Exocyst complex component Sec10

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASW5_LEIMU

TriTrypDb:

LmxM.36.1920

Length:

496

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASW5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.623
CLV_C14_Caspase3-7	268	272	PF00656	0.479
CLV_NRD_NRD_1	21	23	PF00675	0.612
CLV_NRD_NRD_1	219	221	PF00675	0.576
CLV_NRD_NRD_1	436	438	PF00675	0.466
CLV_PCSK_KEX2_1	160	162	PF00082	0.618
CLV_PCSK_KEX2_1	219	221	PF00082	0.523
CLV_PCSK_KEX2_1	435	437	PF00082	0.509
CLV_PCSK_KEX2_1	485	487	PF00082	0.548
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.596
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.583
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.542
CLV_PCSK_SKI1_1	136	140	PF00082	0.425
CLV_PCSK_SKI1_1	160	164	PF00082	0.593
CLV_PCSK_SKI1_1	172	176	PF00082	0.441
CLV_PCSK_SKI1_1	300	304	PF00082	0.477
CLV_PCSK_SKI1_1	322	326	PF00082	0.581
CLV_PCSK_SKI1_1	414	418	PF00082	0.484
CLV_PCSK_SKI1_1	446	450	PF00082	0.567
DEG_APCC_DBOX_1	246	254	PF00400	0.487
DEG_Nend_UBRbox_3	1	3	PF02207	0.590
DOC_CYCLIN_RxL_1	297	307	PF00134	0.488
DOC_CYCLIN_RxL_1	319	326	PF00134	0.486
DOC_MAPK_gen_1	183	191	PF00069	0.520
DOC_MAPK_gen_1	225	234	PF00069	0.535
DOC_MAPK_MEF2A_6	330	337	PF00069	0.543
DOC_PP4_FxxP_1	162	165	PF00568	0.533
DOC_USP7_MATH_1	10	14	PF00917	0.562
DOC_USP7_MATH_1	108	112	PF00917	0.583
DOC_USP7_MATH_1	274	278	PF00917	0.512
DOC_USP7_MATH_1	360	364	PF00917	0.470
DOC_USP7_MATH_1	426	430	PF00917	0.610
DOC_USP7_MATH_1	489	493	PF00917	0.646
DOC_USP7_MATH_1	64	68	PF00917	0.515
DOC_USP7_UBL2_3	472	476	PF12436	0.546
DOC_WW_Pin1_4	328	333	PF00397	0.616
DOC_WW_Pin1_4	422	427	PF00397	0.637
DOC_WW_Pin1_4	60	65	PF00397	0.606
LIG_14-3-3_CanoR_1	161	165	PF00244	0.467
LIG_14-3-3_CanoR_1	177	183	PF00244	0.566
LIG_14-3-3_CanoR_1	22	26	PF00244	0.458
LIG_14-3-3_CanoR_1	319	325	PF00244	0.399
LIG_14-3-3_CanoR_1	402	407	PF00244	0.400
LIG_14-3-3_CanoR_1	420	424	PF00244	0.498
LIG_Actin_WH2_2	7	24	PF00022	0.522
LIG_BH_BH3_1	39	55	PF00452	0.400
LIG_BRCT_BRCA1_1	276	280	PF00533	0.505
LIG_BRCT_BRCA1_1	385	389	PF00533	0.446
LIG_BRCT_BRCA1_1	50	54	PF00533	0.558
LIG_CaM_IQ_9	348	364	PF13499	0.502
LIG_eIF4E_1	290	296	PF01652	0.495
LIG_FAT_LD_1	175	183	PF03623	0.401
LIG_FHA_1	142	148	PF00498	0.446
LIG_FHA_1	184	190	PF00498	0.523
LIG_FHA_1	48	54	PF00498	0.596
LIG_FHA_2	107	113	PF00498	0.642
LIG_FHA_2	193	199	PF00498	0.463
LIG_FHA_2	249	255	PF00498	0.581
LIG_FHA_2	266	272	PF00498	0.362
LIG_FHA_2	321	327	PF00498	0.431
LIG_FHA_2	37	43	PF00498	0.569
LIG_FHA_2	428	434	PF00498	0.569
LIG_Integrin_RGD_1	220	222	PF01839	0.497
LIG_LIR_Apic_2	159	165	PF02991	0.555
LIG_LIR_Apic_2	422	426	PF02991	0.608
LIG_LIR_Gen_1	201	211	PF02991	0.468
LIG_LIR_Gen_1	277	287	PF02991	0.484
LIG_LIR_Gen_1	306	317	PF02991	0.354
LIG_LIR_Gen_1	386	396	PF02991	0.604
LIG_LIR_Gen_1	463	471	PF02991	0.536
LIG_LIR_Nem_3	116	121	PF02991	0.408
LIG_LIR_Nem_3	137	142	PF02991	0.431
LIG_LIR_Nem_3	201	207	PF02991	0.468
LIG_LIR_Nem_3	277	283	PF02991	0.408
LIG_LIR_Nem_3	306	312	PF02991	0.358
LIG_LIR_Nem_3	338	343	PF02991	0.616
LIG_LIR_Nem_3	386	392	PF02991	0.637
LIG_LIR_Nem_3	459	464	PF02991	0.470
LIG_LIR_Nem_3	5	11	PF02991	0.541
LIG_LYPXL_yS_3	273	276	PF13949	0.498
LIG_Pex14_1	461	465	PF04695	0.586
LIG_Pex14_2	280	284	PF04695	0.415
LIG_SH2_CRK	465	469	PF00017	0.553
LIG_SH2_PTP2	423	426	PF00017	0.609
LIG_SH2_STAP1	121	125	PF00017	0.435
LIG_SH2_STAP1	236	240	PF00017	0.431
LIG_SH2_STAP1	465	469	PF00017	0.513
LIG_SH2_STAT5	196	199	PF00017	0.534
LIG_SH2_STAT5	265	268	PF00017	0.471
LIG_SH2_STAT5	290	293	PF00017	0.624
LIG_SH2_STAT5	311	314	PF00017	0.467
LIG_SH2_STAT5	357	360	PF00017	0.433
LIG_SH2_STAT5	423	426	PF00017	0.492
LIG_SH2_STAT6	409	413	PF00017	0.530
LIG_SH3_3	326	332	PF00018	0.603
LIG_SUMO_SIM_par_1	331	336	PF11976	0.568
LIG_SUMO_SIM_par_1	366	373	PF11976	0.358
LIG_SUMO_SIM_par_1	67	73	PF11976	0.480
LIG_TRAF2_1	286	289	PF00917	0.471
LIG_UBA3_1	178	185	PF00899	0.402
LIG_UBA3_1	324	330	PF00899	0.485
LIG_UBA3_1	53	60	PF00899	0.511
MOD_CK1_1	104	110	PF00069	0.592
MOD_CK1_1	181	187	PF00069	0.553
MOD_CK1_1	192	198	PF00069	0.446
MOD_CK1_1	450	456	PF00069	0.530
MOD_CK2_1	108	114	PF00069	0.568
MOD_CK2_1	248	254	PF00069	0.545
MOD_CK2_1	283	289	PF00069	0.523
MOD_CK2_1	312	318	PF00069	0.398
MOD_CK2_1	320	326	PF00069	0.398
MOD_CK2_1	339	345	PF00069	0.557
MOD_CK2_1	36	42	PF00069	0.715
MOD_CK2_1	427	433	PF00069	0.576
MOD_CK2_1	453	459	PF00069	0.544
MOD_CK2_1	64	70	PF00069	0.540
MOD_Cter_Amidation	483	486	PF01082	0.596
MOD_GlcNHglycan	106	109	PF01048	0.589
MOD_GlcNHglycan	191	194	PF01048	0.607
