylation	2	11
GO:0070989	oxidative demethylation	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	5
GO:0016491	oxidoreductase activity	2	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0032451	demethylase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.353
CLV_NRD_NRD_1	142	144	PF00675	0.378
CLV_NRD_NRD_1	240	242	PF00675	0.415
CLV_NRD_NRD_1	266	268	PF00675	0.297
CLV_PCSK_FUR_1	264	268	PF00082	0.386
CLV_PCSK_KEX2_1	134	136	PF00082	0.353
CLV_PCSK_KEX2_1	142	144	PF00082	0.378
CLV_PCSK_KEX2_1	240	242	PF00082	0.415
CLV_PCSK_KEX2_1	266	268	PF00082	0.297
CLV_PCSK_SKI1_1	143	147	PF00082	0.472
CLV_PCSK_SKI1_1	148	152	PF00082	0.394
CLV_PCSK_SKI1_1	241	245	PF00082	0.283
DEG_Nend_UBRbox_2	1	3	PF02207	0.554
DOC_MAPK_gen_1	142	152	PF00069	0.519
DOC_MAPK_gen_1	264	272	PF00069	0.344
DOC_MAPK_MEF2A_6	264	272	PF00069	0.376
DOC_USP7_MATH_1	184	188	PF00917	0.322
DOC_USP7_MATH_1	34	38	PF00917	0.469
DOC_USP7_MATH_1	79	83	PF00917	0.402
DOC_USP7_UBL2_3	147	151	PF12436	0.398
LIG_14-3-3_CanoR_1	240	244	PF00244	0.210
LIG_14-3-3_CanoR_1	266	271	PF00244	0.316
LIG_14-3-3_CanoR_1	50	59	PF00244	0.352
LIG_APCC_ABBA_1	199	204	PF00400	0.291
LIG_APCC_ABBA_1	99	104	PF00400	0.324
LIG_BIR_III_2	104	108	PF00653	0.230
LIG_BRCT_BRCA1_1	120	124	PF00533	0.427
LIG_BRCT_BRCA1_1	268	272	PF00533	0.301
LIG_BRCT_BRCA1_1	52	56	PF00533	0.314
LIG_BRCT_BRCA1_1	62	66	PF00533	0.277
LIG_deltaCOP1_diTrp_1	204	209	PF00928	0.296
LIG_FHA_1	110	116	PF00498	0.438
LIG_FHA_1	240	246	PF00498	0.205
LIG_FHA_2	269	275	PF00498	0.285
LIG_LIR_Gen_1	163	172	PF02991	0.346
LIG_LIR_Gen_1	53	64	PF02991	0.311
LIG_LIR_Nem_3	163	169	PF02991	0.482
LIG_LIR_Nem_3	269	275	PF02991	0.303
LIG_LIR_Nem_3	53	59	PF02991	0.309
LIG_Pex14_2	162	166	PF04695	0.412
LIG_SH2_STAT5	237	240	PF00017	0.416
LIG_SH3_2	123	128	PF14604	0.497
LIG_SH3_3	120	126	PF00018	0.492
LIG_SH3_3	153	159	PF00018	0.352
LIG_SH3_3	233	239	PF00018	0.313
MOD_CK1_1	167	173	PF00069	0.399
MOD_CK1_1	291	297	PF00069	0.477
MOD_CK1_1	36	42	PF00069	0.509
MOD_CK1_1	52	58	PF00069	0.299
MOD_CK1_1	6	12	PF00069	0.465
MOD_CK1_1	62	68	PF00069	0.341
MOD_CK2_1	168	174	PF00069	0.371
MOD_CK2_1	184	190	PF00069	0.380
MOD_CK2_1	268	274	PF00069	0.319
MOD_CK2_1	37	43	PF00069	0.435
MOD_Cter_Amidation	132	135	PF01082	0.339
MOD_Cter_Amidation	264	267	PF01082	0.395
MOD_GlcNHglycan	131	134	PF01048	0.374
MOD_GlcNHglycan	185	189	PF01048	0.362
MOD_GlcNHglycan	246	249	PF01048	0.367
MOD_GlcNHglycan	29	32	PF01048	0.452
MOD_GlcNHglycan	290	293	PF01048	0.409
MOD_GlcNHglycan	36	39	PF01048	0.469
MOD_GlcNHglycan	5	8	PF01048	0.420
MOD_GlcNHglycan	96	99	PF01048	0.405
MOD_GSK3_1	164	171	PF00069	0.386
MOD_GSK3_1	2	9	PF00069	0.532
MOD_GSK3_1	222	229	PF00069	0.202
MOD_GSK3_1	29	36	PF00069	0.447
MOD_GSK3_1	55	62	PF00069	0.292
MOD_GSK3_1	69	76	PF00069	0.402
MOD_GSK3_1	90	97	PF00069	0.363
MOD_NEK2_1	118	123	PF00069	0.374
MOD_NEK2_1	172	177	PF00069	0.470
MOD_NEK2_1	288	293	PF00069	0.328
MOD_NEK2_1	29	34	PF00069	0.453
MOD_NEK2_1	90	95	PF00069	0.484
MOD_NEK2_2	239	244	PF00069	0.314
MOD_PIKK_1	127	133	PF00454	0.360
MOD_PKA_1	266	272	PF00069	0.286
MOD_PKA_2	239	245	PF00069	0.208
MOD_PKA_2	266	272	PF00069	0.317
MOD_PKA_2	49	55	PF00069	0.359
MOD_PKB_1	264	272	PF00069	0.374
MOD_Plk_1	109	115	PF00069	0.426
MOD_Plk_1	184	190	PF00069	0.301
MOD_Plk_1	20	26	PF00069	0.288
MOD_Plk_1	203	209	PF00069	0.233
MOD_Plk_4	203	209	PF00069	0.354
MOD_Plk_4	222	228	PF00069	0.196
MOD_Plk_4	37	43	PF00069	0.274
MOD_Plk_4	69	75	PF00069	0.339
MOD_SUMO_for_1	74	77	PF00179	0.429
MOD_SUMO_rev_2	187	197	PF00179	0.392
TRG_ENDOCYTIC_2	252	255	PF00928	0.355
TRG_ER_diArg_1	141	143	PF00400	0.442
TRG_ER_diArg_1	239	241	PF00400	0.392
TRG_ER_diArg_1	263	266	PF00400	0.329
TRG_NLS_Bipartite_1	134	152	PF00514	0.370
TRG_NLS_MonoCore_2	145	150	PF00514	0.413
TRG_NLS_MonoExtC_3	146	151	PF00514	0.433
TRG_NLS_MonoExtN_4	143	150	PF00514	0.413
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I860	Leptomonas seymouri	65%	97%
A0A0S4JT39	Bodo saltans	38%	87%
A0A1X0P7R1	Trypanosomatidae	48%	100%
A0A3Q8IH64	Leishmania donovani	93%	100%
A0A422N9C6	Trypanosoma rangeli	48%	100%
A4HP64	Leishmania braziliensis	81%	100%
A4IDG9	Leishmania infantum	93%	100%
D0A357	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	98%
Q4Q1M6	Leishmania major	90%	100%
Q8MNT9	Caenorhabditis elegans	33%	100%
Q9D8F1	Mus musculus	27%	99%
Q9NXW9	Homo sapiens	30%	98%