LeishMANIAdb
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TLDc domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TLDc domain-containing protein
Gene product:
TLD, putative
Species:
Leishmania mexicana
UniProt:
E9ASX0_LEIMU
TriTrypDb:
LmxM.36.1955
Length:
369

Annotations

LeishMANIAdb annotations

Distantly related to a domain found in MEAK7, a regulatory subunit of animal mTOR complex. The hydrophobic segment is likely a perimembrane anchor, not a TM region (used instead of a mirystoylation site found in mammals)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 9
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

E9ASX0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASX0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004386 helicase activity 2 3
GO:0140640 catalytic activity, acting on a nucleic acid 2 3
GO:0140657 ATP-dependent activity 1 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 342 346 PF00656 0.663
CLV_NRD_NRD_1 363 365 PF00675 0.527
CLV_PCSK_KEX2_1 363 365 PF00082 0.527
CLV_PCSK_KEX2_1 97 99 PF00082 0.531
CLV_PCSK_PC1ET2_1 97 99 PF00082 0.357
CLV_PCSK_SKI1_1 184 188 PF00082 0.381
CLV_PCSK_SKI1_1 40 44 PF00082 0.330
CLV_PCSK_SKI1_1 97 101 PF00082 0.477
DEG_Nend_UBRbox_3 1 3 PF02207 0.363
DOC_CKS1_1 54 59 PF01111 0.645
DOC_MAPK_HePTP_8 149 161 PF00069 0.417
DOC_MAPK_MEF2A_6 152 161 PF00069 0.417
DOC_MAPK_MEF2A_6 347 355 PF00069 0.599
DOC_PP2B_PxIxI_1 153 159 PF00149 0.420
DOC_PP4_FxxP_1 297 300 PF00568 0.309
DOC_PP4_FxxP_1 54 57 PF00568 0.645
DOC_USP7_MATH_1 190 194 PF00917 0.401
DOC_USP7_MATH_1 309 313 PF00917 0.230
DOC_USP7_UBL2_3 72 76 PF12436 0.646
DOC_WW_Pin1_4 100 105 PF00397 0.528
DOC_WW_Pin1_4 161 166 PF00397 0.420
DOC_WW_Pin1_4 53 58 PF00397 0.725
DOC_WW_Pin1_4 83 88 PF00397 0.510
LIG_14-3-3_CanoR_1 204 209 PF00244 0.437
LIG_14-3-3_CanoR_1 293 298 PF00244 0.328
LIG_14-3-3_CanoR_1 301 310 PF00244 0.328
LIG_Actin_WH2_2 315 330 PF00022 0.491
LIG_BIR_III_2 112 116 PF00653 0.521
LIG_BRCT_BRCA1_1 212 216 PF00533 0.331
LIG_FAT_LD_1 34 42 PF03623 0.283
LIG_FHA_1 101 107 PF00498 0.432
LIG_FHA_1 153 159 PF00498 0.328
LIG_FHA_1 230 236 PF00498 0.461
LIG_FHA_1 256 262 PF00498 0.379
LIG_FHA_1 305 311 PF00498 0.243
LIG_FHA_1 332 338 PF00498 0.674
LIG_FHA_2 327 333 PF00498 0.603
LIG_GBD_Chelix_1 106 114 PF00786 0.501
LIG_LIR_Apic_2 295 300 PF02991 0.311
LIG_LIR_Apic_2 53 57 PF02991 0.638
LIG_LIR_Gen_1 141 149 PF02991 0.309
LIG_LIR_Gen_1 173 180 PF02991 0.296
LIG_LIR_Gen_1 20 31 PF02991 0.463
LIG_LIR_Gen_1 250 260 PF02991 0.381
LIG_LIR_Gen_1 6 15 PF02991 0.509
LIG_LIR_Nem_3 127 133 PF02991 0.450
LIG_LIR_Nem_3 141 145 PF02991 0.309
LIG_LIR_Nem_3 173 179 PF02991 0.302
LIG_LIR_Nem_3 20 24 PF02991 0.428
LIG_LIR_Nem_3 250 255 PF02991 0.381
LIG_LIR_Nem_3 6 10 PF02991 0.496
LIG_NRBOX 33 39 PF00104 0.266
LIG_PDZ_Class_1 364 369 PF00595 0.733
LIG_Pex14_1 129 133 PF04695 0.309
LIG_Pex14_2 252 256 PF04695 0.309
LIG_Pex14_2 279 283 PF04695 0.309
LIG_SH2_CRK 21 25 PF00017 0.408
LIG_SH2_CRK 29 33 PF00017 0.475
LIG_SH2_CRK 7 11 PF00017 0.468
LIG_SH2_CRK 78 82 PF00017 0.697
