Proteasome subunit alpha type

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome subunit alpha type-1, putative

Species:

Leishmania mexicana

UniProt:

E9AST1_LEIMU

TriTrypDb:

LmxM.36.1600

Length:

264

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005737	cytoplasm	2	12
GO:0019773	proteasome core complex, alpha-subunit complex	2	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0005654	nucleoplasm	2	1
GO:0005839	proteasome core complex	3	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9AST1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AST1

PDB structure(s): 6qm7_F , 6qm7_T , 6qm8_F , 6qm8_T

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	12
GO:0010498	proteasomal protein catabolic process	5	1
GO:0030163	protein catabolic process	4	1
GO:1901565	organonitrogen compound catabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016787	hydrolase activity	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	231	233	PF00675	0.421
CLV_PCSK_KEX2_1	126	128	PF00082	0.294
CLV_PCSK_KEX2_1	231	233	PF00082	0.492
CLV_PCSK_KEX2_1	50	52	PF00082	0.269
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.275
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.269
DEG_Nend_Nbox_1	1	3	PF02207	0.520
DOC_MAPK_gen_1	126	133	PF00069	0.506
DOC_MAPK_gen_1	39	46	PF00069	0.489
DOC_MAPK_MEF2A_6	126	135	PF00069	0.500
DOC_PP1_RVXF_1	117	124	PF00149	0.490
DOC_USP7_MATH_1	195	199	PF00917	0.493
DOC_WW_Pin1_4	11	16	PF00397	0.466
DOC_WW_Pin1_4	217	222	PF00397	0.426
DOC_WW_Pin1_4	49	54	PF00397	0.489
LIG_14-3-3_CanoR_1	87	96	PF00244	0.475
LIG_14-3-3_CanoR_1	97	106	PF00244	0.475
LIG_APCC_ABBA_1	222	227	PF00400	0.499
LIG_Clathr_ClatBox_1	19	23	PF01394	0.475
LIG_CSL_BTD_1	12	15	PF09270	0.464
LIG_EH1_1	128	136	PF00400	0.464
LIG_FHA_1	14	20	PF00498	0.475
LIG_FHA_1	210	216	PF00498	0.503
LIG_FHA_1	33	39	PF00498	0.520
LIG_FHA_2	169	175	PF00498	0.470
LIG_FHA_2	182	188	PF00498	0.609
LIG_FHA_2	221	227	PF00498	0.506
LIG_LIR_Gen_1	174	185	PF02991	0.489
LIG_LIR_Gen_1	219	230	PF02991	0.413
LIG_LIR_Gen_1	42	49	PF02991	0.467
LIG_LIR_LC3C_4	186	190	PF02991	0.389
LIG_LIR_Nem_3	174	180	PF02991	0.464
LIG_LIR_Nem_3	219	225	PF02991	0.393
LIG_LIR_Nem_3	42	46	PF02991	0.467
LIG_SH2_CRK	146	150	PF00017	0.507
LIG_SH2_GRB2like	24	27	PF00017	0.473
LIG_SH2_PTP2	43	46	PF00017	0.415
LIG_SH2_STAP1	155	159	PF00017	0.531
LIG_SH2_STAP1	24	28	PF00017	0.391
LIG_SH2_STAP1	6	10	PF00017	0.521
LIG_SH2_STAT3	138	141	PF00017	0.515
LIG_SH2_STAT5	172	175	PF00017	0.464
LIG_SH2_STAT5	233	236	PF00017	0.427
LIG_SH2_STAT5	43	46	PF00017	0.415
LIG_SUMO_SIM_anti_2	211	217	PF11976	0.464
LIG_SUMO_SIM_par_1	257	264	PF11976	0.676
LIG_TRAF2_1	59	62	PF00917	0.464
MOD_CDK_SPxxK_3	11	18	PF00069	0.464
MOD_CK1_1	166	172	PF00069	0.567
MOD_CK1_1	198	204	PF00069	0.567
MOD_CK1_1	8	14	PF00069	0.544
MOD_CK2_1	168	174	PF00069	0.475
MOD_CK2_1	181	187	PF00069	0.505
MOD_CK2_1	220	226	PF00069	0.495
MOD_CK2_1	56	62	PF00069	0.464
MOD_Cter_Amidation	124	127	PF01082	0.275
MOD_GlcNHglycan	150	153	PF01048	0.275
MOD_GlcNHglycan	197	200	PF01048	0.308
MOD_GlcNHglycan	226	231	PF01048	0.599
MOD_GlcNHglycan	32	35	PF01048	0.277
MOD_GlcNHglycan	75	78	PF01048	0.340
MOD_GSK3_1	5	12	PF00069	0.300
MOD_N-GLC_1	209	214	PF02516	0.264
MOD_N-GLC_1	30	35	PF02516	0.275
MOD_NEK2_1	145	150	PF00069	0.470
MOD_NEK2_1	73	78	PF00069	0.507
MOD_PIKK_1	163	169	PF00454	0.474
MOD_Plk_1	181	187	PF00069	0.503
MOD_Plk_1	209	215	PF00069	0.464
MOD_Plk_1	55	61	PF00069	0.535
MOD_Plk_1	8	14	PF00069	0.485
MOD_Plk_2-3	56	62	PF00069	0.507
MOD_ProDKin_1	11	17	PF00069	0.466
MOD_ProDKin_1	217	223	PF00069	0.427
MOD_ProDKin_1	49	55	PF00069	0.489
MOD_SUMO_for_1	2	5	PF00179	0.608
MOD_SUMO_rev_2	151	160	PF00179	0.465
MOD_SUMO_rev_2	235	239	PF00179	0.345
TRG_ENDOCYTIC_2	146	149	PF00928	0.507
TRG_ENDOCYTIC_2	43	46	PF00928	0.415
TRG_ENDOCYTIC_2	96	99	PF00928	0.475
TRG_ER_diArg_1	231	233	PF00400	0.492
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.324
TRG_Pf-PMV_PEXEL_1	87	92	PF00026	0.289

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I1	Leptomonas seymouri	36%	100%
A0A0N0P4E6	Leptomonas seymouri	34%	100%
A0A0N1I173	Leptomonas seymouri	39%	100%
A0A0N1I278	Leptomonas seymouri	38%	100%
A0A0N1I2E0	Leptomonas seymouri	30%	100%
A0A0N1ILS9	Leptomonas seymouri	89%	100%
A0A0N1PBJ3	Leptomonas seymouri	32%	93%
A0A0S4INC9	Bodo saltans	34%	100%
A0A0S4IQU5	Bodo saltans	35%	99%
A0A0S4IU58	Bodo saltans	39%	100%
A0A0S4IWG0	Bodo saltans	69%	99%
A0A0S4J6W0	Bodo saltans	30%	100%
A0A0S4JLA2	Bodo saltans	30%	94%
A0A1X0NHF3	Trypanosomatidae	40%	100%
A0A1X0NJ65	Trypanosomatidae	39%	100%
A0A1X0NMF1	Trypanosomatidae	32%	100%
A0A1X0NNS5	Trypanosomatidae	33%	92%
A0A1X0NVU4	Trypanosomatidae	36%	100%
A0A1X0P5Y6	Trypanosomatidae	27%	100%
A0A1X0P853	Trypanosomatidae	77%	100%
A0A3Q8IB07	Leishmania donovani	40%	100%
A0A3Q8IC41	Leishmania donovani	37%	100%
A0A3Q8IFZ3	Leishmania donovani	96%	100%
A0A3R7KUN3	Trypanosoma rangeli	32%	92%
A0A3R7LAV3	Trypanosoma rangeli	35%	100%
A0A3R7MIT1	Trypanosoma rangeli	76%	100%
A0A3S5H6I0	Leishmania donovani	38%	100%
A0A3S5H7H2	Leishmania donovani	33%	100%
A0A3S5IS75	Trypanosoma rangeli	33%	100%
A0A3S7WST4	Leishmania donovani	31%	93%
A0A422N8R3	Trypanosoma rangeli	38%	100%
A0A422N8U2	Trypanosoma rangeli	41%	100%
A0A422P146	Trypanosoma rangeli	28%	100%
A0A6L0XSJ0	Leishmania infantum	30%	100%
A0RXV1	Cenarchaeum symbiosum (strain A)	28%	100%
A1RSJ8	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	31%	100%
A1RWY6	Thermofilum pendens (strain DSM 2475 / Hrk 5)	31%	100%
A2BN24	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	24%	100%
A2BN27	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	29%	100%
A2SS78	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	29%	100%
A2Y9X7	Oryza sativa subsp. indica	37%	100%
A2YVR7	Oryza sativa subsp. indica	35%	100%
A2YXU2	Oryza sativa subsp. indica	40%	100%
A2Z3I9	Oryza sativa subsp. indica	38%	100%
A3CW55	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	37%	100%
A3DN27	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	31%	100%
A3MS44	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	29%	100%
A3MXQ6	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	27%	100%
A4FZT6	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	41%	100%
A4H7J0	Leishmania braziliensis	32%	100%
A4H9T4	Leishmania braziliensis	37%	100%
A4HC34	Leishmania braziliensis	40%	100%
A4HFD7	Leishmania braziliensis	32%	100%
A4HLC5	Leishmania braziliensis	38%	100%
A4HNE9	Leishmania braziliensis	30%	100%
A4HP20	Leishmania braziliensis	91%	100%
A4HUT6	Leishmania infantum	38%	100%
A4HVX3	Leishmania infantum	31%	93%
A4HZI9	Leishmania infantum	37%	100%
A4I357	Leishmania infantum	33%	100%
A4IDD0	Leishmania infantum	97%	100%
A4WMZ0	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	30%	100%
A4YCU9	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	35%	100%
A5UJS2	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	37%	100%
A6URN9	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	40%	100%
A6UT20	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	25%	100%
A6VIP0	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	41%	100%
A7I9C7	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	39%	100%
A8AA46	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	27%	100%
A8AB58	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	30%	100%
A9A2U7	Nitrosopumilus maritimus (strain SCM1)	26%	100%
A9A846	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	41%	100%
B0R2T2	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	39%	100%
B1L6S7	Korarchaeum cryptofilum (strain OPF8)	28%	100%
B5IEE5	Aciduliprofundum boonei (strain DSM 19572 / T469)	25%	100%
B6YSH9	Thermococcus onnurineus (strain NA1)	38%	100%