MOD_GlcNHglycan	372	375	PF01048	0.393
MOD_GlcNHglycan	385	388	PF01048	0.383
MOD_GlcNHglycan	491	494	PF01048	0.533
MOD_GlcNHglycan	72	75	PF01048	0.568
MOD_GSK3_1	104	111	PF00069	0.656
MOD_GSK3_1	130	137	PF00069	0.362
MOD_GSK3_1	160	167	PF00069	0.513
MOD_GSK3_1	34	41	PF00069	0.719
MOD_GSK3_1	422	429	PF00069	0.568
MOD_GSK3_1	453	460	PF00069	0.528
MOD_GSK3_1	474	481	PF00069	0.583
MOD_GSK3_1	60	67	PF00069	0.494
MOD_NEK2_1	106	111	PF00069	0.578
MOD_NEK2_1	134	139	PF00069	0.421
MOD_NEK2_1	178	183	PF00069	0.519
MOD_NEK2_1	189	194	PF00069	0.431
MOD_NEK2_1	283	288	PF00069	0.491
MOD_NEK2_1	312	317	PF00069	0.372
MOD_NEK2_1	320	325	PF00069	0.373
MOD_PIKK_1	184	190	PF00454	0.377
MOD_PIKK_1	360	366	PF00454	0.471
MOD_PKA_1	160	166	PF00069	0.522
MOD_PKA_2	153	159	PF00069	0.629
MOD_PKA_2	160	166	PF00069	0.453
MOD_PKA_2	21	27	PF00069	0.452
MOD_PKA_2	318	324	PF00069	0.421
MOD_PKA_2	33	39	PF00069	0.474
MOD_PKA_2	419	425	PF00069	0.502
MOD_Plk_1	34	40	PF00069	0.573
MOD_Plk_2-3	164	170	PF00069	0.492
MOD_Plk_2-3	478	484	PF00069	0.601
MOD_Plk_4	192	198	PF00069	0.455
MOD_Plk_4	240	246	PF00069	0.339
MOD_Plk_4	320	326	PF00069	0.487
MOD_Plk_4	419	425	PF00069	0.476
MOD_Plk_4	427	433	PF00069	0.495
MOD_Plk_4	64	70	PF00069	0.666
MOD_ProDKin_1	328	334	PF00069	0.614
MOD_ProDKin_1	422	428	PF00069	0.638
MOD_ProDKin_1	60	66	PF00069	0.604
MOD_SUMO_for_1	475	478	PF00179	0.547
MOD_SUMO_rev_2	159	167	PF00179	0.622
MOD_SUMO_rev_2	226	232	PF00179	0.519
MOD_SUMO_rev_2	442	450	PF00179	0.453
MOD_SUMO_rev_2	466	474	PF00179	0.538
MOD_SUMO_rev_2	65	74	PF00179	0.501
TRG_DiLeu_BaEn_2	113	119	PF01217	0.431
TRG_ENDOCYTIC_2	273	276	PF00928	0.390
TRG_ENDOCYTIC_2	311	314	PF00928	0.467
TRG_ENDOCYTIC_2	410	413	PF00928	0.471
TRG_ENDOCYTIC_2	465	468	PF00928	0.558
TRG_ENDOCYTIC_2	8	11	PF00928	0.565
TRG_ER_diArg_1	218	220	PF00400	0.504
TRG_ER_FFAT_1	439	447	PF00635	0.383
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	356	361	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT1	Leptomonas seymouri	61%	97%
A0A1X0P7R8	Trypanosomatidae	32%	97%
A0A3S7XAS3	Leishmania donovani	93%	100%
A0A422MV92	Trypanosoma rangeli	31%	100%
A4HP57	Leishmania braziliensis	75%	100%
A4IDG3	Leishmania infantum	93%	100%
Q4Q1N2	Leishmania major	91%	100%
V5DKS4	Trypanosoma cruzi	31%	100%