LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9ASU7_LEIMU
TriTrypDb:
LmxM.36.1750
Length:
544

Annotations

LeishMANIAdb annotations

A membrane-associated WD40 domain protein. Might be a receptor for some unidentified partner molecule.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 7, no: 4
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

E9ASU7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASU7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 217 221 PF00656 0.431
CLV_NRD_NRD_1 167 169 PF00675 0.627
CLV_NRD_NRD_1 409 411 PF00675 0.519
CLV_NRD_NRD_1 536 538 PF00675 0.426
CLV_PCSK_KEX2_1 409 411 PF00082 0.532
CLV_PCSK_KEX2_1 536 538 PF00082 0.426
CLV_PCSK_SKI1_1 190 194 PF00082 0.599
CLV_PCSK_SKI1_1 239 243 PF00082 0.498
CLV_PCSK_SKI1_1 398 402 PF00082 0.604
DEG_APCC_DBOX_1 119 127 PF00400 0.319
DEG_Kelch_Keap1_1 286 291 PF01344 0.404
DOC_ANK_TNKS_1 248 255 PF00023 0.428
DOC_ANK_TNKS_1 81 88 PF00023 0.340
DOC_CYCLIN_yCln2_LP_2 136 142 PF00134 0.309
DOC_MAPK_DCC_7 329 337 PF00069 0.410
DOC_MAPK_DCC_7 66 75 PF00069 0.421
DOC_MAPK_gen_1 4 12 PF00069 0.411
DOC_MAPK_gen_1 74 83 PF00069 0.314
DOC_MAPK_HePTP_8 63 75 PF00069 0.412
DOC_MAPK_MEF2A_6 329 337 PF00069 0.407
DOC_MAPK_MEF2A_6 66 75 PF00069 0.421
DOC_PP2B_LxvP_1 296 299 PF13499 0.373
DOC_PP2B_PxIxI_1 332 338 PF00149 0.384
DOC_PP4_FxxP_1 330 333 PF00568 0.323
DOC_SPAK_OSR1_1 329 333 PF12202 0.416
DOC_USP7_MATH_1 178 182 PF00917 0.550
DOC_USP7_MATH_1 219 223 PF00917 0.412
DOC_USP7_MATH_1 3 7 PF00917 0.723
DOC_USP7_MATH_1 94 98 PF00917 0.414
DOC_WW_Pin1_4 170 175 PF00397 0.438
DOC_WW_Pin1_4 241 246 PF00397 0.288
DOC_WW_Pin1_4 297 302 PF00397 0.287
DOC_WW_Pin1_4 381 386 PF00397 0.462
DOC_WW_Pin1_4 413 418 PF00397 0.299
DOC_WW_Pin1_4 426 431 PF00397 0.324
DOC_WW_Pin1_4 528 533 PF00397 0.725
LIG_14-3-3_CanoR_1 4 10 PF00244 0.699
LIG_14-3-3_CanoR_1 409 415 PF00244 0.313
LIG_Actin_WH2_2 49 67 PF00022 0.412
LIG_BIR_II_1 1 5 PF00653 0.552
LIG_BIR_III_4 520 524 PF00653 0.528
LIG_BRCT_BRCA1_1 221 225 PF00533 0.375
LIG_BRCT_BRCA1_1 257 261 PF00533 0.444
LIG_BRCT_BRCA1_1 79 83 PF00533 0.406
LIG_BRCT_BRCA1_1 98 102 PF00533 0.187
LIG_deltaCOP1_diTrp_1 48 53 PF00928 0.336
LIG_EH_1 132 136 PF12763 0.333
LIG_EH1_1 444 452 PF00400 0.380
LIG_FHA_1 171 177 PF00498 0.492
LIG_FHA_1 279 285 PF00498 0.385
LIG_FHA_1 35 41 PF00498 0.360
LIG_FHA_2 111 117 PF00498 0.414
LIG_FHA_2 123 129 PF00498 0.292
LIG_FHA_2 336 342 PF00498 0.291
LIG_FHA_2 447 453 PF00498 0.321
LIG_GBD_Chelix_1 483 491 PF00786 0.388
LIG_HCF-1_HBM_1 137 140 PF13415 0.304
LIG_Integrin_isoDGR_2 407 409 PF01839 0.557
LIG_IRF3_LxIS_1 238 244 PF10401 0.325
LIG_LIR_Apic_2 327 333 PF02991 0.328
