Conserved oligomeric Golgi complex subunit 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASU5_LEIMU

TriTrypDb:

LmxM.36.1730

Length:

961

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005801	cis-Golgi network	5	12
GO:0016020	membrane	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005794	Golgi apparatus	5	1
GO:0017119	Golgi transport complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0099023	vesicle tethering complex	2	1

Expansion

Sequence features

E9ASU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASU5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0006891	intra-Golgi vesicle-mediated transport	6	1
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0048193	Golgi vesicle transport	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	390	394	PF00656	0.419
CLV_C14_Caspase3-7	423	427	PF00656	0.649
CLV_C14_Caspase3-7	609	613	PF00656	0.656
CLV_C14_Caspase3-7	673	677	PF00656	0.556
CLV_C14_Caspase3-7	695	699	PF00656	0.585
CLV_C14_Caspase3-7	73	77	PF00656	0.461
CLV_NRD_NRD_1	170	172	PF00675	0.328
CLV_NRD_NRD_1	353	355	PF00675	0.430
CLV_NRD_NRD_1	716	718	PF00675	0.544
CLV_PCSK_FUR_1	714	718	PF00082	0.698
CLV_PCSK_KEX2_1	353	355	PF00082	0.430
CLV_PCSK_KEX2_1	716	718	PF00082	0.591
CLV_PCSK_SKI1_1	103	107	PF00082	0.629
CLV_PCSK_SKI1_1	125	129	PF00082	0.617
CLV_PCSK_SKI1_1	171	175	PF00082	0.428
CLV_PCSK_SKI1_1	179	183	PF00082	0.344
CLV_PCSK_SKI1_1	232	236	PF00082	0.385
CLV_PCSK_SKI1_1	274	278	PF00082	0.442
CLV_PCSK_SKI1_1	479	483	PF00082	0.267
CLV_PCSK_SKI1_1	568	572	PF00082	0.386
CLV_PCSK_SKI1_1	678	682	PF00082	0.476
CLV_PCSK_SKI1_1	824	828	PF00082	0.675
CLV_Separin_Metazoa	176	180	PF03568	0.449
DEG_APCC_DBOX_1	102	110	PF00400	0.631
DEG_APCC_DBOX_1	453	461	PF00400	0.638
DEG_APCC_DBOX_1	517	525	PF00400	0.418
DOC_CKS1_1	835	840	PF01111	0.657
DOC_CKS1_1	877	882	PF01111	0.508
DOC_CYCLIN_RxL_1	713	724	PF00134	0.686
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.645
DOC_CYCLIN_yCln2_LP_2	35	41	PF00134	0.693
DOC_MAPK_FxFP_2	31	34	PF00069	0.687
DOC_MAPK_gen_1	100	108	PF00069	0.643
DOC_MAPK_gen_1	171	177	PF00069	0.430
DOC_MAPK_gen_1	232	241	PF00069	0.449
DOC_MAPK_gen_1	30	37	PF00069	0.656
DOC_MAPK_gen_1	725	735	PF00069	0.594
DOC_MAPK_MEF2A_6	111	118	PF00069	0.365
DOC_MAPK_MEF2A_6	18	27	PF00069	0.607
DOC_MAPK_MEF2A_6	235	243	PF00069	0.437
DOC_MAPK_MEF2A_6	399	406	PF00069	0.487
DOC_PP1_RVXF_1	566	572	PF00149	0.390
DOC_PP1_RVXF_1	627	634	PF00149	0.526
DOC_PP1_RVXF_1	779	786	PF00149	0.558
DOC_PP2B_LxvP_1	23	26	PF13499	0.638
