Tetratricopeptide repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania mexicana

UniProt:

E9ASV0_LEIMU

TriTrypDb:

LmxM.36.1780

Length:

743

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASV0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	265	269	PF00656	0.523
CLV_C14_Caspase3-7	392	396	PF00656	0.626
CLV_C14_Caspase3-7	495	499	PF00656	0.507
CLV_C14_Caspase3-7	546	550	PF00656	0.568
CLV_MEL_PAP_1	708	714	PF00089	0.479
CLV_NRD_NRD_1	101	103	PF00675	0.559
CLV_NRD_NRD_1	344	346	PF00675	0.535
CLV_NRD_NRD_1	383	385	PF00675	0.692
CLV_NRD_NRD_1	443	445	PF00675	0.486
CLV_NRD_NRD_1	644	646	PF00675	0.723
CLV_NRD_NRD_1	681	683	PF00675	0.739
CLV_NRD_NRD_1	710	712	PF00675	0.743
CLV_NRD_NRD_1	733	735	PF00675	0.717
CLV_NRD_NRD_1	85	87	PF00675	0.312
CLV_PCSK_KEX2_1	101	103	PF00082	0.559
CLV_PCSK_KEX2_1	383	385	PF00082	0.680
CLV_PCSK_KEX2_1	443	445	PF00082	0.505
CLV_PCSK_KEX2_1	644	646	PF00082	0.723
CLV_PCSK_KEX2_1	652	654	PF00082	0.652
CLV_PCSK_KEX2_1	681	683	PF00082	0.704
CLV_PCSK_KEX2_1	710	712	PF00082	0.777
CLV_PCSK_KEX2_1	716	718	PF00082	0.770
CLV_PCSK_KEX2_1	733	735	PF00082	0.623
CLV_PCSK_KEX2_1	85	87	PF00082	0.312
CLV_PCSK_PC1ET2_1	652	654	PF00082	0.652
CLV_PCSK_PC1ET2_1	716	718	PF00082	0.737
CLV_PCSK_SKI1_1	341	345	PF00082	0.425
CLV_PCSK_SKI1_1	348	352	PF00082	0.424
CLV_PCSK_SKI1_1	404	408	PF00082	0.526
CLV_PCSK_SKI1_1	459	463	PF00082	0.424
CLV_PCSK_SKI1_1	606	610	PF00082	0.342
CLV_PCSK_SKI1_1	85	89	PF00082	0.356
DEG_APCC_DBOX_1	232	240	PF00400	0.494
DEG_APCC_DBOX_1	605	613	PF00400	0.468
DEG_APCC_DBOX_1	84	92	PF00400	0.312
DEG_SPOP_SBC_1	169	173	PF00917	0.502
DOC_CYCLIN_RxL_1	345	355	PF00134	0.435
DOC_CYCLIN_RxL_1	401	409	PF00134	0.564
DOC_CYCLIN_RxL_1	82	90	PF00134	0.389
DOC_MAPK_gen_1	28	37	PF00069	0.551
DOC_MAPK_gen_1	345	351	PF00069	0.521
DOC_MAPK_gen_1	443	449	PF00069	0.512
DOC_MAPK_gen_1	508	517	PF00069	0.529
DOC_MAPK_gen_1	82	91	PF00069	0.331
DOC_MAPK_MEF2A_6	510	518	PF00069	0.479
DOC_PP2B_LxvP_1	218	221	PF13499	0.677
DOC_USP7_MATH_1	116	120	PF00917	0.748
DOC_USP7_MATH_1	151	155	PF00917	0.510
DOC_USP7_MATH_1	163	167	PF00917	0.491
DOC_USP7_MATH_1	168	172	PF00917	0.502
DOC_USP7_MATH_1	18	22	PF00917	0.593
DOC_USP7_MATH_1	271	275	PF00917	0.467
DOC_USP7_MATH_1	396	400	PF00917	0.614
DOC_USP7_MATH_1	418	422	PF00917	0.506
DOC_USP7_MATH_1	639	643	PF00917	0.733
DOC_USP7_MATH_1	656	660	PF00917	0.577
DOC_USP7_UBL2_3	26	30	PF12436	0.554
DOC_USP7_UBL2_3	455	459	PF12436	0.476
DOC_WW_Pin1_4	103	108	PF00397	0.713
DOC_WW_Pin1_4	124	129	PF00397	0.739
DOC_WW_Pin1_4	170	175	PF00397	0.793
DOC_WW_Pin1_4	216	221	PF00397	0.662
DOC_WW_Pin1_4	223	228	PF00397	0.685
DOC_WW_Pin1_4	283	288	PF00397	0.656
DOC_WW_Pin1_4	363	368	PF00397	0.700
DOC_WW_Pin1_4	5	10	PF00397	0.630
DOC_WW_Pin1_4	662	667	PF00397	0.744
LIG_14-3-3_CanoR_1	16	25	PF00244	0.369
LIG_14-3-3_CanoR_1	194	202	PF00244	0.717
LIG_14-3-3_CanoR_1	258	267	PF00244	0.471
LIG_14-3-3_CanoR_1	3	9	PF00244	0.472
LIG_14-3-3_CanoR_1	327	335	PF00244	0.473
LIG_14-3-3_CanoR_1	383	387	PF00244	0.678
LIG_14-3-3_CanoR_1	444	450	PF00244	0.516
LIG_14-3-3_CanoR_1	553	558	PF00244	0.538
LIG_14-3-3_CanoR_1	710	715	PF00244	0.729
LIG_14-3-3_CanoR_1	86	92	PF00244	0.381
LIG_Actin_WH2_2	243	260	PF00022	0.447
LIG_APCC_ABBA_1	47	52	PF00400	0.555
LIG_BIR_III_2	224	228	PF00653	0.398
LIG_BIR_III_4	241	245	PF00653	0.552
LIG_BIR_III_4	395	399	PF00653	0.558
LIG_BRCT_BRCA1_1	285	289	PF00533	0.525
LIG_BRCT_BRCA1_1	434	438	PF00533	0.478
LIG_deltaCOP1_diTrp_1	559	566	PF00928	0.400
LIG_DLG_GKlike_1	553	560	PF00625	0.540
LIG_eIF4E_1	44	50	PF01652	0.545
LIG_FHA_1	106	112	PF00498	0.712
LIG_FHA_1	17	23	PF00498	0.610
LIG_FHA_1	224	230	PF00498	0.547
LIG_FHA_1	259	265	PF00498	0.512
LIG_FHA_1	292	298	PF00498	0.530
LIG_FHA_1	328	334	PF00498	0.456
LIG_FHA_1	392	398	PF00498	0.488
LIG_FHA_1	414	420	PF00498	0.481
LIG_FHA_1	426	432	PF00498	0.345
LIG_FHA_1	478	484	PF00498	0.425
LIG_FHA_1	577	583	PF00498	0.384
LIG_FHA_1	700	706	PF00498	0.708
LIG_FHA_2	108	114	PF00498	0.741
LIG_FHA_2	156	162	PF00498	0.734
LIG_FHA_2	226	232	PF00498	0.601
LIG_FHA_2	364	370	PF00498	0.745
LIG_FHA_2	466	472	PF00498	0.567
LIG_FHA_2	523	529	PF00498	0.508
LIG_GBD_Chelix_1	402	410	PF00786	0.524
LIG_HP1_1	63	67	PF01393	0.488
LIG_Integrin_RGD_1	520	522	PF01839	0.399
LIG_LIR_Gen_1	317	328	PF02991	0.550
LIG_LIR_Gen_1	435	445	PF02991	0.498
LIG_LIR_Gen_1	522	530	PF02991	0.395
LIG_LIR_Gen_1	536	545	PF02991	0.420
LIG_LIR_Gen_1	69	77	PF02991	0.355
LIG_LIR_Nem_3	317	323	PF02991	0.525
LIG_LIR_Nem_3	408	414	PF02991	0.408
LIG_LIR_Nem_3	435	441	PF02991	0.532
LIG_LIR_Nem_3	460	465	PF02991	0.412
LIG_LIR_Nem_3	536	540	PF02991	0.396
LIG_LIR_Nem_3	69	74	PF02991	0.335
LIG_Pex14_2	438	442	PF04695	0.447
LIG_PTAP_UEV_1	619	624	PF05743	0.517
LIG_PTB_Apo_2	585	592	PF02174	0.447
LIG_Rb_LxCxE_1	611	621	PF01857	0.487
LIG_SH2_GRB2like	434	437	PF00017	0.477
LIG_SH2_NCK_1	44	48	PF00017	0.562
LIG_SH2_PTP2	71	74	PF00017	0.408
LIG_SH2_SRC	632	635	PF00017	0.561
LIG_SH2_STAP1	434	438	PF00017	0.478
LIG_SH2_STAP1	503	507	PF00017	0.406
LIG_SH2_STAP1	537	541	PF00017	0.545
LIG_SH2_STAT5	302	305	PF00017	0.410
LIG_SH2_STAT5	338	341	PF00017	0.405
LIG_SH2_STAT5	405	408	PF00017	0.523
LIG_SH2_STAT5	524	527	PF00017	0.392
LIG_SH2_STAT5	632	635	PF00017	0.639
LIG_SH2_STAT5	71	74	PF00017	0.408
LIG_SH2_STAT5	99	102	PF00017	0.717
LIG_SH3_3	385	391	PF00018	0.739
LIG_SH3_3	539	545	PF00018	0.351
LIG_SH3_3	617	623	PF00018	0.493
LIG_SH3_3	633	639	PF00018	0.552
LIG_SUMO_SIM_anti_2	260	268	PF11976	0.587
LIG_SUMO_SIM_anti_2	512	518	PF11976	0.511
LIG_SUMO_SIM_anti_2	538	544	PF11976	0.282
LIG_SUMO_SIM_par_1	538	544	PF11976	0.282
LIG_SUMO_SIM_par_1	63	69	PF11976	0.447
LIG_TRAF2_1	353	356	PF00917	0.488
LIG_TYR_ITIM	42	47	PF00017	0.558
LIG_UBA3_1	88	94	PF00899	0.484
MOD_CDK_SPxxK_3	223	230	PF00069	0.445
MOD_CK1_1	172	178	PF00069	0.730
MOD_CK1_1	20	26	PF00069	0.459
MOD_CK1_1	205	211	PF00069	0.683
MOD_CK1_1	283	289	PF00069	0.689
MOD_CK1_1	363	369	PF00069	0.572
MOD_CK1_1	389	395	PF00069	0.733
MOD_CK1_1	432	438	PF00069	0.474
MOD_CK1_1	699	705	PF00069	0.680
MOD_CK1_1	8	14	PF00069	0.697
MOD_CK2_1	107	113	PF00069	0.768
MOD_CK2_1	151	157	PF00069	0.538
MOD_CK2_1	170	176	PF00069	0.493
MOD_CK2_1	363	369	PF00069	0.759
MOD_CK2_1	465	471	PF00069	0.528
MOD_CK2_1	522	528	PF00069	0.508
MOD_CK2_1	611	617	PF00069	0.467
MOD_GlcNHglycan	112	117	PF01048	0.714
MOD_GlcNHglycan	134	137	PF01048	0.609
MOD_GlcNHglycan	187	190	PF01048	0.768
MOD_GlcNHglycan	207	210	PF01048	0.680
MOD_GlcNHglycan	717	720	PF01048	0.778
MOD_GlcNHglycan	78	81	PF01048	0.430
MOD_GSK3_1	103	110	PF00069	0.624
MOD_GSK3_1	112	119	PF00069	0.681
MOD_GSK3_1	124	131	PF00069	0.746
MOD_GSK3_1	132	139	PF00069	0.727
MOD_GSK3_1	151	158	PF00069	0.529
MOD_GSK3_1	16	23	PF00069	0.615
MOD_GSK3_1	168	175	PF00069	0.643
MOD_GSK3_1	198	205	PF00069	0.663
MOD_GSK3_1	382	389	PF00069	0.750
MOD_GSK3_1	4	11	PF00069	0.735
MOD_GSK3_1	425	432	PF00069	0.458
MOD_GSK3_1	477	484	PF00069	0.491
MOD_GSK3_1	683	690	PF00069	0.644
MOD_LATS_1	325	331	PF00433	0.365
MOD_N-GLC_1	103	108	PF02516	0.585
MOD_N-GLC_1	645	650	PF02516	0.680
MOD_N-GLC_2	118	120	PF02516	0.576
MOD_NEK2_1	202	207	PF00069	0.554
MOD_NEK2_1	243	248	PF00069	0.558
MOD_NEK2_1	361	366	PF00069	0.596
MOD_NEK2_1	478	483	PF00069	0.286
MOD_NEK2_2	116	121	PF00069	0.601
MOD_NEK2_2	503	508	PF00069	0.507
MOD_NEK2_2	687	692	PF00069	0.605
MOD_NEK2_2	727	732	PF00069	0.733
MOD_NEK2_2	87	92	PF00069	0.426
MOD_PIKK_1	163	169	PF00454	0.628
MOD_PIKK_1	639	645	PF00454	0.681
MOD_PK_1	429	435	PF00069	0.490
MOD_PKA_1	644	650	PF00069	0.442
MOD_PKA_1	710	716	PF00069	0.726
MOD_PKA_1	733	739	PF00069	0.626
MOD_PKA_2	132	138	PF00069	0.722
MOD_PKA_2	193	199	PF00069	0.769
MOD_PKA_2	257	263	PF00069	0.492
MOD_PKA_2	271	277	PF00069	0.629
MOD_PKA_2	382	388	PF00069	0.692
MOD_PKA_2	465	471	PF00069	0.596
MOD_PKA_2	644	650	PF00069	0.504
MOD_PKA_2	683	689	PF00069	0.800
MOD_PKA_2	710	716	PF00069	0.764
MOD_PKA_2	733	739	PF00069	0.787
MOD_PKB_1	551	559	PF00069	0.550
MOD_Plk_1	175	181	PF00069	0.669
MOD_Plk_1	355	361	PF00069	0.380
MOD_Plk_1	51	57	PF00069	0.543
MOD_Plk_1	687	693	PF00069	0.699
MOD_Plk_2-3	355	361	PF00069	0.380
MOD_Plk_4	243	249	PF00069	0.446
MOD_Plk_4	429	435	PF00069	0.521
MOD_Plk_4	478	484	PF00069	0.405
MOD_Plk_4	498	504	PF00069	0.538
MOD_Plk_4	51	57	PF00069	0.432
MOD_ProDKin_1	103	109	PF00069	0.718
MOD_ProDKin_1	124	130	PF00069	0.738
MOD_ProDKin_1	170	176	PF00069	0.791
MOD_ProDKin_1	216	222	PF00069	0.662
MOD_ProDKin_1	223	229	PF00069	0.672
MOD_ProDKin_1	283	289	PF00069	0.643
MOD_ProDKin_1	363	369	PF00069	0.700
MOD_ProDKin_1	5	11	PF00069	0.630
MOD_ProDKin_1	662	668	PF00069	0.741
MOD_SUMO_rev_2	467	475	PF00179	0.553
TRG_DiLeu_BaEn_1	262	267	PF01217	0.529
TRG_DiLeu_BaEn_1	311	316	PF01217	0.512
TRG_DiLeu_BaEn_2	68	74	PF01217	0.447
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.540
TRG_ENDOCYTIC_2	44	47	PF00928	0.556
TRG_ENDOCYTIC_2	524	527	PF00928	0.392
TRG_ENDOCYTIC_2	537	540	PF00928	0.361
TRG_ENDOCYTIC_2	71	74	PF00928	0.408
TRG_ER_diArg_1	232	235	PF00400	0.514
TRG_ER_diArg_1	442	444	PF00400	0.505
TRG_ER_diArg_1	551	554	PF00400	0.543
TRG_ER_diArg_1	710	712	PF00400	0.736
TRG_ER_diArg_1	84	86	PF00400	0.312
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6L1	Leptomonas seymouri	53%	89%
A0A1X0P7U7	Trypanosomatidae	34%	100%
A0A3R7KED7	Trypanosoma rangeli	33%	100%
A0A3S7XAR1	Leishmania donovani	86%	100%
A4HP42	Leishmania braziliensis	70%	100%
A4IDE9	Leishmania infantum	86%	100%
D0A326	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4Q1P6	Leishmania major	86%	100%
V5BPH3	Trypanosoma cruzi	32%	100%