LIG_LIR_Apic_2 412 417 PF02991 0.288
LIG_LIR_Gen_1 121 132 PF02991 0.448
LIG_LIR_Gen_1 268 277 PF02991 0.362
LIG_LIR_Gen_1 331 341 PF02991 0.350
LIG_LIR_Gen_1 52 60 PF02991 0.396
LIG_LIR_Gen_1 97 104 PF02991 0.359
LIG_LIR_Nem_3 121 127 PF02991 0.425
LIG_LIR_Nem_3 267 273 PF02991 0.327
LIG_LIR_Nem_3 331 337 PF02991 0.326
LIG_LIR_Nem_3 429 434 PF02991 0.385
LIG_LIR_Nem_3 494 498 PF02991 0.427
LIG_LIR_Nem_3 52 56 PF02991 0.383
LIG_LIR_Nem_3 97 101 PF02991 0.365
LIG_Pex14_1 229 233 PF04695 0.317
LIG_Pex14_2 185 189 PF04695 0.362
LIG_Pex14_2 225 229 PF04695 0.300
LIG_Pex14_2 431 435 PF04695 0.319
LIG_REV1ctd_RIR_1 432 439 PF16727 0.389
LIG_SH2_CRK 414 418 PF00017 0.324
LIG_SH2_CRK 471 475 PF00017 0.233
LIG_SH2_CRK 498 502 PF00017 0.616
LIG_SH2_CRK 98 102 PF00017 0.298
LIG_SH2_GRB2like 393 396 PF00017 0.320
LIG_SH2_NCK_1 414 418 PF00017 0.342
LIG_SH2_NCK_1 98 102 PF00017 0.298
LIG_SH2_PTP2 334 337 PF00017 0.350
LIG_SH2_SRC 334 337 PF00017 0.350
LIG_SH2_SRC 393 396 PF00017 0.320
LIG_SH2_STAP1 140 144 PF00017 0.303
LIG_SH2_STAP1 393 397 PF00017 0.418
LIG_SH2_STAP1 98 102 PF00017 0.298
LIG_SH2_STAT5 122 125 PF00017 0.326
LIG_SH2_STAT5 152 155 PF00017 0.389
LIG_SH2_STAT5 164 167 PF00017 0.352
LIG_SH2_STAT5 271 274 PF00017 0.267
LIG_SH2_STAT5 311 314 PF00017 0.520
LIG_SH2_STAT5 334 337 PF00017 0.297
LIG_SH2_STAT5 378 381 PF00017 0.283
LIG_SH2_STAT5 41 44 PF00017 0.301
LIG_SH2_STAT5 422 425 PF00017 0.465
LIG_SH2_STAT5 516 519 PF00017 0.697
LIG_SH2_STAT5 59 62 PF00017 0.252
LIG_SH2_STAT5 90 93 PF00017 0.281
LIG_SH3_1 437 443 PF00018 0.370
LIG_SH3_3 209 215 PF00018 0.463
LIG_SH3_3 242 248 PF00018 0.295
LIG_SH3_3 281 287 PF00018 0.369
LIG_SH3_3 295 301 PF00018 0.242
LIG_SH3_3 437 443 PF00018 0.315
LIG_SUMO_SIM_anti_2 399 405 PF11976 0.375
LIG_SUMO_SIM_par_1 399 405 PF11976 0.314
LIG_SUMO_SIM_par_1 488 494 PF11976 0.415
LIG_TRAF2_1 113 116 PF00917 0.467
LIG_TRAF2_1 207 210 PF00917 0.475
LIG_TRAF2_2 326 331 PF00917 0.300
LIG_TYR_ITIM 332 337 PF00017 0.441
LIG_TYR_ITIM 496 501 PF00017 0.524
LIG_UBA3_1 123 131 PF00899 0.361
LIG_WRC_WIRS_1 492 497 PF05994 0.449
LIG_WRC_WIRS_1 50 55 PF05994 0.440
MOD_CK1_1 2 8 PF00069 0.533
MOD_CK1_1 227 233 PF00069 0.423
MOD_CK1_1 234 240 PF00069 0.380
MOD_CK1_1 278 284 PF00069 0.486
MOD_CK1_1 413 419 PF00069 0.416
MOD_CK1_1 52 58 PF00069 0.476
MOD_CK2_1 110 116 PF00069 0.532
MOD_CK2_1 122 128 PF00069 0.351
MOD_CK2_1 204 210 PF00069 0.651
MOD_CK2_1 335 341 PF00069 0.390
MOD_CK2_1 446 452 PF00069 0.376
MOD_Cter_Amidation 407 410 PF01082 0.411
MOD_Cter_Amidation 534 537 PF01082 0.539
MOD_GlcNHglycan 104 107 PF01048 0.379
MOD_GlcNHglycan 206 209 PF01048 0.610
MOD_GlcNHglycan 220 224 PF01048 0.439
MOD_GlcNHglycan 257 260 PF01048 0.627
MOD_GlcNHglycan 288 291 PF01048 0.576
MOD_GlcNHglycan 320 323 PF01048 0.619
MOD_GlcNHglycan 389 392 PF01048 0.363
MOD_GlcNHglycan 394 398 PF01048 0.426
MOD_GlcNHglycan 423 426 PF01048 0.522
MOD_GlcNHglycan 518 524 PF01048 0.657
MOD_GlcNHglycan 526 529 PF01048 0.662
MOD_GlcNHglycan 92 95 PF01048 0.344
MOD_GSK3_1 151 158 PF00069 0.416
MOD_GSK3_1 224 231 PF00069 0.403
MOD_GSK3_1 261 268 PF00069 0.549
MOD_GSK3_1 30 37 PF00069 0.535
MOD_GSK3_1 314 321 PF00069 0.561
MOD_GSK3_1 409 416 PF00069 0.342
MOD_GSK3_1 417 424 PF00069 0.347
MOD_GSK3_1 524 531 PF00069 0.675
MOD_GSK3_1 90 97 PF00069 0.452
MOD_N-GLC_1 110 115 PF02516 0.489
MOD_N-GLC_1 116 121 PF02516 0.420
MOD_N-GLC_1 264 269 PF02516 0.517
MOD_NEK2_1 102 107 PF00069 0.326
MOD_NEK2_1 151 156 PF00069 0.423
MOD_NEK2_1 21 26 PF00069 0.649
MOD_NEK2_1 224 229 PF00069 0.369
MOD_NEK2_1 445 450 PF00069 0.358
MOD_NEK2_1 524 529 PF00069 0.697
MOD_NEK2_1 89 94 PF00069 0.360
MOD_NEK2_2 140 145 PF00069 0.405
MOD_NEK2_2 23 28 PF00069 0.384
MOD_PIKK_1 178 184 PF00454 0.650
MOD_PIKK_1 324 330 PF00454 0.469
MOD_PKA_1 409 415 PF00069 0.238
MOD_PKA_2 162 168 PF00069 0.523
MOD_PKA_2 3 9 PF00069 0.640
MOD_PKA_2 348 354 PF00069 0.550
MOD_PKA_2 409 415 PF00069 0.306
MOD_PKA_2 94 100 PF00069 0.462
MOD_Plk_1 140 146 PF00069 0.434
MOD_Plk_1 202 208 PF00069 0.652
MOD_Plk_1 264 270 PF00069 0.512
MOD_Plk_1 313 319 PF00069 0.544
MOD_Plk_4 265 271 PF00069 0.461
MOD_Plk_4 36 42 PF00069 0.509
MOD_Plk_4 446 452 PF00069 0.435
MOD_Plk_4 491 497 PF00069 0.318
MOD_ProDKin_1 170 176 PF00069 0.563
MOD_ProDKin_1 241 247 PF00069 0.345
MOD_ProDKin_1 297 303 PF00069 0.341
MOD_ProDKin_1 381 387 PF00069 0.584
MOD_ProDKin_1 413 419 PF00069 0.373
MOD_ProDKin_1 426 432 PF00069 0.395
MOD_ProDKin_1 528 534 PF00069 0.679
MOD_SUMO_rev_2 462 469 PF00179 0.605
TRG_DiLeu_BaLyEn_6 242 247 PF01217 0.415
TRG_DiLeu_BaLyEn_6 529 534 PF01217 0.679
TRG_ENDOCYTIC_2 270 273 PF00928 0.344
TRG_ENDOCYTIC_2 334 337 PF00928 0.370
TRG_ENDOCYTIC_2 471 474 PF00928 0.449
TRG_ENDOCYTIC_2 498 501 PF00928 0.526
TRG_ENDOCYTIC_2 98 101 PF00928 0.362
TRG_ER_diArg_1 409 411 PF00400 0.391
TRG_ER_diArg_1 513 516 PF00400 0.564
TRG_Pf-PMV_PEXEL_1 249 253 PF00026 0.397

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7G1 Leptomonas seymouri 68% 100%
A0A0S4ISR8 Bodo saltans 40% 100%
A0A1X0P7T5 Trypanosomatidae 53% 100%
A0A3Q8IKI2 Leishmania donovani 91% 100%
A0A3R7NQT8 Trypanosoma rangeli 49% 100%
A4HP39 Leishmania braziliensis 79% 100%
A4IDE6 Leishmania infantum 90% 99%
D0A322 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
Q4Q1P9 Leishmania major 90% 100%
V5BJV5 Trypanosoma cruzi 50% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS