Putative phosphatidylinositolN-acetylglucosaminyltransfe ra sesubunit c

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositolN-acetylglucosaminyltransfe ra sesubunit c, putative

Species:

Leishmania mexicana

UniProt:

E9ASU3_LEIMU

TriTrypDb:

LmxM.36.1710

Length:

386

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	3	1
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0016020	membrane	2	12
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1

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Expansion

Sequence features

E9ASU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASU3

Function

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Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	12
GO:0006505	GPI anchor metabolic process	6	12
GO:0006506	GPI anchor biosynthetic process	6	12
GO:0006629	lipid metabolic process	3	12
GO:0006643	membrane lipid metabolic process	4	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006661	phosphatidylinositol biosynthetic process	6	12
GO:0006664	glycolipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008194	UDP-glycosyltransferase activity	4	7
GO:0008375	acetylglucosaminyltransferase activity	5	7
GO:0016740	transferase activity	2	11
GO:0016757	glycosyltransferase activity	3	11
GO:0016758	hexosyltransferase activity	4	7
GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	6	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	40	42	PF00675	0.518
CLV_NRD_NRD_1	46	48	PF00675	0.457
CLV_NRD_NRD_1	71	73	PF00675	0.263
CLV_PCSK_KEX2_1	40	42	PF00082	0.518
CLV_PCSK_KEX2_1	46	48	PF00082	0.457
CLV_PCSK_KEX2_1	71	73	PF00082	0.252
CLV_PCSK_SKI1_1	190	194	PF00082	0.300
CLV_PCSK_SKI1_1	61	65	PF00082	0.470
CLV_PCSK_SKI1_1	71	75	PF00082	0.214
CLV_PCSK_SKI1_1	98	102	PF00082	0.335

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE33	Leptomonas seymouri	71%	97%
A0A0S4IX12	Bodo saltans	46%	100%
A0A1X0P843	Trypanosomatidae	52%	100%
A0A3R7MPS8	Trypanosoma rangeli	50%	100%
A0A3S7XAV4	Leishmania donovani	94%	100%
A4HP35	Leishmania braziliensis	84%	100%
A4IDE2	Leishmania infantum	94%	100%
D0A318	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
O59802	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q3ZBX1	Bos taurus	30%	100%

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