Putative universal minicircle sequence binding protein (UMSBP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

universal minicircle sequence binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9AST6_LEIMU

TriTrypDb:

LmxM.36.1640

Length:

298

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AST6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AST6

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034250	positive regulation of amide metabolic process	6	1
GO:0045727	positive regulation of translation	7	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051247	positive regulation of protein metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1
GO:2000765	regulation of cytoplasmic translation	7	1
GO:2000767	positive regulation of cytoplasmic translation	8	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0005488	binding	1	9
GO:0008270	zinc ion binding	6	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003723	RNA binding	4	1
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0045182	translation regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	195	197	PF00675	0.443
CLV_PCSK_KEX2_1	126	128	PF00082	0.682
CLV_PCSK_KEX2_1	8	10	PF00082	0.685
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.682
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.685
DOC_USP7_MATH_1	240	244	PF00917	0.691
DOC_USP7_MATH_2	59	65	PF00917	0.623
LIG_BIR_II_1	1	5	PF00653	0.709
LIG_BRCT_BRCA1_1	42	46	PF00533	0.174
LIG_FHA_1	2	8	PF00498	0.698
LIG_SH3_3	4	10	PF00018	0.692
MOD_CK1_1	213	219	PF00069	0.595
MOD_CK1_1	252	258	PF00069	0.174
MOD_GlcNHglycan	162	165	PF01048	0.641
MOD_GlcNHglycan	190	193	PF01048	0.569
MOD_GlcNHglycan	203	206	PF01048	0.245
MOD_GlcNHglycan	212	215	PF01048	0.594
MOD_GlcNHglycan	218	221	PF01048	0.315
MOD_GlcNHglycan	270	273	PF01048	0.400
MOD_GlcNHglycan	276	279	PF01048	0.358
MOD_GlcNHglycan	63	66	PF01048	0.571
MOD_GlcNHglycan	87	90	PF01048	0.609
MOD_GSK3_1	112	119	PF00069	0.607
MOD_GSK3_1	201	208	PF00069	0.334
MOD_GSK3_1	210	217	PF00069	0.514
MOD_GSK3_1	240	247	PF00069	0.683
MOD_GSK3_1	268	275	PF00069	0.390
MOD_GSK3_1	9	16	PF00069	0.649
MOD_NEK2_2	166	171	PF00069	0.458
MOD_NEK2_2	220	225	PF00069	0.380
MOD_NEK2_2	68	73	PF00069	0.474
MOD_PIKK_1	112	118	PF00454	0.617
MOD_PKA_2	40	46	PF00069	0.640
MOD_PKB_1	9	17	PF00069	0.638
MOD_Plk_1	166	172	PF00069	0.458
MOD_Plk_1	220	226	PF00069	0.380
MOD_Plk_1	252	258	PF00069	0.355
MOD_SUMO_rev_2	2	10	PF00179	0.695
TRG_NLS_MonoCore_2	7	12	PF00514	0.679
TRG_NLS_MonoExtC_3	7	13	PF00514	0.674

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P715	Leptomonas seymouri	52%	100%
A0A0S4JI86	Bodo saltans	29%	100%
A0A1X0P815	Trypanosomatidae	50%	100%
A0A3Q8IQS7	Leishmania donovani	93%	100%
A4HP28	Leishmania braziliensis	86%	100%
A4IDD5	Leishmania infantum	93%	100%
D0A309	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
O65639	Arabidopsis thaliana	41%	100%
Q04832	Leishmania major	94%	100%
Q4Q1R0	Leishmania major	93%	100%
Q94C69	Arabidopsis thaliana	38%	99%