LeishMANIAdb
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CBF domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CBF domain-containing protein
Gene product:
CBF/Mak21 family, putative
Species:
Leishmania mexicana
UniProt:
E9ASW0_LEIMU
TriTrypDb:
LmxM.36.1880
Length:
634

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 11
GO:0043226 organelle 2 12
GO:0043228 non-membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 12
GO:0043232 intracellular non-membrane-bounded organelle 4 11
GO:0110165 cellular anatomical entity 1 12
GO:0005634 nucleus 5 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

E9ASW0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASW0

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006259 DNA metabolic process 4 1
GO:0006270 DNA replication initiation 5 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003682 chromatin binding 2 1
GO:0005488 binding 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 152 156 PF00656 0.367
CLV_C14_Caspase3-7 320 324 PF00656 0.717
CLV_NRD_NRD_1 174 176 PF00675 0.384
CLV_NRD_NRD_1 231 233 PF00675 0.459
CLV_NRD_NRD_1 478 480 PF00675 0.266
CLV_NRD_NRD_1 620 622 PF00675 0.463
CLV_NRD_NRD_1 64 66 PF00675 0.507
CLV_NRD_NRD_1 91 93 PF00675 0.361
CLV_NRD_NRD_1 95 97 PF00675 0.389
CLV_PCSK_KEX2_1 176 178 PF00082 0.528
CLV_PCSK_KEX2_1 212 214 PF00082 0.562
CLV_PCSK_KEX2_1 231 233 PF00082 0.459
CLV_PCSK_KEX2_1 478 480 PF00082 0.266
CLV_PCSK_KEX2_1 622 624 PF00082 0.454
CLV_PCSK_PC1ET2_1 176 178 PF00082 0.578
CLV_PCSK_PC1ET2_1 212 214 PF00082 0.510
CLV_PCSK_PC1ET2_1 622 624 PF00082 0.451
CLV_PCSK_PC7_1 172 178 PF00082 0.533
CLV_PCSK_SKI1_1 112 116 PF00082 0.431
CLV_PCSK_SKI1_1 212 216 PF00082 0.585
CLV_PCSK_SKI1_1 353 357 PF00082 0.281
CLV_PCSK_SKI1_1 501 505 PF00082 0.328
DEG_Nend_UBRbox_3 1 3 PF02207 0.539
DEG_SPOP_SBC_1 386 390 PF00917 0.411
DOC_MAPK_gen_1 240 250 PF00069 0.370
DOC_MAPK_MEF2A_6 184 192 PF00069 0.347
DOC_MAPK_MEF2A_6 247 255 PF00069 0.312
DOC_MAPK_MEF2A_6 280 289 PF00069 0.385
DOC_PP2B_LxvP_1 381 384 PF13499 0.266
DOC_USP7_MATH_1 104 108 PF00917 0.344
DOC_USP7_MATH_1 333 337 PF00917 0.363
DOC_USP7_MATH_1 386 390 PF00917 0.411
DOC_USP7_MATH_1 483 487 PF00917 0.264
DOC_USP7_MATH_1 539 543 PF00917 0.266
DOC_USP7_UBL2_3 208 212 PF12436 0.530
DOC_USP7_UBL2_3 215 219 PF12436 0.463
DOC_USP7_UBL2_3 298 302 PF12436 0.510
DOC_USP7_UBL2_3 567 571 PF12436 0.531
DOC_USP7_UBL2_3 93 97 PF12436 0.413
DOC_WW_Pin1_4 260 265 PF00397 0.502
LIG_14-3-3_CanoR_1 112 121 PF00244 0.428
LIG_14-3-3_CanoR_1 175 180 PF00244 0.448
LIG_14-3-3_CanoR_1 472 480 PF00244 0.281
LIG_14-3-3_CanoR_1 51 57 PF00244 0.580
LIG_Actin_WH2_2 241 256 PF00022 0.382
LIG_Actin_WH2_2 543 561 PF00022 0.383
LIG_APCC_ABBA_1 197 202 PF00400 0.628
LIG_BIR_III_4 588 592 PF00653 0.312
