LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9ASU9_LEIMU
TriTrypDb:
LmxM.36.1770
Length:
106

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

E9ASU9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASU9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 23 25 PF00675 0.657
CLV_NRD_NRD_1 3 5 PF00675 0.611
CLV_NRD_NRD_1 77 79 PF00675 0.386
CLV_PCSK_KEX2_1 23 25 PF00082 0.657
CLV_PCSK_KEX2_1 3 5 PF00082 0.622
CLV_PCSK_KEX2_1 77 79 PF00082 0.419
CLV_PCSK_SKI1_1 3 7 PF00082 0.667
DEG_MDM2_SWIB_1 48 56 PF02201 0.447
DEG_Nend_Nbox_1 1 3 PF02207 0.435
DOC_USP7_MATH_1 10 14 PF00917 0.421
DOC_USP7_MATH_1 19 23 PF00917 0.498
LIG_14-3-3_CanoR_1 12 21 PF00244 0.436
LIG_14-3-3_CanoR_1 23 32 PF00244 0.499
LIG_BIR_III_4 88 92 PF00653 0.605
LIG_deltaCOP1_diTrp_1 88 97 PF00928 0.653
LIG_LIR_Gen_1 25 34 PF02991 0.410
LIG_LIR_Gen_1 71 80 PF02991 0.608
LIG_LIR_Nem_3 25 29 PF02991 0.436
LIG_LIR_Nem_3 71 75 PF02991 0.590
LIG_LIR_Nem_3 95 101 PF02991 0.611
LIG_Pex14_2 48 52 PF04695 0.355
LIG_REV1ctd_RIR_1 95 101 PF16727 0.698
LIG_SH2_CRK 38 42 PF00017 0.362
LIG_SH2_STAT5 26 29 PF00017 0.419
LIG_SH2_STAT5 47 50 PF00017 0.335
LIG_SH2_STAT5 72 75 PF00017 0.588
LIG_TYR_ITIM 36 41 PF00017 0.431
LIG_TYR_ITIM 45 50 PF00017 0.342
LIG_WRC_WIRS_1 94 99 PF05994 0.715
MOD_CK1_1 13 19 PF00069 0.486
MOD_CK1_1 22 28 PF00069 0.479
MOD_CK1_1 60 66 PF00069 0.594
MOD_CK2_1 22 28 PF00069 0.478
MOD_GlcNHglycan 17 20 PF01048 0.689
MOD_GlcNHglycan 8 11 PF01048 0.677
MOD_GSK3_1 15 22 PF00069 0.491
MOD_GSK3_1 6 13 PF00069 0.481
MOD_NEK2_1 6 11 PF00069 0.404
MOD_PKA_2 22 28 PF00069 0.458
MOD_Plk_1 27 33 PF00069 0.495
MOD_Plk_4 93 99 PF00069 0.623
TRG_ENDOCYTIC_2 26 29 PF00928 0.415
TRG_ENDOCYTIC_2 38 41 PF00928 0.257
TRG_ENDOCYTIC_2 47 50 PF00928 0.418
TRG_ENDOCYTIC_2 72 75 PF00928 0.588
TRG_ER_diArg_1 2 4 PF00400 0.429
TRG_ER_diArg_1 76 78 PF00400 0.618
TRG_Pf-PMV_PEXEL_1 99 103 PF00026 0.511

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P701 Leptomonas seymouri 76% 100%
A0A1X0P839 Trypanosomatidae 57% 100%
A0A3Q8IK31 Leishmania donovani 95% 100%
A0A422NLR1 Trypanosoma rangeli 57% 100%
A4HP41 Leishmania braziliensis 90% 100%
A4IDE8 Leishmania infantum 95% 100%
D0A325 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
Q4Q1P7 Leishmania major 92% 100%
V5B4H5 Trypanosoma cruzi 57% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS