Mitochondrial inner membrane protease ATP23

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Peptidase M76 family, putative

Species:

Leishmania mexicana

UniProt:

E9ASU1_LEIMU

TriTrypDb:

LmxM.36.1690

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0019898	extrinsic component of membrane	2	1
GO:0031312	extrinsic component of organelle membrane	3	1
GO:0031314	extrinsic component of mitochondrial inner membrane	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASU1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016485	protein processing	5	1
GO:0022607	cellular component assembly	4	1
GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly	8	1
GO:0034982	mitochondrial protein processing	6	1
GO:0043461	proton-transporting ATP synthase complex assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0051604	protein maturation	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0070071	proton-transporting two-sector ATPase complex assembly	6	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004175	endopeptidase activity	4	12
GO:0004222	metalloendopeptidase activity	5	12
GO:0005488	binding	1	12
GO:0008233	peptidase activity	3	12
GO:0008237	metallopeptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.400
CLV_C14_Caspase3-7	29	33	PF00656	0.562
CLV_C14_Caspase3-7	295	299	PF00656	0.551
CLV_NRD_NRD_1	137	139	PF00675	0.155
CLV_NRD_NRD_1	235	237	PF00675	0.352
CLV_NRD_NRD_1	252	254	PF00675	0.173
CLV_PCSK_KEX2_1	251	253	PF00082	0.362
CLV_PCSK_SKI1_1	68	72	PF00082	0.464
DOC_MAPK_gen_1	248	258	PF00069	0.324
DOC_MAPK_gen_1	72	80	PF00069	0.245
DOC_PP4_FxxP_1	286	289	PF00568	0.391
DOC_USP7_MATH_1	147	151	PF00917	0.419
DOC_USP7_MATH_1	159	163	PF00917	0.385
DOC_USP7_MATH_1	292	296	PF00917	0.493
DOC_WW_Pin1_4	160	165	PF00397	0.425
DOC_WW_Pin1_4	166	171	PF00397	0.440
DOC_WW_Pin1_4	33	38	PF00397	0.397
DOC_WW_Pin1_4	92	97	PF00397	0.407
LIG_14-3-3_CanoR_1	265	272	PF00244	0.314
LIG_14-3-3_CanoR_1	50	56	PF00244	0.408
LIG_BIR_III_2	15	19	PF00653	0.515
LIG_BIR_III_4	202	206	PF00653	0.315
LIG_FHA_2	150	156	PF00498	0.369
LIG_FHA_2	27	33	PF00498	0.463
LIG_LIR_Apic_2	284	289	PF02991	0.300
LIG_LIR_Nem_3	281	286	PF02991	0.296
LIG_LIR_Nem_3	97	103	PF02991	0.447
LIG_MYND_3	182	186	PF01753	0.447
LIG_NRBOX	172	178	PF00104	0.422
LIG_PDZ_Class_2	303	308	PF00595	0.525
LIG_SH2_STAT3	57	60	PF00017	0.447
LIG_SH2_STAT5	47	50	PF00017	0.345
LIG_SH3_1	76	82	PF00018	0.420
LIG_SH3_3	76	82	PF00018	0.387
LIG_SUMO_SIM_anti_2	116	122	PF11976	0.315
LIG_SUMO_SIM_par_1	116	122	PF11976	0.315
LIG_TRAF2_1	61	64	PF00917	0.315
MOD_CDK_SPxK_1	92	98	PF00069	0.420
MOD_CK1_1	107	113	PF00069	0.330
MOD_CK1_1	11	17	PF00069	0.601
MOD_CK1_1	149	155	PF00069	0.414
MOD_CK1_1	162	168	PF00069	0.416
MOD_CK1_1	3	9	PF00069	0.699
MOD_CK1_1	33	39	PF00069	0.490
MOD_CK2_1	278	284	PF00069	0.300
MOD_CK2_1	58	64	PF00069	0.315
MOD_GlcNHglycan	106	109	PF01048	0.388
MOD_GlcNHglycan	149	152	PF01048	0.241
MOD_GlcNHglycan	164	167	PF01048	0.167
MOD_GlcNHglycan	225	228	PF01048	0.293
MOD_GSK3_1	146	153	PF00069	0.397
MOD_GSK3_1	160	167	PF00069	0.352
MOD_GSK3_1	2	9	PF00069	0.702
MOD_GSK3_1	26	33	PF00069	0.584
MOD_GSK3_1	292	299	PF00069	0.593
MOD_N-GLC_1	302	307	PF02516	0.584
MOD_NEK2_1	104	109	PF00069	0.440
MOD_NEK2_1	127	132	PF00069	0.447
MOD_NEK2_1	177	182	PF00069	0.460
MOD_NEK2_1	4	9	PF00069	0.704
MOD_NEK2_2	271	276	PF00069	0.447
MOD_NEK2_2	302	307	PF00069	0.556
MOD_NMyristoyl	1	7	PF02799	0.652
MOD_PIKK_1	168	174	PF00454	0.397
MOD_PIKK_1	177	183	PF00454	0.426
MOD_PIKK_1	296	302	PF00454	0.581
MOD_PKA_2	223	229	PF00069	0.293
MOD_Plk_4	271	277	PF00069	0.391
MOD_Plk_4	30	36	PF00069	0.527
MOD_ProDKin_1	160	166	PF00069	0.425
MOD_ProDKin_1	33	39	PF00069	0.397
MOD_ProDKin_1	92	98	PF00069	0.407
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.447
TRG_ENDOCYTIC_2	283	286	PF00928	0.300
TRG_ER_diArg_1	250	253	PF00400	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ07	Leptomonas seymouri	70%	100%
A0A0S4IYE0	Bodo saltans	38%	100%
A0A1X0P8Q9	Trypanosomatidae	50%	100%
A0A3Q8IJ83	Leishmania donovani	93%	99%
A0A422MWT3	Trypanosoma rangeli	51%	100%
A4HP33	Leishmania braziliensis	81%	100%
A4IDE0	Leishmania infantum	93%	99%
D0A316	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
Q4Q1Q5	Leishmania major	92%	100%
Q6CTY3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	31%	100%
Q75EL5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	33%	100%
Q9Y6H3	Homo sapiens	29%	100%
V5B4E2	Trypanosoma cruzi	51%	100%