Universal minicircle sequence binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

universal minicircle sequence binding protein

Species:

Leishmania mexicana

UniProt:

E9AST3_LEIMU

TriTrypDb:

LmxM.36.1620

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AST3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AST3

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	3
GO:0009889	regulation of biosynthetic process	4	3
GO:0009891	positive regulation of biosynthetic process	5	3
GO:0009893	positive regulation of metabolic process	4	3
GO:0010468	regulation of gene expression	5	3
GO:0010556	regulation of macromolecule biosynthetic process	5	3
GO:0010557	positive regulation of macromolecule biosynthetic process	6	3
GO:0010604	positive regulation of macromolecule metabolic process	5	3
GO:0010608	post-transcriptional regulation of gene expression	6	3
GO:0010628	positive regulation of gene expression	6	3
GO:0019222	regulation of metabolic process	3	3
GO:0031323	regulation of cellular metabolic process	4	3
GO:0031325	positive regulation of cellular metabolic process	5	3
GO:0031326	regulation of cellular biosynthetic process	5	3
GO:0031328	positive regulation of cellular biosynthetic process	6	3
GO:0034248	regulation of amide metabolic process	5	3
GO:0034250	positive regulation of amide metabolic process	6	3
GO:0045727	positive regulation of translation	7	3
GO:0048518	positive regulation of biological process	3	3
GO:0048522	positive regulation of cellular process	4	3
GO:0050789	regulation of biological process	2	3
GO:0050794	regulation of cellular process	3	3
GO:0051171	regulation of nitrogen compound metabolic process	4	3
GO:0051173	positive regulation of nitrogen compound metabolic process	5	3
GO:0051246	regulation of protein metabolic process	5	3
GO:0051247	positive regulation of protein metabolic process	6	3
GO:0060255	regulation of macromolecule metabolic process	4	3
GO:0065007	biological regulation	1	3
GO:0080090	regulation of primary metabolic process	4	3
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	3
GO:2000765	regulation of cytoplasmic translation	7	3
GO:2000767	positive regulation of cytoplasmic translation	8	3

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	16
GO:0005488	binding	1	16
GO:0008270	zinc ion binding	6	16
GO:0043167	ion binding	2	16
GO:0043169	cation binding	3	16
GO:0046872	metal ion binding	4	16
GO:0046914	transition metal ion binding	5	16
GO:0097159	organic cyclic compound binding	2	16
GO:1901363	heterocyclic compound binding	2	16
GO:0003723	RNA binding	4	3
GO:0003727	single-stranded RNA binding	5	3
GO:0003729	mRNA binding	5	3
GO:0045182	translation regulator activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.490
CLV_NRD_NRD_1	159	161	PF00675	0.537
CLV_NRD_NRD_1	44	46	PF00675	0.431
CLV_PCSK_KEX2_1	44	46	PF00082	0.478
CLV_PCSK_PC7_1	40	46	PF00082	0.416
CLV_PCSK_SKI1_1	26	30	PF00082	0.380
DEG_APCC_DBOX_1	44	52	PF00400	0.412
DEG_Nend_UBRbox_4	1	3	PF02207	0.406
DOC_CDC14_PxL_1	31	39	PF14671	0.388
DOC_CYCLIN_RxL_1	23	32	PF00134	0.382
DOC_MAPK_MEF2A_6	61	68	PF00069	0.414
DOC_PP2B_LxvP_1	33	36	PF13499	0.385
DOC_PP4_FxxP_1	60	63	PF00568	0.416
DOC_USP7_MATH_1	91	95	PF00917	0.417
DOC_WW_Pin1_4	16	21	PF00397	0.408
DOC_WW_Pin1_4	59	64	PF00397	0.417
LIG_14-3-3_CanoR_1	26	32	PF00244	0.385
LIG_14-3-3_CanoR_1	45	53	PF00244	0.416
LIG_14-3-3_CanoR_1	54	63	PF00244	0.427
LIG_BRCT_BRCA1_1	48	52	PF00533	0.412
LIG_BRCT_BRCA1_1	56	60	PF00533	0.412
LIG_FHA_1	121	127	PF00498	0.296
LIG_FHA_1	169	175	PF00498	0.355
LIG_LIR_Apic_2	57	63	PF02991	0.419
LIG_LIR_Gen_1	19	29	PF02991	0.392
LIG_LIR_Nem_3	19	24	PF02991	0.392
LIG_LIR_Nem_3	30	34	PF02991	0.381
LIG_LYPXL_S_1	33	37	PF13949	0.387
LIG_LYPXL_yS_3	34	37	PF13949	0.387
LIG_NRBOX	24	30	PF00104	0.392
LIG_TRFH_1	31	35	PF08558	0.386
LIG_UBA3_1	67	75	PF00899	0.208
LIG_WRC_WIRS_1	28	33	PF05994	0.394
MOD_CK1_1	59	65	PF00069	0.428
MOD_CK1_1	69	75	PF00069	0.200
MOD_GlcNHglycan	5	8	PF01048	0.389
MOD_GlcNHglycan	68	71	PF01048	0.604
MOD_GSK3_1	120	127	PF00069	0.327
MOD_GSK3_1	146	153	PF00069	0.296
MOD_GSK3_1	168	175	PF00069	0.448
MOD_GSK3_1	62	69	PF00069	0.633
MOD_GSK3_1	98	105	PF00069	0.341
MOD_NEK2_1	29	34	PF00069	0.412
MOD_NEK2_1	56	61	PF00069	0.671
MOD_NEK2_1	82	87	PF00069	0.386
MOD_NEK2_2	91	96	PF00069	0.468
MOD_PIKK_1	46	52	PF00454	0.410
MOD_Plk_4	62	68	PF00069	0.420
MOD_ProDKin_1	16	22	PF00069	0.407
MOD_ProDKin_1	59	65	PF00069	0.414
MOD_SUMO_rev_2	105	114	PF00179	0.300
MOD_SUMO_rev_2	127	136	PF00179	0.355
MOD_SUMO_rev_2	153	162	PF00179	0.355
TRG_ENDOCYTIC_2	34	37	PF00928	0.387
TRG_ER_diArg_1	43	45	PF00400	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P815	Trypanosomatidae	48%	89%
A0A1X0P8V4	Trypanosomatidae	34%	94%
A0A3Q8IK17	Leishmania donovani	81%	100%
A0A3Q8IQS7	Leishmania donovani	43%	67%
A0A3R7K9Q9	Trypanosoma rangeli	35%	95%
A0A3S5H821	Leishmania donovani	35%	100%
A4HP24	Leishmania braziliensis	39%	100%
A4IDD4	Leishmania infantum	35%	100%
A4IDD5	Leishmania infantum	43%	67%
D0A309	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	85%
D0A311	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AST5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
O42395	Gallus gallus	34%	100%
P36627	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
P53996	Mus musculus	32%	100%
P62633	Homo sapiens	32%	100%
P62634	Rattus norvegicus	32%	100%
Q04832	Leishmania major	42%	67%
Q3T0Q6	Bos taurus	34%	100%
Q4Q1R0	Leishmania major	36%	100%
Q4Q1R1	Leishmania major	41%	100%
Q4Q1R3	Leishmania major	82%	100%
Q5R5R5	Pongo abelii	32%	100%
Q8T8R1	Drosophila melanogaster	35%	100%
V5BJZ6	Trypanosoma cruzi	35%	95%
V5BU64	Trypanosoma cruzi	49%	94%
V5BU71	Trypanosoma cruzi	46%	100%