SCD domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

STAG domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ASS9_LEIMU

TriTrypDb:

LmxM.36.1590

Length:

1209

Annotations

LeishMANIAdb annotations

Cohesin-like helical repat protein. Almost certainly non-TM

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000785	chromatin	2	1
GO:0005634	nucleus	5	1
GO:0008278	cohesin complex	3	1
GO:0016020	membrane	2	3
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0044815	DNA packaging complex	2	1

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Expansion

Sequence features

E9ASS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASS9

Function

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Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0007062	sister chromatid cohesion	3	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0051276	chromosome organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

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Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1191	1195	PF00656	0.490
CLV_C14_Caspase3-7	22	26	PF00656	0.714
CLV_MEL_PAP_1	836	842	PF00089	0.540
CLV_NRD_NRD_1	1062	1064	PF00675	0.516
CLV_NRD_NRD_1	1175	1177	PF00675	0.673
CLV_NRD_NRD_1	186	188	PF00675	0.299
CLV_NRD_NRD_1	269	271	PF00675	0.539
CLV_NRD_NRD_1	307	309	PF00675	0.572
CLV_NRD_NRD_1	538	540	PF00675	0.637
CLV_NRD_NRD_1	617	619	PF00675	0.496

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P719	Leptomonas seymouri	67%	98%
A0A0S4ISV4	Bodo saltans	37%	100%
A0A1X0P8R9	Trypanosomatidae	36%	100%
A0A3S7XAM5	Leishmania donovani	93%	100%
A0A422NCR0	Trypanosoma rangeli	39%	100%
A4HP18	Leishmania braziliensis	84%	100%
A4IDC8	Leishmania infantum	93%	100%
D0A303	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
O35638	Mus musculus	21%	98%
Q4Q1R7	Leishmania major	94%	100%

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