DOC_PP2B_LxvP_1	35	38	PF13499	0.712
DOC_PP2B_LxvP_1	92	95	PF13499	0.424
DOC_PP4_FxxP_1	31	34	PF00568	0.655
DOC_PP4_FxxP_1	619	622	PF00568	0.533
DOC_PP4_FxxP_1	877	880	PF00568	0.686
DOC_USP7_MATH_1	285	289	PF00917	0.676
DOC_USP7_MATH_1	312	316	PF00917	0.534
DOC_USP7_MATH_1	419	423	PF00917	0.501
DOC_USP7_MATH_1	606	610	PF00917	0.697
DOC_USP7_MATH_1	69	73	PF00917	0.767
DOC_USP7_MATH_1	758	762	PF00917	0.587
DOC_USP7_MATH_1	80	84	PF00917	0.758
DOC_USP7_MATH_1	809	813	PF00917	0.571
DOC_USP7_MATH_1	86	90	PF00917	0.480
DOC_USP7_MATH_1	863	867	PF00917	0.729
DOC_USP7_MATH_1	886	890	PF00917	0.755
DOC_USP7_MATH_1	909	913	PF00917	0.551
DOC_USP7_MATH_1	950	954	PF00917	0.790
DOC_WW_Pin1_4	267	272	PF00397	0.527
DOC_WW_Pin1_4	443	448	PF00397	0.675
DOC_WW_Pin1_4	58	63	PF00397	0.721
DOC_WW_Pin1_4	582	587	PF00397	0.499
DOC_WW_Pin1_4	834	839	PF00397	0.647
DOC_WW_Pin1_4	870	875	PF00397	0.656
DOC_WW_Pin1_4	876	881	PF00397	0.555
LIG_14-3-3_CanoR_1	100	109	PF00244	0.627
LIG_14-3-3_CanoR_1	125	134	PF00244	0.566
LIG_14-3-3_CanoR_1	139	145	PF00244	0.328
LIG_14-3-3_CanoR_1	210	215	PF00244	0.378
LIG_14-3-3_CanoR_1	257	261	PF00244	0.398
LIG_14-3-3_CanoR_1	294	299	PF00244	0.668
LIG_14-3-3_CanoR_1	408	414	PF00244	0.507
LIG_14-3-3_CanoR_1	479	488	PF00244	0.236
LIG_14-3-3_CanoR_1	539	543	PF00244	0.524
LIG_14-3-3_CanoR_1	572	576	PF00244	0.369
LIG_14-3-3_CanoR_1	578	586	PF00244	0.416
LIG_14-3-3_CanoR_1	922	926	PF00244	0.763
LIG_14-3-3_CanoR_1	951	960	PF00244	0.752
LIG_Actin_WH2_2	345	361	PF00022	0.581
LIG_Actin_WH2_2	661	677	PF00022	0.535
LIG_AP2alpha_2	899	901	PF02296	0.463
LIG_APCC_ABBA_1	643	648	PF00400	0.390
LIG_BIR_II_1	1	5	PF00653	0.745
LIG_BRCT_BRCA1_1	207	211	PF00533	0.449
LIG_BRCT_BRCA1_1	269	273	PF00533	0.552
LIG_BRCT_BRCA1_1	676	680	PF00533	0.543
LIG_BRCT_BRCA1_1	911	915	PF00533	0.487
LIG_Clathr_ClatBox_1	521	525	PF01394	0.424
LIG_deltaCOP1_diTrp_1	632	640	PF00928	0.548
LIG_EH_1	200	204	PF12763	0.449
LIG_FHA_1	149	155	PF00498	0.331
LIG_FHA_1	275	281	PF00498	0.536
LIG_FHA_1	297	303	PF00498	0.512
LIG_FHA_1	317	323	PF00498	0.621
LIG_FHA_1	428	434	PF00498	0.404
LIG_FHA_1	480	486	PF00498	0.391
LIG_FHA_1	585	591	PF00498	0.548
LIG_FHA_1	749	755	PF00498	0.559
LIG_FHA_1	823	829	PF00498	0.631
LIG_FHA_1	835	841	PF00498	0.648
LIG_FHA_1	918	924	PF00498	0.780
LIG_FHA_2	188	194	PF00498	0.363
LIG_FHA_2	4	10	PF00498	0.734
LIG_FHA_2	40	46	PF00498	0.725
LIG_FHA_2	671	677	PF00498	0.592
LIG_FHA_2	700	706	PF00498	0.524
LIG_FHA_2	790	796	PF00498	0.571
LIG_FHA_2	952	958	PF00498	0.575
LIG_GBD_Chelix_1	469	477	PF00786	0.418
LIG_GBD_Chelix_1	553	561	PF00786	0.525
LIG_LIR_Apic_2	616	622	PF02991	0.581
LIG_LIR_Apic_2	632	636	PF02991	0.547
LIG_LIR_Apic_2	932	938	PF02991	0.574
LIG_LIR_Gen_1	208	219	PF02991	0.385
LIG_LIR_Gen_1	330	338	PF02991	0.514
LIG_LIR_Gen_1	347	356	PF02991	0.546
LIG_LIR_Gen_1	555	562	PF02991	0.462
LIG_LIR_Gen_1	637	647	PF02991	0.421
LIG_LIR_Gen_1	744	754	PF02991	0.551
LIG_LIR_Gen_1	898	909	PF02991	0.684
LIG_LIR_Nem_3	208	214	PF02991	0.385
LIG_LIR_Nem_3	330	334	PF02991	0.519
LIG_LIR_Nem_3	347	352	PF02991	0.555
LIG_LIR_Nem_3	412	417	PF02991	0.462
LIG_LIR_Nem_3	511	517	PF02991	0.404
LIG_LIR_Nem_3	632	638	PF02991	0.421
LIG_LIR_Nem_3	639	643	PF02991	0.388
LIG_LIR_Nem_3	744	750	PF02991	0.544
LIG_LIR_Nem_3	898	904	PF02991	0.687
LIG_LIR_Nem_3	912	918	PF02991	0.521
LIG_LYPXL_S_1	634	638	PF13949	0.386
LIG_LYPXL_yS_3	635	638	PF13949	0.393
LIG_MYND_1	503	507	PF01753	0.542
LIG_NRBOX	19	25	PF00104	0.609
LIG_NRBOX	795	801	PF00104	0.550
LIG_PCNA_PIPBox_1	779	788	PF02747	0.563
LIG_PCNA_yPIPBox_3	793	803	PF02747	0.606
LIG_PDZ_Class_3	956	961	PF00595	0.765
LIG_Rb_LxCxE_1	732	751	PF01857	0.557
LIG_SH2_CRK	935	939	PF00017	0.607
LIG_SH2_NCK_1	925	929	PF00017	0.710
LIG_SH2_SRC	416	419	PF00017	0.549
LIG_SH2_SRC	620	623	PF00017	0.413
LIG_SH2_SRC	74	77	PF00017	0.678
LIG_SH2_SRC	786	789	PF00017	0.567
LIG_SH2_STAP1	237	241	PF00017	0.328
LIG_SH2_STAP1	74	78	PF00017	0.466
LIG_SH2_STAT3	576	579	PF00017	0.529
LIG_SH2_STAT5	395	398	PF00017	0.503
LIG_SH2_STAT5	416	419	PF00017	0.516
LIG_SH2_STAT5	576	579	PF00017	0.476
LIG_SH2_STAT5	594	597	PF00017	0.508
LIG_SH2_STAT5	602	605	PF00017	0.567
LIG_SH2_STAT5	620	623	PF00017	0.413
LIG_SH2_STAT5	786	789	PF00017	0.543
LIG_SH3_3	399	405	PF00018	0.415
LIG_SH3_3	56	62	PF00018	0.767
LIG_SH3_3	747	753	PF00018	0.492
LIG_SH3_3	846	852	PF00018	0.799
LIG_SH3_3	913	919	PF00018	0.702
LIG_SUMO_SIM_anti_2	21	26	PF11976	0.604
LIG_SUMO_SIM_anti_2	484	489	PF11976	0.314
LIG_SUMO_SIM_anti_2	654	659	PF11976	0.500
LIG_TRAF2_1	10	13	PF00917	0.614
LIG_TRAF2_1	330	333	PF00917	0.470
LIG_UBA3_1	214	220	PF00899	0.475
MOD_CDK_SPxK_1	582	588	PF00069	0.518
MOD_CDK_SPxxK_3	267	274	PF00069	0.402
MOD_CK1_1	142	148	PF00069	0.441
MOD_CK1_1	259	265	PF00069	0.337
MOD_CK1_1	288	294	PF00069	0.645
MOD_CK1_1	296	302	PF00069	0.598
MOD_CK1_1	303	309	PF00069	0.661
MOD_CK1_1	313	319	PF00069	0.703
MOD_CK1_1	582	588	PF00069	0.533
MOD_CK1_1	641	647	PF00069	0.428
MOD_CK1_1	670	676	PF00069	0.579
MOD_CK1_1	724	730	PF00069	0.502
MOD_CK1_1	866	872	PF00069	0.776
MOD_CK1_1	910	916	PF00069	0.784
MOD_CK1_1	917	923	PF00069	0.762
MOD_CK2_1	327	333	PF00069	0.512
MOD_CK2_1	363	369	PF00069	0.537
MOD_CK2_1	39	45	PF00069	0.665
MOD_CK2_1	391	397	PF00069	0.501
MOD_CK2_1	505	511	PF00069	0.454
MOD_CK2_1	699	705	PF00069	0.517
MOD_CK2_1	720	726	PF00069	0.511
MOD_CK2_1	758	764	PF00069	0.595
MOD_CK2_1	838	844	PF00069	0.786
MOD_GlcNHglycan	103	106	PF01048	0.550
MOD_GlcNHglycan	144	147	PF01048	0.400
MOD_GlcNHglycan	165	168	PF01048	0.348
MOD_GlcNHglycan	207	210	PF01048	0.358
MOD_GlcNHglycan	232	235	PF01048	0.413
MOD_GlcNHglycan	248	251	PF01048	0.266
MOD_GlcNHglycan	281	286	PF01048	0.666
MOD_GlcNHglycan	299	302	PF01048	0.517
MOD_GlcNHglycan	312	315	PF01048	0.652
MOD_GlcNHglycan	344	347	PF01048	0.557
MOD_GlcNHglycan	365	368	PF01048	0.608
MOD_GlcNHglycan	457	460	PF01048	0.728
MOD_GlcNHglycan	754	757	PF01048	0.516
MOD_GlcNHglycan	76	79	PF01048	0.734
MOD_GlcNHglycan	831	834	PF01048	0.807
MOD_GlcNHglycan	865	868	PF01048	0.801
MOD_GlcNHglycan	88	91	PF01048	0.763
MOD_GlcNHglycan	888	891	PF01048	0.720
MOD_GlcNHglycan	909	912	PF01048	0.752
MOD_GlcNHglycan	92	95	PF01048	0.696
MOD_GlcNHglycan	926	929	PF01048	0.763
MOD_GSK3_1	155	162	PF00069	0.328
MOD_GSK3_1	205	212	PF00069	0.344
MOD_GSK3_1	255	262	PF00069	0.361
MOD_GSK3_1	281	288	PF00069	0.636
MOD_GSK3_1	293	300	PF00069	0.592
MOD_GSK3_1	312	319	PF00069	0.657
MOD_GSK3_1	4	11	PF00069	0.576
MOD_GSK3_1	443	450	PF00069	0.734
MOD_GSK3_1	47	54	PF00069	0.486
MOD_GSK3_1	548	555	PF00069	0.525
MOD_GSK3_1	596	603	PF00069	0.494
MOD_GSK3_1	634	641	PF00069	0.435
MOD_GSK3_1	670	677	PF00069	0.571
MOD_GSK3_1	70	77	PF00069	0.609
MOD_GSK3_1	720	727	PF00069	0.525
MOD_GSK3_1	736	743	PF00069	0.435
MOD_GSK3_1	748	755	PF00069	0.389
MOD_GSK3_1	834	841	PF00069	0.658
MOD_GSK3_1	86	93	PF00069	0.707
MOD_GSK3_1	866	873	PF00069	0.600
MOD_GSK3_1	886	893	PF00069	0.670
MOD_GSK3_1	910	917	PF00069	0.689
MOD_GSK3_1	951	958	PF00069	0.783
MOD_N-GLC_1	163	168	PF02516	0.328
MOD_N-GLC_1	699	704	PF02516	0.511
MOD_NEK2_1	101	106	PF00069	0.687
MOD_NEK2_1	224	229	PF00069	0.404
MOD_NEK2_1	363	368	PF00069	0.579
MOD_NEK2_1	477	482	PF00069	0.485
MOD_NEK2_1	516	521	PF00069	0.519
MOD_NEK2_1	543	548	PF00069	0.585
MOD_NEK2_1	571	576	PF00069	0.375
MOD_NEK2_1	577	582	PF00069	0.400
MOD_NEK2_1	638	643	PF00069	0.441
MOD_NEK2_1	674	679	PF00069	0.511
MOD_NEK2_1	690	695	PF00069	0.484
MOD_NEK2_1	720	725	PF00069	0.637
MOD_NEK2_2	348	353	PF00069	0.583
MOD_PIKK_1	125	131	PF00454	0.602
MOD_PIKK_1	274	280	PF00454	0.602
MOD_PIKK_1	548	554	PF00454	0.484
MOD_PIKK_1	562	568	PF00454	0.352
MOD_PIKK_1	613	619	PF00454	0.510
MOD_PIKK_1	748	754	PF00454	0.556
MOD_PIKK_1	789	795	PF00454	0.616
MOD_PKA_2	140	146	PF00069	0.457
MOD_PKA_2	148	154	PF00069	0.436
MOD_PKA_2	209	215	PF00069	0.378
MOD_PKA_2	256	262	PF00069	0.437
MOD_PKA_2	293	299	PF00069	0.715
MOD_PKA_2	538	544	PF00069	0.523
MOD_PKA_2	571	577	PF00069	0.376
MOD_PKA_2	674	680	PF00069	0.490
MOD_PKA_2	724	730	PF00069	0.501
MOD_PKA_2	736	742	PF00069	0.415
MOD_PKA_2	921	927	PF00069	0.790
MOD_PKA_2	950	956	PF00069	0.715
MOD_PKB_1	949	957	PF00069	0.699
MOD_Plk_1	163	169	PF00069	0.344
MOD_Plk_1	281	287	PF00069	0.680
MOD_Plk_1	288	294	PF00069	0.751
MOD_Plk_1	638	644	PF00069	0.428
MOD_Plk_1	699	705	PF00069	0.533
MOD_Plk_1	809	815	PF00069	0.607
MOD_Plk_1	843	849	PF00069	0.576
MOD_Plk_4	210	216	PF00069	0.340
MOD_Plk_4	288	294	PF00069	0.680
MOD_Plk_4	409	415	PF00069	0.503
MOD_Plk_4	538	544	PF00069	0.611
MOD_Plk_4	571	577	PF00069	0.379
MOD_Plk_4	589	595	PF00069	0.493
MOD_Plk_4	930	936	PF00069	0.662
MOD_ProDKin_1	267	273	PF00069	0.524
MOD_ProDKin_1	443	449	PF00069	0.673
MOD_ProDKin_1	58	64	PF00069	0.725
MOD_ProDKin_1	582	588	PF00069	0.504
MOD_ProDKin_1	834	840	PF00069	0.652
MOD_ProDKin_1	870	876	PF00069	0.652
MOD_SUMO_for_1	173	176	PF00179	0.413
MOD_SUMO_for_1	826	829	PF00179	0.579
MOD_SUMO_rev_2	422	430	PF00179	0.658
MOD_SUMO_rev_2	670	680	PF00179	0.550
TRG_DiLeu_BaEn_1	12	17	PF01217	0.666
TRG_DiLeu_BaLyEn_6	402	407	PF01217	0.377
TRG_DiLeu_BaLyEn_6	517	522	PF01217	0.452
TRG_ENDOCYTIC_2	134	137	PF00928	0.449
TRG_ENDOCYTIC_2	514	517	PF00928	0.386
TRG_ENDOCYTIC_2	635	638	PF00928	0.388
TRG_ER_diArg_1	352	354	PF00400	0.404
TRG_ER_diArg_1	517	520	PF00400	0.452
TRG_ER_diArg_1	713	716	PF00400	0.574
TRG_ER_diArg_1	949	952	PF00400	0.739
TRG_NES_CRM1_1	333	347	PF08389	0.458
TRG_NES_CRM1_1	484	496	PF08389	0.328
TRG_NLS_MonoExtC_3	170	176	PF00514	0.328
TRG_Pf-PMV_PEXEL_1	479	484	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	520	525	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	560	564	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	716	721	PF00026	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I905	Leptomonas seymouri	61%	100%
A0A0S4J053	Bodo saltans	29%	100%
A0A1X0P8U2	Trypanosomatidae	35%	100%
A0A3R7KGY7	Trypanosoma rangeli	35%	100%
A0A3S7XAQ6	Leishmania donovani	90%	100%
A4HP37	Leishmania braziliensis	79%	100%
A4IDE4	Leishmania infantum	90%	100%
D0A320	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4Q1Q1	Leishmania major	88%	99%
V5DKX4	Trypanosoma cruzi	35%	100%