Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASV2_LEIMU

TriTrypDb:

LmxM.36.1800

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005882	intermediate filament	6	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASV2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.368
CLV_NRD_NRD_1	14	16	PF00675	0.612
CLV_NRD_NRD_1	179	181	PF00675	0.497
CLV_NRD_NRD_1	336	338	PF00675	0.530
CLV_PCSK_KEX2_1	14	16	PF00082	0.612
CLV_PCSK_KEX2_1	151	153	PF00082	0.563
CLV_PCSK_KEX2_1	176	178	PF00082	0.467
CLV_PCSK_KEX2_1	181	183	PF00082	0.507
CLV_PCSK_KEX2_1	336	338	PF00082	0.504
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.438
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.477
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.469
CLV_PCSK_PC7_1	147	153	PF00082	0.558
CLV_PCSK_PC7_1	177	183	PF00082	0.322
CLV_PCSK_SKI1_1	165	169	PF00082	0.546
CLV_PCSK_SKI1_1	173	177	PF00082	0.533
CLV_PCSK_SKI1_1	276	280	PF00082	0.552
CLV_PCSK_SKI1_1	336	340	PF00082	0.472
CLV_PCSK_SKI1_1	78	82	PF00082	0.473
DEG_APCC_DBOX_1	315	323	PF00400	0.516
DEG_Nend_UBRbox_4	1	3	PF02207	0.457
DOC_MAPK_gen_1	180	189	PF00069	0.521
DOC_PP4_FxxP_1	81	84	PF00568	0.407
DOC_USP7_MATH_1	225	229	PF00917	0.572
DOC_USP7_MATH_1	379	383	PF00917	0.401
DOC_USP7_MATH_1	4	8	PF00917	0.459
DOC_USP7_MATH_1	66	70	PF00917	0.703
DOC_USP7_MATH_1	92	96	PF00917	0.596
DOC_WW_Pin1_4	27	32	PF00397	0.625
DOC_WW_Pin1_4	62	67	PF00397	0.624
LIG_14-3-3_CanoR_1	14	19	PF00244	0.664
LIG_14-3-3_CanoR_1	165	175	PF00244	0.400
LIG_14-3-3_CanoR_1	231	237	PF00244	0.397
LIG_14-3-3_CanoR_1	368	376	PF00244	0.491
LIG_14-3-3_CanoR_1	41	47	PF00244	0.544
LIG_Actin_WH2_2	207	223	PF00022	0.348
LIG_APCC_ABBA_1	187	192	PF00400	0.370
LIG_APCC_ABBAyCdc20_2	186	192	PF00400	0.373
LIG_FHA_1	183	189	PF00498	0.377
LIG_FHA_1	89	95	PF00498	0.619
LIG_FHA_2	373	379	PF00498	0.496
LIG_FHA_2	47	53	PF00498	0.517
LIG_PCNA_PIPBox_1	109	118	PF02747	0.391
LIG_Pex14_2	179	183	PF04695	0.318
LIG_SH2_GRB2like	115	118	PF00017	0.388
LIG_SH2_GRB2like	351	354	PF00017	0.337
LIG_SH2_NCK_1	351	355	PF00017	0.464
LIG_SH2_SRC	115	118	PF00017	0.388
LIG_SH2_STAP1	190	194	PF00017	0.397
LIG_SH2_STAP1	206	210	PF00017	0.343
LIG_SH2_STAT3	247	250	PF00017	0.392
LIG_SH2_STAT5	115	118	PF00017	0.353
LIG_SH2_STAT5	247	250	PF00017	0.369
LIG_SH2_STAT5	253	256	PF00017	0.361
LIG_TRAF2_1	216	219	PF00917	0.539
LIG_TRAF2_1	303	306	PF00917	0.305
LIG_WRC_WIRS_1	5	10	PF05994	0.462
MOD_CK1_1	232	238	PF00069	0.575
MOD_CK1_1	26	32	PF00069	0.671
MOD_CK1_1	65	71	PF00069	0.698
MOD_CK1_1	7	13	PF00069	0.423
MOD_CK2_1	261	267	PF00069	0.522
MOD_CK2_1	372	378	PF00069	0.469
MOD_CK2_1	65	71	PF00069	0.472
MOD_GlcNHglycan	125	128	PF01048	0.329
MOD_GlcNHglycan	194	197	PF01048	0.383
MOD_GlcNHglycan	221	224	PF01048	0.429
MOD_GlcNHglycan	32	35	PF01048	0.589
MOD_GlcNHglycan	68	71	PF01048	0.675
MOD_GlcNHglycan	88	91	PF01048	0.673
MOD_GlcNHglycan	94	97	PF01048	0.427
MOD_GSK3_1	14	21	PF00069	0.681
MOD_GSK3_1	225	232	PF00069	0.619
MOD_GSK3_1	23	30	PF00069	0.671
MOD_GSK3_1	3	10	PF00069	0.458
MOD_GSK3_1	39	46	PF00069	0.508
MOD_GSK3_1	62	69	PF00069	0.663
MOD_GSK3_1	88	95	PF00069	0.615
MOD_LATS_1	274	280	PF00433	0.386
MOD_N-GLC_1	192	197	PF02516	0.432
MOD_N-GLC_1	276	281	PF02516	0.479
MOD_NEK2_1	175	180	PF00069	0.377
MOD_NEK2_1	229	234	PF00069	0.442
MOD_NEK2_1	372	377	PF00069	0.522
MOD_NEK2_1	8	13	PF00069	0.600
MOD_NEK2_2	4	9	PF00069	0.414
MOD_PIKK_1	367	373	PF00454	0.470
MOD_PKA_1	14	20	PF00069	0.505
MOD_PKA_2	13	19	PF00069	0.569
MOD_PKA_2	359	365	PF00069	0.501
MOD_PKA_2	367	373	PF00069	0.418
MOD_PKA_2	40	46	PF00069	0.545
MOD_PKB_1	180	188	PF00069	0.327
MOD_Plk_1	192	198	PF00069	0.428
MOD_Plk_1	276	282	PF00069	0.426
MOD_Plk_1	70	76	PF00069	0.608
MOD_Plk_4	232	238	PF00069	0.391
MOD_ProDKin_1	27	33	PF00069	0.626
MOD_ProDKin_1	62	68	PF00069	0.623
TRG_DiLeu_BaEn_1	170	175	PF01217	0.396
TRG_DiLeu_BaEn_3	334	340	PF01217	0.417
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.405
TRG_DiLeu_LyEn_5	170	175	PF01217	0.396
TRG_ER_diArg_1	13	15	PF00400	0.599
TRG_ER_diArg_1	179	182	PF00400	0.565
TRG_ER_diArg_1	336	338	PF00400	0.522
TRG_NLS_MonoExtC_3	179	184	PF00514	0.450
TRG_NLS_MonoExtN_4	177	184	PF00514	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEW3	Leptomonas seymouri	45%	95%
A0A0S4IWZ6	Bodo saltans	23%	100%
A0A1X0P838	Trypanosomatidae	27%	97%
A0A3S5H822	Leishmania donovani	85%	99%
A0A422NLC8	Trypanosoma rangeli	27%	100%
A4HP44	Leishmania braziliensis	64%	100%
Q4Q1P4	Leishmania major	85%	100%
V5B4D1	Trypanosoma cruzi	26%	100%