LIG_SH2_PTP2 11 14 PF00017 0.336
LIG_SH2_PTP2 15 18 PF00017 0.320
LIG_SH2_SRC 11 14 PF00017 0.336
LIG_SH2_SRC 15 18 PF00017 0.320
LIG_SH2_STAP1 133 137 PF00017 0.381
LIG_SH2_STAP1 29 33 PF00017 0.421
LIG_SH2_STAT5 11 14 PF00017 0.336
LIG_SH2_STAT5 130 133 PF00017 0.352
LIG_SH2_STAT5 15 18 PF00017 0.320
LIG_SH2_STAT5 23 26 PF00017 0.266
LIG_SH2_STAT5 254 257 PF00017 0.293
LIG_SH3_3 79 85 PF00018 0.627
LIG_SUMO_SIM_anti_2 155 160 PF11976 0.328
LIG_SUMO_SIM_par_1 98 103 PF11976 0.431
LIG_TRAF2_1 260 263 PF00917 0.420
LIG_TRAF2_1 71 74 PF00917 0.713
LIG_TYR_ITIM 27 32 PF00017 0.255
LIG_TYR_ITIM 9 14 PF00017 0.272
LIG_UBA3_1 156 162 PF00899 0.401
LIG_UBA3_1 99 105 PF00899 0.415
LIG_WRC_WIRS_1 133 138 PF05994 0.372
MOD_CDK_SPK_2 100 105 PF00069 0.533
MOD_CDK_SPK_2 161 166 PF00069 0.452
MOD_CK1_1 124 130 PF00069 0.472
MOD_CK1_1 244 250 PF00069 0.344
MOD_CK1_1 3 9 PF00069 0.333
MOD_CK1_1 304 310 PF00069 0.429
MOD_CK1_1 331 337 PF00069 0.641
MOD_CK1_1 53 59 PF00069 0.737
MOD_CK2_1 300 306 PF00069 0.352
MOD_CK2_1 67 73 PF00069 0.722
MOD_GlcNHglycan 122 126 PF01048 0.536
MOD_GlcNHglycan 187 190 PF01048 0.396
MOD_GlcNHglycan 192 195 PF01048 0.252
MOD_GlcNHglycan 233 238 PF01048 0.164
MOD_GlcNHglycan 334 337 PF01048 0.698
MOD_GlcNHglycan 67 72 PF01048 0.722
MOD_GSK3_1 148 155 PF00069 0.396
MOD_GSK3_1 171 178 PF00069 0.400
MOD_GSK3_1 190 197 PF00069 0.333
MOD_GSK3_1 229 236 PF00069 0.410
MOD_GSK3_1 243 250 PF00069 0.298
MOD_GSK3_1 300 307 PF00069 0.340
MOD_GSK3_1 328 335 PF00069 0.561
MOD_GSK3_1 46 53 PF00069 0.610
MOD_N-GLC_1 210 215 PF02516 0.368
MOD_N-GLC_1 355 360 PF02516 0.634
MOD_N-GLC_2 64 66 PF02516 0.752
MOD_NEK2_1 131 136 PF00069 0.317
MOD_NEK2_1 216 221 PF00069 0.246
MOD_NEK2_1 255 260 PF00069 0.396
MOD_NEK2_1 326 331 PF00069 0.596
MOD_NEK2_1 50 55 PF00069 0.633
MOD_PKA_2 194 200 PF00069 0.406
MOD_PKA_2 203 209 PF00069 0.365
MOD_PKA_2 292 298 PF00069 0.346
MOD_PKA_2 300 306 PF00069 0.303
MOD_PKA_2 332 338 PF00069 0.608
MOD_Plk_4 132 138 PF00069 0.403
MOD_Plk_4 152 158 PF00069 0.319
MOD_Plk_4 17 23 PF00069 0.351
MOD_ProDKin_1 100 106 PF00069 0.524
MOD_ProDKin_1 161 167 PF00069 0.420
MOD_ProDKin_1 53 59 PF00069 0.728
MOD_ProDKin_1 83 89 PF00069 0.500
MOD_SUMO_for_1 71 74 PF00179 0.657
MOD_SUMO_rev_2 257 265 PF00179 0.381
MOD_SUMO_rev_2 342 348 PF00179 0.688
MOD_SUMO_rev_2 68 77 PF00179 0.707
TRG_ENDOCYTIC_2 11 14 PF00928 0.456
TRG_ENDOCYTIC_2 133 136 PF00928 0.372
TRG_ENDOCYTIC_2 15 18 PF00928 0.460
TRG_ENDOCYTIC_2 21 24 PF00928 0.465
TRG_ENDOCYTIC_2 276 279 PF00928 0.406
TRG_ENDOCYTIC_2 29 32 PF00928 0.234
TRG_ENDOCYTIC_2 7 10 PF00928 0.478

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZW5 Leptomonas seymouri 62% 100%
A0A0S4JCM6 Bodo saltans 25% 100%
A0A0S4JIE3 Bodo saltans 42% 100%
A0A1X0P7Q9 Trypanosomatidae 49% 100%
A0A3R7M9V1 Trypanosoma rangeli 47% 100%
A0A3S7XAT0 Leishmania donovani 88% 99%
A4HP62 Leishmania braziliensis 77% 100%
E9AG16 Leishmania major 90% 100%
E9AHX4 Leishmania infantum 86% 100%
Q8K0P3 Mus musculus 26% 81%
V5BGD9 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS