Proteasome subunit alpha type

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome subunit alpha type-1, putative

Species:

Leishmania mexicana

UniProt:

E9AST1_LEIMU

TriTrypDb:

LmxM.36.1600

Length:

264

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	12
GO:0005839	proteasome core complex	3	1
GO:0019773	proteasome core complex, alpha-subunit complex	2	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11

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Expansion

Sequence features

E9AST1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AST1

PDB structure(s): 6qm7_F , 6qm7_T , 6qm8_F , 6qm8_T

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016787	hydrolase activity	2	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	231	233	PF00675	0.421
CLV_PCSK_KEX2_1	126	128	PF00082	0.294
CLV_PCSK_KEX2_1	231	233	PF00082	0.492
CLV_PCSK_KEX2_1	50	52	PF00082	0.269
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.275
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.269
DEG_Nend_Nbox_1	1	3	PF02207	0.520
DOC_MAPK_gen_1	126	133	PF00069	0.506
DOC_MAPK_gen_1	39	46	PF00069	0.489
DOC_MAPK_MEF2A_6	126	135	PF00069	0.500

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I1	Leptomonas seymouri	36%	100%
A0A0N0P4E6	Leptomonas seymouri	34%	100%
A0A0N1I173	Leptomonas seymouri	39%	100%
A0A0N1I278	Leptomonas seymouri	38%	100%
A0A0N1I2E0	Leptomonas seymouri	30%	100%
A0A0N1ILS9	Leptomonas seymouri	89%	100%
A0A0N1PBJ3	Leptomonas seymouri	32%	93%
A0A0S4INC9	Bodo saltans	34%	100%
A0A0S4IQU5	Bodo saltans	35%	99%
A0A0S4IU58	Bodo saltans	39%	100%

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