LIG_BRCT_BRCA1_1 423 427 PF00533 0.266
LIG_Clathr_ClatBox_1 284 288 PF01394 0.376
LIG_deltaCOP1_diTrp_1 361 369 PF00928 0.281
LIG_deltaCOP1_diTrp_1 446 449 PF00928 0.281
LIG_EH1_1 164 172 PF00400 0.424
LIG_eIF4E_1 368 374 PF01652 0.281
LIG_FHA_1 161 167 PF00498 0.336
LIG_FHA_1 240 246 PF00498 0.437
LIG_FHA_1 266 272 PF00498 0.393
LIG_FHA_1 336 342 PF00498 0.370
LIG_FHA_1 432 438 PF00498 0.286
LIG_FHA_1 446 452 PF00498 0.259
LIG_FHA_1 472 478 PF00498 0.297
LIG_FHA_1 542 548 PF00498 0.306
LIG_FHA_1 582 588 PF00498 0.416
LIG_FHA_1 6 12 PF00498 0.400
LIG_FHA_1 607 613 PF00498 0.453
LIG_FHA_1 83 89 PF00498 0.474
LIG_FHA_2 23 29 PF00498 0.419
LIG_FHA_2 356 362 PF00498 0.300
LIG_FHA_2 393 399 PF00498 0.299
LIG_LIR_Gen_1 288 297 PF02991 0.387
LIG_LIR_Gen_1 367 377 PF02991 0.266
LIG_LIR_Gen_1 82 91 PF02991 0.345
LIG_LIR_Nem_3 28 32 PF02991 0.395
LIG_LIR_Nem_3 288 293 PF02991 0.395
LIG_LIR_Nem_3 367 372 PF02991 0.266
LIG_LIR_Nem_3 82 87 PF02991 0.343
LIG_NRBOX 149 155 PF00104 0.328
LIG_NRBOX 184 190 PF00104 0.346
LIG_PCNA_PIPBox_1 12 21 PF02747 0.501
LIG_PCNA_yPIPBox_3 12 24 PF02747 0.528
LIG_PCNA_yPIPBox_3 141 154 PF02747 0.421
LIG_PCNA_yPIPBox_3 175 189 PF02747 0.400
LIG_PDZ_Class_3 629 634 PF00595 0.453
LIG_PTAP_UEV_1 607 612 PF05743 0.355
LIG_PTB_Apo_2 4 11 PF02174 0.423
LIG_PTB_Phospho_1 4 10 PF10480 0.434
LIG_SH2_CRK 290 294 PF00017 0.382
LIG_SH2_CRK 569 573 PF00017 0.459
LIG_SH2_SRC 599 602 PF00017 0.435
LIG_SH2_STAP1 329 333 PF00017 0.456
LIG_SH2_STAP1 84 88 PF00017 0.323
LIG_SH2_STAT3 71 74 PF00017 0.408
LIG_SH2_STAT5 10 13 PF00017 0.374
LIG_SH2_STAT5 252 255 PF00017 0.361
LIG_SH2_STAT5 368 371 PF00017 0.281
LIG_SH2_STAT5 4 7 PF00017 0.462
LIG_SH2_STAT5 84 87 PF00017 0.433
LIG_SH3_3 139 145 PF00018 0.363
LIG_SH3_3 482 488 PF00018 0.330
LIG_SH3_3 605 611 PF00018 0.459
LIG_Sin3_3 124 131 PF02671 0.351
LIG_SUMO_SIM_anti_2 459 464 PF11976 0.267
LIG_SUMO_SIM_anti_2 546 551 PF11976 0.277
LIG_SUMO_SIM_par_1 343 349 PF11976 0.266
LIG_SUMO_SIM_par_1 459 464 PF11976 0.281
LIG_TRAF2_1 395 398 PF00917 0.288
LIG_TYR_ITIM 250 255 PF00017 0.313
LIG_UBA3_1 170 176 PF00899 0.383
LIG_UBA3_1 293 302 PF00899 0.366
LIG_UBA3_1 460 466 PF00899 0.266
LIG_UBA3_1 90 97 PF00899 0.367
MOD_CK1_1 160 166 PF00069 0.352
MOD_CK1_1 336 342 PF00069 0.370
MOD_CK1_1 357 363 PF00069 0.304
MOD_CK1_1 385 391 PF00069 0.411
MOD_CK1_1 412 418 PF00069 0.266
MOD_CK1_1 421 427 PF00069 0.266
MOD_CK1_1 541 547 PF00069 0.300
MOD_CK1_1 548 554 PF00069 0.300
MOD_CK2_1 114 120 PF00069 0.355
MOD_CK2_1 355 361 PF00069 0.325
MOD_CK2_1 392 398 PF00069 0.272
MOD_CK2_1 51 57 PF00069 0.486
MOD_GlcNHglycan 116 119 PF01048 0.455
MOD_GlcNHglycan 384 387 PF01048 0.375
MOD_GlcNHglycan 390 393 PF01048 0.346
MOD_GlcNHglycan 417 420 PF01048 0.266
MOD_GlcNHglycan 535 538 PF01048 0.329
MOD_GSK3_1 256 263 PF00069 0.357
MOD_GSK3_1 313 320 PF00069 0.614
MOD_GSK3_1 332 339 PF00069 0.373
MOD_GSK3_1 353 360 PF00069 0.325
MOD_GSK3_1 382 389 PF00069 0.336
MOD_GSK3_1 409 416 PF00069 0.266
MOD_GSK3_1 421 428 PF00069 0.266
MOD_GSK3_1 441 448 PF00069 0.281
MOD_GSK3_1 46 53 PF00069 0.476
MOD_GSK3_1 541 548 PF00069 0.313
MOD_GSK3_1 550 557 PF00069 0.272
MOD_N-GLC_1 22 27 PF02516 0.422
MOD_N-GLC_1 441 446 PF02516 0.281
MOD_N-GLC_1 6 11 PF02516 0.401
MOD_NEK2_1 113 118 PF00069 0.497
MOD_NEK2_1 134 139 PF00069 0.492
MOD_NEK2_1 225 230 PF00069 0.444
MOD_NEK2_1 461 466 PF00069 0.292
MOD_NEK2_1 5 10 PF00069 0.425
MOD_NEK2_1 550 555 PF00069 0.320
MOD_PIKK_1 409 415 PF00454 0.266
MOD_PIKK_1 421 427 PF00454 0.266
MOD_PIKK_1 431 437 PF00454 0.266
MOD_PIKK_1 461 467 PF00454 0.316
MOD_PIKK_1 79 85 PF00454 0.475
MOD_PKA_1 175 181 PF00069 0.437
MOD_PKA_1 92 98 PF00069 0.534
MOD_PKA_2 471 477 PF00069 0.281
MOD_PKA_2 50 56 PF00069 0.571
MOD_Plk_1 22 28 PF00069 0.419
MOD_Plk_1 364 370 PF00069 0.271
MOD_Plk_1 38 44 PF00069 0.403
MOD_Plk_1 445 451 PF00069 0.266
MOD_Plk_1 539 545 PF00069 0.266
MOD_Plk_1 6 12 PF00069 0.400
MOD_Plk_2-3 202 208 PF00069 0.421
MOD_Plk_2-3 317 323 PF00069 0.600
MOD_Plk_4 14 20 PF00069 0.373
MOD_Plk_4 364 370 PF00069 0.328
MOD_Plk_4 38 44 PF00069 0.366
MOD_Plk_4 491 497 PF00069 0.300
MOD_Plk_4 545 551 PF00069 0.320
MOD_Plk_4 6 12 PF00069 0.400
MOD_ProDKin_1 260 266 PF00069 0.501
MOD_SUMO_for_1 214 217 PF00179 0.479
MOD_SUMO_for_1 616 619 PF00179 0.597
MOD_SUMO_rev_2 202 209 PF00179 0.554
TRG_DiLeu_BaEn_4 38 44 PF01217 0.457
TRG_ENDOCYTIC_2 252 255 PF00928 0.361
TRG_ENDOCYTIC_2 29 32 PF00928 0.391
TRG_ENDOCYTIC_2 290 293 PF00928 0.388
TRG_ENDOCYTIC_2 569 572 PF00928 0.454
TRG_ENDOCYTIC_2 593 596 PF00928 0.414
TRG_ENDOCYTIC_2 84 87 PF00928 0.330
TRG_ER_diArg_1 174 177 PF00400 0.486
TRG_ER_diArg_1 308 311 PF00400 0.710
TRG_ER_diArg_1 477 479 PF00400 0.266
TRG_ER_diArg_1 620 623 PF00400 0.543
TRG_NES_CRM1_1 371 387 PF08389 0.360
TRG_NLS_MonoExtC_3 211 216 PF00514 0.499
TRG_NLS_MonoExtC_3 620 625 PF00514 0.509
TRG_NLS_MonoExtN_4 172 179 PF00514 0.533
TRG_NLS_MonoExtN_4 210 216 PF00514 0.505
TRG_Pf-PMV_PEXEL_1 375 379 PF00026 0.266
TRG_Pf-PMV_PEXEL_1 478 482 PF00026 0.266
TRG_Pf-PMV_PEXEL_1 96 101 PF00026 0.310

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6K8 Leptomonas seymouri 87% 100%
A0A0S4J058 Bodo saltans 63% 100%
A0A1X0P7S6 Trypanosomatidae 72% 100%
A0A3R7JWC9 Trypanosoma rangeli 71% 100%
A0A3S7XAS0 Leishmania donovani 96% 100%
A4HP52 Leishmania braziliensis 92% 100%
A4IDF9 Leishmania infantum 96% 100%
D0A338 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 70% 100%
Q4Q1N6 Leishmania major 97% 100%
V5DKS9 Trypanosoma cruzi 71% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS