Queuosine salvage protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2419), putative

Species:

Leishmania mexicana

UniProt:

E9AST9_LEIMU

TriTrypDb:

LmxM.36.1670

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AST9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AST9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0101030	tRNA-guanine transglycosylation	7	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.473
CLV_C14_Caspase3-7	50	54	PF00656	0.541
CLV_NRD_NRD_1	204	206	PF00675	0.429
CLV_PCSK_KEX2_1	204	206	PF00082	0.424
CLV_PCSK_KEX2_1	511	513	PF00082	0.415
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.415
CLV_PCSK_SKI1_1	372	376	PF00082	0.547
CLV_PCSK_SKI1_1	451	455	PF00082	0.492
CLV_PCSK_SKI1_1	466	470	PF00082	0.438
CLV_PCSK_SKI1_1	528	532	PF00082	0.503
CLV_Separin_Metazoa	277	281	PF03568	0.247
DOC_CKS1_1	480	485	PF01111	0.492
DOC_CYCLIN_RxL_1	472	482	PF00134	0.492
DOC_MAPK_gen_1	255	264	PF00069	0.441
DOC_MAPK_gen_1	431	440	PF00069	0.433
DOC_MAPK_gen_1	511	519	PF00069	0.492
DOC_MAPK_MEF2A_6	25	32	PF00069	0.527
DOC_MAPK_MEF2A_6	255	264	PF00069	0.410
DOC_MAPK_NFAT4_5	257	265	PF00069	0.424
DOC_PP1_RVXF_1	233	239	PF00149	0.477
DOC_PP1_RVXF_1	473	480	PF00149	0.393
DOC_PP2B_LxvP_1	249	252	PF13499	0.571
DOC_PP2B_LxvP_1	286	289	PF13499	0.463
DOC_PP2B_LxvP_1	375	378	PF13499	0.453
DOC_PP2B_LxvP_1	454	457	PF13499	0.438
DOC_PP2B_LxvP_1	87	90	PF13499	0.424
DOC_USP7_MATH_1	229	233	PF00917	0.546
DOC_USP7_MATH_1	365	369	PF00917	0.537
DOC_USP7_MATH_1	383	387	PF00917	0.482
DOC_USP7_MATH_1	407	411	PF00917	0.625
DOC_USP7_MATH_1	65	69	PF00917	0.681
DOC_WW_Pin1_4	244	249	PF00397	0.536
DOC_WW_Pin1_4	479	484	PF00397	0.475
LIG_14-3-3_CanoR_1	124	130	PF00244	0.556
LIG_14-3-3_CanoR_1	466	471	PF00244	0.438
LIG_14-3-3_CanoR_1	512	517	PF00244	0.390
LIG_APCC_ABBA_1	412	417	PF00400	0.201
LIG_APCC_ABBA_1	438	443	PF00400	0.492
LIG_BIR_II_1	1	5	PF00653	0.647
LIG_BRCT_BRCA1_1	408	412	PF00533	0.648
LIG_BRCT_BRCA1_1	91	95	PF00533	0.513
LIG_CSL_BTD_1	249	252	PF09270	0.490
LIG_CtBP_PxDLS_1	90	94	PF00389	0.393
LIG_FHA_1	125	131	PF00498	0.626
LIG_FHA_1	321	327	PF00498	0.408
LIG_FHA_1	39	45	PF00498	0.395
LIG_FHA_2	495	501	PF00498	0.429
LIG_Integrin_RGD_1	224	226	PF01839	0.594
LIG_LIR_Apic_2	208	213	PF02991	0.266
LIG_LIR_Apic_2	426	430	PF02991	0.357
LIG_LIR_Gen_1	166	176	PF02991	0.413
LIG_LIR_Gen_1	273	281	PF02991	0.399
LIG_LIR_Gen_1	314	320	PF02991	0.554
LIG_LIR_Nem_3	135	140	PF02991	0.503
LIG_LIR_Nem_3	166	171	PF02991	0.392
LIG_LIR_Nem_3	273	279	PF02991	0.385
LIG_LIR_Nem_3	314	318	PF02991	0.538
LIG_LIR_Nem_3	409	415	PF02991	0.277
LIG_PAM2_1	378	390	PF00658	0.665
LIG_Pex14_2	215	219	PF04695	0.505
LIG_PTAP_UEV_1	182	187	PF05743	0.422
LIG_PTAP_UEV_1	379	384	PF05743	0.710
LIG_SH2_CRK	427	431	PF00017	0.357
LIG_SH2_CRK	529	533	PF00017	0.438
LIG_SH2_PTP2	141	144	PF00017	0.280
LIG_SH2_SRC	427	430	PF00017	0.391
LIG_SH2_SRC	441	444	PF00017	0.391
LIG_SH2_STAP1	441	445	PF00017	0.438
LIG_SH2_STAP1	521	525	PF00017	0.438
LIG_SH2_STAT5	103	106	PF00017	0.350
LIG_SH2_STAT5	141	144	PF00017	0.305
LIG_SH2_STAT5	201	204	PF00017	0.454
LIG_SH2_STAT5	525	528	PF00017	0.401
LIG_SH2_STAT5	9	12	PF00017	0.585
LIG_SH3_3	141	147	PF00018	0.509
LIG_SH3_3	180	186	PF00018	0.430
LIG_SH3_3	377	383	PF00018	0.694
LIG_SH3_3	499	505	PF00018	0.477
LIG_SUMO_SIM_anti_2	256	263	PF11976	0.487
LIG_SUMO_SIM_par_1	106	111	PF11976	0.388
LIG_SUMO_SIM_par_1	259	266	PF11976	0.431
LIG_SUMO_SIM_par_1	85	92	PF11976	0.386
LIG_TRAF2_1	459	462	PF00917	0.438
LIG_TRAF2_1	498	501	PF00917	0.201
LIG_UBA3_1	476	485	PF00899	0.269
MOD_CDK_SPxK_1	479	485	PF00069	0.201
MOD_CK1_1	13	19	PF00069	0.485
MOD_CK1_1	148	154	PF00069	0.627
MOD_CK1_1	346	352	PF00069	0.457
MOD_CK1_1	367	373	PF00069	0.602
MOD_CK1_1	386	392	PF00069	0.442
MOD_CK1_1	4	10	PF00069	0.536
MOD_CK2_1	126	132	PF00069	0.559
MOD_CK2_1	271	277	PF00069	0.354
MOD_CK2_1	395	401	PF00069	0.560
MOD_CK2_1	456	462	PF00069	0.492
MOD_CK2_1	494	500	PF00069	0.429
MOD_CK2_1	85	91	PF00069	0.456
MOD_Cter_Amidation	509	512	PF01082	0.201
MOD_GlcNHglycan	147	150	PF01048	0.586
MOD_GlcNHglycan	15	18	PF01048	0.333
MOD_GlcNHglycan	160	163	PF01048	0.546
MOD_GlcNHglycan	172	175	PF01048	0.711
MOD_GlcNHglycan	195	198	PF01048	0.494
MOD_GlcNHglycan	231	234	PF01048	0.549
MOD_GlcNHglycan	367	370	PF01048	0.530
MOD_GlcNHglycan	380	383	PF01048	0.650
MOD_GlcNHglycan	397	400	PF01048	0.534
MOD_GlcNHglycan	458	461	PF01048	0.415
MOD_GlcNHglycan	67	70	PF01048	0.656
MOD_GSK3_1	1	8	PF00069	0.650
MOD_GSK3_1	122	129	PF00069	0.562
MOD_GSK3_1	166	173	PF00069	0.650
MOD_GSK3_1	364	371	PF00069	0.516
MOD_GSK3_1	395	402	PF00069	0.664
MOD_GSK3_1	75	82	PF00069	0.548
MOD_GSK3_1	85	92	PF00069	0.369
MOD_NEK2_1	1	6	PF00069	0.630
MOD_NEK2_1	193	198	PF00069	0.457
MOD_NEK2_1	260	265	PF00069	0.421
MOD_NEK2_1	33	38	PF00069	0.533
MOD_NEK2_1	343	348	PF00069	0.453
MOD_NEK2_1	494	499	PF00069	0.455
MOD_NEK2_1	539	544	PF00069	0.350
MOD_NEK2_1	79	84	PF00069	0.371
MOD_NEK2_2	407	412	PF00069	0.402
MOD_PIKK_1	343	349	PF00454	0.461
MOD_PK_1	512	518	PF00069	0.317
MOD_PKA_2	123	129	PF00069	0.638
MOD_PKA_2	193	199	PF00069	0.420
MOD_PKB_1	222	230	PF00069	0.485
MOD_Plk_1	407	413	PF00069	0.652
MOD_Plk_1	461	467	PF00069	0.393
MOD_Plk_2-3	401	407	PF00069	0.426
MOD_Plk_4	188	194	PF00069	0.552
MOD_Plk_4	271	277	PF00069	0.407
MOD_Plk_4	28	34	PF00069	0.518
MOD_Plk_4	301	307	PF00069	0.453
MOD_Plk_4	383	389	PF00069	0.625
MOD_Plk_4	40	46	PF00069	0.487
MOD_Plk_4	407	413	PF00069	0.384
MOD_Plk_4	466	472	PF00069	0.430
MOD_Plk_4	47	53	PF00069	0.266
MOD_Plk_4	512	518	PF00069	0.317
MOD_ProDKin_1	244	250	PF00069	0.535
MOD_ProDKin_1	479	485	PF00069	0.475
TRG_DiLeu_BaEn_1	256	261	PF01217	0.486
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.408
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.438
TRG_ENDOCYTIC_2	103	106	PF00928	0.350
TRG_ENDOCYTIC_2	141	144	PF00928	0.436
TRG_ENDOCYTIC_2	275	278	PF00928	0.450
TRG_ENDOCYTIC_2	312	315	PF00928	0.395
TRG_ER_diArg_1	203	205	PF00400	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P722	Leptomonas seymouri	51%	100%
A0A1X0P849	Trypanosomatidae	34%	100%
A0A3Q8INL6	Leishmania donovani	89%	100%
A4HP31	Leishmania braziliensis	74%	100%
A4IDD8	Leishmania infantum	89%	100%
D0A314	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4Q1Q7	Leishmania major	88%	100%