B8D673	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	28%	100%
B8D683	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	31%	100%
B8GEZ3	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	39%	100%
B8GG66	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	25%	100%
C3MQ43	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	36%	100%
C3MVG1	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	36%	100%
C3N5R0	Sulfolobus islandicus (strain M.16.27)	36%	100%
C3NEC6	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	36%	100%
C3NHC6	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	36%	100%
C4KHD9	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	36%	100%
C5A2C2	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	41%	100%
C5A2D5	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	23%	100%
C5A7L1	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	32%	100%
C6A2V9	Thermococcus sibiricus (strain DSM 12597 / MM 739)	29%	100%
C6A3R1	Thermococcus sibiricus (strain DSM 12597 / MM 739)	25%	100%
C6A459	Thermococcus sibiricus (strain DSM 12597 / MM 739)	38%	100%
C7P6N4	Methanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86)	28%	100%
C9ZKV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZT49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	92%
C9ZYH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A0Z1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A0Z7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A305	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	99%
D0A7M5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D2RGT4	Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)	27%	100%
D3E0A3	Methanobrevibacter ruminantium (strain ATCC 35063 / DSM 1093 / JCM 13430 / OCM 146 / M1)	27%	100%
D3RX66	Ferroglobus placidus (strain DSM 10642 / AEDII12DO)	28%	100%
D3S8M7	Methanocaldococcus sp. (strain FS406-22)	27%	100%
D4GYZ1	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	29%	100%
E9ACZ6	Leishmania major	33%	100%
E9AFW0	Leishmania major	30%	100%
E9ANH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9APM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AVG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AVH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AYS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B713	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
F4JJE5	Arabidopsis thaliana	30%	100%
O13268	Gallus gallus	38%	100%
O14250	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	97%
O14818	Homo sapiens	38%	100%
O16811	Drosophila virilis	35%	100%
O16812	Drosophila virilis	31%	100%
O17586	Caenorhabditis elegans	29%	100%
O23708	Arabidopsis thaliana	36%	100%
O23712	Arabidopsis thaliana	44%	95%
O23715	Arabidopsis thaliana	36%	100%
O24030	Solanum lycopersicum	39%	100%
O24362	Spinacia oleracea	37%	100%
O24616	Arabidopsis thaliana	37%	100%
O24733	Thermococcus sp. (strain JCM 11816 / KS-1)	42%	100%
O26782	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	37%	100%
O27270	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	28%	100%
O29760	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	42%	100%
O42265	Gallus gallus	46%	100%
O44156	Caenorhabditis elegans	48%	100%
O48551	Glycine max	33%	100%
O50110	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	28%	100%
O57983	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	23%	100%
O59219	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	39%	100%
O59770	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
O73672	Carassius auratus	37%	100%
O81146	Arabidopsis thaliana	34%	100%
O81147	Arabidopsis thaliana	35%	100%
O81148	Arabidopsis thaliana	39%	100%
O81149	Arabidopsis thaliana	40%	100%
O82530	Petunia hybrida	37%	100%
O94517	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
O94579	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
O96788	Trypanosoma brucei rhodesiense	77%	99%
P0C8Y9	Oryza sativa subsp. indica	37%	100%
P0DKK3	Oryza sativa subsp. japonica	37%	100%
P0DKK4	Oryza sativa subsp. japonica	37%	100%
P12881	Drosophila melanogaster	48%	95%
P17220	Rattus norvegicus	35%	100%
P18053	Drosophila melanogaster	31%	100%
P18420	Rattus norvegicus	46%	100%
P21242	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	92%
P21243	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
P21670	Rattus norvegicus	34%	100%
P22769	Drosophila melanogaster	34%	100%
P23638	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
P23639	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
P23724	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P24495	Xenopus laevis	37%	100%
P25156	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	38%	100%
P25786	Homo sapiens	46%	100%
P25787	Homo sapiens	35%	100%
P25789	Homo sapiens	34%	100%
P28061	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	28%	100%
P28066	Homo sapiens	36%	100%
P30186	Arabidopsis thaliana	39%	100%
P32379	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
P34064	Rattus norvegicus	35%	100%
P34066	Arabidopsis thaliana	45%	95%
P34119	Dictyostelium discoideum	38%	100%
P34120	Dictyostelium discoideum	36%	100%
P40301	Drosophila melanogaster	36%	100%
P40302	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	100%
P40303	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
P48004	Rattus norvegicus	38%	100%
P49722	Mus musculus	35%	100%
P52427	Spinacia oleracea	39%	100%
P52428	Oryza sativa subsp. japonica	48%	98%
P57697	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	39%	100%
P60900	Homo sapiens	33%	100%
P60901	Rattus norvegicus	33%	100%
P90513	Acanthamoeba castellanii	34%	100%
P92188	Trypanosoma cruzi	74%	100%
Q09583	Caenorhabditis elegans	31%	100%
Q09682	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q0J006	Oryza sativa subsp. japonica	38%	100%
Q0W2D6	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	25%	100%
Q10329	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
Q10KF0	Oryza sativa subsp. japonica	35%	100%
Q18K08	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	36%	100%
Q24178	Drosophila melanogaster	31%	100%
Q27488	Caenorhabditis elegans	38%	100%
Q27562	Dictyostelium discoideum	53%	100%
Q27563	Dictyostelium discoideum	36%	100%
Q27575	Drosophila melanogaster	33%	100%
Q2NI68	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	28%	100%
Q2YDE4	Bos taurus	33%	100%
Q3IPJ1	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	35%	100%
Q3T0X5	Bos taurus	45%	100%
Q3T0Y5	Bos taurus	35%	100%
Q3ZBG0	Bos taurus	38%	100%
Q3ZCK9	Bos taurus	34%	100%
Q42134	Arabidopsis thaliana	40%	100%
Q469M6	Methanosarcina barkeri (strain Fusaro / DSM 804)	37%	100%
Q46G14	Methanosarcina barkeri (strain Fusaro / DSM 804)	27%	100%
Q4JB24	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	36%	100%
Q4Q1R5	Leishmania major	95%	100%
Q4QC00	Leishmania major	37%	100%
Q4QC13	Leishmania major	40%	99%
Q4QFV4	Leishmania major	31%	100%
Q4QH56	Leishmania major	36%	100%
Q4R3H2	Macaca fascicularis	45%	100%
Q4R7D9	Macaca fascicularis	36%	100%
Q4R932	Macaca fascicularis	33%	100%
Q54DM7	Dictyostelium discoideum	36%	100%
Q54XM7	Dictyostelium discoideum	31%	100%
Q55G04	Dictyostelium discoideum	37%	100%
Q58634	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	29%	100%
Q59565	Methanosarcina thermophila	37%	100%
Q5E987	Bos taurus	36%	100%
Q5JDJ9	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	31%	100%
Q5JHL8	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	25%	100%
Q5JIU9	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	42%	100%
Q5RDH8	Pongo abelii	38%	100%
Q5REN2	Pongo abelii	46%	100%
Q5V1D4	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	39%	100%
Q5V1D5	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	24%	100%
Q5V2X8	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	38%	100%
Q5VRG3	Oryza sativa subsp. japonica	37%	100%
Q60177	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	41%	100%
Q6L0W3	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	37%	100%
Q6L181	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	28%	100%
Q6M0L9	Methanococcus maripaludis (strain S2 / LL)	41%	100%
Q6YT00	Oryza sativa subsp. japonica	40%	100%
Q8L4A7	Arabidopsis thaliana	36%	100%
Q8PTU1	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	41%	100%
Q8PZ04	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	28%	100%
Q8SQP9	Encephalitozoon cuniculi (strain GB-M1)	25%	100%
Q8SQS5	Encephalitozoon cuniculi (strain GB-M1)	30%	100%
Q8SRU3	Encephalitozoon cuniculi (strain GB-M1)	28%	100%
Q8TAA3	Homo sapiens	35%	100%
Q8TPX5	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	41%	100%
Q8TW10	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	26%	100%
Q8TYB7	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	41%	100%
Q8U0L6	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	39%	100%
Q8U4C9	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	25%	100%
Q8X077	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	38%	100%
Q8ZST5	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	31%	100%
Q8ZVM1	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	45%	100%
Q8ZYF2	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	29%	100%
Q94561	Entamoeba histolytica	40%	100%
Q95005	Caenorhabditis elegans	39%	100%
Q95008	Caenorhabditis elegans	33%	100%
Q95083	Drosophila melanogaster	35%	100%
Q975D1	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	29%	100%
Q975G5	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	36%	100%
Q97AZ7	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	28%	100%
Q97BZ8	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	38%	100%
Q9CWH6	Mus musculus	38%	100%
Q9GNZ8	Leishmania infantum	40%	100%
Q9GU37	Trypanosoma brucei brucei	28%	99%
Q9LSU0	Oryza sativa subsp. japonica	35%	100%
Q9LSU1	Oryza sativa subsp. japonica	40%	100%
Q9LSU3	Oryza sativa subsp. japonica	32%	100%
Q9M4T8	Glycine max	40%	100%
Q9N599	Caenorhabditis elegans	34%	100%
Q9NDA2	Trypanosoma brucei brucei	36%	100%
Q9P992	Methanosarcina thermophila	27%	100%
Q9P996	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	27%	100%
Q9PTW9	Carassius auratus	38%	100%
Q9PVQ1	Xenopus laevis	38%	100%
Q9PVY6	Xenopus laevis	38%	100%
Q9QUM9	Mus musculus	33%	100%
Q9R1P0	Mus musculus	34%	100%
Q9R1P4	Mus musculus	47%	100%
Q9SXU1	Cicer arietinum	39%	100%
Q9U793	Trypanosoma brucei brucei	39%	100%
Q9UAB4	Leishmania donovani	30%	100%
Q9UT97	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
Q9UXC6	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	35%	100%
Q9V0N9	Pyrococcus abyssi (strain GE5 / Orsay)	27%	100%
Q9V122	Pyrococcus abyssi (strain GE5 / Orsay)	39%	100%
Q9V2V5	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	33%	100%
Q9V2V6	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	38%	100%
Q9V5C6	Drosophila melanogaster	35%	100%
Q9VA12	Drosophila melanogaster	32%	100%
Q9XG77	Nicotiana tabacum	31%	100%
Q9XZG5	Trypanosoma brucei brucei	37%	100%
Q9XZJ4	Drosophila melanogaster	29%	100%
Q9YC01	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	35%	100%
Q9YER0	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	31%	100%
Q9Z2U0	Mus musculus	38%	100%
Q9Z2U1	Mus musculus	36%	100%
V5AWB3	Trypanosoma cruzi	34%	100%
V5B1X4	Trypanosoma cruzi	37%	100%
V5B4E8	Trypanosoma cruzi	74%	100%
V5BLX4	Trypanosoma cruzi	40%	100%
V5BW71	Trypanosoma cruzi	36%	84%