Putative ras-like small GTPases

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras-like small GTPases, putative

Species:

Leishmania mexicana

UniProt:

E9ASV4_LEIMU

TriTrypDb:

LmxM.36.1820

Length:

872

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E9ASV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASV4

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	6
GO:0009987	cellular process	1	6
GO:0050789	regulation of biological process	2	6
GO:0050794	regulation of cellular process	3	6
GO:0065007	biological regulation	1	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0003924	GTPase activity	7	6
GO:0005488	binding	1	6
GO:0005525	GTP binding	5	6
GO:0016462	pyrophosphatase activity	5	6
GO:0016787	hydrolase activity	2	6
GO:0016817	hydrolase activity, acting on acid anhydrides	3	6
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	6
GO:0019001	guanyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032561	guanyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6
GO:0019003	GDP binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.640
CLV_C14_Caspase3-7	235	239	PF00656	0.685
CLV_C14_Caspase3-7	316	320	PF00656	0.588
CLV_C14_Caspase3-7	378	382	PF00656	0.555
CLV_C14_Caspase3-7	537	541	PF00656	0.587
CLV_C14_Caspase3-7	54	58	PF00656	0.470
CLV_NRD_NRD_1	105	107	PF00675	0.470
CLV_NRD_NRD_1	210	212	PF00675	0.682
CLV_NRD_NRD_1	214	216	PF00675	0.570
CLV_NRD_NRD_1	722	724	PF00675	0.663
CLV_NRD_NRD_1	823	825	PF00675	0.666
CLV_NRD_NRD_1	829	831	PF00675	0.619
CLV_NRD_NRD_1	836	838	PF00675	0.611
CLV_PCSK_KEX2_1	214	216	PF00082	0.653
CLV_PCSK_KEX2_1	564	566	PF00082	0.566
CLV_PCSK_KEX2_1	722	724	PF00082	0.663
CLV_PCSK_KEX2_1	823	825	PF00082	0.699
CLV_PCSK_KEX2_1	829	831	PF00082	0.681
CLV_PCSK_KEX2_1	834	836	PF00082	0.721
CLV_PCSK_KEX2_1	843	845	PF00082	0.749
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.566
CLV_PCSK_PC1ET2_1	834	836	PF00082	0.697
CLV_PCSK_PC1ET2_1	843	845	PF00082	0.568
CLV_PCSK_PC7_1	830	836	PF00082	0.569
CLV_PCSK_PC7_1	839	845	PF00082	0.539
CLV_PCSK_SKI1_1	107	111	PF00082	0.483
CLV_PCSK_SKI1_1	123	127	PF00082	0.317
CLV_PCSK_SKI1_1	296	300	PF00082	0.591
CLV_PCSK_SKI1_1	32	36	PF00082	0.375
CLV_PCSK_SKI1_1	393	397	PF00082	0.519
CLV_PCSK_SKI1_1	531	535	PF00082	0.541
CLV_PCSK_SKI1_1	71	75	PF00082	0.470
DEG_APCC_DBOX_1	105	113	PF00400	0.470
DEG_APCC_DBOX_1	308	316	PF00400	0.582
