Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASU0_LEIMU

TriTrypDb:

LmxM.36.1680

Length:

782

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASU0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.672
CLV_C14_Caspase3-7	624	628	PF00656	0.502
CLV_C14_Caspase3-7	639	643	PF00656	0.502
CLV_NRD_NRD_1	126	128	PF00675	0.519
CLV_NRD_NRD_1	173	175	PF00675	0.700
CLV_NRD_NRD_1	178	180	PF00675	0.533
CLV_NRD_NRD_1	205	207	PF00675	0.560
CLV_NRD_NRD_1	347	349	PF00675	0.727
CLV_NRD_NRD_1	41	43	PF00675	0.666
CLV_NRD_NRD_1	48	50	PF00675	0.639
CLV_NRD_NRD_1	489	491	PF00675	0.516
CLV_NRD_NRD_1	56	58	PF00675	0.542
CLV_NRD_NRD_1	604	606	PF00675	0.646
CLV_NRD_NRD_1	634	636	PF00675	0.626
CLV_NRD_NRD_1	663	665	PF00675	0.644
CLV_NRD_NRD_1	688	690	PF00675	0.689
CLV_NRD_NRD_1	70	72	PF00675	0.538
CLV_PCSK_FUR_1	661	665	PF00082	0.748
CLV_PCSK_KEX2_1	126	128	PF00082	0.519
CLV_PCSK_KEX2_1	173	175	PF00082	0.700
CLV_PCSK_KEX2_1	178	180	PF00082	0.533
CLV_PCSK_KEX2_1	205	207	PF00082	0.560
CLV_PCSK_KEX2_1	347	349	PF00082	0.769
CLV_PCSK_KEX2_1	41	43	PF00082	0.626
CLV_PCSK_KEX2_1	489	491	PF00082	0.516
CLV_PCSK_KEX2_1	604	606	PF00082	0.646
CLV_PCSK_KEX2_1	663	665	PF00082	0.641
CLV_PCSK_KEX2_1	688	690	PF00082	0.697
CLV_PCSK_KEX2_1	70	72	PF00082	0.589
CLV_PCSK_PC7_1	174	180	PF00082	0.583
CLV_PCSK_SKI1_1	126	130	PF00082	0.530
CLV_PCSK_SKI1_1	162	166	PF00082	0.646
CLV_PCSK_SKI1_1	174	178	PF00082	0.527
CLV_PCSK_SKI1_1	268	272	PF00082	0.525
CLV_PCSK_SKI1_1	314	318	PF00082	0.551
CLV_PCSK_SKI1_1	323	327	PF00082	0.545
CLV_PCSK_SKI1_1	536	540	PF00082	0.731
CLV_PCSK_SKI1_1	741	745	PF00082	0.685
DEG_SPOP_SBC_1	228	232	PF00917	0.506
DEG_SPOP_SBC_1	722	726	PF00917	0.735
DOC_CKS1_1	10	15	PF01111	0.484
DOC_CYCLIN_RxL_1	738	748	PF00134	0.607
DOC_CYCLIN_yCln2_LP_2	653	659	PF00134	0.507
DOC_MAPK_DCC_7	7	16	PF00069	0.647
DOC_MAPK_gen_1	178	184	PF00069	0.543
DOC_MAPK_RevD_3	112	127	PF00069	0.524
DOC_PP2B_LxvP_1	364	367	PF13499	0.711
DOC_PP2B_LxvP_1	539	542	PF13499	0.679
DOC_PP4_FxxP_1	555	558	PF00568	0.599
DOC_USP7_MATH_1	200	204	PF00917	0.603
DOC_USP7_MATH_1	228	232	PF00917	0.635
DOC_USP7_MATH_1	233	237	PF00917	0.566
DOC_USP7_MATH_1	286	290	PF00917	0.705
DOC_USP7_MATH_1	391	395	PF00917	0.570
DOC_USP7_MATH_1	502	506	PF00917	0.635
DOC_USP7_MATH_1	532	536	PF00917	0.699
DOC_USP7_MATH_1	691	695	PF00917	0.586
DOC_USP7_MATH_1	703	707	PF00917	0.650
DOC_USP7_MATH_1	716	720	PF00917	0.629
DOC_USP7_MATH_1	775	779	PF00917	0.654
DOC_WW_Pin1_4	229	234	PF00397	0.592
DOC_WW_Pin1_4	248	253	PF00397	0.776
DOC_WW_Pin1_4	255	260	PF00397	0.720
DOC_WW_Pin1_4	272	277	PF00397	0.552
DOC_WW_Pin1_4	315	320	PF00397	0.551
DOC_WW_Pin1_4	334	339	PF00397	0.562
DOC_WW_Pin1_4	521	526	PF00397	0.644
DOC_WW_Pin1_4	527	532	PF00397	0.635
DOC_WW_Pin1_4	542	547	PF00397	0.546
DOC_WW_Pin1_4	652	657	PF00397	0.648
DOC_WW_Pin1_4	682	687	PF00397	0.602
DOC_WW_Pin1_4	714	719	PF00397	0.675
DOC_WW_Pin1_4	9	14	PF00397	0.481
LIG_14-3-3_CanoR_1	115	123	PF00244	0.544
LIG_14-3-3_CanoR_1	410	414	PF00244	0.723
LIG_14-3-3_CanoR_1	420	425	PF00244	0.528
LIG_14-3-3_CanoR_1	536	542	PF00244	0.536
LIG_14-3-3_CanoR_1	604	613	PF00244	0.682
LIG_14-3-3_CanoR_1	768	773	PF00244	0.480
LIG_Actin_WH2_2	149	164	PF00022	0.598
LIG_BIR_III_2	30	34	PF00653	0.689
LIG_BIR_III_4	352	356	PF00653	0.658
LIG_BRCT_BRCA1_1	336	340	PF00533	0.702
LIG_BRCT_BRCA1_1	91	95	PF00533	0.581
LIG_CaM_IQ_9	107	123	PF13499	0.504
LIG_CaM_IQ_9	62	78	PF13499	0.594
LIG_CaM_NSCaTE_8	617	624	PF13499	0.609
LIG_CtBP_PxDLS_1	13	17	PF00389	0.545
LIG_eIF4E_1	210	216	PF01652	0.576
LIG_eIF4E_1	647	653	PF01652	0.515
LIG_FHA_1	133	139	PF00498	0.577
LIG_FHA_1	218	224	PF00498	0.529
LIG_FHA_1	261	267	PF00498	0.730
LIG_FHA_1	545	551	PF00498	0.683
LIG_FHA_1	558	564	PF00498	0.552
LIG_FHA_1	647	653	PF00498	0.515
LIG_FHA_1	702	708	PF00498	0.614
LIG_FHA_1	73	79	PF00498	0.595
LIG_FHA_1	749	755	PF00498	0.527
LIG_FHA_2	293	299	PF00498	0.531
LIG_FHA_2	622	628	PF00498	0.634
LIG_FHA_2	637	643	PF00498	0.525
LIG_Integrin_RGD_1	245	247	PF01839	0.700
LIG_Integrin_RGD_1	456	458	PF01839	0.664
LIG_LIR_Apic_2	553	558	PF02991	0.606
LIG_LIR_Gen_1	706	716	PF02991	0.511
LIG_LIR_Gen_1	734	744	PF02991	0.516
LIG_LIR_Gen_1	84	93	PF02991	0.520
LIG_LIR_Nem_3	312	316	PF02991	0.585
LIG_LIR_Nem_3	320	325	PF02991	0.581
LIG_LIR_Nem_3	706	711	PF02991	0.511
LIG_LIR_Nem_3	734	739	PF02991	0.475
LIG_LIR_Nem_3	84	89	PF02991	0.556
LIG_LIR_Nem_3	92	98	PF02991	0.603
LIG_PTB_Apo_2	443	450	PF02174	0.515
LIG_SH2_CRK	313	317	PF00017	0.735
LIG_SH2_CRK	451	455	PF00017	0.523
LIG_SH2_CRK	86	90	PF00017	0.526
LIG_SH2_GRB2like	747	750	PF00017	0.620
LIG_SH2_NCK_1	351	355	PF00017	0.495
LIG_SH2_NCK_1	388	392	PF00017	0.550
LIG_SH2_STAP1	388	392	PF00017	0.550
LIG_SH2_STAT3	677	680	PF00017	0.681
LIG_SH2_STAT5	210	213	PF00017	0.530
LIG_SH2_STAT5	4	7	PF00017	0.637
LIG_SH2_STAT5	677	680	PF00017	0.681
LIG_SH2_STAT5	747	750	PF00017	0.682
LIG_SH3_1	7	13	PF00018	0.644
LIG_SH3_2	656	661	PF14604	0.614
LIG_SH3_3	246	252	PF00018	0.697
LIG_SH3_3	273	279	PF00018	0.571
LIG_SH3_3	332	338	PF00018	0.552
LIG_SH3_3	648	654	PF00018	0.628
LIG_SH3_3	669	675	PF00018	0.701
LIG_SH3_3	7	13	PF00018	0.696
LIG_SUMO_SIM_anti_2	762	771	PF11976	0.632
LIG_SUMO_SIM_par_1	12	17	PF11976	0.618
LIG_SUMO_SIM_par_1	507	513	PF11976	0.674
LIG_TRAF2_1	318	321	PF00917	0.653
LIG_UBA3_1	324	329	PF00899	0.609
MOD_CDC14_SPxK_1	685	688	PF00782	0.520
MOD_CDK_SPxK_1	682	688	PF00069	0.519
MOD_CDK_SPxxK_3	521	528	PF00069	0.508
MOD_CDK_SPxxK_3	682	689	PF00069	0.522
MOD_CK1_1	217	223	PF00069	0.609
MOD_CK1_1	232	238	PF00069	0.613
MOD_CK1_1	258	264	PF00069	0.767
MOD_CK1_1	394	400	PF00069	0.640
MOD_CK1_1	462	468	PF00069	0.629
MOD_CK1_1	537	543	PF00069	0.804
MOD_CK1_1	583	589	PF00069	0.657
MOD_CK1_1	717	723	PF00069	0.659
MOD_CK1_1	84	90	PF00069	0.686
MOD_CK2_1	315	321	PF00069	0.663
MOD_CK2_1	419	425	PF00069	0.637
MOD_CK2_1	606	612	PF00069	0.621
MOD_CK2_1	771	777	PF00069	0.727
MOD_Cter_Amidation	345	348	PF01082	0.670
MOD_Cter_Amidation	633	636	PF01082	0.571
MOD_GlcNHglycan	18	21	PF01048	0.689
MOD_GlcNHglycan	216	219	PF01048	0.516
MOD_GlcNHglycan	22	25	PF01048	0.555
MOD_GlcNHglycan	235	238	PF01048	0.612
MOD_GlcNHglycan	260	263	PF01048	0.775
MOD_GlcNHglycan	288	291	PF01048	0.605
MOD_GlcNHglycan	341	344	PF01048	0.633
MOD_GlcNHglycan	393	396	PF01048	0.578
MOD_GlcNHglycan	467	470	PF01048	0.550
MOD_GlcNHglycan	498	501	PF01048	0.606
MOD_GlcNHglycan	591	594	PF01048	0.574
MOD_GlcNHglycan	608	611	PF01048	0.557
MOD_GlcNHglycan	639	642	PF01048	0.527
MOD_GlcNHglycan	692	696	PF01048	0.668
MOD_GlcNHglycan	773	776	PF01048	0.667
MOD_GSK3_1	16	23	PF00069	0.708
MOD_GSK3_1	224	231	PF00069	0.663
MOD_GSK3_1	254	261	PF00069	0.636
MOD_GSK3_1	405	412	PF00069	0.672
MOD_GSK3_1	459	466	PF00069	0.635
MOD_GSK3_1	5	12	PF00069	0.579
MOD_GSK3_1	523	530	PF00069	0.670
MOD_GSK3_1	567	574	PF00069	0.631
MOD_GSK3_1	577	584	PF00069	0.585
MOD_GSK3_1	585	592	PF00069	0.571
MOD_GSK3_1	714	721	PF00069	0.748
MOD_GSK3_1	748	755	PF00069	0.463
MOD_GSK3_1	767	774	PF00069	0.618
MOD_GSK3_1	81	88	PF00069	0.690
MOD_N-GLC_1	192	197	PF02516	0.398
MOD_N-GLC_1	20	25	PF02516	0.705
MOD_N-GLC_1	748	753	PF02516	0.467
MOD_N-GLC_1	755	760	PF02516	0.435
MOD_NEK2_1	116	121	PF00069	0.602
MOD_NEK2_1	131	136	PF00069	0.427
MOD_NEK2_1	16	21	PF00069	0.698
MOD_NEK2_1	192	197	PF00069	0.398
MOD_NEK2_1	328	333	PF00069	0.549
MOD_NEK2_1	339	344	PF00069	0.611
MOD_NEK2_1	34	39	PF00069	0.555
MOD_NEK2_1	464	469	PF00069	0.522
MOD_NEK2_1	5	10	PF00069	0.763
MOD_NEK2_1	620	625	PF00069	0.532
MOD_NEK2_1	767	772	PF00069	0.698
MOD_NEK2_2	143	148	PF00069	0.590
MOD_NEK2_2	149	154	PF00069	0.629
MOD_NEK2_2	187	192	PF00069	0.448
MOD_NEK2_2	200	205	PF00069	0.607
MOD_NEK2_2	459	464	PF00069	0.600
MOD_NEK2_2	469	474	PF00069	0.505
MOD_NEK2_2	703	708	PF00069	0.510
MOD_PIKK_1	523	529	PF00454	0.681
MOD_PK_1	81	87	PF00069	0.621
MOD_PKA_1	57	63	PF00069	0.552
MOD_PKA_2	409	415	PF00069	0.723
MOD_PKA_2	419	425	PF00069	0.524
MOD_PKA_2	760	766	PF00069	0.546
MOD_PKA_2	767	773	PF00069	0.569
MOD_PKA_2	89	95	PF00069	0.583
MOD_Plk_1	192	198	PF00069	0.400
MOD_Plk_1	459	465	PF00069	0.631
MOD_Plk_1	755	761	PF00069	0.452
MOD_Plk_1	775	781	PF00069	0.582
MOD_Plk_4	134	140	PF00069	0.576
MOD_Plk_4	187	193	PF00069	0.474
MOD_Plk_4	394	400	PF00069	0.704
MOD_Plk_4	502	508	PF00069	0.692
MOD_Plk_4	514	520	PF00069	0.531
MOD_Plk_4	585	591	PF00069	0.483
MOD_Plk_4	673	679	PF00069	0.736
MOD_Plk_4	703	709	PF00069	0.560
MOD_Plk_4	81	87	PF00069	0.518
MOD_ProDKin_1	229	235	PF00069	0.593
MOD_ProDKin_1	248	254	PF00069	0.772
MOD_ProDKin_1	255	261	PF00069	0.721
MOD_ProDKin_1	272	278	PF00069	0.551
MOD_ProDKin_1	315	321	PF00069	0.548
MOD_ProDKin_1	334	340	PF00069	0.564
MOD_ProDKin_1	521	527	PF00069	0.647
MOD_ProDKin_1	542	548	PF00069	0.639
MOD_ProDKin_1	652	658	PF00069	0.650
MOD_ProDKin_1	682	688	PF00069	0.603
MOD_ProDKin_1	714	720	PF00069	0.677
MOD_ProDKin_1	9	15	PF00069	0.483
MOD_SUMO_rev_2	321	331	PF00179	0.562
TRG_DiLeu_BaEn_1	172	177	PF01217	0.708
TRG_DiLeu_BaEn_1	320	325	PF01217	0.650
TRG_DiLeu_BaEn_4	320	326	PF01217	0.653
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.503
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.566
TRG_DiLeu_BaLyEn_6	440	445	PF01217	0.550
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.445
TRG_DiLeu_BaLyEn_6	648	653	PF01217	0.520
TRG_DiLeu_BaLyEn_6	738	743	PF01217	0.561
TRG_DiLeu_LyEn_5	320	325	PF01217	0.588
TRG_ENDOCYTIC_2	313	316	PF00928	0.562
TRG_ENDOCYTIC_2	451	454	PF00928	0.506
TRG_ENDOCYTIC_2	86	89	PF00928	0.523
TRG_ER_diArg_1	126	128	PF00400	0.485
TRG_ER_diArg_1	177	179	PF00400	0.591
TRG_ER_diArg_1	204	206	PF00400	0.562
TRG_ER_diArg_1	347	349	PF00400	0.559
TRG_ER_diArg_1	40	42	PF00400	0.626
TRG_ER_diArg_1	488	490	PF00400	0.537
TRG_ER_diArg_1	604	606	PF00400	0.692
TRG_ER_diArg_1	660	663	PF00400	0.634
TRG_ER_diArg_1	687	689	PF00400	0.697
TRG_ER_diArg_1	69	71	PF00400	0.650
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.663
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	741	746	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF83	Leptomonas seymouri	32%	87%
A0A3S7XAQ0	Leishmania donovani	84%	100%
A4HP32	Leishmania braziliensis	62%	100%
A4IDD9	Leishmania infantum	84%	100%
Q4Q1Q6	Leishmania major	83%	100%