Putative endochitinase

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endochitinase, putative

Species:

Leishmania mexicana

UniProt:

E9ASW1_LEIMU

TriTrypDb:

LmxM.36.1890

Length:

179

Annotations

LeishMANIAdb annotations

Probably part of some larger protein. The previous identification as endochitinase is highly tenuous.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 2
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9ASW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASW1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	125	127	PF00082	0.595
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.560
CLV_PCSK_SKI1_1	13	17	PF00082	0.596
DOC_MAPK_MEF2A_6	13	20	PF00069	0.531
DOC_USP7_MATH_1	168	172	PF00917	0.644
DOC_USP7_MATH_1	32	36	PF00917	0.599
DOC_WW_Pin1_4	35	40	PF00397	0.445
DOC_WW_Pin1_4	50	55	PF00397	0.326
LIG_14-3-3_CanoR_1	97	105	PF00244	0.286
LIG_Actin_WH2_2	9	27	PF00022	0.434
LIG_BIR_II_1	1	5	PF00653	0.628
LIG_FHA_1	100	106	PF00498	0.440
LIG_FHA_1	125	131	PF00498	0.371
LIG_FHA_1	84	90	PF00498	0.385
LIG_FHA_2	28	34	PF00498	0.635
LIG_GBD_Chelix_1	16	24	PF00786	0.542
LIG_LIR_Gen_1	148	157	PF02991	0.381
LIG_LIR_Nem_3	148	152	PF02991	0.336
LIG_LIR_Nem_3	153	158	PF02991	0.307
LIG_LIR_Nem_3	174	179	PF02991	0.609
LIG_SH2_CRK	144	148	PF00017	0.279
LIG_SH2_GRB2like	176	179	PF00017	0.597
LIG_SH2_NCK_1	144	148	PF00017	0.279
LIG_SH2_SRC	165	168	PF00017	0.645
LIG_SH2_STAP1	135	139	PF00017	0.404
LIG_SH2_STAT5	165	168	PF00017	0.605
LIG_SH2_STAT5	176	179	PF00017	0.572
LIG_SH2_STAT5	76	79	PF00017	0.333
LIG_SUMO_SIM_anti_2	109	115	PF11976	0.417
LIG_SUMO_SIM_par_1	100	107	PF11976	0.427
LIG_SUMO_SIM_par_1	109	115	PF11976	0.329
LIG_TYR_ITIM	142	147	PF00017	0.400
LIG_UBA3_1	154	163	PF00899	0.417
LIG_WRC_WIRS_1	146	151	PF05994	0.335
MOD_CK1_1	145	151	PF00069	0.324
MOD_CK1_1	34	40	PF00069	0.416
MOD_CK1_1	53	59	PF00069	0.362
MOD_CK2_1	168	174	PF00069	0.651
MOD_CK2_1	27	33	PF00069	0.628
MOD_CK2_1	61	67	PF00069	0.423
MOD_GSK3_1	120	127	PF00069	0.424
MOD_GSK3_1	27	34	PF00069	0.560
MOD_GSK3_1	56	63	PF00069	0.384
MOD_N-GLC_1	56	61	PF02516	0.505
MOD_N-GLC_2	66	68	PF02516	0.504
MOD_NEK2_1	99	104	PF00069	0.485
MOD_NEK2_2	117	122	PF00069	0.267
MOD_OFUCOSY	119	124	PF10250	0.656
MOD_PIKK_1	76	82	PF00454	0.428
MOD_PKA_1	125	131	PF00069	0.332
MOD_PKA_2	125	131	PF00069	0.336
MOD_Plk_1	32	38	PF00069	0.578
MOD_Plk_1	56	62	PF00069	0.299
MOD_Plk_4	142	148	PF00069	0.277
MOD_Plk_4	150	156	PF00069	0.326
MOD_Plk_4	99	105	PF00069	0.492
MOD_ProDKin_1	35	41	PF00069	0.434
MOD_ProDKin_1	50	56	PF00069	0.328
MOD_SUMO_for_1	130	133	PF00179	0.305
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.386
TRG_ENDOCYTIC_2	144	147	PF00928	0.279
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILH5	Leptomonas seymouri	81%	100%
A0A0S4IW86	Bodo saltans	47%	100%
A0A0S4JL05	Bodo saltans	29%	75%
A0A0S4JS45	Bodo saltans	30%	67%
A0A1X0P825	Trypanosomatidae	63%	100%
A0A3Q8IJ94	Leishmania donovani	94%	100%
A0A422MXC2	Trypanosoma rangeli	60%	100%
A4HP53	Leishmania braziliensis	83%	100%
A4IDG0	Leishmania infantum	94%	100%
Q4Q1N5	Leishmania major	93%	100%
V5DL10	Trypanosoma cruzi	57%	96%