DEG_SPOP_SBC_1	476	480	PF00917	0.561
DOC_CKS1_1	558	563	PF01111	0.551
DOC_CKS1_1	774	779	PF01111	0.640
DOC_CYCLIN_yClb1_LxF_4	69	74	PF00134	0.470
DOC_MAPK_gen_1	104	112	PF00069	0.470
DOC_MAPK_gen_1	214	225	PF00069	0.502
DOC_MAPK_MEF2A_6	218	227	PF00069	0.426
DOC_MAPK_MEF2A_6	328	337	PF00069	0.574
DOC_MAPK_MEF2A_6	93	100	PF00069	0.527
DOC_MAPK_NFAT4_5	328	336	PF00069	0.572
DOC_PP1_RVXF_1	69	75	PF00149	0.470
DOC_PP2B_LxvP_1	300	303	PF13499	0.695
DOC_PP2B_PxIxI_1	17	23	PF00149	0.538
DOC_PP4_FxxP_1	424	427	PF00568	0.678
DOC_USP7_MATH_1	239	243	PF00917	0.549
DOC_USP7_MATH_1	358	362	PF00917	0.772
DOC_USP7_MATH_1	367	371	PF00917	0.612
DOC_USP7_MATH_1	373	377	PF00917	0.563
DOC_USP7_MATH_1	387	391	PF00917	0.568
DOC_USP7_MATH_1	406	410	PF00917	0.499
DOC_USP7_MATH_1	436	440	PF00917	0.512
DOC_USP7_MATH_1	45	49	PF00917	0.470
DOC_USP7_MATH_1	476	480	PF00917	0.600
DOC_USP7_MATH_1	552	556	PF00917	0.666
DOC_USP7_MATH_1	743	747	PF00917	0.640
DOC_USP7_MATH_1	815	819	PF00917	0.688
DOC_USP7_MATH_1	825	829	PF00917	0.594
DOC_USP7_UBL2_3	502	506	PF12436	0.576
DOC_USP7_UBL2_3	545	549	PF12436	0.706
DOC_WW_Pin1_4	213	218	PF00397	0.736
DOC_WW_Pin1_4	259	264	PF00397	0.732
DOC_WW_Pin1_4	273	278	PF00397	0.631
DOC_WW_Pin1_4	349	354	PF00397	0.786
DOC_WW_Pin1_4	444	449	PF00397	0.676
DOC_WW_Pin1_4	557	562	PF00397	0.592
DOC_WW_Pin1_4	591	596	PF00397	0.605
DOC_WW_Pin1_4	714	719	PF00397	0.680
DOC_WW_Pin1_4	726	731	PF00397	0.581
DOC_WW_Pin1_4	769	774	PF00397	0.637
LIG_14-3-3_CanoR_1	104	110	PF00244	0.470
LIG_14-3-3_CanoR_1	130	140	PF00244	0.448
LIG_14-3-3_CanoR_1	215	221	PF00244	0.532
LIG_14-3-3_CanoR_1	29	39	PF00244	0.231
LIG_14-3-3_CanoR_1	296	301	PF00244	0.529
LIG_14-3-3_CanoR_1	304	313	PF00244	0.374
LIG_14-3-3_CanoR_1	328	334	PF00244	0.592
LIG_14-3-3_CanoR_1	419	425	PF00244	0.685
LIG_14-3-3_CanoR_1	601	609	PF00244	0.551
LIG_14-3-3_CanoR_1	694	702	PF00244	0.702
LIG_14-3-3_CanoR_1	771	777	PF00244	0.714
LIG_14-3-3_CanoR_1	807	817	PF00244	0.744
LIG_14-3-3_CanoR_1	844	853	PF00244	0.700
LIG_APCC_ABBAyCdc20_2	37	43	PF00400	0.470
LIG_FHA_1	132	138	PF00498	0.231
LIG_FHA_1	274	280	PF00498	0.757
LIG_FHA_1	295	301	PF00498	0.765
LIG_FHA_1	31	37	PF00498	0.511
LIG_FHA_1	411	417	PF00498	0.574
LIG_FHA_1	575	581	PF00498	0.597
LIG_FHA_1	660	666	PF00498	0.671
LIG_FHA_1	668	674	PF00498	0.755
LIG_FHA_1	847	853	PF00498	0.644
LIG_FHA_1	860	866	PF00498	0.533
LIG_FHA_2	159	165	PF00498	0.711
