Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASW3_LEIMU

TriTrypDb:

LmxM.36.1905

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASW3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	147	149	PF00675	0.691
CLV_NRD_NRD_1	160	162	PF00675	0.779
CLV_NRD_NRD_1	3	5	PF00675	0.661
CLV_NRD_NRD_1	313	315	PF00675	0.761
CLV_NRD_NRD_1	380	382	PF00675	0.771
CLV_NRD_NRD_1	396	398	PF00675	0.575
CLV_NRD_NRD_1	409	411	PF00675	0.660
CLV_PCSK_FUR_1	410	414	PF00082	0.830
CLV_PCSK_KEX2_1	160	162	PF00082	0.690
CLV_PCSK_KEX2_1	2	4	PF00082	0.744
CLV_PCSK_KEX2_1	313	315	PF00082	0.761
CLV_PCSK_KEX2_1	396	398	PF00082	0.778
CLV_PCSK_KEX2_1	409	411	PF00082	0.660
CLV_PCSK_KEX2_1	412	414	PF00082	0.677
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.744
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.842
CLV_PCSK_SKI1_1	243	247	PF00082	0.595
CLV_PCSK_SKI1_1	265	269	PF00082	0.799
CLV_PCSK_SKI1_1	41	45	PF00082	0.764
CLV_Separin_Metazoa	42	46	PF03568	0.767
DEG_Nend_UBRbox_1	1	4	PF02207	0.847
DEG_SPOP_SBC_1	164	168	PF00917	0.687
DOC_CKS1_1	209	214	PF01111	0.829
DOC_CKS1_1	85	90	PF01111	0.673
DOC_CYCLIN_RxL_1	394	404	PF00134	0.789
DOC_MAPK_gen_1	2	8	PF00069	0.542
DOC_PP1_RVXF_1	395	402	PF00149	0.784
DOC_PP4_FxxP_1	97	100	PF00568	0.803
DOC_PP4_MxPP_1	207	210	PF00568	0.543
DOC_USP7_MATH_1	10	14	PF00917	0.822
DOC_USP7_MATH_1	109	113	PF00917	0.743
DOC_USP7_MATH_1	171	175	PF00917	0.653
DOC_USP7_MATH_1	198	202	PF00917	0.585
DOC_USP7_MATH_1	231	235	PF00917	0.637
DOC_USP7_MATH_1	271	275	PF00917	0.806
DOC_USP7_MATH_1	296	300	PF00917	0.700
DOC_USP7_MATH_1	373	377	PF00917	0.812
DOC_USP7_MATH_1	48	52	PF00917	0.806
DOC_USP7_MATH_1	60	64	PF00917	0.623
DOC_USP7_MATH_1	75	79	PF00917	0.665
DOC_WW_Pin1_4	115	120	PF00397	0.809
DOC_WW_Pin1_4	148	153	PF00397	0.808
DOC_WW_Pin1_4	165	170	PF00397	0.777
DOC_WW_Pin1_4	18	23	PF00397	0.677
DOC_WW_Pin1_4	194	199	PF00397	0.776
DOC_WW_Pin1_4	205	210	PF00397	0.786
DOC_WW_Pin1_4	235	240	PF00397	0.661
DOC_WW_Pin1_4	26	31	PF00397	0.730
DOC_WW_Pin1_4	299	304	PF00397	0.751
DOC_WW_Pin1_4	343	348	PF00397	0.660
DOC_WW_Pin1_4	383	388	PF00397	0.646
DOC_WW_Pin1_4	69	74	PF00397	0.647
DOC_WW_Pin1_4	84	89	PF00397	0.793
LIG_14-3-3_CanoR_1	148	152	PF00244	0.733
LIG_14-3-3_CanoR_1	292	298	PF00244	0.591
LIG_14-3-3_CanoR_1	349	355	PF00244	0.534
LIG_14-3-3_CanoR_1	375	379	PF00244	0.818
LIG_Actin_WH2_2	29	47	PF00022	0.782
LIG_BRCT_BRCA1_1	233	237	PF00533	0.709
LIG_FHA_1	262	268	PF00498	0.594
LIG_FHA_1	33	39	PF00498	0.677
LIG_FHA_1	375	381	PF00498	0.737
LIG_LIR_Apic_2	95	100	PF02991	0.790
LIG_LIR_Gen_1	140	146	PF02991	0.710
LIG_LIR_Gen_1	338	347	PF02991	0.729
LIG_LIR_Nem_3	140	145	PF02991	0.795
LIG_LIR_Nem_3	338	343	PF02991	0.726
LIG_MYND_1	115	119	PF01753	0.809
LIG_NRP_CendR_1	412	414	PF00754	0.764
LIG_PCNA_TLS_4	214	221	PF02747	0.756
LIG_PCNA_yPIPBox_3	349	358	PF02747	0.725
LIG_Pex14_1	282	286	PF04695	0.703
LIG_Pex14_1	98	102	PF04695	0.802
LIG_SH2_CRK	366	370	PF00017	0.818
LIG_SH2_PTP2	68	71	PF00017	0.552
LIG_SH2_STAT5	14	17	PF00017	0.554
LIG_SH2_STAT5	220	223	PF00017	0.751
LIG_SH2_STAT5	68	71	PF00017	0.766
LIG_SH3_1	113	119	PF00018	0.520
LIG_SH3_2	209	214	PF14604	0.751
LIG_SH3_2	77	82	PF14604	0.846
LIG_SH3_3	113	119	PF00018	0.812
LIG_SH3_3	206	212	PF00018	0.834
LIG_SH3_3	3	9	PF00018	0.790
LIG_SH3_3	354	360	PF00018	0.659
LIG_SH3_3	381	387	PF00018	0.602
LIG_SH3_3	74	80	PF00018	0.833
LIG_SH3_3	97	103	PF00018	0.692
LIG_WW_3	386	390	PF00397	0.675
LIG_WW_3	79	83	PF00397	0.784
MOD_CDC14_SPxK_1	346	349	PF00782	0.743
MOD_CDC14_SPxK_1	386	389	PF00782	0.759
MOD_CDK_SPxK_1	208	214	PF00069	0.751
MOD_CDK_SPxK_1	343	349	PF00069	0.738
MOD_CDK_SPxK_1	383	389	PF00069	0.768
MOD_CDK_SPxxK_3	148	155	PF00069	0.776
MOD_CK1_1	151	157	PF00069	0.784
MOD_CK1_1	163	169	PF00069	0.857
MOD_CK1_1	174	180	PF00069	0.652
MOD_CK1_1	200	206	PF00069	0.766
MOD_CK1_1	208	214	PF00069	0.689
MOD_CK1_1	21	27	PF00069	0.766
MOD_CK1_1	254	260	PF00069	0.757
MOD_CK1_1	299	305	PF00069	0.824
MOD_CK1_1	307	313	PF00069	0.693
MOD_CK1_1	338	344	PF00069	0.797
MOD_CK2_1	198	204	PF00069	0.742
MOD_Cter_Amidation	146	149	PF01082	0.553
MOD_GlcNHglycan	139	142	PF01048	0.636
MOD_GlcNHglycan	177	180	PF01048	0.625
MOD_GlcNHglycan	227	230	PF01048	0.690
MOD_GlcNHglycan	256	259	PF01048	0.756
MOD_GlcNHglycan	26	29	PF01048	0.640
MOD_GlcNHglycan	293	296	PF01048	0.800
MOD_GlcNHglycan	298	301	PF01048	0.743
MOD_GlcNHglycan	306	309	PF01048	0.615
MOD_GlcNHglycan	55	58	PF01048	0.741
MOD_GlcNHglycan	62	65	PF01048	0.704
MOD_GlcNHglycan	73	76	PF01048	0.617
MOD_GSK3_1	10	17	PF00069	0.725
MOD_GSK3_1	120	127	PF00069	0.797
MOD_GSK3_1	147	154	PF00069	0.600
MOD_GSK3_1	156	163	PF00069	0.854
MOD_GSK3_1	171	178	PF00069	0.680
MOD_GSK3_1	194	201	PF00069	0.795
MOD_GSK3_1	20	27	PF00069	0.626
MOD_GSK3_1	231	238	PF00069	0.765
MOD_GSK3_1	261	268	PF00069	0.769
MOD_GSK3_1	338	345	PF00069	0.728
MOD_GSK3_1	383	390	PF00069	0.802
MOD_GSK3_1	44	51	PF00069	0.771
MOD_GSK3_1	71	78	PF00069	0.825
MOD_LATS_1	263	269	PF00433	0.717
MOD_N-GLC_2	253	255	PF02516	0.458
MOD_NEK2_1	291	296	PF00069	0.800
MOD_NEK2_1	335	340	PF00069	0.783
MOD_NEK2_1	350	355	PF00069	0.643
MOD_NEK2_1	44	49	PF00069	0.740
MOD_NEK2_2	241	246	PF00069	0.737
MOD_PIKK_1	75	81	PF00454	0.695
MOD_PK_1	160	166	PF00069	0.691
MOD_PK_1	4	10	PF00069	0.532
MOD_PKA_1	160	166	PF00069	0.788
MOD_PKA_2	147	153	PF00069	0.733
MOD_PKA_2	160	166	PF00069	0.698
MOD_PKA_2	291	297	PF00069	0.586
MOD_PKA_2	321	327	PF00069	0.781
MOD_PKA_2	374	380	PF00069	0.820
MOD_PKA_2	44	50	PF00069	0.745
MOD_Plk_1	120	126	PF00069	0.613
MOD_Plk_1	172	178	PF00069	0.543
MOD_Plk_1	4	10	PF00069	0.609
MOD_Plk_4	120	126	PF00069	0.636
MOD_Plk_4	134	140	PF00069	0.652
MOD_Plk_4	244	250	PF00069	0.547
MOD_Plk_4	374	380	PF00069	0.529
MOD_Plk_4	93	99	PF00069	0.706
MOD_ProDKin_1	115	121	PF00069	0.807
MOD_ProDKin_1	148	154	PF00069	0.809
MOD_ProDKin_1	165	171	PF00069	0.776
MOD_ProDKin_1	18	24	PF00069	0.676
MOD_ProDKin_1	194	200	PF00069	0.779
MOD_ProDKin_1	205	211	PF00069	0.784
MOD_ProDKin_1	235	241	PF00069	0.658
MOD_ProDKin_1	26	32	PF00069	0.728
MOD_ProDKin_1	299	305	PF00069	0.750
MOD_ProDKin_1	343	349	PF00069	0.663
MOD_ProDKin_1	383	389	PF00069	0.644
MOD_ProDKin_1	69	75	PF00069	0.648
MOD_ProDKin_1	84	90	PF00069	0.790
TRG_ENDOCYTIC_2	68	71	PF00928	0.788
TRG_ER_diArg_1	160	162	PF00400	0.768
TRG_ER_diArg_1	395	397	PF00400	0.773
TRG_ER_diArg_1	409	411	PF00400	0.817

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IG15	Leishmania donovani	87%	100%
A4HP55	Leishmania braziliensis	59%	100%
E9AG15	Leishmania major	85%	100%
E9AHX3	Leishmania infantum	87%	100%