LIG_FHA_2	184	190	PF00498	0.475
LIG_FHA_2	217	223	PF00498	0.521
LIG_FHA_2	243	249	PF00498	0.717
LIG_FHA_2	376	382	PF00498	0.551
LIG_FHA_2	52	58	PF00498	0.426
LIG_FHA_2	809	815	PF00498	0.568
LIG_HP1_1	427	431	PF01393	0.502
LIG_Integrin_RGD_1	653	655	PF01839	0.642
LIG_LIR_Apic_2	423	427	PF02991	0.680
LIG_LIR_Apic_2	772	777	PF02991	0.631
LIG_LIR_Gen_1	219	228	PF02991	0.495
LIG_LIR_Gen_1	57	67	PF02991	0.470
LIG_LIR_Nem_3	219	223	PF02991	0.498
LIG_LIR_Nem_3	528	533	PF02991	0.546
LIG_LIR_Nem_3	57	62	PF02991	0.470
LIG_RPA_C_Fungi	449	461	PF08784	0.552
LIG_SH2_CRK	530	534	PF00017	0.539
LIG_SH2_CRK	70	74	PF00017	0.470
LIG_SH2_CRK	774	778	PF00017	0.638
LIG_SH2_NCK_1	59	63	PF00017	0.470
LIG_SH2_NCK_1	774	778	PF00017	0.638
LIG_SH2_SRC	39	42	PF00017	0.470
LIG_SH2_STAP1	51	55	PF00017	0.327
LIG_SH2_STAT5	179	182	PF00017	0.671
LIG_SH2_STAT5	39	42	PF00017	0.530
LIG_SH2_STAT5	59	62	PF00017	0.470
LIG_SH2_STAT5	64	67	PF00017	0.402
LIG_SH2_STAT5	90	93	PF00017	0.498
LIG_SH3_2	822	827	PF14604	0.729
LIG_SH3_3	257	263	PF00018	0.643
LIG_SH3_3	274	280	PF00018	0.512
LIG_SH3_3	712	718	PF00018	0.585
LIG_SH3_3	819	825	PF00018	0.717
LIG_SH3_4	506	513	PF00018	0.528
LIG_SUMO_SIM_anti_2	95	102	PF11976	0.406
LIG_SUMO_SIM_par_1	21	27	PF11976	0.476
LIG_SUMO_SIM_par_1	798	803	PF11976	0.636
LIG_SUMO_SIM_par_1	95	102	PF11976	0.467
LIG_SxIP_EBH_1	419	431	PF03271	0.687
LIG_WW_3	804	808	PF00397	0.633
MOD_CDK_SPK_2	213	218	PF00069	0.673
MOD_CDK_SPK_2	596	601	PF00069	0.555
MOD_CDK_SPxxK_3	444	451	PF00069	0.634
MOD_CDK_SPxxK_3	557	564	PF00069	0.553
MOD_CK1_1	155	161	PF00069	0.552
MOD_CK1_1	196	202	PF00069	0.609
MOD_CK1_1	216	222	PF00069	0.531
MOD_CK1_1	242	248	PF00069	0.579
MOD_CK1_1	262	268	PF00069	0.691
MOD_CK1_1	271	277	PF00069	0.655
MOD_CK1_1	414	420	PF00069	0.700
MOD_CK1_1	444	450	PF00069	0.728
MOD_CK1_1	465	471	PF00069	0.667
MOD_CK1_1	483	489	PF00069	0.614
MOD_CK1_1	495	501	PF00069	0.570
MOD_CK1_1	596	602	PF00069	0.596
MOD_CK1_1	628	634	PF00069	0.735
MOD_CK1_1	647	653	PF00069	0.769
MOD_CK1_1	685	691	PF00069	0.607
MOD_CK1_1	713	719	PF00069	0.644
MOD_CK1_1	746	752	PF00069	0.655
MOD_CK1_1	772	778	PF00069	0.708
MOD_CK1_1	78	84	PF00069	0.458
MOD_CK1_1	808	814	PF00069	0.667
MOD_CK1_1	828	834	PF00069	0.626
MOD_CK1_1	845	851	PF00069	0.688
MOD_CK2_1	159	165	PF00069	0.568
MOD_CK2_1	183	189	PF00069	0.470
MOD_CK2_1	358	364	PF00069	0.737
MOD_CK2_1	475	481	PF00069	0.737
MOD_CK2_1	567	573	PF00069	0.719
MOD_CK2_1	7	13	PF00069	0.699
MOD_CK2_1	761	767	PF00069	0.532
MOD_CK2_1	79	85	PF00069	0.470
MOD_CK2_1	790	796	PF00069	0.749
MOD_CK2_1	808	814	PF00069	0.686
MOD_CK2_1	815	821	PF00069	0.713
MOD_Cter_Amidation	209	212	PF01082	0.555
MOD_Cter_Amidation	524	527	PF01082	0.768
MOD_Cter_Amidation	841	844	PF01082	0.650
MOD_GlcNHglycan	127	130	PF01048	0.231
MOD_GlcNHglycan	175	178	PF01048	0.549
MOD_GlcNHglycan	271	274	PF01048	0.640
MOD_GlcNHglycan	343	346	PF01048	0.586
MOD_GlcNHglycan	347	350	PF01048	0.785
MOD_GlcNHglycan	369	372	PF01048	0.704
MOD_GlcNHglycan	408	411	PF01048	0.737
MOD_GlcNHglycan	418	422	PF01048	0.631
MOD_GlcNHglycan	438	441	PF01048	0.558
MOD_GlcNHglycan	443	446	PF01048	0.584
MOD_GlcNHglycan	540	543	PF01048	0.571
MOD_GlcNHglycan	554	557	PF01048	0.630
MOD_GlcNHglycan	604	607	PF01048	0.740
MOD_GlcNHglycan	630	633	PF01048	0.735
MOD_GlcNHglycan	684	687	PF01048	0.615
MOD_GlcNHglycan	689	692	PF01048	0.579
MOD_GlcNHglycan	712	715	PF01048	0.667
MOD_GlcNHglycan	745	748	PF01048	0.640
MOD_GlcNHglycan	763	766	PF01048	0.527
MOD_GlcNHglycan	78	81	PF01048	0.406
MOD_GlcNHglycan	792	795	PF01048	0.727
MOD_GlcNHglycan	844	847	PF01048	0.689
MOD_GSK3_1	151	158	PF00069	0.672
MOD_GSK3_1	238	245	PF00069	0.725
MOD_GSK3_1	268	275	PF00069	0.764
MOD_GSK3_1	3	10	PF00069	0.754
MOD_GSK3_1	341	348	PF00069	0.735
MOD_GSK3_1	352	359	PF00069	0.796
MOD_GSK3_1	406	413	PF00069	0.589
MOD_GSK3_1	446	453	PF00069	0.688
MOD_GSK3_1	476	483	PF00069	0.593
MOD_GSK3_1	491	498	PF00069	0.693
MOD_GSK3_1	51	58	PF00069	0.401
MOD_GSK3_1	525	532	PF00069	0.628
MOD_GSK3_1	534	541	PF00069	0.702
MOD_GSK3_1	587	594	PF00069	0.641
MOD_GSK3_1	596	603	PF00069	0.715
MOD_GSK3_1	640	647	PF00069	0.719
MOD_GSK3_1	655	662	PF00069	0.620
MOD_GSK3_1	663	670	PF00069	0.782
MOD_GSK3_1	710	717	PF00069	0.674
MOD_GSK3_1	72	79	PF00069	0.470
MOD_GSK3_1	742	749	PF00069	0.770
MOD_GSK3_1	769	776	PF00069	0.701
MOD_GSK3_1	842	849	PF00069	0.725
MOD_LATS_1	452	458	PF00433	0.648
MOD_N-GLC_1	151	156	PF02516	0.453
MOD_N-GLC_1	294	299	PF02516	0.743
MOD_N-GLC_1	476	481	PF02516	0.658
MOD_N-GLC_1	491	496	PF02516	0.689
MOD_N-GLC_1	534	539	PF02516	0.541
MOD_N-GLC_1	601	606	PF02516	0.555
MOD_N-GLC_1	726	731	PF02516	0.727
MOD_N-GLC_1	790	795	PF02516	0.732
MOD_N-GLC_2	267	269	PF02516	0.722
MOD_NEK2_1	125	130	PF00069	0.231
MOD_NEK2_1	227	232	PF00069	0.538
MOD_NEK2_1	286	291	PF00069	0.629
MOD_NEK2_1	313	318	PF00069	0.566
MOD_NEK2_1	374	379	PF00069	0.552
MOD_NEK2_1	533	538	PF00069	0.542
MOD_NEK2_1	55	60	PF00069	0.498
MOD_NEK2_1	574	579	PF00069	0.610
MOD_NEK2_1	580	585	PF00069	0.683
MOD_NEK2_1	758	763	PF00069	0.570
MOD_NEK2_1	99	104	PF00069	0.470
MOD_NEK2_2	329	334	PF00069	0.564
MOD_NEK2_2	731	736	PF00069	0.565
MOD_PIKK_1	196	202	PF00454	0.673
MOD_PIKK_1	250	256	PF00454	0.620
MOD_PIKK_1	515	521	PF00454	0.706
MOD_PIKK_1	663	669	PF00454	0.731
MOD_PIKK_1	815	821	PF00454	0.759
MOD_PIKK_1	828	834	PF00454	0.713
MOD_PIKK_1	859	865	PF00454	0.692
MOD_PKA_2	105	111	PF00069	0.470
MOD_PKA_2	327	333	PF00069	0.468
MOD_PKA_2	450	456	PF00069	0.724
MOD_PKA_2	483	489	PF00069	0.649
MOD_PKA_2	600	606	PF00069	0.550
MOD_PKA_2	693	699	PF00069	0.787
MOD_PKA_2	708	714	PF00069	0.612
MOD_PKA_2	808	814	PF00069	0.791
MOD_PKA_2	828	834	PF00069	0.664
MOD_Plk_1	3	9	PF00069	0.687
MOD_Plk_1	388	394	PF00069	0.525
MOD_Plk_1	495	501	PF00069	0.705
MOD_Plk_1	51	57	PF00069	0.406
MOD_Plk_2-3	185	191	PF00069	0.633
MOD_Plk_4	105	111	PF00069	0.470
MOD_Plk_4	393	399	PF00069	0.599
MOD_Plk_4	420	426	PF00069	0.676
MOD_Plk_4	51	57	PF00069	0.470
MOD_ProDKin_1	213	219	PF00069	0.728
MOD_ProDKin_1	259	265	PF00069	0.732
MOD_ProDKin_1	273	279	PF00069	0.633
MOD_ProDKin_1	349	355	PF00069	0.785
MOD_ProDKin_1	444	450	PF00069	0.678
MOD_ProDKin_1	557	563	PF00069	0.591
MOD_ProDKin_1	591	597	PF00069	0.607
MOD_ProDKin_1	714	720	PF00069	0.684
MOD_ProDKin_1	726	732	PF00069	0.582
MOD_ProDKin_1	769	775	PF00069	0.638
MOD_SUMO_for_1	501	504	PF00179	0.541
MOD_SUMO_for_1	784	787	PF00179	0.657
MOD_SUMO_rev_2	316	323	PF00179	0.585
MOD_SUMO_rev_2	504	513	PF00179	0.617
MOD_SUMO_rev_2	808	818	PF00179	0.661
TRG_DiLeu_BaEn_1	529	534	PF01217	0.541
TRG_DiLeu_BaEn_2	138	144	PF01217	0.470
TRG_DiLeu_BaEn_4	189	195	PF01217	0.500
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.533
TRG_ENDOCYTIC_2	530	533	PF00928	0.538
TRG_ENDOCYTIC_2	59	62	PF00928	0.470
TRG_ENDOCYTIC_2	70	73	PF00928	0.321
TRG_ER_diArg_1	103	106	PF00400	0.375
TRG_ER_diArg_1	721	723	PF00400	0.666
TRG_ER_diArg_1	806	809	PF00400	0.572
TRG_ER_diArg_1	822	824	PF00400	0.610
TRG_ER_diArg_1	835	837	PF00400	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IQV2	Leishmania donovani	76%	100%
A4HP46	Leishmania braziliensis	46%	99%
A4IDF3	Leishmania infantum	76%	100%
Q4Q1P2	Leishmania major	72%	100%